1H-NMR metabonomic view on schizophrenia
Аутори
Avramović, NatašaSimić, Katarina
Miladinović, Zoran
Todorović, Nina
Trifunović, Snežana
Gavrilović, Aleksandra
Jovanović, Silvana
Gođevac, Dejan
Vujisić, Ljubodrag
Tešević, Vele
Tasić, Ljubica
Mandić, Boris
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Schizophrenia (SCZ) is a brain disease leading to significant functional impairments and premature death, and it affects 20 million people worldwide. Due to the complexity of this disease including different genetic and environmental factors, there is a lack in understanding pathophysiology and diagnosis of schizophrenia. In order to overcome existing gaps, the establishment of a universal set of SCZ biomarkers has a crucial role. Metabonomic study of serum samples of Serbian patients with schizophrenia (51) and healthy controls (39) by 1H-NMR analyses associated with chemometrics, provided the identification of 26 metabolites/biomarkers for this disorder. The biomarker set including aspartate/aspartic acid, lysine, 2-hydroxybutyric acid, and acylglycerols was established for the first-time in SCZ serum samples of Serbian patients by 1H-NMR experiments. The other 22 identified metabolites are in agreement with the previously confirmed NMR-based serum biomarker sets of Brazilian and/or ...Chinese patient samples. The same 13 metabolites (lactate/lactic acid, threonine, leucine, isoleucine, valine, glutamine, asparagine, alanine, gamma-aminobutyric acid, choline, glucose, glycine and tyrosine) were established in all SCZ samples from three countries of different ethnicity and geographical origins (Serbia, Brazil and China). These results emphasize the crucial role in the possibility of their application as biomarkers for diagnosis of SCZ, reliable monitoring of treatment response and clinical outcomes.
Извор:
Book of Abstracts, 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK, September 4-6, 2023, Belgrade, Serbia, 2023, 68-68Издавач:
- International Association of Physical Chemists
Финансирање / пројекти:
- Organization for the Prohibition of Chemical Weapons (Projects L/ICA/ICB-217652/18 and L/ICA/ICB-108/21)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200026 (Универзитет у Београду, Институт за хемију, технологију и металургију - ИХТМ) (RS-MESTD-inst-2020-200026)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200051 (Институт за општу и физичку хемију, Београд) (RS-MESTD-inst-2020-200051)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200110 (Универзитет у Београду, Медицински факултет) (RS-MESTD-inst-2020-200110)
Институција/група
IHTMTY - CONF AU - Avramović, Nataša AU - Simić, Katarina AU - Miladinović, Zoran AU - Todorović, Nina AU - Trifunović, Snežana AU - Gavrilović, Aleksandra AU - Jovanović, Silvana AU - Gođevac, Dejan AU - Vujisić, Ljubodrag AU - Tešević, Vele AU - Tasić, Ljubica AU - Mandić, Boris PY - 2023 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/7392 AB - Schizophrenia (SCZ) is a brain disease leading to significant functional impairments and premature death, and it affects 20 million people worldwide. Due to the complexity of this disease including different genetic and environmental factors, there is a lack in understanding pathophysiology and diagnosis of schizophrenia. In order to overcome existing gaps, the establishment of a universal set of SCZ biomarkers has a crucial role. Metabonomic study of serum samples of Serbian patients with schizophrenia (51) and healthy controls (39) by 1H-NMR analyses associated with chemometrics, provided the identification of 26 metabolites/biomarkers for this disorder. The biomarker set including aspartate/aspartic acid, lysine, 2-hydroxybutyric acid, and acylglycerols was established for the first-time in SCZ serum samples of Serbian patients by 1H-NMR experiments. The other 22 identified metabolites are in agreement with the previously confirmed NMR-based serum biomarker sets of Brazilian and/or Chinese patient samples. The same 13 metabolites (lactate/lactic acid, threonine, leucine, isoleucine, valine, glutamine, asparagine, alanine, gamma-aminobutyric acid, choline, glucose, glycine and tyrosine) were established in all SCZ samples from three countries of different ethnicity and geographical origins (Serbia, Brazil and China). These results emphasize the crucial role in the possibility of their application as biomarkers for diagnosis of SCZ, reliable monitoring of treatment response and clinical outcomes. PB - International Association of Physical Chemists C3 - Book of Abstracts, 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK, September 4-6, 2023, Belgrade, Serbia T1 - 1H-NMR metabonomic view on schizophrenia SP - 68 EP - 68 UR - https://hdl.handle.net/21.15107/rcub_cer_7392 ER -
@conference{ author = "Avramović, Nataša and Simić, Katarina and Miladinović, Zoran and Todorović, Nina and Trifunović, Snežana and Gavrilović, Aleksandra and Jovanović, Silvana and Gođevac, Dejan and Vujisić, Ljubodrag and Tešević, Vele and Tasić, Ljubica and Mandić, Boris", year = "2023", abstract = "Schizophrenia (SCZ) is a brain disease leading to significant functional impairments and premature death, and it affects 20 million people worldwide. Due to the complexity of this disease including different genetic and environmental factors, there is a lack in understanding pathophysiology and diagnosis of schizophrenia. In order to overcome existing gaps, the establishment of a universal set of SCZ biomarkers has a crucial role. Metabonomic study of serum samples of Serbian patients with schizophrenia (51) and healthy controls (39) by 1H-NMR analyses associated with chemometrics, provided the identification of 26 metabolites/biomarkers for this disorder. The biomarker set including aspartate/aspartic acid, lysine, 2-hydroxybutyric acid, and acylglycerols was established for the first-time in SCZ serum samples of Serbian patients by 1H-NMR experiments. The other 22 identified metabolites are in agreement with the previously confirmed NMR-based serum biomarker sets of Brazilian and/or Chinese patient samples. The same 13 metabolites (lactate/lactic acid, threonine, leucine, isoleucine, valine, glutamine, asparagine, alanine, gamma-aminobutyric acid, choline, glucose, glycine and tyrosine) were established in all SCZ samples from three countries of different ethnicity and geographical origins (Serbia, Brazil and China). These results emphasize the crucial role in the possibility of their application as biomarkers for diagnosis of SCZ, reliable monitoring of treatment response and clinical outcomes.", publisher = "International Association of Physical Chemists", journal = "Book of Abstracts, 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK, September 4-6, 2023, Belgrade, Serbia", title = "1H-NMR metabonomic view on schizophrenia", pages = "68-68", url = "https://hdl.handle.net/21.15107/rcub_cer_7392" }
Avramović, N., Simić, K., Miladinović, Z., Todorović, N., Trifunović, S., Gavrilović, A., Jovanović, S., Gođevac, D., Vujisić, L., Tešević, V., Tasić, L.,& Mandić, B.. (2023). 1H-NMR metabonomic view on schizophrenia. in Book of Abstracts, 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK, September 4-6, 2023, Belgrade, Serbia International Association of Physical Chemists., 68-68. https://hdl.handle.net/21.15107/rcub_cer_7392
Avramović N, Simić K, Miladinović Z, Todorović N, Trifunović S, Gavrilović A, Jovanović S, Gođevac D, Vujisić L, Tešević V, Tasić L, Mandić B. 1H-NMR metabonomic view on schizophrenia. in Book of Abstracts, 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK, September 4-6, 2023, Belgrade, Serbia. 2023;:68-68. https://hdl.handle.net/21.15107/rcub_cer_7392 .
Avramović, Nataša, Simić, Katarina, Miladinović, Zoran, Todorović, Nina, Trifunović, Snežana, Gavrilović, Aleksandra, Jovanović, Silvana, Gođevac, Dejan, Vujisić, Ljubodrag, Tešević, Vele, Tasić, Ljubica, Mandić, Boris, "1H-NMR metabonomic view on schizophrenia" in Book of Abstracts, 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK, September 4-6, 2023, Belgrade, Serbia (2023):68-68, https://hdl.handle.net/21.15107/rcub_cer_7392 .