TY  - JOUR
AU  - Tolic, Ljiljana
AU  - Lović, Jelena
AU  - Petrović, Slobodan D.
AU  - Mijin, Dušan
AU  - Grujic, Svetlana
AU  - Lausevic, Mila
AU  - Avramov Ivić, Milka
PY  - 2015
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/1725
AB  - Anisomycin is an immunosuppressant in low doses ( LT 0.1 mu M) with possible application in treatment of some autoimmune diseases and in inhibiting transplantation rejection. Anisomycin suppresses malignant tumor cell growth and affects memory. For the first time it was the subject of the electrochemical investigations by cyclic voltammetry and square wave voltammetry on gold electrode in 0.05 M NaHCO3 using its electrochemical activity. The cyclic voltammetry experiments at different sweep rates show that electrochemical process is irreversible and diffusion controlled. Based on square wave voltammetry measurements, the calculated values of LOD and LOQ were 1 and 4 nM (in the absence of biological fluid), as well as 2 and 6 nM (in the presence of spiked urine) indicating the high sensitivity of the proposed electroanalytical method. High performance liquid chromatography-tandem mass spectrometry was a reference method for quantification of anisomycin and served for structural identification of its hydrolysis product (deacetylanisomycin).
PB  - Elsevier Science Inc, New York
T2  - Electrochemistry Communications
T1  - Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis
VL  - 58
SP  - 20
EP  - 24
DO  - 10.1016/j.elecom.2015.05.017
ER  - 

@article{
author = "Tolic, Ljiljana and Lović, Jelena and Petrović, Slobodan D. and Mijin, Dušan and Grujic, Svetlana and Lausevic, Mila and Avramov Ivić, Milka",
year = "2015",
abstract = "Anisomycin is an immunosuppressant in low doses ( LT 0.1 mu M) with possible application in treatment of some autoimmune diseases and in inhibiting transplantation rejection. Anisomycin suppresses malignant tumor cell growth and affects memory. For the first time it was the subject of the electrochemical investigations by cyclic voltammetry and square wave voltammetry on gold electrode in 0.05 M NaHCO3 using its electrochemical activity. The cyclic voltammetry experiments at different sweep rates show that electrochemical process is irreversible and diffusion controlled. Based on square wave voltammetry measurements, the calculated values of LOD and LOQ were 1 and 4 nM (in the absence of biological fluid), as well as 2 and 6 nM (in the presence of spiked urine) indicating the high sensitivity of the proposed electroanalytical method. High performance liquid chromatography-tandem mass spectrometry was a reference method for quantification of anisomycin and served for structural identification of its hydrolysis product (deacetylanisomycin).",
publisher = "Elsevier Science Inc, New York",
journal = "Electrochemistry Communications",
title = "Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis",
volume = "58",
pages = "20-24",
doi = "10.1016/j.elecom.2015.05.017"
}

Tolic, L., Lović, J., Petrović, S. D., Mijin, D., Grujic, S., Lausevic, M.,& Avramov Ivić, M.. (2015). Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis. in Electrochemistry Communications
Elsevier Science Inc, New York., 58, 20-24.
https://doi.org/10.1016/j.elecom.2015.05.017

Tolic L, Lović J, Petrović SD, Mijin D, Grujic S, Lausevic M, Avramov Ivić M. Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis. in Electrochemistry Communications. 2015;58:20-24.
doi:10.1016/j.elecom.2015.05.017 .

Tolic, Ljiljana, Lović, Jelena, Petrović, Slobodan D., Mijin, Dušan, Grujic, Svetlana, Lausevic, Mila, Avramov Ivić, Milka, "Investigation of electrochemical behavior of anisomycin on gold electrode followed by HPLC-MS/MS analysis" in Electrochemistry Communications, 58 (2015):20-24,
https://doi.org/10.1016/j.elecom.2015.05.017 . .