TY  - JOUR
AU  - Tomić, Ana
AU  - Šovljanski, Olja
AU  - Nikolić, Višnja
AU  - Lato, Pezo
AU  - Aćimović, Milica
AU  - Cvetković, Mirjana
AU  - Stanojev, Jovana
AU  - Kuzmanović, Nebojša
AU  - Markov, Siniša
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5630
AB  - The main challenge in controlling the microbiological contamination of historical paper is
finding an adequate method that includes the use of cost-effective, harmless, and non-toxic biocides
whose effectiveness is maintained over time and without adverse effects on cultural heritage and
human health. Therefore, this study demonstrated the possibility of using a non-invasive method
of historical paper conservation based on plant essential oils (EOs) application. Evaluation of antimicrobial
effects of different EOs (lemongrass, oregano, rosemary, peppermint, and eucalyptus)
was conducted against Cladosporium cladosporoides, Aspergillus fumigatus, and Penicillium chrysogenum,
which are commonly found on archive papers. Using a mixture of oregano, lemongrass and peppermint
in ratio 1:1:1, the lower minimal inhibition concentration (0.78%) and better efficiency during
a vapour test at the highest tested distance (5.5 cm) compared with individual EOs was proven.
At the final step, this EOs mixture was used in the in situ conservation of historical paper samples
obtained from the Archives of Vojvodina. According to the SEM imaging, the applied EOs mixture
demonstrates complete efficiency in the inhibition of fungi colonization of archive papers, since
fungal growth was not observed on samples, unlike the control samples.
PB  - Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Antibiotics
T1  - Screening of Antifungal Activity of Essential Oils in Controlling Biocontamination of Historical Papers in Archives
VL  - 12
IS  - 103
DO  - 10.3390/antibiotics12010103
ER  - 

@article{
author = "Tomić, Ana and Šovljanski, Olja and Nikolić, Višnja and Lato, Pezo and Aćimović, Milica and Cvetković, Mirjana and Stanojev, Jovana and Kuzmanović, Nebojša and Markov, Siniša",
year = "2023",
abstract = "The main challenge in controlling the microbiological contamination of historical paper is
finding an adequate method that includes the use of cost-effective, harmless, and non-toxic biocides
whose effectiveness is maintained over time and without adverse effects on cultural heritage and
human health. Therefore, this study demonstrated the possibility of using a non-invasive method
of historical paper conservation based on plant essential oils (EOs) application. Evaluation of antimicrobial
effects of different EOs (lemongrass, oregano, rosemary, peppermint, and eucalyptus)
was conducted against Cladosporium cladosporoides, Aspergillus fumigatus, and Penicillium chrysogenum,
which are commonly found on archive papers. Using a mixture of oregano, lemongrass and peppermint
in ratio 1:1:1, the lower minimal inhibition concentration (0.78%) and better efficiency during
a vapour test at the highest tested distance (5.5 cm) compared with individual EOs was proven.
At the final step, this EOs mixture was used in the in situ conservation of historical paper samples
obtained from the Archives of Vojvodina. According to the SEM imaging, the applied EOs mixture
demonstrates complete efficiency in the inhibition of fungi colonization of archive papers, since
fungal growth was not observed on samples, unlike the control samples.",
publisher = "Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Antibiotics",
title = "Screening of Antifungal Activity of Essential Oils in Controlling Biocontamination of Historical Papers in Archives",
volume = "12",
number = "103",
doi = "10.3390/antibiotics12010103"
}

Tomić, A., Šovljanski, O., Nikolić, V., Lato, P., Aćimović, M., Cvetković, M., Stanojev, J., Kuzmanović, N.,& Markov, S.. (2023). Screening of Antifungal Activity of Essential Oils in Controlling Biocontamination of Historical Papers in Archives. in Antibiotics
Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)., 12(103).
https://doi.org/10.3390/antibiotics12010103

Tomić A, Šovljanski O, Nikolić V, Lato P, Aćimović M, Cvetković M, Stanojev J, Kuzmanović N, Markov S. Screening of Antifungal Activity of Essential Oils in Controlling Biocontamination of Historical Papers in Archives. in Antibiotics. 2023;12(103).
doi:10.3390/antibiotics12010103 .

Tomić, Ana, Šovljanski, Olja, Nikolić, Višnja, Lato, Pezo, Aćimović, Milica, Cvetković, Mirjana, Stanojev, Jovana, Kuzmanović, Nebojša, Markov, Siniša, "Screening of Antifungal Activity of Essential Oils in Controlling Biocontamination of Historical Papers in Archives" in Antibiotics, 12, no. 103 (2023),
https://doi.org/10.3390/antibiotics12010103 . .

TY  - JOUR
AU  - Krstić, Gordana
AU  - Nikolić, Biljana
AU  - Todosijević, Marina
AU  - Mitić, Zorica
AU  - Stanković Jeremić, Jovana
AU  - Cvetković, Mirjana
AU  - Bojović, Srđan
AU  - Marin, Petar
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5428
AB  - In this study we have reported the chemical composition of the essential oils obtained from the needles of twelve Pinus taxa, belonging to the subgenera Pinus (sections Pinus and Trifoliae) and Strobus (sect. Quinquefoliae). Monoterpenes dominated over sesquiterpenes in most of the investigated taxa of both subgenera, except in representatives of the subsection Pinaster, subgenus Pinus. α-Pinene was the most abundant terpene in eight pines, but other dominant terpenes were found in some taxa - trans-caryophyllene, germacrene D, abietadiene and β-pinene. In the subsect. Pinaster, the most dominant compounds varied from species to species. In addition, P. halepensis and P. pinaster had the highest percentage of diterpenes, while P. heldreichii was the richest in germacrene D. In the PCA and cluster analyses, three species from the subsect. Pinaster emerged as the most distant: P. halepensis, P. pinaster, and P. heldreichii. In addition, the possible taxonomic implications of the terpene profile in the analysed Pinus taxa were also discussed.
AB  - U ovom proučavanju objavili smo hemijski sastav etarskih ulja dobijenih iz iglica 12 taksona roda Pinus, koji pripadaju podrodovima Pinus
(sekcije Pinus i Trifoliae) i Strobus (sekcija Quinquefoliae). U većini istraživanih taksona monoterpeni dominiraju nad seskviterpenima kod
oba podroda, osim kod uzoraka podsekcije Pinaster podroda Pinus. α-Pinen je najobilniji kod 8 borova, ali kod nekih taksona dominantni su
trans-kariofilen, germakren D, abietadien i β-pinen. U subcekciji Pinaster dominantne komponente variraju od vrste do vrste. Nadalje, P. halepensis
i P. pinaster imaju najveći procenat diterpena, dok je P. heldreichii najbogatiji u germakrenu D. U PCA i klaster analizama pokazale su
se najudaljenije tri vrste subsekcije Pinaster: P. halepensis, P. pinaster i P. heldreichii. Nadalje, u analiziranim vrstama roda Pinus diskutovane
su moguće taksonomske implikacije terpenskog profila.
PB  - Belgrade :  Institute of Botany and Botanical Garden "Jevremovac"
T2  - Botanica Serbia
T1  - Terpene relationships among some soft and hard pine species
T1  - Terpenski odnosi između nekih mekih i tvrdih borova
VL  - 46
IS  - 1
SP  - 39
EP  - 48
DO  - 10.2298/BOTSERB2201039K
ER  - 

@article{
author = "Krstić, Gordana and Nikolić, Biljana and Todosijević, Marina and Mitić, Zorica and Stanković Jeremić, Jovana and Cvetković, Mirjana and Bojović, Srđan and Marin, Petar",
year = "2022",
abstract = "In this study we have reported the chemical composition of the essential oils obtained from the needles of twelve Pinus taxa, belonging to the subgenera Pinus (sections Pinus and Trifoliae) and Strobus (sect. Quinquefoliae). Monoterpenes dominated over sesquiterpenes in most of the investigated taxa of both subgenera, except in representatives of the subsection Pinaster, subgenus Pinus. α-Pinene was the most abundant terpene in eight pines, but other dominant terpenes were found in some taxa - trans-caryophyllene, germacrene D, abietadiene and β-pinene. In the subsect. Pinaster, the most dominant compounds varied from species to species. In addition, P. halepensis and P. pinaster had the highest percentage of diterpenes, while P. heldreichii was the richest in germacrene D. In the PCA and cluster analyses, three species from the subsect. Pinaster emerged as the most distant: P. halepensis, P. pinaster, and P. heldreichii. In addition, the possible taxonomic implications of the terpene profile in the analysed Pinus taxa were also discussed., U ovom proučavanju objavili smo hemijski sastav etarskih ulja dobijenih iz iglica 12 taksona roda Pinus, koji pripadaju podrodovima Pinus
(sekcije Pinus i Trifoliae) i Strobus (sekcija Quinquefoliae). U većini istraživanih taksona monoterpeni dominiraju nad seskviterpenima kod
oba podroda, osim kod uzoraka podsekcije Pinaster podroda Pinus. α-Pinen je najobilniji kod 8 borova, ali kod nekih taksona dominantni su
trans-kariofilen, germakren D, abietadien i β-pinen. U subcekciji Pinaster dominantne komponente variraju od vrste do vrste. Nadalje, P. halepensis
i P. pinaster imaju najveći procenat diterpena, dok je P. heldreichii najbogatiji u germakrenu D. U PCA i klaster analizama pokazale su
se najudaljenije tri vrste subsekcije Pinaster: P. halepensis, P. pinaster i P. heldreichii. Nadalje, u analiziranim vrstama roda Pinus diskutovane
su moguće taksonomske implikacije terpenskog profila.",
publisher = "Belgrade :  Institute of Botany and Botanical Garden "Jevremovac"",
journal = "Botanica Serbia",
title = "Terpene relationships among some soft and hard pine species, Terpenski odnosi između nekih mekih i tvrdih borova",
volume = "46",
number = "1",
pages = "39-48",
doi = "10.2298/BOTSERB2201039K"
}

Krstić, G., Nikolić, B., Todosijević, M., Mitić, Z., Stanković Jeremić, J., Cvetković, M., Bojović, S.,& Marin, P.. (2022). Terpene relationships among some soft and hard pine species. in Botanica Serbia
Belgrade :  Institute of Botany and Botanical Garden "Jevremovac"., 46(1), 39-48.
https://doi.org/10.2298/BOTSERB2201039K

Krstić G, Nikolić B, Todosijević M, Mitić Z, Stanković Jeremić J, Cvetković M, Bojović S, Marin P. Terpene relationships among some soft and hard pine species. in Botanica Serbia. 2022;46(1):39-48.
doi:10.2298/BOTSERB2201039K .

Krstić, Gordana, Nikolić, Biljana, Todosijević, Marina, Mitić, Zorica, Stanković Jeremić, Jovana, Cvetković, Mirjana, Bojović, Srđan, Marin, Petar, "Terpene relationships among some soft and hard pine species" in Botanica Serbia, 46, no. 1 (2022):39-48,
https://doi.org/10.2298/BOTSERB2201039K . .

TY  - CONF
AU  - Jadranin, Milka
AU  - Cvetković, Mirjana
AU  - Đorđević, Iris
AU  - Krstić, Gordana
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5863
AB  - This study revealed results from reinvestigation of  sesquiterpene lactones composition in the crude and leaf  surface extracts of Amphoricarpos plants by rapid  resolution liquid chromatography (RRLC) coupled with  quadrupole time-of-flight mass spectrometry (QToF MS)  and the tentative identification of undescribed  sesquiterpene lactones is presented.
PB  - Macedonian Pharmaceutical Association
C3  - Macedonian Pharmaceutical Bulletin
T1  - New insights into sesquiterpene lactones composition of 
Western Balkan’s genus Amphoricarpos revealed by rapid 
resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
VL  - 68
IS  - Suppl.2
SP  - 71
EP  - 72
DO  - 10.33320/maced.pharm.bull.2022.68.04.030
ER  - 

@conference{
author = "Jadranin, Milka and Cvetković, Mirjana and Đorđević, Iris and Krstić, Gordana and Tešević, Vele and Milosavljević, Slobodan",
year = "2022",
abstract = "This study revealed results from reinvestigation of  sesquiterpene lactones composition in the crude and leaf  surface extracts of Amphoricarpos plants by rapid  resolution liquid chromatography (RRLC) coupled with  quadrupole time-of-flight mass spectrometry (QToF MS)  and the tentative identification of undescribed  sesquiterpene lactones is presented.",
publisher = "Macedonian Pharmaceutical Association",
journal = "Macedonian Pharmaceutical Bulletin",
title = "New insights into sesquiterpene lactones composition of 
Western Balkan’s genus Amphoricarpos revealed by rapid 
resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry",
volume = "68",
number = "Suppl.2",
pages = "71-72",
doi = "10.33320/maced.pharm.bull.2022.68.04.030"
}

Jadranin, M., Cvetković, M., Đorđević, I., Krstić, G., Tešević, V.,& Milosavljević, S.. (2022). New insights into sesquiterpene lactones composition of 
Western Balkan’s genus Amphoricarpos revealed by rapid 
resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 68(Suppl.2), 71-72.
https://doi.org/10.33320/maced.pharm.bull.2022.68.04.030

Jadranin M, Cvetković M, Đorđević I, Krstić G, Tešević V, Milosavljević S. New insights into sesquiterpene lactones composition of 
Western Balkan’s genus Amphoricarpos revealed by rapid 
resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. in Macedonian Pharmaceutical Bulletin. 2022;68(Suppl.2):71-72.
doi:10.33320/maced.pharm.bull.2022.68.04.030 .

Jadranin, Milka, Cvetković, Mirjana, Đorđević, Iris, Krstić, Gordana, Tešević, Vele, Milosavljević, Slobodan, "New insights into sesquiterpene lactones composition of 
Western Balkan’s genus Amphoricarpos revealed by rapid 
resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry" in Macedonian Pharmaceutical Bulletin, 68, no. Suppl.2 (2022):71-72,
https://doi.org/10.33320/maced.pharm.bull.2022.68.04.030 . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Lončar, Biljana
AU  - Pezo, Milada
AU  - Stanković Jeremić, Jovana
AU  - Cvetković, Mirjana
AU  - Rat, Milica
AU  - Pezo, Lato
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5265
AB  - Unlike other studies that only determined the chemical composition of essential oils depending on their geographic origin, this research investigated the effect of weather conditions (temperature, precipitation, and insolation) on the chemical composition of Nepeta nuda L. essential oil. The collection of wild-growing N. nuda was carried out during three successive years, 2019, 2020, and 2021 at Rtanj Mountain (Serbia) on the same date (July 7th). Essential oil extraction from the plant was performed by hydro-distillation. After gas chromatographic-mass spectrometric analysis, a total of 102 volatile compounds were separated from N. nuda, during the observed period, 28 were unidentified, compromising between 5.0% and 8.7%, depending on the year. A multiple linear regression model was created, and statistical analyses were performed to provide knowledge about the prediction, feature profile, and the similarity in contents of active compounds of the N. nuda essential oil. The influence of temperature on the accumulation of the most abundant component, 1,8-cineole, was positive, while the impact of precipitation and insolation was negative. According to the cluster tree, there are four chemotypes of N. nuda essential oil: with nepetalactone, 1,8-cineole, mixed (nepetalactone+1,8-cineole+germacrene D), and nonspecific chemotypes. Bearing in mind that the biological activity of a raw material depends on the chemotype and environmental factors, this is a topic that deserves a more detailed approach. The N. nuda and its essential oil are promising materials with high biological potential, and these deserve further detailed investigation.
T2  - Horticulturae
T1  - Volatile Compounds of Nepeta nuda L. from Rtanj Mountain (Serbia)
VL  - 8
IS  - 2
SP  - 85
DO  - 10.3390/horticulturae8020085
ER  - 

@article{
author = "Aćimović, Milica and Lončar, Biljana and Pezo, Milada and Stanković Jeremić, Jovana and Cvetković, Mirjana and Rat, Milica and Pezo, Lato",
year = "2022",
abstract = "Unlike other studies that only determined the chemical composition of essential oils depending on their geographic origin, this research investigated the effect of weather conditions (temperature, precipitation, and insolation) on the chemical composition of Nepeta nuda L. essential oil. The collection of wild-growing N. nuda was carried out during three successive years, 2019, 2020, and 2021 at Rtanj Mountain (Serbia) on the same date (July 7th). Essential oil extraction from the plant was performed by hydro-distillation. After gas chromatographic-mass spectrometric analysis, a total of 102 volatile compounds were separated from N. nuda, during the observed period, 28 were unidentified, compromising between 5.0% and 8.7%, depending on the year. A multiple linear regression model was created, and statistical analyses were performed to provide knowledge about the prediction, feature profile, and the similarity in contents of active compounds of the N. nuda essential oil. The influence of temperature on the accumulation of the most abundant component, 1,8-cineole, was positive, while the impact of precipitation and insolation was negative. According to the cluster tree, there are four chemotypes of N. nuda essential oil: with nepetalactone, 1,8-cineole, mixed (nepetalactone+1,8-cineole+germacrene D), and nonspecific chemotypes. Bearing in mind that the biological activity of a raw material depends on the chemotype and environmental factors, this is a topic that deserves a more detailed approach. The N. nuda and its essential oil are promising materials with high biological potential, and these deserve further detailed investigation.",
journal = "Horticulturae",
title = "Volatile Compounds of Nepeta nuda L. from Rtanj Mountain (Serbia)",
volume = "8",
number = "2",
pages = "85",
doi = "10.3390/horticulturae8020085"
}

Aćimović, M., Lončar, B., Pezo, M., Stanković Jeremić, J., Cvetković, M., Rat, M.,& Pezo, L.. (2022). Volatile Compounds of Nepeta nuda L. from Rtanj Mountain (Serbia). in Horticulturae, 8(2), 85.
https://doi.org/10.3390/horticulturae8020085

Aćimović M, Lončar B, Pezo M, Stanković Jeremić J, Cvetković M, Rat M, Pezo L. Volatile Compounds of Nepeta nuda L. from Rtanj Mountain (Serbia). in Horticulturae. 2022;8(2):85.
doi:10.3390/horticulturae8020085 .

Aćimović, Milica, Lončar, Biljana, Pezo, Milada, Stanković Jeremić, Jovana, Cvetković, Mirjana, Rat, Milica, Pezo, Lato, "Volatile Compounds of Nepeta nuda L. from Rtanj Mountain (Serbia)" in Horticulturae, 8, no. 2 (2022):85,
https://doi.org/10.3390/horticulturae8020085 . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Cvetković, Mirjana
AU  - Stanković Jeremić, Jovana
AU  - Pezo, Lato
AU  - Varga, Ana
AU  - Čabarkapa, Ivana
AU  - Kiprovski, Biljana
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5406
AB  - Salvia sclarea L. or clary sage is cultivated worldwide in temperate and sub-tropical climates, as an ornamental and essential oil (EO) bearing plant. EO is obtained from fresh spikes in full flowering stage and is recognized as an important commercial product for food, beverage and cosmetic industries. This study investigated the EO composition of S. sclarea grown in Serbia (Southeast Europe) obtained by two different methods, steam (SD) and hydrodistillation (HD). GC-MS analysis identified oxygenated monoterpenes as the main class of compounds for all EOs (between 81.8% and 88.2% depending on the distillation process). The most abundant oxygenated monoterpenes were linalyl acetate and linalool. In addition, in vitro antimicrobial (modified resazurin microtitre-plate assay) and antioxidant activities (DPPH• assay) and total polyphenol content of obtained EOs were also evaluated. According to the assay used for the evaluation of the antibacterial activity, Gram-negative bacteria were more sensitive to S. sclarea EO in comparison to Gram-positive bacteria. EOs exhibited low antioxidant capacity, below 3% neutralized DPPH• radicals, reaching up to approximately 400 µg AAE mL-1. This study also investigated a possibility for predicting retention indices (RIs) of compounds isolated from EOs. In total, 78 experimentally obtained RIs were applied to construct the prediction model. The quantitative structure-chromatographic retention relationship (QSRR) model was used to anticipate the experimentally obtained RIs. Five molecular descriptors were selected by factor analysis and genetic algorithm to predict RIs. The obtained accuracy of the QSRR model reached r2 =.912, which showed that these models might be applied for predicting retention indices.
PB  - Wiley
T2  - Flavour and Fragrance Journal
T1  - Biological activity and profiling of Salvia sclarea essential oil obtained by steam and hydrodistillation extraction methods via chemometrics tools
VL  - 37
IS  - 1
SP  - 20
EP  - 32
DO  - 10.1002/ffj.3684
ER  - 

@article{
author = "Aćimović, Milica and Cvetković, Mirjana and Stanković Jeremić, Jovana and Pezo, Lato and Varga, Ana and Čabarkapa, Ivana and Kiprovski, Biljana",
year = "2022",
abstract = "Salvia sclarea L. or clary sage is cultivated worldwide in temperate and sub-tropical climates, as an ornamental and essential oil (EO) bearing plant. EO is obtained from fresh spikes in full flowering stage and is recognized as an important commercial product for food, beverage and cosmetic industries. This study investigated the EO composition of S. sclarea grown in Serbia (Southeast Europe) obtained by two different methods, steam (SD) and hydrodistillation (HD). GC-MS analysis identified oxygenated monoterpenes as the main class of compounds for all EOs (between 81.8% and 88.2% depending on the distillation process). The most abundant oxygenated monoterpenes were linalyl acetate and linalool. In addition, in vitro antimicrobial (modified resazurin microtitre-plate assay) and antioxidant activities (DPPH• assay) and total polyphenol content of obtained EOs were also evaluated. According to the assay used for the evaluation of the antibacterial activity, Gram-negative bacteria were more sensitive to S. sclarea EO in comparison to Gram-positive bacteria. EOs exhibited low antioxidant capacity, below 3% neutralized DPPH• radicals, reaching up to approximately 400 µg AAE mL-1. This study also investigated a possibility for predicting retention indices (RIs) of compounds isolated from EOs. In total, 78 experimentally obtained RIs were applied to construct the prediction model. The quantitative structure-chromatographic retention relationship (QSRR) model was used to anticipate the experimentally obtained RIs. Five molecular descriptors were selected by factor analysis and genetic algorithm to predict RIs. The obtained accuracy of the QSRR model reached r2 =.912, which showed that these models might be applied for predicting retention indices.",
publisher = "Wiley",
journal = "Flavour and Fragrance Journal",
title = "Biological activity and profiling of Salvia sclarea essential oil obtained by steam and hydrodistillation extraction methods via chemometrics tools",
volume = "37",
number = "1",
pages = "20-32",
doi = "10.1002/ffj.3684"
}

Aćimović, M., Cvetković, M., Stanković Jeremić, J., Pezo, L., Varga, A., Čabarkapa, I.,& Kiprovski, B.. (2022). Biological activity and profiling of Salvia sclarea essential oil obtained by steam and hydrodistillation extraction methods via chemometrics tools. in Flavour and Fragrance Journal
Wiley., 37(1), 20-32.
https://doi.org/10.1002/ffj.3684

Aćimović M, Cvetković M, Stanković Jeremić J, Pezo L, Varga A, Čabarkapa I, Kiprovski B. Biological activity and profiling of Salvia sclarea essential oil obtained by steam and hydrodistillation extraction methods via chemometrics tools. in Flavour and Fragrance Journal. 2022;37(1):20-32.
doi:10.1002/ffj.3684 .

Aćimović, Milica, Cvetković, Mirjana, Stanković Jeremić, Jovana, Pezo, Lato, Varga, Ana, Čabarkapa, Ivana, Kiprovski, Biljana, "Biological activity and profiling of Salvia sclarea essential oil obtained by steam and hydrodistillation extraction methods via chemometrics tools" in Flavour and Fragrance Journal, 37, no. 1 (2022):20-32,
https://doi.org/10.1002/ffj.3684 . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Lončar, Biljana
AU  - Stanković Jeremić, Jovana
AU  - Cvetković, Mirjana
AU  - Pezo, Lato
AU  - Pezo, Milada
AU  - Todosijević, Marina
AU  - Tešević, Vele
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5409
AB  - Lavandula sp. essential oil and hydrolate are commercially valuable in various industry
branches with the potential for wide-ranging applications. This study aimed to evaluate the quality
of these products obtained from L. x intermedia cv. ‘Budrovka’ for the first time cultivated on Fruška
Gora Mt. (Serbia) during three successive seasons (2019, 2020, and 2021). Essential oil extraction
was obtained by steam distillation, and the composition and influence of weather conditions were
also assessed, using flowering tops. The obtained essential oils and hydrolates were analysed by
gas chromatography with a flame ionization detector (GC-FID) and gas chromatography coupled to
mass spectrometry (GC-MS). A linear regression model was developed to predict L. x intermedia cv.
‘Budrovka’ essential oil volatile compound content and hydrolate composition during three years,
according to temperature and precipitation data, and the appropriate regression coefficients were
calculated, while the correlation analysis was employed to analyse the correlations in hydrolate
and essential oil compounds. To completely describe the structure of the research data that would
present a better insight into the similarities and differences among the diverse L. x intermedia cv.
‘Budrovka’ samples, the PCA was used. The most dominant in L. intermedia cv. ‘Budrovka’ essential
oil and hydrolate were oxygenated monoterpenes: linalool, 1,8-cineole, borneol, linalyl acetate, and
terpinene-4-ol. It is established that the temperature was positively correlated with all essential oil
and hydrolate compounds. The precipitations were positively correlated with the main compounds
(linalool, 1,8-cineole, and borneol), while the other compounds’ content negatively correlated to
precipitation. The results indicated that Fruška Gora Mt. has suitable agro-ecological requirements
for cultivating Lavandula sp. and providing satisfactory essential oil and hydrolate.
PB  - Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Horticulturae
T1  - Weather Conditions Influence on Lavandin Essential Oil and Hydrolate Quality
VL  - 8
SP  - 281
DO  - 10.3390/horticulturae8040281
ER  - 

@article{
author = "Aćimović, Milica and Lončar, Biljana and Stanković Jeremić, Jovana and Cvetković, Mirjana and Pezo, Lato and Pezo, Milada and Todosijević, Marina and Tešević, Vele",
year = "2022",
abstract = "Lavandula sp. essential oil and hydrolate are commercially valuable in various industry
branches with the potential for wide-ranging applications. This study aimed to evaluate the quality
of these products obtained from L. x intermedia cv. ‘Budrovka’ for the first time cultivated on Fruška
Gora Mt. (Serbia) during three successive seasons (2019, 2020, and 2021). Essential oil extraction
was obtained by steam distillation, and the composition and influence of weather conditions were
also assessed, using flowering tops. The obtained essential oils and hydrolates were analysed by
gas chromatography with a flame ionization detector (GC-FID) and gas chromatography coupled to
mass spectrometry (GC-MS). A linear regression model was developed to predict L. x intermedia cv.
‘Budrovka’ essential oil volatile compound content and hydrolate composition during three years,
according to temperature and precipitation data, and the appropriate regression coefficients were
calculated, while the correlation analysis was employed to analyse the correlations in hydrolate
and essential oil compounds. To completely describe the structure of the research data that would
present a better insight into the similarities and differences among the diverse L. x intermedia cv.
‘Budrovka’ samples, the PCA was used. The most dominant in L. intermedia cv. ‘Budrovka’ essential
oil and hydrolate were oxygenated monoterpenes: linalool, 1,8-cineole, borneol, linalyl acetate, and
terpinene-4-ol. It is established that the temperature was positively correlated with all essential oil
and hydrolate compounds. The precipitations were positively correlated with the main compounds
(linalool, 1,8-cineole, and borneol), while the other compounds’ content negatively correlated to
precipitation. The results indicated that Fruška Gora Mt. has suitable agro-ecological requirements
for cultivating Lavandula sp. and providing satisfactory essential oil and hydrolate.",
publisher = "Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Horticulturae",
title = "Weather Conditions Influence on Lavandin Essential Oil and Hydrolate Quality",
volume = "8",
pages = "281",
doi = "10.3390/horticulturae8040281"
}

Aćimović, M., Lončar, B., Stanković Jeremić, J., Cvetković, M., Pezo, L., Pezo, M., Todosijević, M.,& Tešević, V.. (2022). Weather Conditions Influence on Lavandin Essential Oil and Hydrolate Quality. in Horticulturae
Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)., 8, 281.
https://doi.org/10.3390/horticulturae8040281

Aćimović M, Lončar B, Stanković Jeremić J, Cvetković M, Pezo L, Pezo M, Todosijević M, Tešević V. Weather Conditions Influence on Lavandin Essential Oil and Hydrolate Quality. in Horticulturae. 2022;8:281.
doi:10.3390/horticulturae8040281 .

Aćimović, Milica, Lončar, Biljana, Stanković Jeremić, Jovana, Cvetković, Mirjana, Pezo, Lato, Pezo, Milada, Todosijević, Marina, Tešević, Vele, "Weather Conditions Influence on Lavandin Essential Oil and Hydrolate Quality" in Horticulturae, 8 (2022):281,
https://doi.org/10.3390/horticulturae8040281 . .

TY  - JOUR
AU  - Božanić Tanjga, Biljana
AU  - Lončar, Biljana
AU  - Aćimović, Milica
AU  - Kiprovski, Biljana
AU  - Šovljanski, Olja
AU  - Tomić, Ana
AU  - Travičić, Vanja
AU  - Cvetković, Mirjana
AU  - Raičević, Vidak
AU  - Zeremski, Tijana
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5364
AB  - Garden rose, Rosa hybrida, is primarily used for decoration and has a wide range of growing
area, contrary to R. damascena that has a limited area of distribution (Turkey and Bulgaria), yet it is
extensively used for commercial production of valuable and expensive rose oil. Since the content of
essential oil in rose petals is low (0.03–0.04%), its production is quite limited; however, during this
process, a significant amount of rose hydrosol is obtained as a secondary product. The aim of this
research was to determine the chemical composition of garden rose hydrosols and to evaluate their
biological properties. Obtained results show that R. hybrida hydrosol containing phenylethyl alcohol,
nerol, linalool, and geraniol may be used as an alternative for R. damascena hydrosol. However, the
total phenolic content was quite low (4.96 _g GAE/mL), which is related to a low level of observed
antioxidant activity based on different antioxidant activity assays. Furthermore, R. hybrida hydrosol
did not exhibit antimicrobial activity against several gram-positive and gram-negative bacteria, as
well as yeast and fungi. Anti-inflammatory activity was also low, while no antihyperglycemic activity
was detected. With these results in mind, no potential is evident for the therapeutic application of
rose hydrosol beyond that found in complimentary medicine such as aromatherapy.
PB  - Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Horticulturae
T1  - Volatile Profile of Garden Rose (Rosa hybrida) Hydrosol and Evaluation of Its Biological Activity In Vitro
VL  - 8
IS  - 10
SP  - 895
DO  - 10.3390/horticulturae8100895
ER  - 

@article{
author = "Božanić Tanjga, Biljana and Lončar, Biljana and Aćimović, Milica and Kiprovski, Biljana and Šovljanski, Olja and Tomić, Ana and Travičić, Vanja and Cvetković, Mirjana and Raičević, Vidak and Zeremski, Tijana",
year = "2022",
abstract = "Garden rose, Rosa hybrida, is primarily used for decoration and has a wide range of growing
area, contrary to R. damascena that has a limited area of distribution (Turkey and Bulgaria), yet it is
extensively used for commercial production of valuable and expensive rose oil. Since the content of
essential oil in rose petals is low (0.03–0.04%), its production is quite limited; however, during this
process, a significant amount of rose hydrosol is obtained as a secondary product. The aim of this
research was to determine the chemical composition of garden rose hydrosols and to evaluate their
biological properties. Obtained results show that R. hybrida hydrosol containing phenylethyl alcohol,
nerol, linalool, and geraniol may be used as an alternative for R. damascena hydrosol. However, the
total phenolic content was quite low (4.96 _g GAE/mL), which is related to a low level of observed
antioxidant activity based on different antioxidant activity assays. Furthermore, R. hybrida hydrosol
did not exhibit antimicrobial activity against several gram-positive and gram-negative bacteria, as
well as yeast and fungi. Anti-inflammatory activity was also low, while no antihyperglycemic activity
was detected. With these results in mind, no potential is evident for the therapeutic application of
rose hydrosol beyond that found in complimentary medicine such as aromatherapy.",
publisher = "Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Horticulturae",
title = "Volatile Profile of Garden Rose (Rosa hybrida) Hydrosol and Evaluation of Its Biological Activity In Vitro",
volume = "8",
number = "10",
pages = "895",
doi = "10.3390/horticulturae8100895"
}

Božanić Tanjga, B., Lončar, B., Aćimović, M., Kiprovski, B., Šovljanski, O., Tomić, A., Travičić, V., Cvetković, M., Raičević, V.,& Zeremski, T.. (2022). Volatile Profile of Garden Rose (Rosa hybrida) Hydrosol and Evaluation of Its Biological Activity In Vitro. in Horticulturae
Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)., 8(10), 895.
https://doi.org/10.3390/horticulturae8100895

Božanić Tanjga B, Lončar B, Aćimović M, Kiprovski B, Šovljanski O, Tomić A, Travičić V, Cvetković M, Raičević V, Zeremski T. Volatile Profile of Garden Rose (Rosa hybrida) Hydrosol and Evaluation of Its Biological Activity In Vitro. in Horticulturae. 2022;8(10):895.
doi:10.3390/horticulturae8100895 .

Božanić Tanjga, Biljana, Lončar, Biljana, Aćimović, Milica, Kiprovski, Biljana, Šovljanski, Olja, Tomić, Ana, Travičić, Vanja, Cvetković, Mirjana, Raičević, Vidak, Zeremski, Tijana, "Volatile Profile of Garden Rose (Rosa hybrida) Hydrosol and Evaluation of Its Biological Activity In Vitro" in Horticulturae, 8, no. 10 (2022):895,
https://doi.org/10.3390/horticulturae8100895 . .

TY  - CONF
AU  - Anđelković, Boban
AU  - Gođevac, Dejan
AU  - Stanković, Jovana
AU  - Cvetković, Mirjana
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan
AU  - Simić, Katarina
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5526
AB  - A large number of plant metabolites has provided an incomparable chemical source of the pharmaceutical
products. The two major fields of chemical research on biological active small molecules, metabolomics and
natural product discovery, have the similar goals of identifying and characterizing small molecules, either in
their isolated active state (natural product chemistry). Metabolomics generate a profile of small molecules
from plant extracts, which could be directly responsible for bioactivity effects. Using dry-column flash
chromatography enable a rapid and inexpensive method for the very efficient separation of plant extract with
a high resolution. This separation method coupled to NMR and FTIR-based metabolomics is applied to identify
bioactive natural products. OPLS multivariate analysis method, was used for correlation the chemical
composition of the plant extracts, Amphoricarpos autariatus, with the results of cytotoxic activity against
Human cervical adenocarcinoma cell line (HeLa) and epithelial lung cancer cell line (A549). In this way, the
highest contribution to the cytotoxic activity was recorded for the guaianolide sesquiterpene lactone were
tested, and their cytotoxic activity were conformed.
PB  - Portugal : PROTEOMASS Scientific Society
C3  - Book of abstracts - 5th International Caparica Christmas Conference  on Sample Treatment (ST 2021), 15th – 18th November 2021, Caparica, Portugal
T1  - Integration	of	dry-column	flash	chromatography	with	NMR	 and	 FTIR	 metabolomics	 to	 reveal	 cytotoxic	 metabolites	 from	 Amphoricarpos	autariatus
SP  - 148
EP  - 148
UR  - https://hdl.handle.net/21.15107/rcub_cer_5526
ER  - 

@conference{
author = "Anđelković, Boban and Gođevac, Dejan and Stanković, Jovana and Cvetković, Mirjana and Tešević, Vele and Milosavljević, Slobodan and Simić, Katarina",
year = "2021",
abstract = "A large number of plant metabolites has provided an incomparable chemical source of the pharmaceutical
products. The two major fields of chemical research on biological active small molecules, metabolomics and
natural product discovery, have the similar goals of identifying and characterizing small molecules, either in
their isolated active state (natural product chemistry). Metabolomics generate a profile of small molecules
from plant extracts, which could be directly responsible for bioactivity effects. Using dry-column flash
chromatography enable a rapid and inexpensive method for the very efficient separation of plant extract with
a high resolution. This separation method coupled to NMR and FTIR-based metabolomics is applied to identify
bioactive natural products. OPLS multivariate analysis method, was used for correlation the chemical
composition of the plant extracts, Amphoricarpos autariatus, with the results of cytotoxic activity against
Human cervical adenocarcinoma cell line (HeLa) and epithelial lung cancer cell line (A549). In this way, the
highest contribution to the cytotoxic activity was recorded for the guaianolide sesquiterpene lactone were
tested, and their cytotoxic activity were conformed.",
publisher = "Portugal : PROTEOMASS Scientific Society",
journal = "Book of abstracts - 5th International Caparica Christmas Conference  on Sample Treatment (ST 2021), 15th – 18th November 2021, Caparica, Portugal",
title = "Integration	of	dry-column	flash	chromatography	with	NMR	 and	 FTIR	 metabolomics	 to	 reveal	 cytotoxic	 metabolites	 from	 Amphoricarpos	autariatus",
pages = "148-148",
url = "https://hdl.handle.net/21.15107/rcub_cer_5526"
}

Anđelković, B., Gođevac, D., Stanković, J., Cvetković, M., Tešević, V., Milosavljević, S.,& Simić, K.. (2021). Integration	of	dry-column	flash	chromatography	with	NMR	 and	 FTIR	 metabolomics	 to	 reveal	 cytotoxic	 metabolites	 from	 Amphoricarpos	autariatus. in Book of abstracts - 5th International Caparica Christmas Conference  on Sample Treatment (ST 2021), 15th – 18th November 2021, Caparica, Portugal
Portugal : PROTEOMASS Scientific Society., 148-148.
https://hdl.handle.net/21.15107/rcub_cer_5526

Anđelković B, Gođevac D, Stanković J, Cvetković M, Tešević V, Milosavljević S, Simić K. Integration	of	dry-column	flash	chromatography	with	NMR	 and	 FTIR	 metabolomics	 to	 reveal	 cytotoxic	 metabolites	 from	 Amphoricarpos	autariatus. in Book of abstracts - 5th International Caparica Christmas Conference  on Sample Treatment (ST 2021), 15th – 18th November 2021, Caparica, Portugal. 2021;:148-148.
https://hdl.handle.net/21.15107/rcub_cer_5526 .

Anđelković, Boban, Gođevac, Dejan, Stanković, Jovana, Cvetković, Mirjana, Tešević, Vele, Milosavljević, Slobodan, Simić, Katarina, "Integration	of	dry-column	flash	chromatography	with	NMR	 and	 FTIR	 metabolomics	 to	 reveal	 cytotoxic	 metabolites	 from	 Amphoricarpos	autariatus" in Book of abstracts - 5th International Caparica Christmas Conference  on Sample Treatment (ST 2021), 15th – 18th November 2021, Caparica, Portugal (2021):148-148,
https://hdl.handle.net/21.15107/rcub_cer_5526 .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Pezo, Lato
AU  - Zeremski, Tijana
AU  - Lončar, Biljana
AU  - Marjanović  Jeromela, Ana
AU  - Stanković Jeremić, Jovana
AU  - Cvetković, Mirjana
AU  - Sikora, Vladimir
AU  - Ignjatov, Maja
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4829
AB  - This paper is a study of the chemical composition of Hyssopus officinalis ssp. Officinalis grown during three years (2017-2019) at the Institute of Field and Vegetable Crops Novi Sad (Vojvodina Province, Serbia). Furthermore, comparisons with ISO standards during the years were also investigated, as well as a prediction model of retention indices of compounds from the essential oils. An essential oil obtained by hydrodistillation and analysed by GC-FID and GC-MS was isopinocamphone chemotype. The gathered information about the volatile compounds from H. officinalis was used to classify the samples using the unrooted cluster tree. The correlation analysis was applied to investigate the similarity of different samples, according to GC-MS data. The quantitative structure- retention relationship (QSRR) was also employed to predict the retention indices of the identified compounds. A total of 74 experimentally obtained retention indices were used to build a prediction model. The coefficient of determination for the training cycle was 0.910, indicating that this model could be used for the prediction of retention indices for H. officinalis essential oil compounds.
PB  - MDPI
T2  - Processes
T1  - Weather conditions influence on hyssop essential oil quality
VL  - 9
IS  - 7
SP  - 1152
DO  - 10.3390/pr9071152
ER  - 

@article{
author = "Aćimović, Milica and Pezo, Lato and Zeremski, Tijana and Lončar, Biljana and Marjanović  Jeromela, Ana and Stanković Jeremić, Jovana and Cvetković, Mirjana and Sikora, Vladimir and Ignjatov, Maja",
year = "2021",
abstract = "This paper is a study of the chemical composition of Hyssopus officinalis ssp. Officinalis grown during three years (2017-2019) at the Institute of Field and Vegetable Crops Novi Sad (Vojvodina Province, Serbia). Furthermore, comparisons with ISO standards during the years were also investigated, as well as a prediction model of retention indices of compounds from the essential oils. An essential oil obtained by hydrodistillation and analysed by GC-FID and GC-MS was isopinocamphone chemotype. The gathered information about the volatile compounds from H. officinalis was used to classify the samples using the unrooted cluster tree. The correlation analysis was applied to investigate the similarity of different samples, according to GC-MS data. The quantitative structure- retention relationship (QSRR) was also employed to predict the retention indices of the identified compounds. A total of 74 experimentally obtained retention indices were used to build a prediction model. The coefficient of determination for the training cycle was 0.910, indicating that this model could be used for the prediction of retention indices for H. officinalis essential oil compounds.",
publisher = "MDPI",
journal = "Processes",
title = "Weather conditions influence on hyssop essential oil quality",
volume = "9",
number = "7",
pages = "1152",
doi = "10.3390/pr9071152"
}

Aćimović, M., Pezo, L., Zeremski, T., Lončar, B., Marjanović  Jeromela, A., Stanković Jeremić, J., Cvetković, M., Sikora, V.,& Ignjatov, M.. (2021). Weather conditions influence on hyssop essential oil quality. in Processes
MDPI., 9(7), 1152.
https://doi.org/10.3390/pr9071152

Aćimović M, Pezo L, Zeremski T, Lončar B, Marjanović  Jeromela A, Stanković Jeremić J, Cvetković M, Sikora V, Ignjatov M. Weather conditions influence on hyssop essential oil quality. in Processes. 2021;9(7):1152.
doi:10.3390/pr9071152 .

Aćimović, Milica, Pezo, Lato, Zeremski, Tijana, Lončar, Biljana, Marjanović  Jeromela, Ana, Stanković Jeremić, Jovana, Cvetković, Mirjana, Sikora, Vladimir, Ignjatov, Maja, "Weather conditions influence on hyssop essential oil quality" in Processes, 9, no. 7 (2021):1152,
https://doi.org/10.3390/pr9071152 . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Stanković Jeremić, Jovana
AU  - Simić, Katarina
AU  - Ivanović, Stefan
AU  - Ljujić, Jovana
AU  - Čabarkapa, Ivana
AU  - Radojčin, Milivoj
AU  - Todosijević, Marina
AU  - Cvetković, Mirjana
PY  - 2021
UR  - http://letopisnaucnihradova.rs/wp-content/uploads/2021/09/Essential_oil_quality_of_chamomile_grown_in_Province_of_Vojvodina-Acimovic_et_al..pdf
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5167
AB  - Chamomile (Matricaria chamomilla L., Asteraceae) is one of the most popular medicinal plants used as a herb
infusion for treating numerous ailments, including sleep disorders, anxiety, digestion and intestinal conditions
etc. Chamomile essential oil is used in a wide variety of consumer goods such as detergents, soaps, toiletries,
cosmetics, pharmaceuticals, perfumes, confectionery food products, soft drinks, distilled alcoholic beverages
(hard liquor) and as insecticide. According to the European Pharmacopoeia, there are two types of essential
oils, one rich in bisabolol oxides and the other in α-bisabolol, which are preferred for tea brewing because of
its sweet, grassy, and slightly fruity aroma. From the other side, varieties rich in chamazulene and β-farnesene
have bitter taste, and because of that they are low valuable raw material. According to the results of the
essential oil composition obtained from three different chamomile samples grown in Province of Vojvodina, it
could be concluded that domestic cultivars “Banatska” and “Tetraploidna” contains β-farnesene as dominant
compound, while the content of bisabolol oxides and α-bisabolol was lower than required standards in
European Pharmacopoeia. Because of that they could not be classified as quality raw material. The German
cultivar “Mabamille” grown in agroecological conditions of Vojvodina region, with 37.5% of α-bisabolol can be
classified as a bisabolol rich type, and as high quality row material.
AB  - Kamilica (Matricaria chamomilla L., Asteraceae) je jedna od najpopularnijih lekovitih biljaka koja se 
upotrebljava u obliku infuza (čaja) za lečenje mnogih stanja i bolesti, uključujući poremećaje sna, napetost, probleme organa za varenje itd. Etarsko ulje kamilice se koristi u mnogim granama industrije: hemijskoj (kao dodatak deterdžentima), kozmetičkoj (u sapunima, sredstvima za ličnu higijenu), farmaceutskoj, parfimerijskoj i prehrambenoj industriji (u slatkišima, alkoholnim i bezalkoholnim pićima) i kao insekticid. Prema Evropskoj Farmakopeji, postoje dva tipa etarskog ulja kamilice, prvi koji je bogat bisabolol oksidima i drugi bogat α-bisabololom. Oba tipa su poželjna u industriji čajnih napitaka zbog njihovog slatkog, osvežavajućeg ukusa blago voćne arome. Sa druge strane, varijeteti bogati hamazulenom i β-farnezenom imaju gorak ukus i zbog toga predstavljaju manje vrednu biljnu sirovinu. Na osnovu rezultata hemijskog sastava etarskog ulja tri 
različita uzorka kamilice gajene u Pokrajini Vojvodini od strane individualnih poljoprivrednih proizvođača, može se zaključiti da domaće sorte “Banatska” i “Tetraploidna” sadrže β-farnezen kao dominantnu komponentu, dok je sadržaj bisabolol oksida i α-bisabolola niži nego što zahtevaju standardi u Evropskoj Farmakopeji, zbog čega se ne mogu kategorisati kao kvalitetni biljni materijal. Nemačka sorta “Mabamille” gajena u agroekološkim uslovima pokrajine Vojvodine, sa 37,5% α-bisabolola pripada bisabolol tipu kamilice i predstavlja visoko kvalitetnu sirovinu.
PB  - Novi Sad: Poljoprivredni fakultet
T2  - Letopis naučnih radova Poljoprivrednog fakulteta, Novi Sad
T1  - Essential oil quality of chamomile grown in Province of Vojvodina
VL  - 45
IS  - 1
SP  - 1
EP  - 8
UR  - https://hdl.handle.net/21.15107/rcub_cer_5167
ER  - 

@article{
author = "Aćimović, Milica and Stanković Jeremić, Jovana and Simić, Katarina and Ivanović, Stefan and Ljujić, Jovana and Čabarkapa, Ivana and Radojčin, Milivoj and Todosijević, Marina and Cvetković, Mirjana",
year = "2021",
abstract = "Chamomile (Matricaria chamomilla L., Asteraceae) is one of the most popular medicinal plants used as a herb
infusion for treating numerous ailments, including sleep disorders, anxiety, digestion and intestinal conditions
etc. Chamomile essential oil is used in a wide variety of consumer goods such as detergents, soaps, toiletries,
cosmetics, pharmaceuticals, perfumes, confectionery food products, soft drinks, distilled alcoholic beverages
(hard liquor) and as insecticide. According to the European Pharmacopoeia, there are two types of essential
oils, one rich in bisabolol oxides and the other in α-bisabolol, which are preferred for tea brewing because of
its sweet, grassy, and slightly fruity aroma. From the other side, varieties rich in chamazulene and β-farnesene
have bitter taste, and because of that they are low valuable raw material. According to the results of the
essential oil composition obtained from three different chamomile samples grown in Province of Vojvodina, it
could be concluded that domestic cultivars “Banatska” and “Tetraploidna” contains β-farnesene as dominant
compound, while the content of bisabolol oxides and α-bisabolol was lower than required standards in
European Pharmacopoeia. Because of that they could not be classified as quality raw material. The German
cultivar “Mabamille” grown in agroecological conditions of Vojvodina region, with 37.5% of α-bisabolol can be
classified as a bisabolol rich type, and as high quality row material., Kamilica (Matricaria chamomilla L., Asteraceae) je jedna od najpopularnijih lekovitih biljaka koja se 
upotrebljava u obliku infuza (čaja) za lečenje mnogih stanja i bolesti, uključujući poremećaje sna, napetost, probleme organa za varenje itd. Etarsko ulje kamilice se koristi u mnogim granama industrije: hemijskoj (kao dodatak deterdžentima), kozmetičkoj (u sapunima, sredstvima za ličnu higijenu), farmaceutskoj, parfimerijskoj i prehrambenoj industriji (u slatkišima, alkoholnim i bezalkoholnim pićima) i kao insekticid. Prema Evropskoj Farmakopeji, postoje dva tipa etarskog ulja kamilice, prvi koji je bogat bisabolol oksidima i drugi bogat α-bisabololom. Oba tipa su poželjna u industriji čajnih napitaka zbog njihovog slatkog, osvežavajućeg ukusa blago voćne arome. Sa druge strane, varijeteti bogati hamazulenom i β-farnezenom imaju gorak ukus i zbog toga predstavljaju manje vrednu biljnu sirovinu. Na osnovu rezultata hemijskog sastava etarskog ulja tri 
različita uzorka kamilice gajene u Pokrajini Vojvodini od strane individualnih poljoprivrednih proizvođača, može se zaključiti da domaće sorte “Banatska” i “Tetraploidna” sadrže β-farnezen kao dominantnu komponentu, dok je sadržaj bisabolol oksida i α-bisabolola niži nego što zahtevaju standardi u Evropskoj Farmakopeji, zbog čega se ne mogu kategorisati kao kvalitetni biljni materijal. Nemačka sorta “Mabamille” gajena u agroekološkim uslovima pokrajine Vojvodine, sa 37,5% α-bisabolola pripada bisabolol tipu kamilice i predstavlja visoko kvalitetnu sirovinu.",
publisher = "Novi Sad: Poljoprivredni fakultet",
journal = "Letopis naučnih radova Poljoprivrednog fakulteta, Novi Sad",
title = "Essential oil quality of chamomile grown in Province of Vojvodina",
volume = "45",
number = "1",
pages = "1-8",
url = "https://hdl.handle.net/21.15107/rcub_cer_5167"
}

Aćimović, M., Stanković Jeremić, J., Simić, K., Ivanović, S., Ljujić, J., Čabarkapa, I., Radojčin, M., Todosijević, M.,& Cvetković, M.. (2021). Essential oil quality of chamomile grown in Province of Vojvodina. in Letopis naučnih radova Poljoprivrednog fakulteta, Novi Sad
Novi Sad: Poljoprivredni fakultet., 45(1), 1-8.
https://hdl.handle.net/21.15107/rcub_cer_5167

Aćimović M, Stanković Jeremić J, Simić K, Ivanović S, Ljujić J, Čabarkapa I, Radojčin M, Todosijević M, Cvetković M. Essential oil quality of chamomile grown in Province of Vojvodina. in Letopis naučnih radova Poljoprivrednog fakulteta, Novi Sad. 2021;45(1):1-8.
https://hdl.handle.net/21.15107/rcub_cer_5167 .

Aćimović, Milica, Stanković Jeremić, Jovana, Simić, Katarina, Ivanović, Stefan, Ljujić, Jovana, Čabarkapa, Ivana, Radojčin, Milivoj, Todosijević, Marina, Cvetković, Mirjana, "Essential oil quality of chamomile grown in Province of Vojvodina" in Letopis naučnih radova Poljoprivrednog fakulteta, Novi Sad, 45, no. 1 (2021):1-8,
https://hdl.handle.net/21.15107/rcub_cer_5167 .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Pezo, Lato
AU  - Stanković Jeremić, Jovana
AU  - Todosijević, Marina
AU  - Rat, Milica
AU  - Tešević, Vele
AU  - Cvetković, Mirjana
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5291
AB  - In the essential oil of yarrow (Achillea millefolium L. sensu lato) collected from natural popula-
tion on Mt. Rtanj (Serbia) and distilled by Clevenger apparatus 104 compounds were detected, and

the most abundant were camphor (9.8%), caryophyllene oxide (6.5%), terpinen-4-ol (6.3%) and 1,8-

cineole (5.6%). The quantitative structure-retention relationship (QSRR) model was employed to pre-
dict the retention indices, using four molecular descriptors selected by factor analysis and a genetic

algorithm. The coefficients of determination reached the value of 0.862, demonstrating that this mo-
del could be used for prediction purposes.
PB  - Novi Sad : Faculty of Technology
T2  - Acta Periodica Technologica
T1  - The quantitative structure retention relationship of the gs ms profile of yarrow essential oil
IS  - 52
SP  - 123
EP  - 132
DO  - 10.2298/APT2152123A
ER  - 

@article{
author = "Aćimović, Milica and Pezo, Lato and Stanković Jeremić, Jovana and Todosijević, Marina and Rat, Milica and Tešević, Vele and Cvetković, Mirjana",
year = "2021",
abstract = "In the essential oil of yarrow (Achillea millefolium L. sensu lato) collected from natural popula-
tion on Mt. Rtanj (Serbia) and distilled by Clevenger apparatus 104 compounds were detected, and

the most abundant were camphor (9.8%), caryophyllene oxide (6.5%), terpinen-4-ol (6.3%) and 1,8-

cineole (5.6%). The quantitative structure-retention relationship (QSRR) model was employed to pre-
dict the retention indices, using four molecular descriptors selected by factor analysis and a genetic

algorithm. The coefficients of determination reached the value of 0.862, demonstrating that this mo-
del could be used for prediction purposes.",
publisher = "Novi Sad : Faculty of Technology",
journal = "Acta Periodica Technologica",
title = "The quantitative structure retention relationship of the gs ms profile of yarrow essential oil",
number = "52",
pages = "123-132",
doi = "10.2298/APT2152123A"
}

Aćimović, M., Pezo, L., Stanković Jeremić, J., Todosijević, M., Rat, M., Tešević, V.,& Cvetković, M.. (2021). The quantitative structure retention relationship of the gs ms profile of yarrow essential oil. in Acta Periodica Technologica
Novi Sad : Faculty of Technology.(52), 123-132.
https://doi.org/10.2298/APT2152123A

Aćimović M, Pezo L, Stanković Jeremić J, Todosijević M, Rat M, Tešević V, Cvetković M. The quantitative structure retention relationship of the gs ms profile of yarrow essential oil. in Acta Periodica Technologica. 2021;(52):123-132.
doi:10.2298/APT2152123A .

Aćimović, Milica, Pezo, Lato, Stanković Jeremić, Jovana, Todosijević, Marina, Rat, Milica, Tešević, Vele, Cvetković, Mirjana, "The quantitative structure retention relationship of the gs ms profile of yarrow essential oil" in Acta Periodica Technologica, no. 52 (2021):123-132,
https://doi.org/10.2298/APT2152123A . .

TY  - CONF
AU  - Stanković, Jovana
AU  - Gođevac, Dejan
AU  - Cvetković, Mirjana
AU  - Tešević, Vele
AU  - Sofrenić, Ivana
AU  - Ivanović, Stefan
AU  - Novaković, Miroslav
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5527
AB  - A new flavonoid glucoside derivative, patuletin 3-O-(2-O-feruloyl)-β-D-glucuronopyranosyl-(1→2)-β-Dglucopyranoside, named atriplexin IV (1), and three new triterpenoid saponin derivatives, two sulfonylated, β-
D-glucopyranosyl-3-O-(2-O-sulfo-β-D-galactopyranosyl)-(1→2)-α-L-arabinopyranoside-30-alolean-12-en-28-
oate (2), named atriplexogenin I, β-D glucopyranosyl-3-O-(2-O-sulfo-β-D-galactopyranosyl)-(1→2)-α-Larabinopyranoside)-30-hydroxyolean-12-en-28-oate (3), named atriplexogenin II, and β-D-glucopyranosyl-3-
O-(β-D-glucopyranosyl-(1→2)-β-D-galactopyranosyl-(1→2)-α-L-arabinopyranoside)-30-alolean-12-en-28-oate
(4), named atriplexogenin III, were isolated by silica gel column and semipreparative HPLC chromatography
from the n-butanol extract of the salt marsh plant Atriplex tatarica. In addition, two known secondary
metabolites, patuletin 3-O-β-D-apiofuranosyl-(1‴→2″)-β-D-glucopyranoside (5) and patuletin 3-O-5‴-Oferuloyl-β-D-apiofuranosyl-(1‴→2″)-β-D-glucopyranoside (6), were isolated for the first time from A. tatarica.
The structures of the isolated compounds were elucidated by 1D and 2D NMR, HRESIMS, IR, and UV data.
Antibacterial activity by the microdilution method and antibiofilm activity against P. aeruginosa were assessed.
The best activity against Micrococcus flavus and Pseudomonas aeruginosa showed compound 1, while against
Listeria monocytogenes and Escherichia coli the strongest activity was shown by compound 5. Isolated
saponins (2-4) exhibited a more pronounced biofilm inhibition activity than flavonoid glycosides (1, 5-6). The
best anti-biofilm activity showed compound 2.
PB  - Portugal : PROTEOMASS Scientific Society
C3  - Book of abstracts - 5th International Caparica Christmas Conference on Sample Treatment (ST 2021), 15th – 18th November 2021, Caparica, Portugal
T1  - Antibacterial	 and	 Antibiofilm	 Activity	 of	 Flavonoid	 and	 Saponin	 Derivatives	 from	 Atriplex	 tatarica against	 Pseudomonas	 aeruginosa
SP  - 150
EP  - 150
UR  - https://hdl.handle.net/21.15107/rcub_cer_5527
ER  - 

@conference{
author = "Stanković, Jovana and Gođevac, Dejan and Cvetković, Mirjana and Tešević, Vele and Sofrenić, Ivana and Ivanović, Stefan and Novaković, Miroslav",
year = "2021",
abstract = "A new flavonoid glucoside derivative, patuletin 3-O-(2-O-feruloyl)-β-D-glucuronopyranosyl-(1→2)-β-Dglucopyranoside, named atriplexin IV (1), and three new triterpenoid saponin derivatives, two sulfonylated, β-
D-glucopyranosyl-3-O-(2-O-sulfo-β-D-galactopyranosyl)-(1→2)-α-L-arabinopyranoside-30-alolean-12-en-28-
oate (2), named atriplexogenin I, β-D glucopyranosyl-3-O-(2-O-sulfo-β-D-galactopyranosyl)-(1→2)-α-Larabinopyranoside)-30-hydroxyolean-12-en-28-oate (3), named atriplexogenin II, and β-D-glucopyranosyl-3-
O-(β-D-glucopyranosyl-(1→2)-β-D-galactopyranosyl-(1→2)-α-L-arabinopyranoside)-30-alolean-12-en-28-oate
(4), named atriplexogenin III, were isolated by silica gel column and semipreparative HPLC chromatography
from the n-butanol extract of the salt marsh plant Atriplex tatarica. In addition, two known secondary
metabolites, patuletin 3-O-β-D-apiofuranosyl-(1‴→2″)-β-D-glucopyranoside (5) and patuletin 3-O-5‴-Oferuloyl-β-D-apiofuranosyl-(1‴→2″)-β-D-glucopyranoside (6), were isolated for the first time from A. tatarica.
The structures of the isolated compounds were elucidated by 1D and 2D NMR, HRESIMS, IR, and UV data.
Antibacterial activity by the microdilution method and antibiofilm activity against P. aeruginosa were assessed.
The best activity against Micrococcus flavus and Pseudomonas aeruginosa showed compound 1, while against
Listeria monocytogenes and Escherichia coli the strongest activity was shown by compound 5. Isolated
saponins (2-4) exhibited a more pronounced biofilm inhibition activity than flavonoid glycosides (1, 5-6). The
best anti-biofilm activity showed compound 2.",
publisher = "Portugal : PROTEOMASS Scientific Society",
journal = "Book of abstracts - 5th International Caparica Christmas Conference on Sample Treatment (ST 2021), 15th – 18th November 2021, Caparica, Portugal",
title = "Antibacterial	 and	 Antibiofilm	 Activity	 of	 Flavonoid	 and	 Saponin	 Derivatives	 from	 Atriplex	 tatarica against	 Pseudomonas	 aeruginosa",
pages = "150-150",
url = "https://hdl.handle.net/21.15107/rcub_cer_5527"
}

Stanković, J., Gođevac, D., Cvetković, M., Tešević, V., Sofrenić, I., Ivanović, S.,& Novaković, M.. (2021). Antibacterial	 and	 Antibiofilm	 Activity	 of	 Flavonoid	 and	 Saponin	 Derivatives	 from	 Atriplex	 tatarica against	 Pseudomonas	 aeruginosa. in Book of abstracts - 5th International Caparica Christmas Conference on Sample Treatment (ST 2021), 15th – 18th November 2021, Caparica, Portugal
Portugal : PROTEOMASS Scientific Society., 150-150.
https://hdl.handle.net/21.15107/rcub_cer_5527

Stanković J, Gođevac D, Cvetković M, Tešević V, Sofrenić I, Ivanović S, Novaković M. Antibacterial	 and	 Antibiofilm	 Activity	 of	 Flavonoid	 and	 Saponin	 Derivatives	 from	 Atriplex	 tatarica against	 Pseudomonas	 aeruginosa. in Book of abstracts - 5th International Caparica Christmas Conference on Sample Treatment (ST 2021), 15th – 18th November 2021, Caparica, Portugal. 2021;:150-150.
https://hdl.handle.net/21.15107/rcub_cer_5527 .

Stanković, Jovana, Gođevac, Dejan, Cvetković, Mirjana, Tešević, Vele, Sofrenić, Ivana, Ivanović, Stefan, Novaković, Miroslav, "Antibacterial	 and	 Antibiofilm	 Activity	 of	 Flavonoid	 and	 Saponin	 Derivatives	 from	 Atriplex	 tatarica against	 Pseudomonas	 aeruginosa" in Book of abstracts - 5th International Caparica Christmas Conference on Sample Treatment (ST 2021), 15th – 18th November 2021, Caparica, Portugal (2021):150-150,
https://hdl.handle.net/21.15107/rcub_cer_5527 .

TY  - JOUR
AU  - Aćimović, Milica G.
AU  - Pezo, Lato L.
AU  - Cvetković, Mirjana
AU  - Stanković, Jovana
AU  - Čabarkapa, Ivana
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4710
AB  - The aim of this study was the prediction model of retention indices of compounds from the aboveground parts of Achillea clypeolata Sibth. & Sm. essential oil, obtained by hydrodistillation and analysed by GC-MS. The quantitative structure-retention relationship analysis was applied in order to anticipate the retention time of the obtained compounds. The selection of the seven molecular descriptors was done by a genetic algorithm. The chosen descriptors were uncorrelated and were used to construct an artificial neural network. A total of 40 experimentally obtained retention indices was used to build this prediction model. The coefficient of determination for the training, testing and validation cycles were: 0.950, 0.825 and 1.000, respectively, indicating that this model could be used for prediction of retention indices for A.
AB  - Циљ ове студије био је израда модела за предвиђања ретенционог времена хемијских једињења из есенцијалног уља надземних делова биљке Achillea clypeolata Sibth. & Sm., добијеног хидродистилацијом и анализираног GC–MS техником. Квантитативна анализа хемијске структуре и предвиђања ретенционог времена (quantitative structure– retention relationship – QSRR) је примењена да би се предвидело време задржавања хемијских једињења добијених коришћењем GC–MS анализе. Избор седам молекулских дескриптора извршен је коришћењем факторске анализе и генетског алгоритма. Примећено је да изабрани дескриптори нису били у међусобној корелацији, па су коришћени као улазни подаци при изградњи вештачке неуронске мреже. У изградњи модела предвиђања ретенционих времена коришћено је укупно 40 експериментално добијених ретенционих времена. Коефицијент детерминације током циклуса припреме, тестирања и i валидације достигао је вредности 0,950; 0,825 и 1,000, редом, што указује на то да се овај модел може користити за предвиђање ретенционих времена хемијских једињења добијених из есенцијалног уља A. clypeolata
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Achillea clypeolata sibth. & sm. essential oil composition and qsrr model for predicting retention indices
T1  - Hemijski sastav etarskog ulja Achillea clypeolata Sibth. & Sm. И QSRR model za predviđanje retencionog vremena
VL  - 86
IS  - 4
SP  - 355
EP  - 366
DO  - 10.2298/JSC200524008A
ER  - 

@article{
author = "Aćimović, Milica G. and Pezo, Lato L. and Cvetković, Mirjana and Stanković, Jovana and Čabarkapa, Ivana",
year = "2021",
abstract = "The aim of this study was the prediction model of retention indices of compounds from the aboveground parts of Achillea clypeolata Sibth. & Sm. essential oil, obtained by hydrodistillation and analysed by GC-MS. The quantitative structure-retention relationship analysis was applied in order to anticipate the retention time of the obtained compounds. The selection of the seven molecular descriptors was done by a genetic algorithm. The chosen descriptors were uncorrelated and were used to construct an artificial neural network. A total of 40 experimentally obtained retention indices was used to build this prediction model. The coefficient of determination for the training, testing and validation cycles were: 0.950, 0.825 and 1.000, respectively, indicating that this model could be used for prediction of retention indices for A., Циљ ове студије био је израда модела за предвиђања ретенционог времена хемијских једињења из есенцијалног уља надземних делова биљке Achillea clypeolata Sibth. & Sm., добијеног хидродистилацијом и анализираног GC–MS техником. Квантитативна анализа хемијске структуре и предвиђања ретенционог времена (quantitative structure– retention relationship – QSRR) је примењена да би се предвидело време задржавања хемијских једињења добијених коришћењем GC–MS анализе. Избор седам молекулских дескриптора извршен је коришћењем факторске анализе и генетског алгоритма. Примећено је да изабрани дескриптори нису били у међусобној корелацији, па су коришћени као улазни подаци при изградњи вештачке неуронске мреже. У изградњи модела предвиђања ретенционих времена коришћено је укупно 40 експериментално добијених ретенционих времена. Коефицијент детерминације током циклуса припреме, тестирања и i валидације достигао је вредности 0,950; 0,825 и 1,000, редом, што указује на то да се овај модел може користити за предвиђање ретенционих времена хемијских једињења добијених из есенцијалног уља A. clypeolata",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Achillea clypeolata sibth. & sm. essential oil composition and qsrr model for predicting retention indices, Hemijski sastav etarskog ulja Achillea clypeolata Sibth. & Sm. И QSRR model za predviđanje retencionog vremena",
volume = "86",
number = "4",
pages = "355-366",
doi = "10.2298/JSC200524008A"
}

Aćimović, M. G., Pezo, L. L., Cvetković, M., Stanković, J.,& Čabarkapa, I.. (2021). Achillea clypeolata sibth. & sm. essential oil composition and qsrr model for predicting retention indices. in Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 86(4), 355-366.
https://doi.org/10.2298/JSC200524008A

Aćimović MG, Pezo LL, Cvetković M, Stanković J, Čabarkapa I. Achillea clypeolata sibth. & sm. essential oil composition and qsrr model for predicting retention indices. in Journal of the Serbian Chemical Society. 2021;86(4):355-366.
doi:10.2298/JSC200524008A .

Aćimović, Milica G., Pezo, Lato L., Cvetković, Mirjana, Stanković, Jovana, Čabarkapa, Ivana, "Achillea clypeolata sibth. & sm. essential oil composition and qsrr model for predicting retention indices" in Journal of the Serbian Chemical Society, 86, no. 4 (2021):355-366,
https://doi.org/10.2298/JSC200524008A . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Varga, Ana
AU  - Cvetković, Mirjana
AU  - Lato, Pezo
AU  - Lončar, Biljana
AU  - Ignjatov, Maja
AU  - Zeremski, Tijana
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4692
AB  - Hyssop (Hyssopus officinalis L., Lamiaceae) is a perennial shrub or subshrub violet-blue flowers in verticillasters and spicy taste with a pungent flavour. Besides being used as a culinary herb for flavouring and food preservation, this plant is also an ornamental, bee attracting plant and a traditional remedy for respiratory diseases and digestive disturbances. Hyssop is an essential oil-bearing plant, and its essential oil (Hyssopi aetheroleum) is used in the pharmaceutical, perfume and cosmetics industries as well as in aromatherapy. The objective of this study was to determine the chemical composition of essential oil of hyssop CV. "Domaći ljubičasti", grown in Serbia, and investigate its antimicrobial activity against 16 bacteria, mainly pathogens in the food industry. A total of 61 compounds were detected in the hyssop essential oil. The bicyclic monoterpene ketones CIS-pinocamphone (43.8%) and trans-pinocamphone (18.3%) were the most abundant, comprising 62.1%, followed by b-pinene (6.3%) and pinocarvone (6.1%). Hyssop essential oil expressed antibacterial activity against: Staphylococcus aureus, Escherichia coli, Bacillus cereus, Proteus hauseri, Listeria monocytogenes, Rhodococcus equi, Listeria ivanovii, Salmonella Enteritidis, Enterococcus faecalis, Listeria innocua and Bacillus spizizenii. Hyssop essential oil did not express antibacterial activity against Pseudomonas aeruginosa, Salmonella Typhimurium, Klebsiella aerogenes and Staphylococcus epidermidis. Results of this study show that hyssop essential oil has potential for using as natural supplement for control of foodborne diseases of microbiological origin, as well as flavor compositions (herbaceous, camphor-like odour with warm and spicy undernotes), especially for meat products, sauces, soups and seasonings.
AB  - Miloduh (Hyssopus officinalis L., Lamiaceae) je višegodišnji žbun ili polužbun aromatičnog i oštrog mirisa zbog čega se koristi kao začinska biljka. Takođe je i ukrasna i medonosna biljka, ali i tradicionalni lek za bolesti organa za disanje i kod poremećaja varenja. Miloduh je cenjena eterično-aromatična biljka, a etarsko ulje se koristi u farmaceutskoj, parfimerijskoj i kozmetičkoj industriji kao i aromaterapiji. Cilj ovog istraživanja je bio da se determiniše hemijski sastav etarskog ulja miloduha kultivara „Domaći ljubičasti“ gajenog u Srbiji, i da se ispita antimikrobna aktivnost na 16 bakterija, uglavnom patogena u prehrambenoj industriji. Ukupno 61 komponenta je detektovana u etarskom ulju, pri čemu su monoterpenski ketoni cis-pinokamfon (43.8%) i trans-pinokamfon (18.3%) bili najzastupljeniji, čineći 62.1%, a potom slede β-pinen i pinokarvon. Etarsko ulje miloduha je ispoljilo antibakterijsku aktivnost na: Staphylococcus aureus, Escherichia coli, Bacillus cereus, Proteus hauseri, Listeria monocytogenes, Rhodococcus equi, Listeria ivanovii, Salmonella Enteritidis, Enterococcus faecalis, Listeria innocua i Bacillus spizizenii, dok nije delovalo na Pseudomonas aeruginosa, Salmonella Typhimurium, Klebsiella aerogenes i Staphylococcus epidermidis.
PB  - Belgrade : Centre for Evaluation in Education and Science
T2  - Ratarstvo i Povrtarstvo
T1  - Chemical composition of hyssop cv. 'Domaći ljubičasti' essential oil and its antimicrobial activity
T1  - Hemijski sastav etarskog ulja miloduha kultivara  'Domaći ljubičasti' i ocena antimikrobne aktivnosti
VL  - 58
IS  - 1
SP  - 23
EP  - 30
DO  - 10.5937/ratpov58-31751
ER  - 

@article{
author = "Aćimović, Milica and Varga, Ana and Cvetković, Mirjana and Lato, Pezo and Lončar, Biljana and Ignjatov, Maja and Zeremski, Tijana",
year = "2021",
abstract = "Hyssop (Hyssopus officinalis L., Lamiaceae) is a perennial shrub or subshrub violet-blue flowers in verticillasters and spicy taste with a pungent flavour. Besides being used as a culinary herb for flavouring and food preservation, this plant is also an ornamental, bee attracting plant and a traditional remedy for respiratory diseases and digestive disturbances. Hyssop is an essential oil-bearing plant, and its essential oil (Hyssopi aetheroleum) is used in the pharmaceutical, perfume and cosmetics industries as well as in aromatherapy. The objective of this study was to determine the chemical composition of essential oil of hyssop CV. "Domaći ljubičasti", grown in Serbia, and investigate its antimicrobial activity against 16 bacteria, mainly pathogens in the food industry. A total of 61 compounds were detected in the hyssop essential oil. The bicyclic monoterpene ketones CIS-pinocamphone (43.8%) and trans-pinocamphone (18.3%) were the most abundant, comprising 62.1%, followed by b-pinene (6.3%) and pinocarvone (6.1%). Hyssop essential oil expressed antibacterial activity against: Staphylococcus aureus, Escherichia coli, Bacillus cereus, Proteus hauseri, Listeria monocytogenes, Rhodococcus equi, Listeria ivanovii, Salmonella Enteritidis, Enterococcus faecalis, Listeria innocua and Bacillus spizizenii. Hyssop essential oil did not express antibacterial activity against Pseudomonas aeruginosa, Salmonella Typhimurium, Klebsiella aerogenes and Staphylococcus epidermidis. Results of this study show that hyssop essential oil has potential for using as natural supplement for control of foodborne diseases of microbiological origin, as well as flavor compositions (herbaceous, camphor-like odour with warm and spicy undernotes), especially for meat products, sauces, soups and seasonings., Miloduh (Hyssopus officinalis L., Lamiaceae) je višegodišnji žbun ili polužbun aromatičnog i oštrog mirisa zbog čega se koristi kao začinska biljka. Takođe je i ukrasna i medonosna biljka, ali i tradicionalni lek za bolesti organa za disanje i kod poremećaja varenja. Miloduh je cenjena eterično-aromatična biljka, a etarsko ulje se koristi u farmaceutskoj, parfimerijskoj i kozmetičkoj industriji kao i aromaterapiji. Cilj ovog istraživanja je bio da se determiniše hemijski sastav etarskog ulja miloduha kultivara „Domaći ljubičasti“ gajenog u Srbiji, i da se ispita antimikrobna aktivnost na 16 bakterija, uglavnom patogena u prehrambenoj industriji. Ukupno 61 komponenta je detektovana u etarskom ulju, pri čemu su monoterpenski ketoni cis-pinokamfon (43.8%) i trans-pinokamfon (18.3%) bili najzastupljeniji, čineći 62.1%, a potom slede β-pinen i pinokarvon. Etarsko ulje miloduha je ispoljilo antibakterijsku aktivnost na: Staphylococcus aureus, Escherichia coli, Bacillus cereus, Proteus hauseri, Listeria monocytogenes, Rhodococcus equi, Listeria ivanovii, Salmonella Enteritidis, Enterococcus faecalis, Listeria innocua i Bacillus spizizenii, dok nije delovalo na Pseudomonas aeruginosa, Salmonella Typhimurium, Klebsiella aerogenes i Staphylococcus epidermidis.",
publisher = "Belgrade : Centre for Evaluation in Education and Science",
journal = "Ratarstvo i Povrtarstvo",
title = "Chemical composition of hyssop cv. 'Domaći ljubičasti' essential oil and its antimicrobial activity, Hemijski sastav etarskog ulja miloduha kultivara  'Domaći ljubičasti' i ocena antimikrobne aktivnosti",
volume = "58",
number = "1",
pages = "23-30",
doi = "10.5937/ratpov58-31751"
}

Aćimović, M., Varga, A., Cvetković, M., Lato, P., Lončar, B., Ignjatov, M.,& Zeremski, T.. (2021). Chemical composition of hyssop cv. 'Domaći ljubičasti' essential oil and its antimicrobial activity. in Ratarstvo i Povrtarstvo
Belgrade : Centre for Evaluation in Education and Science., 58(1), 23-30.
https://doi.org/10.5937/ratpov58-31751

Aćimović M, Varga A, Cvetković M, Lato P, Lončar B, Ignjatov M, Zeremski T. Chemical composition of hyssop cv. 'Domaći ljubičasti' essential oil and its antimicrobial activity. in Ratarstvo i Povrtarstvo. 2021;58(1):23-30.
doi:10.5937/ratpov58-31751 .

Aćimović, Milica, Varga, Ana, Cvetković, Mirjana, Lato, Pezo, Lončar, Biljana, Ignjatov, Maja, Zeremski, Tijana, "Chemical composition of hyssop cv. 'Domaći ljubičasti' essential oil and its antimicrobial activity" in Ratarstvo i Povrtarstvo, 58, no. 1 (2021):23-30,
https://doi.org/10.5937/ratpov58-31751 . .

TY  - JOUR
AU  - Đorđević, Iris
AU  - Cvetković, Mirjana
AU  - Jadranin, Milka
AU  - Bojović, Srdjan
AU  - Andjelković, Boban
AU  - Sofrenić, Ivana
AU  - Simić, Katarina
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4907
AB  - Phytochemistry deals with the study of secondary metabolites pro­duced by plants that synthesize these compounds for many reasons, including their own protection against attack of herbivores and plant diseases. Secondary metabolites are believed to represent plant adaptation to various environmental factors and that they enabled the survival of the species. Secondary metabolites of plants can have curative or toxic effects in humans and animals. Herbal medicine has a long tradition in folk medicine and until the early 20th century, when synthetic organic chemistry began to develop, plants were the main source of medicines. The two basic goals of our phytochemical research are: isolation and identification of new (biologically active) compounds – potential drugs, and chemotaxonomy (chemo­systematics). In the following text through one selected example, the genus Amphoricarpos Vis., our phytochemical res­earch is shown on both aspects.
AB  - Фитохемија се бави изучавањем секундарних метаболита кoje биљке синтетишу из много разлога, укључујући сопствену заштиту од напада биљоједа и од биљних болести. Сматра се да секундарни метаболити представљају адаптацију биљака на различите факторе околине и да су управо они омогућили опстанак врста. Секундарни метаболити биљака могу испољити лековито или токсично дејство на људе и животиње. Лечење биљем има дугу традицију у народној медицини и све до почетка 20. века, када је почела да се развија синтетичка органска хемија, биљке су биле главни извор лекова. Основни циљеви наших фитохемијских истраживања обухватају: изоловање и идентификацију нових (биолошки активних) једињења – потенцијалних лекова, и хемотаксономију (хемосистематика). У тексту су кроз један одабран пример – род Amphoricarpos Vis. – приказана оба наведена аспекта наших фитохемијских истраживања.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Phytochemical study of the genus amphoricarpos
T1  - Фитохемијско истраживање биљног рода Amphoricarpos
VL  - 86
IS  - 12
SP  - 1177
EP  - 1193
DO  - 10.2298/JSC210726083D
ER  - 

@article{
author = "Đorđević, Iris and Cvetković, Mirjana and Jadranin, Milka and Bojović, Srdjan and Andjelković, Boban and Sofrenić, Ivana and Simić, Katarina",
year = "2021",
abstract = "Phytochemistry deals with the study of secondary metabolites pro­duced by plants that synthesize these compounds for many reasons, including their own protection against attack of herbivores and plant diseases. Secondary metabolites are believed to represent plant adaptation to various environmental factors and that they enabled the survival of the species. Secondary metabolites of plants can have curative or toxic effects in humans and animals. Herbal medicine has a long tradition in folk medicine and until the early 20th century, when synthetic organic chemistry began to develop, plants were the main source of medicines. The two basic goals of our phytochemical research are: isolation and identification of new (biologically active) compounds – potential drugs, and chemotaxonomy (chemo­systematics). In the following text through one selected example, the genus Amphoricarpos Vis., our phytochemical res­earch is shown on both aspects., Фитохемија се бави изучавањем секундарних метаболита кoje биљке синтетишу из много разлога, укључујући сопствену заштиту од напада биљоједа и од биљних болести. Сматра се да секундарни метаболити представљају адаптацију биљака на различите факторе околине и да су управо они омогућили опстанак врста. Секундарни метаболити биљака могу испољити лековито или токсично дејство на људе и животиње. Лечење биљем има дугу традицију у народној медицини и све до почетка 20. века, када је почела да се развија синтетичка органска хемија, биљке су биле главни извор лекова. Основни циљеви наших фитохемијских истраживања обухватају: изоловање и идентификацију нових (биолошки активних) једињења – потенцијалних лекова, и хемотаксономију (хемосистематика). У тексту су кроз један одабран пример – род Amphoricarpos Vis. – приказана оба наведена аспекта наших фитохемијских истраживања.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Phytochemical study of the genus amphoricarpos, Фитохемијско истраживање биљног рода Amphoricarpos",
volume = "86",
number = "12",
pages = "1177-1193",
doi = "10.2298/JSC210726083D"
}

Đorđević, I., Cvetković, M., Jadranin, M., Bojović, S., Andjelković, B., Sofrenić, I.,& Simić, K.. (2021). Phytochemical study of the genus amphoricarpos. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 86(12), 1177-1193.
https://doi.org/10.2298/JSC210726083D

Đorđević I, Cvetković M, Jadranin M, Bojović S, Andjelković B, Sofrenić I, Simić K. Phytochemical study of the genus amphoricarpos. in Journal of the Serbian Chemical Society. 2021;86(12):1177-1193.
doi:10.2298/JSC210726083D .

Đorđević, Iris, Cvetković, Mirjana, Jadranin, Milka, Bojović, Srdjan, Andjelković, Boban, Sofrenić, Ivana, Simić, Katarina, "Phytochemical study of the genus amphoricarpos" in Journal of the Serbian Chemical Society, 86, no. 12 (2021):1177-1193,
https://doi.org/10.2298/JSC210726083D . .

TY  - CONF
AU  - Anđelković, Boban
AU  - Sofrenić, Ivana
AU  - Đorđević, Iris
AU  - Ivanović, Stefan
AU  - Cvetković, Mirjana
AU  - Gođevac, Dejan
AU  - Milosavljević, Slobodan
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5525
AB  - Metabolomics has emerged in recent years as an indispensable tool for the analysis of thousands
of metabolites from crude natural extracts, leading to a paradigm shift in natural products drug
research. Many of the technologies used in metabolomics have method-specific advantages and
drawbacks in terms of diversity of metabolites detected, sensitivity, or resolution.
We will describe the use of metabolomic methods for:
• Correlation of propolis composition to altitude of collection and revealing its major botanical
origin.
• revealing cytotoxic metabolites from Mahonia aquifolium stem-bark
• application for differentiation of the ambiguous taxonomy of the genus Amphoricarpos Vis.
In order to correlate variability in Populus type propolis composition with the altitude of its
collection, NMR spectroscopy followed by OPLS was conducted. The botanical origin of propolis
was established by comparing propolis spectral data to those of buds of various Populus species.
An O2PLS method was utilized to integrate two blocks of data. The utilization of various NMR
experiments, in combination with sophisticated multivariate analysis methods, was demonstrated
to be a powerful tool to correlate propolis composition to altitude of collection and reveal its major
botanical origin. OPLS methods were used to identify changes in the chemical composition of
propolis, while O2PLS methods enabled the identification of the botanical origin of propolis.[1]
A 1H NMR-based metabolomics method was used to reveal cytotoxic metabolites from Mahonia
aquifolium stem-bark. Primary and secondary metabolites in the Mahonia aquifolium extracts
were identified by thorough analysis of 1H and 2D NMR spectra, without prior isolation. An OPLS
multivariate analysis method was used to correlate the chemical composition of the plant extracts
with the results of cytotoxic activity against Human cervical adenocarcinoma cell line.[2]
Metabolomic methods were used to get more insight into the ambiguous taxonomy of the genus
Amphoricarpos Vis. The 1H NMR spectroscopy combined with multivariate data analysis has been
applied. OPLS-DA has been shown to be the best method for clear discrimination of these samples
based on the metabolites present in the extracts. 1H NMR fingerprinting in combination with PCA
and OPLS-DA showed a clear separation between the species resulting in two groups according to
metabolomic similarities.
PB  - Zagreb, Croatia : Department of Chemistry, Faculty of Science, University of Zagreb
C3  - Book of abstracts - The Adriatic NMR Conference, 22–24 September 2020, Peroj, Croatia
T1  - NMR metabolomics insight into phytochemistry
SP  - 30
EP  - 30
UR  - https://hdl.handle.net/21.15107/rcub_cer_5525
ER  - 

@conference{
author = "Anđelković, Boban and Sofrenić, Ivana and Đorđević, Iris and Ivanović, Stefan and Cvetković, Mirjana and Gođevac, Dejan and Milosavljević, Slobodan",
year = "2020",
abstract = "Metabolomics has emerged in recent years as an indispensable tool for the analysis of thousands
of metabolites from crude natural extracts, leading to a paradigm shift in natural products drug
research. Many of the technologies used in metabolomics have method-specific advantages and
drawbacks in terms of diversity of metabolites detected, sensitivity, or resolution.
We will describe the use of metabolomic methods for:
• Correlation of propolis composition to altitude of collection and revealing its major botanical
origin.
• revealing cytotoxic metabolites from Mahonia aquifolium stem-bark
• application for differentiation of the ambiguous taxonomy of the genus Amphoricarpos Vis.
In order to correlate variability in Populus type propolis composition with the altitude of its
collection, NMR spectroscopy followed by OPLS was conducted. The botanical origin of propolis
was established by comparing propolis spectral data to those of buds of various Populus species.
An O2PLS method was utilized to integrate two blocks of data. The utilization of various NMR
experiments, in combination with sophisticated multivariate analysis methods, was demonstrated
to be a powerful tool to correlate propolis composition to altitude of collection and reveal its major
botanical origin. OPLS methods were used to identify changes in the chemical composition of
propolis, while O2PLS methods enabled the identification of the botanical origin of propolis.[1]
A 1H NMR-based metabolomics method was used to reveal cytotoxic metabolites from Mahonia
aquifolium stem-bark. Primary and secondary metabolites in the Mahonia aquifolium extracts
were identified by thorough analysis of 1H and 2D NMR spectra, without prior isolation. An OPLS
multivariate analysis method was used to correlate the chemical composition of the plant extracts
with the results of cytotoxic activity against Human cervical adenocarcinoma cell line.[2]
Metabolomic methods were used to get more insight into the ambiguous taxonomy of the genus
Amphoricarpos Vis. The 1H NMR spectroscopy combined with multivariate data analysis has been
applied. OPLS-DA has been shown to be the best method for clear discrimination of these samples
based on the metabolites present in the extracts. 1H NMR fingerprinting in combination with PCA
and OPLS-DA showed a clear separation between the species resulting in two groups according to
metabolomic similarities.",
publisher = "Zagreb, Croatia : Department of Chemistry, Faculty of Science, University of Zagreb",
journal = "Book of abstracts - The Adriatic NMR Conference, 22–24 September 2020, Peroj, Croatia",
title = "NMR metabolomics insight into phytochemistry",
pages = "30-30",
url = "https://hdl.handle.net/21.15107/rcub_cer_5525"
}

Anđelković, B., Sofrenić, I., Đorđević, I., Ivanović, S., Cvetković, M., Gođevac, D.,& Milosavljević, S.. (2020). NMR metabolomics insight into phytochemistry. in Book of abstracts - The Adriatic NMR Conference, 22–24 September 2020, Peroj, Croatia
Zagreb, Croatia : Department of Chemistry, Faculty of Science, University of Zagreb., 30-30.
https://hdl.handle.net/21.15107/rcub_cer_5525

Anđelković B, Sofrenić I, Đorđević I, Ivanović S, Cvetković M, Gođevac D, Milosavljević S. NMR metabolomics insight into phytochemistry. in Book of abstracts - The Adriatic NMR Conference, 22–24 September 2020, Peroj, Croatia. 2020;:30-30.
https://hdl.handle.net/21.15107/rcub_cer_5525 .

Anđelković, Boban, Sofrenić, Ivana, Đorđević, Iris, Ivanović, Stefan, Cvetković, Mirjana, Gođevac, Dejan, Milosavljević, Slobodan, "NMR metabolomics insight into phytochemistry" in Book of abstracts - The Adriatic NMR Conference, 22–24 September 2020, Peroj, Croatia (2020):30-30,
https://hdl.handle.net/21.15107/rcub_cer_5525 .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Zorić, Miroslav
AU  - Zheljazkov, Valtcho
AU  - Pezo, Lato
AU  - Čabarkapa, Ivana
AU  - Stanković Jeremić, Jovana
AU  - Cvetković, Mirjana
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3952
AB  - The objective of this study was to evaluate wild growing Satureja kitaibelii, Thymus serpyllum,
Origanum vulgare, Achillea millefolium and Achillea clypeolata with respect to their essential oil (EO)
content, composition and antimicrobial activity. The five species were collected at Mt. Rtanj and the
village of Sesalac, Eastern Serbia. The main EO constituents of Lamiaceae plants were p-cymene
(24.4%), geraniol (63.4%) and germacrene D (21.5%) in Satureja kitaibelii, Thymus serpyllum and
Origanum vulgare ssp. vulgare, respectively. A. millefolium EO had multiple constituents with major
ones being camphor (9.8%), caryophyllene oxide (6.5%), terpinen-4-ol (6.3%) and 1,8-cineole (5.6%),
while the main EO constituents of A. clypeolata were 1,8-cineole (45.1%) and camphor (18.2%).
Antimicrobial testing of the EO showed that Staphylococcus aureus (Gram-positive) was more sensitive
to all of the tested EOs than Escherichia coli (Gram-negative). S. kitaibelii EO showed the highest
antimicrobial activity against both tested bacterial strains. This is the first study to characterize
the EO composition and antimicrobial activity of these five medicinal species from Eastern Serbia
in comparison with comprehensive literature data. The results can be utilized by the perfumery,
cosmetics, food and pharmaceutical industries, but also for healing purposes in self-medication.
PB  - MDPI
T2  - Molecules
T1  - Chemical characterization and antibacterial activity of essential oil of medicinal plants from Eastern Serbia
VL  - 25
IS  - 22
SP  - 5482
DO  - 10.3390/molecules25225482
ER  - 

@article{
author = "Aćimović, Milica and Zorić, Miroslav and Zheljazkov, Valtcho and Pezo, Lato and Čabarkapa, Ivana and Stanković Jeremić, Jovana and Cvetković, Mirjana",
year = "2020",
abstract = "The objective of this study was to evaluate wild growing Satureja kitaibelii, Thymus serpyllum,
Origanum vulgare, Achillea millefolium and Achillea clypeolata with respect to their essential oil (EO)
content, composition and antimicrobial activity. The five species were collected at Mt. Rtanj and the
village of Sesalac, Eastern Serbia. The main EO constituents of Lamiaceae plants were p-cymene
(24.4%), geraniol (63.4%) and germacrene D (21.5%) in Satureja kitaibelii, Thymus serpyllum and
Origanum vulgare ssp. vulgare, respectively. A. millefolium EO had multiple constituents with major
ones being camphor (9.8%), caryophyllene oxide (6.5%), terpinen-4-ol (6.3%) and 1,8-cineole (5.6%),
while the main EO constituents of A. clypeolata were 1,8-cineole (45.1%) and camphor (18.2%).
Antimicrobial testing of the EO showed that Staphylococcus aureus (Gram-positive) was more sensitive
to all of the tested EOs than Escherichia coli (Gram-negative). S. kitaibelii EO showed the highest
antimicrobial activity against both tested bacterial strains. This is the first study to characterize
the EO composition and antimicrobial activity of these five medicinal species from Eastern Serbia
in comparison with comprehensive literature data. The results can be utilized by the perfumery,
cosmetics, food and pharmaceutical industries, but also for healing purposes in self-medication.",
publisher = "MDPI",
journal = "Molecules",
title = "Chemical characterization and antibacterial activity of essential oil of medicinal plants from Eastern Serbia",
volume = "25",
number = "22",
pages = "5482",
doi = "10.3390/molecules25225482"
}

Aćimović, M., Zorić, M., Zheljazkov, V., Pezo, L., Čabarkapa, I., Stanković Jeremić, J.,& Cvetković, M.. (2020). Chemical characterization and antibacterial activity of essential oil of medicinal plants from Eastern Serbia. in Molecules
MDPI., 25(22), 5482.
https://doi.org/10.3390/molecules25225482

Aćimović M, Zorić M, Zheljazkov V, Pezo L, Čabarkapa I, Stanković Jeremić J, Cvetković M. Chemical characterization and antibacterial activity of essential oil of medicinal plants from Eastern Serbia. in Molecules. 2020;25(22):5482.
doi:10.3390/molecules25225482 .

Aćimović, Milica, Zorić, Miroslav, Zheljazkov, Valtcho, Pezo, Lato, Čabarkapa, Ivana, Stanković Jeremić, Jovana, Cvetković, Mirjana, "Chemical characterization and antibacterial activity of essential oil of medicinal plants from Eastern Serbia" in Molecules, 25, no. 22 (2020):5482,
https://doi.org/10.3390/molecules25225482 . .

TY  - JOUR
AU  - Cvetković, Mirjana
AU  - Damjanović, Ana
AU  - Stanojković, Tatjana
AU  - Đorđević, Iris
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan
AU  - Gođevac, Dejan
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3054
AB  - Metabolomics generate a profile of small molecules from plant extracts, which could be directly responsible for bioactivity effects. Using dry-column flash chromatography enabled a rapid and inexpensive method for the very efficient separation of plant extract with a high resolution. This separation method coupled to NMR and FTIR based metabolomics is applied to identify bioactive natural products. OPLS multivariate analysis method, was used for correlation the chemical composition of the plant extracts, Amphoricarpos autariatus, with the results of cytotoxic activity against Human cervical adenocarcinoma cell line (HeLa) and epithelial lung cancer cell line
(A549). In this way, the highest contribution to the cytotoxic activity was recorded for the guaianolide sesquiterpene lactones named amphoricarpolides. The compounds indicated as bioactive after metabolomics analysis were tested, and their cytotoxic activity were confirmed.
PB  - Elsevier
T2  - Talanta
T1  - Integration of dry-column flash chromatography with NMR and FTIR metabolomics to reveal cytotoxic metabolites from Amphoricarpos autariatus
VL  - 206
SP  - 120248
DO  - 10.1016/j.talanta.2019.120248
ER  - 

@article{
author = "Cvetković, Mirjana and Damjanović, Ana and Stanojković, Tatjana and Đorđević, Iris and Tešević, Vele and Milosavljević, Slobodan and Gođevac, Dejan",
year = "2020",
abstract = "Metabolomics generate a profile of small molecules from plant extracts, which could be directly responsible for bioactivity effects. Using dry-column flash chromatography enabled a rapid and inexpensive method for the very efficient separation of plant extract with a high resolution. This separation method coupled to NMR and FTIR based metabolomics is applied to identify bioactive natural products. OPLS multivariate analysis method, was used for correlation the chemical composition of the plant extracts, Amphoricarpos autariatus, with the results of cytotoxic activity against Human cervical adenocarcinoma cell line (HeLa) and epithelial lung cancer cell line
(A549). In this way, the highest contribution to the cytotoxic activity was recorded for the guaianolide sesquiterpene lactones named amphoricarpolides. The compounds indicated as bioactive after metabolomics analysis were tested, and their cytotoxic activity were confirmed.",
publisher = "Elsevier",
journal = "Talanta",
title = "Integration of dry-column flash chromatography with NMR and FTIR metabolomics to reveal cytotoxic metabolites from Amphoricarpos autariatus",
volume = "206",
pages = "120248",
doi = "10.1016/j.talanta.2019.120248"
}

Cvetković, M., Damjanović, A., Stanojković, T., Đorđević, I., Tešević, V., Milosavljević, S.,& Gođevac, D.. (2020). Integration of dry-column flash chromatography with NMR and FTIR metabolomics to reveal cytotoxic metabolites from Amphoricarpos autariatus. in Talanta
Elsevier., 206, 120248.
https://doi.org/10.1016/j.talanta.2019.120248

Cvetković M, Damjanović A, Stanojković T, Đorđević I, Tešević V, Milosavljević S, Gođevac D. Integration of dry-column flash chromatography with NMR and FTIR metabolomics to reveal cytotoxic metabolites from Amphoricarpos autariatus. in Talanta. 2020;206:120248.
doi:10.1016/j.talanta.2019.120248 .

Cvetković, Mirjana, Damjanović, Ana, Stanojković, Tatjana, Đorđević, Iris, Tešević, Vele, Milosavljević, Slobodan, Gođevac, Dejan, "Integration of dry-column flash chromatography with NMR and FTIR metabolomics to reveal cytotoxic metabolites from Amphoricarpos autariatus" in Talanta, 206 (2020):120248,
https://doi.org/10.1016/j.talanta.2019.120248 . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Pezo, Lato
AU  - Stanković, Jovana
AU  - Cvetković, Mirjana
AU  - Rat, Milica
AU  - Čabarkapa, Ivana
AU  - Tešević, Vele
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3951
AB  - A total of 26 experimentally obtained retention indices on a logarithmic scale (log RI) from
Thymus serpyllum essential oil were used to build a robust predictive model. The selected descriptors were
used as inputs of an artificial neural network model to build a predictive quantitative structure-retention time
relationship model. The coefficient of determination for the training cycle was 0.977, indicating that this model
could be used for the prediction of retention indices for T. serpyllum essential oil compounds. These 26
compounds comprise about 99.8 % of the total oil, but among them only 6 compounds had the average relative
concentration over 1 percent: geraniol (63.4 %), nerol (or cis-geraniol) (18.9 %), geranyl acetate (4.7 %), transcaryophyllene (4.6 %), β-bisabolene (2.0 %) and geranial (1.2 %). According to these results, it can be concluded
that T. serpyllum from village Sesalac (Serbia) belongs to geraniol chemotype, in total 82.3 % in both, trans and
cis forms (63.4 % and 18.9 %, respectively).
PB  - Taylor & Francis
T2  - Essential Oil Bearing Plants
T1  - QSRR model for predicting retention indices of geraniol chemotype of Thymus serpyllum essential oil
VL  - 23
IS  - 3
SP  - 464
EP  - 473
DO  - 10.1080/0972060X.2020.1790428
ER  - 

@article{
author = "Aćimović, Milica and Pezo, Lato and Stanković, Jovana and Cvetković, Mirjana and Rat, Milica and Čabarkapa, Ivana and Tešević, Vele",
year = "2020",
abstract = "A total of 26 experimentally obtained retention indices on a logarithmic scale (log RI) from
Thymus serpyllum essential oil were used to build a robust predictive model. The selected descriptors were
used as inputs of an artificial neural network model to build a predictive quantitative structure-retention time
relationship model. The coefficient of determination for the training cycle was 0.977, indicating that this model
could be used for the prediction of retention indices for T. serpyllum essential oil compounds. These 26
compounds comprise about 99.8 % of the total oil, but among them only 6 compounds had the average relative
concentration over 1 percent: geraniol (63.4 %), nerol (or cis-geraniol) (18.9 %), geranyl acetate (4.7 %), transcaryophyllene (4.6 %), β-bisabolene (2.0 %) and geranial (1.2 %). According to these results, it can be concluded
that T. serpyllum from village Sesalac (Serbia) belongs to geraniol chemotype, in total 82.3 % in both, trans and
cis forms (63.4 % and 18.9 %, respectively).",
publisher = "Taylor & Francis",
journal = "Essential Oil Bearing Plants",
title = "QSRR model for predicting retention indices of geraniol chemotype of Thymus serpyllum essential oil",
volume = "23",
number = "3",
pages = "464-473",
doi = "10.1080/0972060X.2020.1790428"
}

Aćimović, M., Pezo, L., Stanković, J., Cvetković, M., Rat, M., Čabarkapa, I.,& Tešević, V.. (2020). QSRR model for predicting retention indices of geraniol chemotype of Thymus serpyllum essential oil. in Essential Oil Bearing Plants
Taylor & Francis., 23(3), 464-473.
https://doi.org/10.1080/0972060X.2020.1790428

Aćimović M, Pezo L, Stanković J, Cvetković M, Rat M, Čabarkapa I, Tešević V. QSRR model for predicting retention indices of geraniol chemotype of Thymus serpyllum essential oil. in Essential Oil Bearing Plants. 2020;23(3):464-473.
doi:10.1080/0972060X.2020.1790428 .

Aćimović, Milica, Pezo, Lato, Stanković, Jovana, Cvetković, Mirjana, Rat, Milica, Čabarkapa, Ivana, Tešević, Vele, "QSRR model for predicting retention indices of geraniol chemotype of Thymus serpyllum essential oil" in Essential Oil Bearing Plants, 23, no. 3 (2020):464-473,
https://doi.org/10.1080/0972060X.2020.1790428 . .

TY  - CONF
AU  - Aćimović, Milica
AU  - Stanković, Jovana
AU  - Cvetković, Mirjana
AU  - Simin, Nataša
AU  - Beara, Ivana
AU  - Lesjak, Marija
AU  - Popović, Vera
PY  - 2020
UR  - uri:http://www.gea.ucg.ac.me
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3954
AB  - Most of the Origanum species are locally distributed within the Mediterranean region
where they grow in the mountainous areas on the islands. Due to this, the rate of endemism is high,
as in case of dittany of Crete (O. dictamnus). O. vulgare possesses the largest distribution area and can
be found throughout the Mediterranean region, however, the yield and quality of the essential oil is
controlled genetically and strongly affected by the environmental influences. Origanum essential oils
predominantly containing carvacrol, are generally of superior quality and highly valuable raw
material for food as well as in pharmaceutical industry. Essential oil of O. dictimus contains 70.8% of
carvacrol, while O. vulgare ssp. hirtum essential oil contains 78.5%. This study indicates the high
quality of investigated Origanum species from Greece, and indicates it to be highly valuable raw
material for food and in pharmaceutical industry.
PB  - Faculty of Architecture – University of Montenegro
PB  - Faculty of Philosophy - University of Montenegro
PB  - Biotecnical faculty - University of Montenegro
C3  - Book of Proceedings - GEA (Geo Eco-Eco Agro) International Conference
T1  - Chemical composition of Origanum dictamnus and Origanum vulgare ssp. hirtum from Greece
VL  - 1
SP  - 244
EP  - 249
UR  - https://hdl.handle.net/21.15107/rcub_cer_3954
ER  - 

@conference{
author = "Aćimović, Milica and Stanković, Jovana and Cvetković, Mirjana and Simin, Nataša and Beara, Ivana and Lesjak, Marija and Popović, Vera",
year = "2020",
abstract = "Most of the Origanum species are locally distributed within the Mediterranean region
where they grow in the mountainous areas on the islands. Due to this, the rate of endemism is high,
as in case of dittany of Crete (O. dictamnus). O. vulgare possesses the largest distribution area and can
be found throughout the Mediterranean region, however, the yield and quality of the essential oil is
controlled genetically and strongly affected by the environmental influences. Origanum essential oils
predominantly containing carvacrol, are generally of superior quality and highly valuable raw
material for food as well as in pharmaceutical industry. Essential oil of O. dictimus contains 70.8% of
carvacrol, while O. vulgare ssp. hirtum essential oil contains 78.5%. This study indicates the high
quality of investigated Origanum species from Greece, and indicates it to be highly valuable raw
material for food and in pharmaceutical industry.",
publisher = "Faculty of Architecture – University of Montenegro, Faculty of Philosophy - University of Montenegro, Biotecnical faculty - University of Montenegro",
journal = "Book of Proceedings - GEA (Geo Eco-Eco Agro) International Conference",
title = "Chemical composition of Origanum dictamnus and Origanum vulgare ssp. hirtum from Greece",
volume = "1",
pages = "244-249",
url = "https://hdl.handle.net/21.15107/rcub_cer_3954"
}

Aćimović, M., Stanković, J., Cvetković, M., Simin, N., Beara, I., Lesjak, M.,& Popović, V.. (2020). Chemical composition of Origanum dictamnus and Origanum vulgare ssp. hirtum from Greece. in Book of Proceedings - GEA (Geo Eco-Eco Agro) International Conference
Faculty of Architecture – University of Montenegro., 1, 244-249.
https://hdl.handle.net/21.15107/rcub_cer_3954

Aćimović M, Stanković J, Cvetković M, Simin N, Beara I, Lesjak M, Popović V. Chemical composition of Origanum dictamnus and Origanum vulgare ssp. hirtum from Greece. in Book of Proceedings - GEA (Geo Eco-Eco Agro) International Conference. 2020;1:244-249.
https://hdl.handle.net/21.15107/rcub_cer_3954 .

Aćimović, Milica, Stanković, Jovana, Cvetković, Mirjana, Simin, Nataša, Beara, Ivana, Lesjak, Marija, Popović, Vera, "Chemical composition of Origanum dictamnus and Origanum vulgare ssp. hirtum from Greece" in Book of Proceedings - GEA (Geo Eco-Eco Agro) International Conference, 1 (2020):244-249,
https://hdl.handle.net/21.15107/rcub_cer_3954 .

TY  - JOUR
AU  - Krstić, Gordana
AU  - Aljančić, Ivana
AU  - Stanković, Jovana
AU  - Cvetković, Mirjana
AU  - Marin, Petar D.
AU  - Janaćković, Peđa T.
AU  - Tešević, Vele
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2923
AB  - The presence of n-alkanes, free alcohols and free acids in leaf epicuticular wax extracts of 22 samples of 11 Euphorbia L. species belonging to the sections Paralias, Esula, Myrsiniteae and Helioscopia, 10 of which were never examined before, were analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS), and n-alkane C27 was detected as the principal component of leaf epicuticular waxes in the majority of the examined species, while the most abundant free alcohol was C26. Three Euphorbia species belonging to section Helioscopia were characterized by a predominance of alcohol C28. Free acid (C16) was the major component in 21 investigated samples. The usefulness of n-alkanes and free alcohols and free acids as potential chemotaxonomic markers is briefly discussed.
T2  - Archives of Biological Sciences
T1  - Leaf epicuticular waxes of eleven Euphorbia species (Euphorbiaceae) from the central Balkans: Impact on chemotaxonomy
VL  - 71
IS  - 1
SP  - 21
EP  - 26
DO  - 10.2298/ABS180608041K
ER  - 

@article{
author = "Krstić, Gordana and Aljančić, Ivana and Stanković, Jovana and Cvetković, Mirjana and Marin, Petar D. and Janaćković, Peđa T. and Tešević, Vele",
year = "2019",
abstract = "The presence of n-alkanes, free alcohols and free acids in leaf epicuticular wax extracts of 22 samples of 11 Euphorbia L. species belonging to the sections Paralias, Esula, Myrsiniteae and Helioscopia, 10 of which were never examined before, were analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS), and n-alkane C27 was detected as the principal component of leaf epicuticular waxes in the majority of the examined species, while the most abundant free alcohol was C26. Three Euphorbia species belonging to section Helioscopia were characterized by a predominance of alcohol C28. Free acid (C16) was the major component in 21 investigated samples. The usefulness of n-alkanes and free alcohols and free acids as potential chemotaxonomic markers is briefly discussed.",
journal = "Archives of Biological Sciences",
title = "Leaf epicuticular waxes of eleven Euphorbia species (Euphorbiaceae) from the central Balkans: Impact on chemotaxonomy",
volume = "71",
number = "1",
pages = "21-26",
doi = "10.2298/ABS180608041K"
}

Krstić, G., Aljančić, I., Stanković, J., Cvetković, M., Marin, P. D., Janaćković, P. T.,& Tešević, V.. (2019). Leaf epicuticular waxes of eleven Euphorbia species (Euphorbiaceae) from the central Balkans: Impact on chemotaxonomy. in Archives of Biological Sciences, 71(1), 21-26.
https://doi.org/10.2298/ABS180608041K

Krstić G, Aljančić I, Stanković J, Cvetković M, Marin PD, Janaćković PT, Tešević V. Leaf epicuticular waxes of eleven Euphorbia species (Euphorbiaceae) from the central Balkans: Impact on chemotaxonomy. in Archives of Biological Sciences. 2019;71(1):21-26.
doi:10.2298/ABS180608041K .

Krstić, Gordana, Aljančić, Ivana, Stanković, Jovana, Cvetković, Mirjana, Marin, Petar D., Janaćković, Peđa T., Tešević, Vele, "Leaf epicuticular waxes of eleven Euphorbia species (Euphorbiaceae) from the central Balkans: Impact on chemotaxonomy" in Archives of Biological Sciences, 71, no. 1 (2019):21-26,
https://doi.org/10.2298/ABS180608041K . .

TY  - JOUR
AU  - Cvetković, Mirjana
AU  - Đorđević, Iris
AU  - Jadranin, Milka
AU  - Stanković, Miroslava
AU  - Mandić, Boris
AU  - Milosavljević, Slobodan
AU  - Vujisić, Ljubodrag V.
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3266
AB  - Analysis of composition of CH2Cl2 surface extract of leaves of Amphoricarpos neumayeri Vis. revealed 16 sesquiterpene lactones with guaianolide skeleton, so called amphoricarpolides, typical for this genus. Four of them, 13–16, were new derivatives and their structures were elucidated by detailed analyses of IR, NMR and MS data. Amphoricarpolide (9), its 15-O-acetyl derivative (5), and two 9β-hydroxyamphoricarpolides, 3,15-di-O-acetyl- and 3-O-acetyl-15-O-isovaleroyl derivatives (3 and 6, respectively) were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The tested compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.
PB  - Informa UK Limited
T2  - Natural Product Research
T1  - Leaf-surface guaianolides from Amphoricarpos neumaeyri                    showing protective effect on human lymphocytes DNA
SP  - 1
EP  - 9
DO  - 10.1080/14786419.2019.1687470
ER  - 

@article{
author = "Cvetković, Mirjana and Đorđević, Iris and Jadranin, Milka and Stanković, Miroslava and Mandić, Boris and Milosavljević, Slobodan and Vujisić, Ljubodrag V.",
year = "2019",
abstract = "Analysis of composition of CH2Cl2 surface extract of leaves of Amphoricarpos neumayeri Vis. revealed 16 sesquiterpene lactones with guaianolide skeleton, so called amphoricarpolides, typical for this genus. Four of them, 13–16, were new derivatives and their structures were elucidated by detailed analyses of IR, NMR and MS data. Amphoricarpolide (9), its 15-O-acetyl derivative (5), and two 9β-hydroxyamphoricarpolides, 3,15-di-O-acetyl- and 3-O-acetyl-15-O-isovaleroyl derivatives (3 and 6, respectively) were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The tested compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.",
publisher = "Informa UK Limited",
journal = "Natural Product Research",
title = "Leaf-surface guaianolides from Amphoricarpos neumaeyri                    showing protective effect on human lymphocytes DNA",
pages = "1-9",
doi = "10.1080/14786419.2019.1687470"
}

Cvetković, M., Đorđević, I., Jadranin, M., Stanković, M., Mandić, B., Milosavljević, S.,& Vujisić, L. V.. (2019). Leaf-surface guaianolides from Amphoricarpos neumaeyri                    showing protective effect on human lymphocytes DNA. in Natural Product Research
Informa UK Limited., 1-9.
https://doi.org/10.1080/14786419.2019.1687470

Cvetković M, Đorđević I, Jadranin M, Stanković M, Mandić B, Milosavljević S, Vujisić LV. Leaf-surface guaianolides from Amphoricarpos neumaeyri                    showing protective effect on human lymphocytes DNA. in Natural Product Research. 2019;:1-9.
doi:10.1080/14786419.2019.1687470 .

Cvetković, Mirjana, Đorđević, Iris, Jadranin, Milka, Stanković, Miroslava, Mandić, Boris, Milosavljević, Slobodan, Vujisić, Ljubodrag V., "Leaf-surface guaianolides from Amphoricarpos neumaeyri                    showing protective effect on human lymphocytes DNA" in Natural Product Research (2019):1-9,
https://doi.org/10.1080/14786419.2019.1687470 . .

TY  - THES
AU  - Cvetković, Mirjana
PY  - 2019
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=7045
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:20666/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=51737615
UR  - http://nardus.mpn.gov.rs/123456789/11706
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3429
AB  - Metabolomika je nova naučna multidisciplinarna oblast koja obuhvata različiteaspekte biologije, hemije i matematike. Koristi moderne spektroskopske ihromatografske tehnike (NMR, IC, UV, MS, GC, LC) i multivarijantnu statističkuanalizu podataka sa ciljem da se izmere kvantitativno i kvalitativno svi metaboliti uispitivanom organizmu i na taj način dobije jasna metabolomička slika pod ispitivanimuslovima. Primena metabolomike nije ograničena samo na biljni svet, već se možeprimeniti na sve žive organizme, pa tako i na ljude. Posebno je značajna mogućnostprimene u medicini kao dijagnostičke metode ili u farmakognoziji za otkrivanje novihlekovitih sirovina. U ovoj disertaciji primena metabolomike na endemski biljni rodAmphoricarpos Vis. imala je dva cilja: (a) sticanje novih saznanja o mogućnostiprimene dobijenih rezultata u diferencijaciji balkanskih vrsta ovog roda i (b) razvojmetode za brzo otkrivanje novih farmakološki aktivnih sastojaka u biljnom materijalu.Vrste roda Amphoricarpos Vis. rasprostranjene su na Balkanskom poluostrvu.Anatoliji i Kavkazu. Da bi se dobilo više uvida u taksonomski status balkanskih taksonaovog roda, koji nije do kraja raščišćen, primenjena je metabolomička studija. Po Blečićui Mayeru1 postoje tri taksona: dve vrste A. neumayeri Vis. i A. autariatus Blečić etMayer, koja se deli na dve podvrste - ssp. autariatus i ssp. bertisceus Blečić et Mayer. Sdruge strane, Webb2 priznaje samo jednu vrstu - A. neumayeri Vis., koja sadrži dvepodvrste - ssp. neumayeri i ssp. murbeckii Bošnjak. U novije vreme, na osnovuispitivanja genoma vrsta ovog roda predložena je samo jedna vrsta, А. neumayerianus(Vis.) Greuter.3 U ovom radu analizirana su sva tri taksona (prema Blečiću i Mayeru), auzorci su sakupljeni na različitim lokalitetima u Crnoj Gori u fazi cvetanja. Primenjenaje 1H NMR spektroskopija kombinovana sa multivarijantnom analizom podataka.Pokazano je da je OPLS-DA (engl. Orthogonal Partial Least Squares-DiscriminantAnalysis) najefikasniji metod za diskriminaciju ispitivanih uzoraka na osnovumetabolita prisutnih u ekstraktima. Utvrđeno je da je glavna razlika između A.autariatus i A. neumayeri prisustvo karakterističnih seskviterpenskih laktonagvajanolidnog tipa (amforikarpolida). Glavni seskviterpenski lakton vrste A. neumayerije oksidovan u položaju 2, dok laktoni prisutni u obe podvrste A. autariatus suoksidovani u poziciji 9, što potvrđuje da seskviterpenski laktoni mogu bitihemotaksonomski markeri u porodici Asteraceae...
AB  - Metabolomics is a new scientific multidisciplinary field that includes variousaspects of biology, chemistry and mathematics. It uses modern spectroscopic andchromatographic techniques (NMR, IC, UV, MS, GC, LC) and multivariate statisticaldata analysis to measure quantitatively and qualitatively all of the metabolites in the testorganism and thereby obtain a clear metabolic profile under test conditions. The use ofmetabolomics is not limited to the plant world, but can be applied to all livingorganisms as well as humans. A particularly important possibility is the application inmedicine as a diagnostic method or in pharmacognosy for the discovery of new naturalsources of drugs. In this thesis, the application of metabolomics to the endemic plantgenus Amphoricarpos Vis. was applied with two objectives: (a) acquiring newknowledge of the systematization of the genus, and (b) developing a method for rapiddetection of new pharmacologically active ingredients in plant material.Genus Amphoricarpos Vis. is an endemic of the western part of the BalkanPeninsula. In order to gain more insight into the taxonomic status of the genus that isstill ambiguous, a metabolomic study was applied. Blečić and Mayer1 proposed threetaxa: two species A. neumayeri Vis. and A. autariatus Blečić et Mayer, the latter dividedinto two subspecies, ssp. autariatus i ssp. bertisceus Blečič et Mayer. On the other hand,Webb2 recognizeed only one species, A. neumayeri Vis. divided into two subspecies,ssp. neumayeri i ssp. murbeckii Bošnjak. Recently, on the basis of a genomeexamination of the taxa from the West Balkans, only one species was proposed, A.neumayerianus (Vis.) Greuter.3In this dissertation all three taxa (according to Blečić and Mayer)1 were analysed. Thesamples were collected at different locations in Montenegro at the stage of flowering.1H NMR spectroscopy combined with multivariate data analysis was applied.Orthogonal Partial Least Squares-Discriminant Analysis (OPLS-DA) has been shown tobe the most effective method for discrimination of the tested samples, based on themetabolites present in the extracts. It was found that the main difference between A.autariatus and A. neumayeri was the presence of characteristic guaianolidesesquiterpene lactones (amforicarpolides). The major sesquiterpene lactones in theextract of A. neumayeri were oxidized in position 2, while the lactones present in bothsubspecies of A. autariatus were oxidized at position 9, which confirms thatsesquiterpene lactones may be chemotaxonomic markers in the Asteraceae family...
PB  - Универзитет у Београду, Хемијски факултет
T2  - Универзитет у Београду
T1  - Metabolomička studija balkanskih vrsta roda Amphoricarpos Vis. (Asteraceae)
UR  - https://hdl.handle.net/21.15107/rcub_nardus_11706
ER  - 

@phdthesis{
author = "Cvetković, Mirjana",
year = "2019",
abstract = "Metabolomika je nova naučna multidisciplinarna oblast koja obuhvata različiteaspekte biologije, hemije i matematike. Koristi moderne spektroskopske ihromatografske tehnike (NMR, IC, UV, MS, GC, LC) i multivarijantnu statističkuanalizu podataka sa ciljem da se izmere kvantitativno i kvalitativno svi metaboliti uispitivanom organizmu i na taj način dobije jasna metabolomička slika pod ispitivanimuslovima. Primena metabolomike nije ograničena samo na biljni svet, već se možeprimeniti na sve žive organizme, pa tako i na ljude. Posebno je značajna mogućnostprimene u medicini kao dijagnostičke metode ili u farmakognoziji za otkrivanje novihlekovitih sirovina. U ovoj disertaciji primena metabolomike na endemski biljni rodAmphoricarpos Vis. imala je dva cilja: (a) sticanje novih saznanja o mogućnostiprimene dobijenih rezultata u diferencijaciji balkanskih vrsta ovog roda i (b) razvojmetode za brzo otkrivanje novih farmakološki aktivnih sastojaka u biljnom materijalu.Vrste roda Amphoricarpos Vis. rasprostranjene su na Balkanskom poluostrvu.Anatoliji i Kavkazu. Da bi se dobilo više uvida u taksonomski status balkanskih taksonaovog roda, koji nije do kraja raščišćen, primenjena je metabolomička studija. Po Blečićui Mayeru1 postoje tri taksona: dve vrste A. neumayeri Vis. i A. autariatus Blečić etMayer, koja se deli na dve podvrste - ssp. autariatus i ssp. bertisceus Blečić et Mayer. Sdruge strane, Webb2 priznaje samo jednu vrstu - A. neumayeri Vis., koja sadrži dvepodvrste - ssp. neumayeri i ssp. murbeckii Bošnjak. U novije vreme, na osnovuispitivanja genoma vrsta ovog roda predložena je samo jedna vrsta, А. neumayerianus(Vis.) Greuter.3 U ovom radu analizirana su sva tri taksona (prema Blečiću i Mayeru), auzorci su sakupljeni na različitim lokalitetima u Crnoj Gori u fazi cvetanja. Primenjenaje 1H NMR spektroskopija kombinovana sa multivarijantnom analizom podataka.Pokazano je da je OPLS-DA (engl. Orthogonal Partial Least Squares-DiscriminantAnalysis) najefikasniji metod za diskriminaciju ispitivanih uzoraka na osnovumetabolita prisutnih u ekstraktima. Utvrđeno je da je glavna razlika između A.autariatus i A. neumayeri prisustvo karakterističnih seskviterpenskih laktonagvajanolidnog tipa (amforikarpolida). Glavni seskviterpenski lakton vrste A. neumayerije oksidovan u položaju 2, dok laktoni prisutni u obe podvrste A. autariatus suoksidovani u poziciji 9, što potvrđuje da seskviterpenski laktoni mogu bitihemotaksonomski markeri u porodici Asteraceae..., Metabolomics is a new scientific multidisciplinary field that includes variousaspects of biology, chemistry and mathematics. It uses modern spectroscopic andchromatographic techniques (NMR, IC, UV, MS, GC, LC) and multivariate statisticaldata analysis to measure quantitatively and qualitatively all of the metabolites in the testorganism and thereby obtain a clear metabolic profile under test conditions. The use ofmetabolomics is not limited to the plant world, but can be applied to all livingorganisms as well as humans. A particularly important possibility is the application inmedicine as a diagnostic method or in pharmacognosy for the discovery of new naturalsources of drugs. In this thesis, the application of metabolomics to the endemic plantgenus Amphoricarpos Vis. was applied with two objectives: (a) acquiring newknowledge of the systematization of the genus, and (b) developing a method for rapiddetection of new pharmacologically active ingredients in plant material.Genus Amphoricarpos Vis. is an endemic of the western part of the BalkanPeninsula. In order to gain more insight into the taxonomic status of the genus that isstill ambiguous, a metabolomic study was applied. Blečić and Mayer1 proposed threetaxa: two species A. neumayeri Vis. and A. autariatus Blečić et Mayer, the latter dividedinto two subspecies, ssp. autariatus i ssp. bertisceus Blečič et Mayer. On the other hand,Webb2 recognizeed only one species, A. neumayeri Vis. divided into two subspecies,ssp. neumayeri i ssp. murbeckii Bošnjak. Recently, on the basis of a genomeexamination of the taxa from the West Balkans, only one species was proposed, A.neumayerianus (Vis.) Greuter.3In this dissertation all three taxa (according to Blečić and Mayer)1 were analysed. Thesamples were collected at different locations in Montenegro at the stage of flowering.1H NMR spectroscopy combined with multivariate data analysis was applied.Orthogonal Partial Least Squares-Discriminant Analysis (OPLS-DA) has been shown tobe the most effective method for discrimination of the tested samples, based on themetabolites present in the extracts. It was found that the main difference between A.autariatus and A. neumayeri was the presence of characteristic guaianolidesesquiterpene lactones (amforicarpolides). The major sesquiterpene lactones in theextract of A. neumayeri were oxidized in position 2, while the lactones present in bothsubspecies of A. autariatus were oxidized at position 9, which confirms thatsesquiterpene lactones may be chemotaxonomic markers in the Asteraceae family...",
publisher = "Универзитет у Београду, Хемијски факултет",
journal = "Универзитет у Београду",
title = "Metabolomička studija balkanskih vrsta roda Amphoricarpos Vis. (Asteraceae)",
url = "https://hdl.handle.net/21.15107/rcub_nardus_11706"
}

Cvetković, M.. (2019). Metabolomička studija balkanskih vrsta roda Amphoricarpos Vis. (Asteraceae). in Универзитет у Београду
Универзитет у Београду, Хемијски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_11706

Cvetković M. Metabolomička studija balkanskih vrsta roda Amphoricarpos Vis. (Asteraceae). in Универзитет у Београду. 2019;.
https://hdl.handle.net/21.15107/rcub_nardus_11706 .

Cvetković, Mirjana, "Metabolomička studija balkanskih vrsta roda Amphoricarpos Vis. (Asteraceae)" in Универзитет у Београду (2019),
https://hdl.handle.net/21.15107/rcub_nardus_11706 .

TY  - JOUR
AU  - Paykovic-Lucic, S.
AU  - Todosijević, Marina
AU  - Savić, Tatjana T.
AU  - Trajković, Jelena
AU  - Cvetković, Mirjana
AU  - Stanković, Jovana
AU  - Miličić, Dragana M.
AU  - Lučić, Luka
AU  - Tornic, Vladimir T.
AU  - Makarov, Slobodan E.
AU  - Vujisić, Ljubodrag V.
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2356
AB  - In insects, cuticular hydrocarbon (CHC) profile is involved in many important biological functions and may vary in different conditions. Among fruit fly species, Drosophila subobscura is one of the most frequently used in genetic, ecological and evolutionary research, because of its rich chromosomal polymorphism, specific behavioral repertoires and habitat preferences. In this work, we identified and quantified cuticular chemoprofile of D. subobscura. Using gas chromatography (GC) and gas chromatography coupled with mass spectrometry (GC-MS), 25 chemical compounds were found in males and 23 compounds were found in females. Further, ANOVA confirmed significant sexual dimorphism in cuticular chemoprofile amounts. Knowledge of cuticular chemistry could contribute to further research in D. subobscura, starting from behavioral, up to ecological, since this species is recognized as an important model system for the study and monitoring of global climate changes.
PB  - Pakistan Agricultural Scientists Forum
T2  - Journal of Animal and Plant Sciences
T1  - Cuticular chemoprofile of the fruit fly drosophila subobscura (diptera, drosophilidae)
VL  - 28
IS  - 6
SP  - 1881
EP  - 1886
UR  - https://hdl.handle.net/21.15107/rcub_cer_2356
ER  - 

@article{
author = "Paykovic-Lucic, S. and Todosijević, Marina and Savić, Tatjana T. and Trajković, Jelena and Cvetković, Mirjana and Stanković, Jovana and Miličić, Dragana M. and Lučić, Luka and Tornic, Vladimir T. and Makarov, Slobodan E. and Vujisić, Ljubodrag V.",
year = "2018",
abstract = "In insects, cuticular hydrocarbon (CHC) profile is involved in many important biological functions and may vary in different conditions. Among fruit fly species, Drosophila subobscura is one of the most frequently used in genetic, ecological and evolutionary research, because of its rich chromosomal polymorphism, specific behavioral repertoires and habitat preferences. In this work, we identified and quantified cuticular chemoprofile of D. subobscura. Using gas chromatography (GC) and gas chromatography coupled with mass spectrometry (GC-MS), 25 chemical compounds were found in males and 23 compounds were found in females. Further, ANOVA confirmed significant sexual dimorphism in cuticular chemoprofile amounts. Knowledge of cuticular chemistry could contribute to further research in D. subobscura, starting from behavioral, up to ecological, since this species is recognized as an important model system for the study and monitoring of global climate changes.",
publisher = "Pakistan Agricultural Scientists Forum",
journal = "Journal of Animal and Plant Sciences",
title = "Cuticular chemoprofile of the fruit fly drosophila subobscura (diptera, drosophilidae)",
volume = "28",
number = "6",
pages = "1881-1886",
url = "https://hdl.handle.net/21.15107/rcub_cer_2356"
}

Paykovic-Lucic, S., Todosijević, M., Savić, T. T., Trajković, J., Cvetković, M., Stanković, J., Miličić, D. M., Lučić, L., Tornic, V. T., Makarov, S. E.,& Vujisić, L. V.. (2018). Cuticular chemoprofile of the fruit fly drosophila subobscura (diptera, drosophilidae). in Journal of Animal and Plant Sciences
Pakistan Agricultural Scientists Forum., 28(6), 1881-1886.
https://hdl.handle.net/21.15107/rcub_cer_2356

Paykovic-Lucic S, Todosijević M, Savić TT, Trajković J, Cvetković M, Stanković J, Miličić DM, Lučić L, Tornic VT, Makarov SE, Vujisić LV. Cuticular chemoprofile of the fruit fly drosophila subobscura (diptera, drosophilidae). in Journal of Animal and Plant Sciences. 2018;28(6):1881-1886.
https://hdl.handle.net/21.15107/rcub_cer_2356 .

Paykovic-Lucic, S., Todosijević, Marina, Savić, Tatjana T., Trajković, Jelena, Cvetković, Mirjana, Stanković, Jovana, Miličić, Dragana M., Lučić, Luka, Tornic, Vladimir T., Makarov, Slobodan E., Vujisić, Ljubodrag V., "Cuticular chemoprofile of the fruit fly drosophila subobscura (diptera, drosophilidae)" in Journal of Animal and Plant Sciences, 28, no. 6 (2018):1881-1886,
https://hdl.handle.net/21.15107/rcub_cer_2356 .

TY  - JOUR
AU  - Nikolić, Biljana
AU  - Matovic, Milie
AU  - Todosijević, Marina
AU  - Stanković, Jovana
AU  - Cvetković, Mirjana
AU  - Marin, Petar D.
AU  - Tešević, Vele
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2439
AB  - Terpene compounds of Tanacetum macrophyllum as 1) essential oils, obtained by hydrodistillation (HD), 2) essential oil extracts, obtained by simultaneous' hydrodistillation and extraction (SDE) and 3) volatiles, obtained by Static Headspace GC-MS analysis (HS) were processed. Monoterpenes were the most dominant (49.2%, 49.5% and 90.4%, respectively). Profiles of essential oils obtained by HD and SD were quite similar, with oxygenated monoterpenes (39.3% and 39.4%) being the most abundant. In HS volatiles oxygenated monoterpenes also dominated (57.4%). Total sesquiterpenes were abundant in HD and SDE volatiles (38.2% and 39.2%, resp.), where sesquiterpene hydrocarbons were prevalent (27.3% and 28.7%, resp.). Germacrene D was dominant in HD and SDE oils (22.0% and 23.3%, resp.) and 1,8-cineole in HS volatiles (34.3%). To our knowledge, this is the first use of Headspace technique on T macrophyllum. Furthermore, this is the first comparison of different techniques of volatile extraction in T. macrophyllum.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Volatiles of Tanacetum macrophyllum Obtained by Different Extraction Methods
VL  - 13
IS  - 7
SP  - 891
EP  - 893
UR  - https://hdl.handle.net/21.15107/rcub_cer_2439
ER  - 

@article{
author = "Nikolić, Biljana and Matovic, Milie and Todosijević, Marina and Stanković, Jovana and Cvetković, Mirjana and Marin, Petar D. and Tešević, Vele",
year = "2018",
abstract = "Terpene compounds of Tanacetum macrophyllum as 1) essential oils, obtained by hydrodistillation (HD), 2) essential oil extracts, obtained by simultaneous' hydrodistillation and extraction (SDE) and 3) volatiles, obtained by Static Headspace GC-MS analysis (HS) were processed. Monoterpenes were the most dominant (49.2%, 49.5% and 90.4%, respectively). Profiles of essential oils obtained by HD and SD were quite similar, with oxygenated monoterpenes (39.3% and 39.4%) being the most abundant. In HS volatiles oxygenated monoterpenes also dominated (57.4%). Total sesquiterpenes were abundant in HD and SDE volatiles (38.2% and 39.2%, resp.), where sesquiterpene hydrocarbons were prevalent (27.3% and 28.7%, resp.). Germacrene D was dominant in HD and SDE oils (22.0% and 23.3%, resp.) and 1,8-cineole in HS volatiles (34.3%). To our knowledge, this is the first use of Headspace technique on T macrophyllum. Furthermore, this is the first comparison of different techniques of volatile extraction in T. macrophyllum.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Volatiles of Tanacetum macrophyllum Obtained by Different Extraction Methods",
volume = "13",
number = "7",
pages = "891-893",
url = "https://hdl.handle.net/21.15107/rcub_cer_2439"
}

Nikolić, B., Matovic, M., Todosijević, M., Stanković, J., Cvetković, M., Marin, P. D.,& Tešević, V.. (2018). Volatiles of Tanacetum macrophyllum Obtained by Different Extraction Methods. in Natural Product Communications
Natural Products Inc, Westerville., 13(7), 891-893.
https://hdl.handle.net/21.15107/rcub_cer_2439

Nikolić B, Matovic M, Todosijević M, Stanković J, Cvetković M, Marin PD, Tešević V. Volatiles of Tanacetum macrophyllum Obtained by Different Extraction Methods. in Natural Product Communications. 2018;13(7):891-893.
https://hdl.handle.net/21.15107/rcub_cer_2439 .

Nikolić, Biljana, Matovic, Milie, Todosijević, Marina, Stanković, Jovana, Cvetković, Mirjana, Marin, Petar D., Tešević, Vele, "Volatiles of Tanacetum macrophyllum Obtained by Different Extraction Methods" in Natural Product Communications, 13, no. 7 (2018):891-893,
https://hdl.handle.net/21.15107/rcub_cer_2439 .