Tadić, Vanja

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orcid::0000-0003-1761-604X
  • Tadić, Vanja (6)

Author's Bibliography

Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation

Lović, Jelena; Bogdanović, Aleksandra; Tadić, Vanja; Mijin, Dušan; Vuković, Dragan; Petrović, Slobodan D.; Avramov - Ivić, Milka

(The Electrochemical Society, 2022)

TY  - JOUR
AU  - Lović, Jelena
AU  - Bogdanović, Aleksandra
AU  - Tadić, Vanja
AU  - Mijin, Dušan
AU  - Vuković, Dragan
AU  - Petrović, Slobodan D.
AU  - Avramov -  Ivić, Milka
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5171
AB  - Duloxetine hydrochloride (DUL) is effective in treating depression, and was examined for electroanalytical purposes. The DUL
standard was investigated by cyclic voltammetry (CV) and determined using differential pulse voltammetry (DPV) via its electrooxidation
at the Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs DUL standard
concentrations in the range from 0.1 to 3.33 μg ml−1 with the values of the limit of detection (LOD) and the limit of quantification
(LOQ): 0.133 and 0.667 μg ml−1, respectively. Using the constructed and validated calibration curve, the values of unknown DUL
concentrations in both Taita® tablets and in human serum spiked with the standard were determined. The number of protons and
electrons transferred was calculated and possible reaction mechanisms taking place on the surface of both electrodes were
proposed. The Au electrode exhibited a better sensitivity and a wider range of current vs concentration linear dependency for DUL
quantitative determination than the GC electrode. The study of DUL degradation showed that at the Au and GC electrodes, after
4.5 h of potential cycling, degradation occurs, giving formaldehyde as a product, which was confirmed by high performance liquid
chromatography (HPLC)
PB  - The Electrochemical Society
T2  - Journal of The Electrochemical Society
T1  - Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation
DO  - 10.1149/1945-7111/ac7e74
ER  - 
@article{
author = "Lović, Jelena and Bogdanović, Aleksandra and Tadić, Vanja and Mijin, Dušan and Vuković, Dragan and Petrović, Slobodan D. and Avramov -  Ivić, Milka",
year = "2022",
abstract = "Duloxetine hydrochloride (DUL) is effective in treating depression, and was examined for electroanalytical purposes. The DUL
standard was investigated by cyclic voltammetry (CV) and determined using differential pulse voltammetry (DPV) via its electrooxidation
at the Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs DUL standard
concentrations in the range from 0.1 to 3.33 μg ml−1 with the values of the limit of detection (LOD) and the limit of quantification
(LOQ): 0.133 and 0.667 μg ml−1, respectively. Using the constructed and validated calibration curve, the values of unknown DUL
concentrations in both Taita® tablets and in human serum spiked with the standard were determined. The number of protons and
electrons transferred was calculated and possible reaction mechanisms taking place on the surface of both electrodes were
proposed. The Au electrode exhibited a better sensitivity and a wider range of current vs concentration linear dependency for DUL
quantitative determination than the GC electrode. The study of DUL degradation showed that at the Au and GC electrodes, after
4.5 h of potential cycling, degradation occurs, giving formaldehyde as a product, which was confirmed by high performance liquid
chromatography (HPLC)",
publisher = "The Electrochemical Society",
journal = "Journal of The Electrochemical Society",
title = "Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation",
doi = "10.1149/1945-7111/ac7e74"
}
Lović, J., Bogdanović, A., Tadić, V., Mijin, D., Vuković, D., Petrović, S. D.,& Avramov -  Ivić, M.. (2022). Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation. in Journal of The Electrochemical Society
The Electrochemical Society..
https://doi.org/10.1149/1945-7111/ac7e74
Lović J, Bogdanović A, Tadić V, Mijin D, Vuković D, Petrović SD, Avramov -  Ivić M. Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation. in Journal of The Electrochemical Society. 2022;.
doi:10.1149/1945-7111/ac7e74 .
Lović, Jelena, Bogdanović, Aleksandra, Tadić, Vanja, Mijin, Dušan, Vuković, Dragan, Petrović, Slobodan D., Avramov -  Ivić, Milka, "Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation" in Journal of The Electrochemical Society (2022),
https://doi.org/10.1149/1945-7111/ac7e74 . .

Functionalization of polypropylene, polyamide and cellulose acetate materials with pyrethrum extract as a natural repellent in supercritical carbon dioxide

Pajnik, Jelena; Radetić, Maja; Stojanovic, Dusica B.; Janković-Častvan, Ivona; Tadić, Vanja; Stanković, Miroslav; Jovanović, Dušan M.; Žižović, Irena

(Elsevier, 2018)

TY  - JOUR
AU  - Pajnik, Jelena
AU  - Radetić, Maja
AU  - Stojanovic, Dusica B.
AU  - Janković-Častvan, Ivona
AU  - Tadić, Vanja
AU  - Stanković, Miroslav
AU  - Jovanović, Dušan M.
AU  - Žižović, Irena
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4276
AB  - This study discusses the possibility of supercritical solvent impregnation of polypropylene and polyamide fabrics as well as cellulose acetate in the form of beads and films with pyrethrum extract in order to fabricate functionalized materials with repellent properties. Impregnation experiments were performed at temperature of 40 degrees C and pressures of 10 and 20 MPa in supercritical carbon dioxide. The time of impregnation was varied from 0.5 to 18 h. Loadings of pyrethrum extract into polypropylene fabrics and cellulose acetate films higher than 30% were attainable at 10 MPa. In the case of polyamide fabrics and cellulose acetate beads, the pressure of 20 MPa was needed for obtaining the loadings higher than 11%. Pyrethrum extract release study revealed different capabilities of the tested materials for the repellent release, implying a variety of their possible applications. The impregnated solids were characterized by SEM, DSC, FTIR, Mercury intrusion porosimetry analyses and HPLC analyses.
PB  - Elsevier
T2  - Journal of Supercritical Fluids
T1  - Functionalization of polypropylene, polyamide and cellulose acetate materials with pyrethrum extract as a natural repellent in supercritical carbon dioxide
VL  - 136
SP  - 70
EP  - 81
DO  - 10.1016/j.supflu.2018.02.014
ER  - 
@article{
author = "Pajnik, Jelena and Radetić, Maja and Stojanovic, Dusica B. and Janković-Častvan, Ivona and Tadić, Vanja and Stanković, Miroslav and Jovanović, Dušan M. and Žižović, Irena",
year = "2018",
abstract = "This study discusses the possibility of supercritical solvent impregnation of polypropylene and polyamide fabrics as well as cellulose acetate in the form of beads and films with pyrethrum extract in order to fabricate functionalized materials with repellent properties. Impregnation experiments were performed at temperature of 40 degrees C and pressures of 10 and 20 MPa in supercritical carbon dioxide. The time of impregnation was varied from 0.5 to 18 h. Loadings of pyrethrum extract into polypropylene fabrics and cellulose acetate films higher than 30% were attainable at 10 MPa. In the case of polyamide fabrics and cellulose acetate beads, the pressure of 20 MPa was needed for obtaining the loadings higher than 11%. Pyrethrum extract release study revealed different capabilities of the tested materials for the repellent release, implying a variety of their possible applications. The impregnated solids were characterized by SEM, DSC, FTIR, Mercury intrusion porosimetry analyses and HPLC analyses.",
publisher = "Elsevier",
journal = "Journal of Supercritical Fluids",
title = "Functionalization of polypropylene, polyamide and cellulose acetate materials with pyrethrum extract as a natural repellent in supercritical carbon dioxide",
volume = "136",
pages = "70-81",
doi = "10.1016/j.supflu.2018.02.014"
}
Pajnik, J., Radetić, M., Stojanovic, D. B., Janković-Častvan, I., Tadić, V., Stanković, M., Jovanović, D. M.,& Žižović, I.. (2018). Functionalization of polypropylene, polyamide and cellulose acetate materials with pyrethrum extract as a natural repellent in supercritical carbon dioxide. in Journal of Supercritical Fluids
Elsevier., 136, 70-81.
https://doi.org/10.1016/j.supflu.2018.02.014
Pajnik J, Radetić M, Stojanovic DB, Janković-Častvan I, Tadić V, Stanković M, Jovanović DM, Žižović I. Functionalization of polypropylene, polyamide and cellulose acetate materials with pyrethrum extract as a natural repellent in supercritical carbon dioxide. in Journal of Supercritical Fluids. 2018;136:70-81.
doi:10.1016/j.supflu.2018.02.014 .
Pajnik, Jelena, Radetić, Maja, Stojanovic, Dusica B., Janković-Častvan, Ivona, Tadić, Vanja, Stanković, Miroslav, Jovanović, Dušan M., Žižović, Irena, "Functionalization of polypropylene, polyamide and cellulose acetate materials with pyrethrum extract as a natural repellent in supercritical carbon dioxide" in Journal of Supercritical Fluids, 136 (2018):70-81,
https://doi.org/10.1016/j.supflu.2018.02.014 . .
17
10
16

Functionalization of polypropylene, polyamide and cellulose acetate materials with pyrethrum extract as a natural repellent in supercritical carbon dioxide

Pajnik, Jelena; Radetić, Maja; Stojanovic, Dusica B.; Janković-Častvan, Ivona; Tadić, Vanja; Stanković, Miroslav; Jovanović, Dušan M.; Žižović, Irena

(Elsevier, 2018)

TY  - JOUR
AU  - Pajnik, Jelena
AU  - Radetić, Maja
AU  - Stojanovic, Dusica B.
AU  - Janković-Častvan, Ivona
AU  - Tadić, Vanja
AU  - Stanković, Miroslav
AU  - Jovanović, Dušan M.
AU  - Žižović, Irena
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2298
AB  - This study discusses the possibility of supercritical solvent impregnation of polypropylene and polyamide fabrics as well as cellulose acetate in the form of beads and films with pyrethrum extract in order to fabricate functionalized materials with repellent properties. Impregnation experiments were performed at temperature of 40 degrees C and pressures of 10 and 20 MPa in supercritical carbon dioxide. The time of impregnation was varied from 0.5 to 18 h. Loadings of pyrethrum extract into polypropylene fabrics and cellulose acetate films higher than 30% were attainable at 10 MPa. In the case of polyamide fabrics and cellulose acetate beads, the pressure of 20 MPa was needed for obtaining the loadings higher than 11%. Pyrethrum extract release study revealed different capabilities of the tested materials for the repellent release, implying a variety of their possible applications. The impregnated solids were characterized by SEM, DSC, FTIR, Mercury intrusion porosimetry analyses and HPLC analyses.
PB  - Elsevier
T2  - Journal of Supercritical Fluids
T1  - Functionalization of polypropylene, polyamide and cellulose acetate materials with pyrethrum extract as a natural repellent in supercritical carbon dioxide
VL  - 136
SP  - 70
EP  - 81
DO  - 10.1016/j.supflu.2018.02.014
ER  - 
@article{
author = "Pajnik, Jelena and Radetić, Maja and Stojanovic, Dusica B. and Janković-Častvan, Ivona and Tadić, Vanja and Stanković, Miroslav and Jovanović, Dušan M. and Žižović, Irena",
year = "2018",
abstract = "This study discusses the possibility of supercritical solvent impregnation of polypropylene and polyamide fabrics as well as cellulose acetate in the form of beads and films with pyrethrum extract in order to fabricate functionalized materials with repellent properties. Impregnation experiments were performed at temperature of 40 degrees C and pressures of 10 and 20 MPa in supercritical carbon dioxide. The time of impregnation was varied from 0.5 to 18 h. Loadings of pyrethrum extract into polypropylene fabrics and cellulose acetate films higher than 30% were attainable at 10 MPa. In the case of polyamide fabrics and cellulose acetate beads, the pressure of 20 MPa was needed for obtaining the loadings higher than 11%. Pyrethrum extract release study revealed different capabilities of the tested materials for the repellent release, implying a variety of their possible applications. The impregnated solids were characterized by SEM, DSC, FTIR, Mercury intrusion porosimetry analyses and HPLC analyses.",
publisher = "Elsevier",
journal = "Journal of Supercritical Fluids",
title = "Functionalization of polypropylene, polyamide and cellulose acetate materials with pyrethrum extract as a natural repellent in supercritical carbon dioxide",
volume = "136",
pages = "70-81",
doi = "10.1016/j.supflu.2018.02.014"
}
Pajnik, J., Radetić, M., Stojanovic, D. B., Janković-Častvan, I., Tadić, V., Stanković, M., Jovanović, D. M.,& Žižović, I.. (2018). Functionalization of polypropylene, polyamide and cellulose acetate materials with pyrethrum extract as a natural repellent in supercritical carbon dioxide. in Journal of Supercritical Fluids
Elsevier., 136, 70-81.
https://doi.org/10.1016/j.supflu.2018.02.014
Pajnik J, Radetić M, Stojanovic DB, Janković-Častvan I, Tadić V, Stanković M, Jovanović DM, Žižović I. Functionalization of polypropylene, polyamide and cellulose acetate materials with pyrethrum extract as a natural repellent in supercritical carbon dioxide. in Journal of Supercritical Fluids. 2018;136:70-81.
doi:10.1016/j.supflu.2018.02.014 .
Pajnik, Jelena, Radetić, Maja, Stojanovic, Dusica B., Janković-Častvan, Ivona, Tadić, Vanja, Stanković, Miroslav, Jovanović, Dušan M., Žižović, Irena, "Functionalization of polypropylene, polyamide and cellulose acetate materials with pyrethrum extract as a natural repellent in supercritical carbon dioxide" in Journal of Supercritical Fluids, 136 (2018):70-81,
https://doi.org/10.1016/j.supflu.2018.02.014 . .
17
10
16

Curcumin-loaded low-energy nanoemulsions as a prototype of multifunctional vehicles for different administration routes: Physicochemical and in vitro peculiarities important for dermal application

Nikolić, Ines; Lunter, Dominique Jasmin; Randjelović, Danijela; Žugić, Ana; Tadić, Vanja; Marković, Bojan D.; Cekic, Nebojsa; Živković, Lada; Topalovic, Dijana; Spremo-Potparević, Biljana; Daniels, Rolf; Savić, Snežana D.

(Elsevier, 2018)

TY  - JOUR
AU  - Nikolić, Ines
AU  - Lunter, Dominique Jasmin
AU  - Randjelović, Danijela
AU  - Žugić, Ana
AU  - Tadić, Vanja
AU  - Marković, Bojan D.
AU  - Cekic, Nebojsa
AU  - Živković, Lada
AU  - Topalovic, Dijana
AU  - Spremo-Potparević, Biljana
AU  - Daniels, Rolf
AU  - Savić, Snežana D.
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3719
AB  - The objective of this work was to investigate and profoundly characterize low-energy nanoemulsions as multifunctional carriers, with slight reference to dermal administration. An evidence-based approach was offered for deepening the knowledge on their formation via spontaneous emulsification. Curcumin, a compound of natural origin, potentially powerful therapeutic, was chosen as a model API. Due to curcumin's demanding properties (instability, poor solubility, low permeability), its potentials remain unreached. Low-energy nanoemulsions were considered carriers capable of overcoming imposed obstacles. Formulation consisting of Polysorbate 80 and soybean lecithin as stabilizers (9:1, 10%), medium-chain triglycerides as the oil phase (10%) and ultrapure water was selected for curcumin incorporation in 3 different concentrations (1, 2 and 3 mg/mL). Physicochemical stability was demonstrated during 3 months of monitoring (mean droplet size: 111.3-146.8 nm; PDI  LT  0.2; pH: 4.73-5.73). Curcumin's release from developed vehicles followed Higuchi's kinetics. DPPH (IC50 = 0.1187 mg/ mL) and FRAP (1.19 +/- 0.02 mmol/g) assays confirmed that curcumin acts as a potent antioxidant through different mechanisms, with no alterations after incorporation in the formulation. High biocompatibility in line with antigenotoxic activity of curcumin-loaded formulations (protective and reparative) was estimated through Comet assay. A multidisciplinary approach is needed to fully characterize developed systems, directing them to more concrete application possibilities.
PB  - Elsevier
T2  - International Journal of Pharmaceutics
T1  - Curcumin-loaded low-energy nanoemulsions as a prototype of multifunctional vehicles for different administration routes: Physicochemical and in vitro peculiarities important for dermal application
VL  - 550
IS  - 1-2
SP  - 333
EP  - 346
DO  - 10.1016/j.ijpharm.2018.08.060
ER  - 
@article{
author = "Nikolić, Ines and Lunter, Dominique Jasmin and Randjelović, Danijela and Žugić, Ana and Tadić, Vanja and Marković, Bojan D. and Cekic, Nebojsa and Živković, Lada and Topalovic, Dijana and Spremo-Potparević, Biljana and Daniels, Rolf and Savić, Snežana D.",
year = "2018",
abstract = "The objective of this work was to investigate and profoundly characterize low-energy nanoemulsions as multifunctional carriers, with slight reference to dermal administration. An evidence-based approach was offered for deepening the knowledge on their formation via spontaneous emulsification. Curcumin, a compound of natural origin, potentially powerful therapeutic, was chosen as a model API. Due to curcumin's demanding properties (instability, poor solubility, low permeability), its potentials remain unreached. Low-energy nanoemulsions were considered carriers capable of overcoming imposed obstacles. Formulation consisting of Polysorbate 80 and soybean lecithin as stabilizers (9:1, 10%), medium-chain triglycerides as the oil phase (10%) and ultrapure water was selected for curcumin incorporation in 3 different concentrations (1, 2 and 3 mg/mL). Physicochemical stability was demonstrated during 3 months of monitoring (mean droplet size: 111.3-146.8 nm; PDI  LT  0.2; pH: 4.73-5.73). Curcumin's release from developed vehicles followed Higuchi's kinetics. DPPH (IC50 = 0.1187 mg/ mL) and FRAP (1.19 +/- 0.02 mmol/g) assays confirmed that curcumin acts as a potent antioxidant through different mechanisms, with no alterations after incorporation in the formulation. High biocompatibility in line with antigenotoxic activity of curcumin-loaded formulations (protective and reparative) was estimated through Comet assay. A multidisciplinary approach is needed to fully characterize developed systems, directing them to more concrete application possibilities.",
publisher = "Elsevier",
journal = "International Journal of Pharmaceutics",
title = "Curcumin-loaded low-energy nanoemulsions as a prototype of multifunctional vehicles for different administration routes: Physicochemical and in vitro peculiarities important for dermal application",
volume = "550",
number = "1-2",
pages = "333-346",
doi = "10.1016/j.ijpharm.2018.08.060"
}
Nikolić, I., Lunter, D. J., Randjelović, D., Žugić, A., Tadić, V., Marković, B. D., Cekic, N., Živković, L., Topalovic, D., Spremo-Potparević, B., Daniels, R.,& Savić, S. D.. (2018). Curcumin-loaded low-energy nanoemulsions as a prototype of multifunctional vehicles for different administration routes: Physicochemical and in vitro peculiarities important for dermal application. in International Journal of Pharmaceutics
Elsevier., 550(1-2), 333-346.
https://doi.org/10.1016/j.ijpharm.2018.08.060
Nikolić I, Lunter DJ, Randjelović D, Žugić A, Tadić V, Marković BD, Cekic N, Živković L, Topalovic D, Spremo-Potparević B, Daniels R, Savić SD. Curcumin-loaded low-energy nanoemulsions as a prototype of multifunctional vehicles for different administration routes: Physicochemical and in vitro peculiarities important for dermal application. in International Journal of Pharmaceutics. 2018;550(1-2):333-346.
doi:10.1016/j.ijpharm.2018.08.060 .
Nikolić, Ines, Lunter, Dominique Jasmin, Randjelović, Danijela, Žugić, Ana, Tadić, Vanja, Marković, Bojan D., Cekic, Nebojsa, Živković, Lada, Topalovic, Dijana, Spremo-Potparević, Biljana, Daniels, Rolf, Savić, Snežana D., "Curcumin-loaded low-energy nanoemulsions as a prototype of multifunctional vehicles for different administration routes: Physicochemical and in vitro peculiarities important for dermal application" in International Journal of Pharmaceutics, 550, no. 1-2 (2018):333-346,
https://doi.org/10.1016/j.ijpharm.2018.08.060 . .
30
21
28

Curcumin-loaded low-energy nanoemulsions as a prototype of multifunctional vehicles for different administration routes: Physicochemical and in vitro peculiarities important for dermal application

Nikolić, Ines; Lunter, Dominique Jasmin; Randjelović, Danijela; Žugić, Ana; Tadić, Vanja; Marković, Bojan D.; Cekic, Nebojsa; Živković, Lada; Topalovic, Dijana; Spremo-Potparević, Biljana; Daniels, Rolf; Savić, Snežana D.

(Elsevier, 2018)

TY  - JOUR
AU  - Nikolić, Ines
AU  - Lunter, Dominique Jasmin
AU  - Randjelović, Danijela
AU  - Žugić, Ana
AU  - Tadić, Vanja
AU  - Marković, Bojan D.
AU  - Cekic, Nebojsa
AU  - Živković, Lada
AU  - Topalovic, Dijana
AU  - Spremo-Potparević, Biljana
AU  - Daniels, Rolf
AU  - Savić, Snežana D.
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2425
AB  - The objective of this work was to investigate and profoundly characterize low-energy nanoemulsions as multifunctional carriers, with slight reference to dermal administration. An evidence-based approach was offered for deepening the knowledge on their formation via spontaneous emulsification. Curcumin, a compound of natural origin, potentially powerful therapeutic, was chosen as a model API. Due to curcumin's demanding properties (instability, poor solubility, low permeability), its potentials remain unreached. Low-energy nanoemulsions were considered carriers capable of overcoming imposed obstacles. Formulation consisting of Polysorbate 80 and soybean lecithin as stabilizers (9:1, 10%), medium-chain triglycerides as the oil phase (10%) and ultrapure water was selected for curcumin incorporation in 3 different concentrations (1, 2 and 3 mg/mL). Physicochemical stability was demonstrated during 3 months of monitoring (mean droplet size: 111.3-146.8 nm; PDI  LT  0.2; pH: 4.73-5.73). Curcumin's release from developed vehicles followed Higuchi's kinetics. DPPH (IC50 = 0.1187 mg/ mL) and FRAP (1.19 +/- 0.02 mmol/g) assays confirmed that curcumin acts as a potent antioxidant through different mechanisms, with no alterations after incorporation in the formulation. High biocompatibility in line with antigenotoxic activity of curcumin-loaded formulations (protective and reparative) was estimated through Comet assay. A multidisciplinary approach is needed to fully characterize developed systems, directing them to more concrete application possibilities.
PB  - Elsevier
T2  - International Journal of Pharmaceutics
T1  - Curcumin-loaded low-energy nanoemulsions as a prototype of multifunctional vehicles for different administration routes: Physicochemical and in vitro peculiarities important for dermal application
VL  - 550
IS  - 1-2
SP  - 333
EP  - 346
DO  - 10.1016/j.ijpharm.2018.08.060
ER  - 
@article{
author = "Nikolić, Ines and Lunter, Dominique Jasmin and Randjelović, Danijela and Žugić, Ana and Tadić, Vanja and Marković, Bojan D. and Cekic, Nebojsa and Živković, Lada and Topalovic, Dijana and Spremo-Potparević, Biljana and Daniels, Rolf and Savić, Snežana D.",
year = "2018",
abstract = "The objective of this work was to investigate and profoundly characterize low-energy nanoemulsions as multifunctional carriers, with slight reference to dermal administration. An evidence-based approach was offered for deepening the knowledge on their formation via spontaneous emulsification. Curcumin, a compound of natural origin, potentially powerful therapeutic, was chosen as a model API. Due to curcumin's demanding properties (instability, poor solubility, low permeability), its potentials remain unreached. Low-energy nanoemulsions were considered carriers capable of overcoming imposed obstacles. Formulation consisting of Polysorbate 80 and soybean lecithin as stabilizers (9:1, 10%), medium-chain triglycerides as the oil phase (10%) and ultrapure water was selected for curcumin incorporation in 3 different concentrations (1, 2 and 3 mg/mL). Physicochemical stability was demonstrated during 3 months of monitoring (mean droplet size: 111.3-146.8 nm; PDI  LT  0.2; pH: 4.73-5.73). Curcumin's release from developed vehicles followed Higuchi's kinetics. DPPH (IC50 = 0.1187 mg/ mL) and FRAP (1.19 +/- 0.02 mmol/g) assays confirmed that curcumin acts as a potent antioxidant through different mechanisms, with no alterations after incorporation in the formulation. High biocompatibility in line with antigenotoxic activity of curcumin-loaded formulations (protective and reparative) was estimated through Comet assay. A multidisciplinary approach is needed to fully characterize developed systems, directing them to more concrete application possibilities.",
publisher = "Elsevier",
journal = "International Journal of Pharmaceutics",
title = "Curcumin-loaded low-energy nanoemulsions as a prototype of multifunctional vehicles for different administration routes: Physicochemical and in vitro peculiarities important for dermal application",
volume = "550",
number = "1-2",
pages = "333-346",
doi = "10.1016/j.ijpharm.2018.08.060"
}
Nikolić, I., Lunter, D. J., Randjelović, D., Žugić, A., Tadić, V., Marković, B. D., Cekic, N., Živković, L., Topalovic, D., Spremo-Potparević, B., Daniels, R.,& Savić, S. D.. (2018). Curcumin-loaded low-energy nanoemulsions as a prototype of multifunctional vehicles for different administration routes: Physicochemical and in vitro peculiarities important for dermal application. in International Journal of Pharmaceutics
Elsevier., 550(1-2), 333-346.
https://doi.org/10.1016/j.ijpharm.2018.08.060
Nikolić I, Lunter DJ, Randjelović D, Žugić A, Tadić V, Marković BD, Cekic N, Živković L, Topalovic D, Spremo-Potparević B, Daniels R, Savić SD. Curcumin-loaded low-energy nanoemulsions as a prototype of multifunctional vehicles for different administration routes: Physicochemical and in vitro peculiarities important for dermal application. in International Journal of Pharmaceutics. 2018;550(1-2):333-346.
doi:10.1016/j.ijpharm.2018.08.060 .
Nikolić, Ines, Lunter, Dominique Jasmin, Randjelović, Danijela, Žugić, Ana, Tadić, Vanja, Marković, Bojan D., Cekic, Nebojsa, Živković, Lada, Topalovic, Dijana, Spremo-Potparević, Biljana, Daniels, Rolf, Savić, Snežana D., "Curcumin-loaded low-energy nanoemulsions as a prototype of multifunctional vehicles for different administration routes: Physicochemical and in vitro peculiarities important for dermal application" in International Journal of Pharmaceutics, 550, no. 1-2 (2018):333-346,
https://doi.org/10.1016/j.ijpharm.2018.08.060 . .
30
21
28

Physicochemical characterization of mineral mud from spa Vrujci

Holclajtner-Antunović, Ivanka D.; Pavlović, M.; Dojčinović, Biljana; Tadić, Vanja; Čutović, M.; Bajuk-Bogdanović, Danica; Arsić, Ivana A.; Runjaić-Antić, D.

(Society of Physical Chemists of Serbia, 2010)

TY  - CONF
AU  - Holclajtner-Antunović, Ivanka D.
AU  - Pavlović, M.
AU  - Dojčinović, Biljana
AU  - Tadić, Vanja
AU  - Čutović, M.
AU  - Bajuk-Bogdanović, Danica
AU  - Arsić, Ivana A.
AU  - Runjaić-Antić, D.
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7503
AB  - Mineralogical and physicochemical analysis of healing mud from spa Vrujci wasperformed by ICP-OES analysis and FTIR and micro-Raman spectroscopy. Thetherapeutic effect of mud was improved by plant extracts implementation.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
T1  - Physicochemical characterization of mineral mud from spa Vrujci
UR  - https://hdl.handle.net/21.15107/rcub_cer_7503
ER  - 
@conference{
author = "Holclajtner-Antunović, Ivanka D. and Pavlović, M. and Dojčinović, Biljana and Tadić, Vanja and Čutović, M. and Bajuk-Bogdanović, Danica and Arsić, Ivana A. and Runjaić-Antić, D.",
year = "2010",
abstract = "Mineralogical and physicochemical analysis of healing mud from spa Vrujci wasperformed by ICP-OES analysis and FTIR and micro-Raman spectroscopy. Thetherapeutic effect of mud was improved by plant extracts implementation.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry",
title = "Physicochemical characterization of mineral mud from spa Vrujci",
url = "https://hdl.handle.net/21.15107/rcub_cer_7503"
}
Holclajtner-Antunović, I. D., Pavlović, M., Dojčinović, B., Tadić, V., Čutović, M., Bajuk-Bogdanović, D., Arsić, I. A.,& Runjaić-Antić, D.. (2010). Physicochemical characterization of mineral mud from spa Vrujci. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia..
https://hdl.handle.net/21.15107/rcub_cer_7503
Holclajtner-Antunović ID, Pavlović M, Dojčinović B, Tadić V, Čutović M, Bajuk-Bogdanović D, Arsić IA, Runjaić-Antić D. Physicochemical characterization of mineral mud from spa Vrujci. in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry. 2010;.
https://hdl.handle.net/21.15107/rcub_cer_7503 .
Holclajtner-Antunović, Ivanka D., Pavlović, M., Dojčinović, Biljana, Tadić, Vanja, Čutović, M., Bajuk-Bogdanović, Danica, Arsić, Ivana A., Runjaić-Antić, D., "Physicochemical characterization of mineral mud from spa Vrujci" in Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry (2010),
https://hdl.handle.net/21.15107/rcub_cer_7503 .