TY  - JOUR
AU  - Aćimović, Milica
AU  - Stanković Jeremić, Jovana
AU  - Miljković, Ana
AU  - Rat, Milica
AU  - Lončar, Biljana
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7200
AB  - Ironwort (Sideritis montana L.), mountain germander (Teucrium montanum L.), wall germander (Teucrium chamaedrys L.), and horehound (Marrubium peregrinum L.) are species widely distributedacross Europe and are also found in North Africa and West Asia. Because of their wide distributionthey express significant chemical diversity. For generations, these plants have been used as medicalherbs for treating different aliments. The aim of this paper is to analyze volatile compounds of fourselected species that belong to the subfamily Lamioideae, family Lamiaceae, and inspect scientificallyproven biological activities and potential uses in modern phytotherapy in relation to traditionalmedicine. Therefore, in this research, we analyze the volatile compounds from this plants, obtainedin laboratory by a Clevenger-type apparatus, followed by liquid–liquid extraction with hexane as thesolvent. The identification of volatile compounds is conducted by GC-FID and GC-MS. Althoughthese plants are poor in essential oil, the most abundant class of volatile components are mainlysesquiterpenes: germacrene D (22.6%) in ironwort, 7-epi-trans-sesquisabinene hydrate (15.8%) inmountain germander, germacrene D (31.8%) and trans-caryophyllene (19.7%) in wall germander, andtrans-caryophyllene (32.4%) and trans-thujone (25.1%) in horehound. Furthermore, many studiesshow that, in addition to the essential oil, these plants contain phenols, flavonoids, diterpenes andditerpenoids, iridoids and their glycosides, coumarins, terpenes, and sterols, among other activecompounds, which affect biological activities. The other goal of this study is to review the literaturethat describes the traditional use of these plants in folk medicine in regions where they grow spontaneously and compare them with scientifically confirmed activities. Therefore, a bibliographic searchis conducted on Science Direct, PubMed, and Google Scholar to gather information related to thetopic and recommend potential applications in modern phytotherapy. In conclusion, we can say thatselected plants could be used as natural agents for promoting health, as a source of raw materialin the food industry, and as supplements, as well as in the pharmaceutical industry for developingplant-based remedies for prevention and treatment of many diseases, especially cancer.
PB  - Basel : MDPI
T2  - Molecules - Basel
T1  - Screening of Volatile Compounds, Traditional and Modern Phytotherapy Approaches of Selected Non-Aromatic Medicinal Plants (Lamiaceae, Lamioideae) from Rtanj Mountain, Eastern Serbia
VL  - 28
IS  - 12
SP  - 4611
DO  - 10.3390/molecules28124611
ER  - 

@article{
author = "Aćimović, Milica and Stanković Jeremić, Jovana and Miljković, Ana and Rat, Milica and Lončar, Biljana",
year = "2023",
abstract = "Ironwort (Sideritis montana L.), mountain germander (Teucrium montanum L.), wall germander (Teucrium chamaedrys L.), and horehound (Marrubium peregrinum L.) are species widely distributedacross Europe and are also found in North Africa and West Asia. Because of their wide distributionthey express significant chemical diversity. For generations, these plants have been used as medicalherbs for treating different aliments. The aim of this paper is to analyze volatile compounds of fourselected species that belong to the subfamily Lamioideae, family Lamiaceae, and inspect scientificallyproven biological activities and potential uses in modern phytotherapy in relation to traditionalmedicine. Therefore, in this research, we analyze the volatile compounds from this plants, obtainedin laboratory by a Clevenger-type apparatus, followed by liquid–liquid extraction with hexane as thesolvent. The identification of volatile compounds is conducted by GC-FID and GC-MS. Althoughthese plants are poor in essential oil, the most abundant class of volatile components are mainlysesquiterpenes: germacrene D (22.6%) in ironwort, 7-epi-trans-sesquisabinene hydrate (15.8%) inmountain germander, germacrene D (31.8%) and trans-caryophyllene (19.7%) in wall germander, andtrans-caryophyllene (32.4%) and trans-thujone (25.1%) in horehound. Furthermore, many studiesshow that, in addition to the essential oil, these plants contain phenols, flavonoids, diterpenes andditerpenoids, iridoids and their glycosides, coumarins, terpenes, and sterols, among other activecompounds, which affect biological activities. The other goal of this study is to review the literaturethat describes the traditional use of these plants in folk medicine in regions where they grow spontaneously and compare them with scientifically confirmed activities. Therefore, a bibliographic searchis conducted on Science Direct, PubMed, and Google Scholar to gather information related to thetopic and recommend potential applications in modern phytotherapy. In conclusion, we can say thatselected plants could be used as natural agents for promoting health, as a source of raw materialin the food industry, and as supplements, as well as in the pharmaceutical industry for developingplant-based remedies for prevention and treatment of many diseases, especially cancer.",
publisher = "Basel : MDPI",
journal = "Molecules - Basel",
title = "Screening of Volatile Compounds, Traditional and Modern Phytotherapy Approaches of Selected Non-Aromatic Medicinal Plants (Lamiaceae, Lamioideae) from Rtanj Mountain, Eastern Serbia",
volume = "28",
number = "12",
pages = "4611",
doi = "10.3390/molecules28124611"
}

Aćimović, M., Stanković Jeremić, J., Miljković, A., Rat, M.,& Lončar, B.. (2023). Screening of Volatile Compounds, Traditional and Modern Phytotherapy Approaches of Selected Non-Aromatic Medicinal Plants (Lamiaceae, Lamioideae) from Rtanj Mountain, Eastern Serbia. in Molecules - Basel
Basel : MDPI., 28(12), 4611.
https://doi.org/10.3390/molecules28124611

Aćimović M, Stanković Jeremić J, Miljković A, Rat M, Lončar B. Screening of Volatile Compounds, Traditional and Modern Phytotherapy Approaches of Selected Non-Aromatic Medicinal Plants (Lamiaceae, Lamioideae) from Rtanj Mountain, Eastern Serbia. in Molecules - Basel. 2023;28(12):4611.
doi:10.3390/molecules28124611 .

Aćimović, Milica, Stanković Jeremić, Jovana, Miljković, Ana, Rat, Milica, Lončar, Biljana, "Screening of Volatile Compounds, Traditional and Modern Phytotherapy Approaches of Selected Non-Aromatic Medicinal Plants (Lamiaceae, Lamioideae) from Rtanj Mountain, Eastern Serbia" in Molecules - Basel, 28, no. 12 (2023):4611,
https://doi.org/10.3390/molecules28124611 . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Semerdijeva, Ivanka
AU  - Zheljazkov, Valtcho D.
AU  - Rat, Milica
AU  - Stanković Jeremić, Jovana
AU  - Lončar, Biljana
AU  - Vukić, Vladimir
AU  - Radovanović, Katarina
AU  - Gavarić, Neda
AU  - Pezo, Lato
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6679
AB  - This research investigated a Balkan endemic species, Achillea clypeolata, collected from two locations (Dobrostan and Ivaylovgrad) in Bulgaria and two locations (Ozren and Rtanj) in Serbia. The goal was to compare the essential oil (EO) of A. clypeolata from these four localities. The EO was isolated from dry aboveground plant parts by hydrodistillation, and the identification of the EO constituents was carried out by GC-MS analyses. Principal Component Analysis (PCA), correlation analysis, and an unrooted cluster tree were used to define distinctions in the presence of volatile compounds in A. clypeolata EO. Results showed that A. clypeolata of Serbian origin (Ozren and Rtanj) contained 1,8-cineole as the main constituent, and belonged to the previously described 1,8-cineole as a dominant compound in the EO profile. On the other hand, the results from Bulgaria show an evident chemical diversification within the A. clypeolata species, as 1,8-cineole (23.2%), camphor (5.0%) and borneol (8.9%) prevailed in the EO of the studied samples collected from Ivaylovgrad, while borneol (22.6%), β-eudesmol (12.7%) and elemol (7.8%) were the main ones in the EO from Dobrostan. In sillico analysis revealed the high anti-inflammatory potential of A. clypeolata, which may be highly diverse depending on the population and active compounds it contains.
PB  - Elsevier BV
T2  - Biochemical Systematics and Ecology
T1  - Variation in the essential oil composition and in silico analysis of anti-inflammatory potential of Balkan endemic species Achillea clypeolata Sm
VL  - 110
SP  - 104679
DO  - 10.1016/j.bse.2023.104679
ER  - 

@article{
author = "Aćimović, Milica and Semerdijeva, Ivanka and Zheljazkov, Valtcho D. and Rat, Milica and Stanković Jeremić, Jovana and Lončar, Biljana and Vukić, Vladimir and Radovanović, Katarina and Gavarić, Neda and Pezo, Lato",
year = "2023",
abstract = "This research investigated a Balkan endemic species, Achillea clypeolata, collected from two locations (Dobrostan and Ivaylovgrad) in Bulgaria and two locations (Ozren and Rtanj) in Serbia. The goal was to compare the essential oil (EO) of A. clypeolata from these four localities. The EO was isolated from dry aboveground plant parts by hydrodistillation, and the identification of the EO constituents was carried out by GC-MS analyses. Principal Component Analysis (PCA), correlation analysis, and an unrooted cluster tree were used to define distinctions in the presence of volatile compounds in A. clypeolata EO. Results showed that A. clypeolata of Serbian origin (Ozren and Rtanj) contained 1,8-cineole as the main constituent, and belonged to the previously described 1,8-cineole as a dominant compound in the EO profile. On the other hand, the results from Bulgaria show an evident chemical diversification within the A. clypeolata species, as 1,8-cineole (23.2%), camphor (5.0%) and borneol (8.9%) prevailed in the EO of the studied samples collected from Ivaylovgrad, while borneol (22.6%), β-eudesmol (12.7%) and elemol (7.8%) were the main ones in the EO from Dobrostan. In sillico analysis revealed the high anti-inflammatory potential of A. clypeolata, which may be highly diverse depending on the population and active compounds it contains.",
publisher = "Elsevier BV",
journal = "Biochemical Systematics and Ecology",
title = "Variation in the essential oil composition and in silico analysis of anti-inflammatory potential of Balkan endemic species Achillea clypeolata Sm",
volume = "110",
pages = "104679",
doi = "10.1016/j.bse.2023.104679"
}

Aćimović, M., Semerdijeva, I., Zheljazkov, V. D., Rat, M., Stanković Jeremić, J., Lončar, B., Vukić, V., Radovanović, K., Gavarić, N.,& Pezo, L.. (2023). Variation in the essential oil composition and in silico analysis of anti-inflammatory potential of Balkan endemic species Achillea clypeolata Sm. in Biochemical Systematics and Ecology
Elsevier BV., 110, 104679.
https://doi.org/10.1016/j.bse.2023.104679

Aćimović M, Semerdijeva I, Zheljazkov VD, Rat M, Stanković Jeremić J, Lončar B, Vukić V, Radovanović K, Gavarić N, Pezo L. Variation in the essential oil composition and in silico analysis of anti-inflammatory potential of Balkan endemic species Achillea clypeolata Sm. in Biochemical Systematics and Ecology. 2023;110:104679.
doi:10.1016/j.bse.2023.104679 .

Aćimović, Milica, Semerdijeva, Ivanka, Zheljazkov, Valtcho D., Rat, Milica, Stanković Jeremić, Jovana, Lončar, Biljana, Vukić, Vladimir, Radovanović, Katarina, Gavarić, Neda, Pezo, Lato, "Variation in the essential oil composition and in silico analysis of anti-inflammatory potential of Balkan endemic species Achillea clypeolata Sm" in Biochemical Systematics and Ecology, 110 (2023):104679,
https://doi.org/10.1016/j.bse.2023.104679 . .

TY  - JOUR
AU  - Tomić, Ana
AU  - Šovljanski, Olja
AU  - Nikolić, Višnja
AU  - Lato, Pezo
AU  - Aćimović, Milica
AU  - Cvetković, Mirjana
AU  - Stanojev, Jovana
AU  - Kuzmanović, Nebojša
AU  - Markov, Siniša
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5630
AB  - The main challenge in controlling the microbiological contamination of historical paper is
finding an adequate method that includes the use of cost-effective, harmless, and non-toxic biocides
whose effectiveness is maintained over time and without adverse effects on cultural heritage and
human health. Therefore, this study demonstrated the possibility of using a non-invasive method
of historical paper conservation based on plant essential oils (EOs) application. Evaluation of antimicrobial
effects of different EOs (lemongrass, oregano, rosemary, peppermint, and eucalyptus)
was conducted against Cladosporium cladosporoides, Aspergillus fumigatus, and Penicillium chrysogenum,
which are commonly found on archive papers. Using a mixture of oregano, lemongrass and peppermint
in ratio 1:1:1, the lower minimal inhibition concentration (0.78%) and better efficiency during
a vapour test at the highest tested distance (5.5 cm) compared with individual EOs was proven.
At the final step, this EOs mixture was used in the in situ conservation of historical paper samples
obtained from the Archives of Vojvodina. According to the SEM imaging, the applied EOs mixture
demonstrates complete efficiency in the inhibition of fungi colonization of archive papers, since
fungal growth was not observed on samples, unlike the control samples.
PB  - Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Antibiotics
T1  - Screening of Antifungal Activity of Essential Oils in Controlling Biocontamination of Historical Papers in Archives
VL  - 12
IS  - 103
DO  - 10.3390/antibiotics12010103
ER  - 

@article{
author = "Tomić, Ana and Šovljanski, Olja and Nikolić, Višnja and Lato, Pezo and Aćimović, Milica and Cvetković, Mirjana and Stanojev, Jovana and Kuzmanović, Nebojša and Markov, Siniša",
year = "2023",
abstract = "The main challenge in controlling the microbiological contamination of historical paper is
finding an adequate method that includes the use of cost-effective, harmless, and non-toxic biocides
whose effectiveness is maintained over time and without adverse effects on cultural heritage and
human health. Therefore, this study demonstrated the possibility of using a non-invasive method
of historical paper conservation based on plant essential oils (EOs) application. Evaluation of antimicrobial
effects of different EOs (lemongrass, oregano, rosemary, peppermint, and eucalyptus)
was conducted against Cladosporium cladosporoides, Aspergillus fumigatus, and Penicillium chrysogenum,
which are commonly found on archive papers. Using a mixture of oregano, lemongrass and peppermint
in ratio 1:1:1, the lower minimal inhibition concentration (0.78%) and better efficiency during
a vapour test at the highest tested distance (5.5 cm) compared with individual EOs was proven.
At the final step, this EOs mixture was used in the in situ conservation of historical paper samples
obtained from the Archives of Vojvodina. According to the SEM imaging, the applied EOs mixture
demonstrates complete efficiency in the inhibition of fungi colonization of archive papers, since
fungal growth was not observed on samples, unlike the control samples.",
publisher = "Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Antibiotics",
title = "Screening of Antifungal Activity of Essential Oils in Controlling Biocontamination of Historical Papers in Archives",
volume = "12",
number = "103",
doi = "10.3390/antibiotics12010103"
}

Tomić, A., Šovljanski, O., Nikolić, V., Lato, P., Aćimović, M., Cvetković, M., Stanojev, J., Kuzmanović, N.,& Markov, S.. (2023). Screening of Antifungal Activity of Essential Oils in Controlling Biocontamination of Historical Papers in Archives. in Antibiotics
Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)., 12(103).
https://doi.org/10.3390/antibiotics12010103

Tomić A, Šovljanski O, Nikolić V, Lato P, Aćimović M, Cvetković M, Stanojev J, Kuzmanović N, Markov S. Screening of Antifungal Activity of Essential Oils in Controlling Biocontamination of Historical Papers in Archives. in Antibiotics. 2023;12(103).
doi:10.3390/antibiotics12010103 .

Tomić, Ana, Šovljanski, Olja, Nikolić, Višnja, Lato, Pezo, Aćimović, Milica, Cvetković, Mirjana, Stanojev, Jovana, Kuzmanović, Nebojša, Markov, Siniša, "Screening of Antifungal Activity of Essential Oils in Controlling Biocontamination of Historical Papers in Archives" in Antibiotics, 12, no. 103 (2023),
https://doi.org/10.3390/antibiotics12010103 . .

TY  - JOUR
AU  - Stanković Jeremić, Jovana
AU  - Gođevac, Dejan
AU  - Ivanović, Stefan
AU  - Simić, Katarina
AU  - Trendafilova, Antoaneta
AU  - Aćimović, Milica
AU  - Milosavljević, Slobodan
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5166
AB  - The application of High Performance Thin Layer Chromatography
(HPTLC)-based non-targeted metabolomics as a holistic approach to compare
fingerprints of metabolite changes during Artemisia annua development is
described. Images of HPTLC chromatograms obtained after derivatization with
anisaldehyde-sulphuric acid reagent were used as a dataset for multivariate
analysis. Principal component analysis and Orthogonal Partial Least Squares
Discriminant Analysis confirmed the discrimination of samples belonging to
vegetative phase, flowering stage, and seed formation stage of the plant
development. The obtained results showed that the HPTLC-based metabolomics
approach can be a very reliable technique for the investigation of metabolic
changes during plant development, complementary to GC-MS and NMR-based
metabolomics.
AB  - Описана је холистичка примена нетаргетне метаболомике базиране на високоефикасној танкослојној хроматографији (HPTLC) која омогућава поређење метаболичких профила Artemisia annua и праћење њихових промена током развоја биљке. HPTLC хроматограми након развијања анизалдехидом и сумпорном киселином су коришћени за генерисање података за мултиваријантну анализу. Анализа главних компоненти (PCA) и ортогонална дискриминанта анализа најмањих квадрата (OPLS-DA) су потврдиле разлике између узорака који припадају различитим фенофазама - вегетативној фази, фази цветања и фази формирања семена. Добијени резултати указују да метаболомички приступ заснован на HPTLC методи која је комплементарна са GC-MS и NMR анализом, може бити веома поуздана техника за анализу промене током развоја биљке.
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - HPTLC-based metabolomics for the investigation of metabolic changes during plant development: The case study of Artemisia annua
T1  - Mетаболомикa базиранa на HPTLC за испитивање метаболичких промена током развоја биљке:  Artemisia annua студија случаја
VL  - 87
IS  - 11
SP  - 1237
EP  - 1244
DO  - 10.2298/JSC210507007S
ER  - 

@article{
author = "Stanković Jeremić, Jovana and Gođevac, Dejan and Ivanović, Stefan and Simić, Katarina and Trendafilova, Antoaneta and Aćimović, Milica and Milosavljević, Slobodan",
year = "2022",
abstract = "The application of High Performance Thin Layer Chromatography
(HPTLC)-based non-targeted metabolomics as a holistic approach to compare
fingerprints of metabolite changes during Artemisia annua development is
described. Images of HPTLC chromatograms obtained after derivatization with
anisaldehyde-sulphuric acid reagent were used as a dataset for multivariate
analysis. Principal component analysis and Orthogonal Partial Least Squares
Discriminant Analysis confirmed the discrimination of samples belonging to
vegetative phase, flowering stage, and seed formation stage of the plant
development. The obtained results showed that the HPTLC-based metabolomics
approach can be a very reliable technique for the investigation of metabolic
changes during plant development, complementary to GC-MS and NMR-based
metabolomics., Описана је холистичка примена нетаргетне метаболомике базиране на високоефикасној танкослојној хроматографији (HPTLC) која омогућава поређење метаболичких профила Artemisia annua и праћење њихових промена током развоја биљке. HPTLC хроматограми након развијања анизалдехидом и сумпорном киселином су коришћени за генерисање података за мултиваријантну анализу. Анализа главних компоненти (PCA) и ортогонална дискриминанта анализа најмањих квадрата (OPLS-DA) су потврдиле разлике између узорака који припадају различитим фенофазама - вегетативној фази, фази цветања и фази формирања семена. Добијени резултати указују да метаболомички приступ заснован на HPTLC методи која је комплементарна са GC-MS и NMR анализом, може бити веома поуздана техника за анализу промене током развоја биљке.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "HPTLC-based metabolomics for the investigation of metabolic changes during plant development: The case study of Artemisia annua, Mетаболомикa базиранa на HPTLC за испитивање метаболичких промена током развоја биљке:  Artemisia annua студија случаја",
volume = "87",
number = "11",
pages = "1237-1244",
doi = "10.2298/JSC210507007S"
}

Stanković Jeremić, J., Gođevac, D., Ivanović, S., Simić, K., Trendafilova, A., Aćimović, M.,& Milosavljević, S.. (2022). HPTLC-based metabolomics for the investigation of metabolic changes during plant development: The case study of Artemisia annua. in Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 87(11), 1237-1244.
https://doi.org/10.2298/JSC210507007S

Stanković Jeremić J, Gođevac D, Ivanović S, Simić K, Trendafilova A, Aćimović M, Milosavljević S. HPTLC-based metabolomics for the investigation of metabolic changes during plant development: The case study of Artemisia annua. in Journal of the Serbian Chemical Society. 2022;87(11):1237-1244.
doi:10.2298/JSC210507007S .

Stanković Jeremić, Jovana, Gođevac, Dejan, Ivanović, Stefan, Simić, Katarina, Trendafilova, Antoaneta, Aćimović, Milica, Milosavljević, Slobodan, "HPTLC-based metabolomics for the investigation of metabolic changes during plant development: The case study of Artemisia annua" in Journal of the Serbian Chemical Society, 87, no. 11 (2022):1237-1244,
https://doi.org/10.2298/JSC210507007S . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Lončar, Biljana
AU  - Pezo, Milada
AU  - Stanković Jeremić, Jovana
AU  - Cvetković, Mirjana
AU  - Rat, Milica
AU  - Pezo, Lato
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5265
AB  - Unlike other studies that only determined the chemical composition of essential oils depending on their geographic origin, this research investigated the effect of weather conditions (temperature, precipitation, and insolation) on the chemical composition of Nepeta nuda L. essential oil. The collection of wild-growing N. nuda was carried out during three successive years, 2019, 2020, and 2021 at Rtanj Mountain (Serbia) on the same date (July 7th). Essential oil extraction from the plant was performed by hydro-distillation. After gas chromatographic-mass spectrometric analysis, a total of 102 volatile compounds were separated from N. nuda, during the observed period, 28 were unidentified, compromising between 5.0% and 8.7%, depending on the year. A multiple linear regression model was created, and statistical analyses were performed to provide knowledge about the prediction, feature profile, and the similarity in contents of active compounds of the N. nuda essential oil. The influence of temperature on the accumulation of the most abundant component, 1,8-cineole, was positive, while the impact of precipitation and insolation was negative. According to the cluster tree, there are four chemotypes of N. nuda essential oil: with nepetalactone, 1,8-cineole, mixed (nepetalactone+1,8-cineole+germacrene D), and nonspecific chemotypes. Bearing in mind that the biological activity of a raw material depends on the chemotype and environmental factors, this is a topic that deserves a more detailed approach. The N. nuda and its essential oil are promising materials with high biological potential, and these deserve further detailed investigation.
T2  - Horticulturae
T1  - Volatile Compounds of Nepeta nuda L. from Rtanj Mountain (Serbia)
VL  - 8
IS  - 2
SP  - 85
DO  - 10.3390/horticulturae8020085
ER  - 

@article{
author = "Aćimović, Milica and Lončar, Biljana and Pezo, Milada and Stanković Jeremić, Jovana and Cvetković, Mirjana and Rat, Milica and Pezo, Lato",
year = "2022",
abstract = "Unlike other studies that only determined the chemical composition of essential oils depending on their geographic origin, this research investigated the effect of weather conditions (temperature, precipitation, and insolation) on the chemical composition of Nepeta nuda L. essential oil. The collection of wild-growing N. nuda was carried out during three successive years, 2019, 2020, and 2021 at Rtanj Mountain (Serbia) on the same date (July 7th). Essential oil extraction from the plant was performed by hydro-distillation. After gas chromatographic-mass spectrometric analysis, a total of 102 volatile compounds were separated from N. nuda, during the observed period, 28 were unidentified, compromising between 5.0% and 8.7%, depending on the year. A multiple linear regression model was created, and statistical analyses were performed to provide knowledge about the prediction, feature profile, and the similarity in contents of active compounds of the N. nuda essential oil. The influence of temperature on the accumulation of the most abundant component, 1,8-cineole, was positive, while the impact of precipitation and insolation was negative. According to the cluster tree, there are four chemotypes of N. nuda essential oil: with nepetalactone, 1,8-cineole, mixed (nepetalactone+1,8-cineole+germacrene D), and nonspecific chemotypes. Bearing in mind that the biological activity of a raw material depends on the chemotype and environmental factors, this is a topic that deserves a more detailed approach. The N. nuda and its essential oil are promising materials with high biological potential, and these deserve further detailed investigation.",
journal = "Horticulturae",
title = "Volatile Compounds of Nepeta nuda L. from Rtanj Mountain (Serbia)",
volume = "8",
number = "2",
pages = "85",
doi = "10.3390/horticulturae8020085"
}

Aćimović, M., Lončar, B., Pezo, M., Stanković Jeremić, J., Cvetković, M., Rat, M.,& Pezo, L.. (2022). Volatile Compounds of Nepeta nuda L. from Rtanj Mountain (Serbia). in Horticulturae, 8(2), 85.
https://doi.org/10.3390/horticulturae8020085

Aćimović M, Lončar B, Pezo M, Stanković Jeremić J, Cvetković M, Rat M, Pezo L. Volatile Compounds of Nepeta nuda L. from Rtanj Mountain (Serbia). in Horticulturae. 2022;8(2):85.
doi:10.3390/horticulturae8020085 .

Aćimović, Milica, Lončar, Biljana, Pezo, Milada, Stanković Jeremić, Jovana, Cvetković, Mirjana, Rat, Milica, Pezo, Lato, "Volatile Compounds of Nepeta nuda L. from Rtanj Mountain (Serbia)" in Horticulturae, 8, no. 2 (2022):85,
https://doi.org/10.3390/horticulturae8020085 . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Cvetković, Mirjana
AU  - Stanković Jeremić, Jovana
AU  - Pezo, Lato
AU  - Varga, Ana
AU  - Čabarkapa, Ivana
AU  - Kiprovski, Biljana
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5406
AB  - Salvia sclarea L. or clary sage is cultivated worldwide in temperate and sub-tropical climates, as an ornamental and essential oil (EO) bearing plant. EO is obtained from fresh spikes in full flowering stage and is recognized as an important commercial product for food, beverage and cosmetic industries. This study investigated the EO composition of S. sclarea grown in Serbia (Southeast Europe) obtained by two different methods, steam (SD) and hydrodistillation (HD). GC-MS analysis identified oxygenated monoterpenes as the main class of compounds for all EOs (between 81.8% and 88.2% depending on the distillation process). The most abundant oxygenated monoterpenes were linalyl acetate and linalool. In addition, in vitro antimicrobial (modified resazurin microtitre-plate assay) and antioxidant activities (DPPH• assay) and total polyphenol content of obtained EOs were also evaluated. According to the assay used for the evaluation of the antibacterial activity, Gram-negative bacteria were more sensitive to S. sclarea EO in comparison to Gram-positive bacteria. EOs exhibited low antioxidant capacity, below 3% neutralized DPPH• radicals, reaching up to approximately 400 µg AAE mL-1. This study also investigated a possibility for predicting retention indices (RIs) of compounds isolated from EOs. In total, 78 experimentally obtained RIs were applied to construct the prediction model. The quantitative structure-chromatographic retention relationship (QSRR) model was used to anticipate the experimentally obtained RIs. Five molecular descriptors were selected by factor analysis and genetic algorithm to predict RIs. The obtained accuracy of the QSRR model reached r2 =.912, which showed that these models might be applied for predicting retention indices.
PB  - Wiley
T2  - Flavour and Fragrance Journal
T1  - Biological activity and profiling of Salvia sclarea essential oil obtained by steam and hydrodistillation extraction methods via chemometrics tools
VL  - 37
IS  - 1
SP  - 20
EP  - 32
DO  - 10.1002/ffj.3684
ER  - 

@article{
author = "Aćimović, Milica and Cvetković, Mirjana and Stanković Jeremić, Jovana and Pezo, Lato and Varga, Ana and Čabarkapa, Ivana and Kiprovski, Biljana",
year = "2022",
abstract = "Salvia sclarea L. or clary sage is cultivated worldwide in temperate and sub-tropical climates, as an ornamental and essential oil (EO) bearing plant. EO is obtained from fresh spikes in full flowering stage and is recognized as an important commercial product for food, beverage and cosmetic industries. This study investigated the EO composition of S. sclarea grown in Serbia (Southeast Europe) obtained by two different methods, steam (SD) and hydrodistillation (HD). GC-MS analysis identified oxygenated monoterpenes as the main class of compounds for all EOs (between 81.8% and 88.2% depending on the distillation process). The most abundant oxygenated monoterpenes were linalyl acetate and linalool. In addition, in vitro antimicrobial (modified resazurin microtitre-plate assay) and antioxidant activities (DPPH• assay) and total polyphenol content of obtained EOs were also evaluated. According to the assay used for the evaluation of the antibacterial activity, Gram-negative bacteria were more sensitive to S. sclarea EO in comparison to Gram-positive bacteria. EOs exhibited low antioxidant capacity, below 3% neutralized DPPH• radicals, reaching up to approximately 400 µg AAE mL-1. This study also investigated a possibility for predicting retention indices (RIs) of compounds isolated from EOs. In total, 78 experimentally obtained RIs were applied to construct the prediction model. The quantitative structure-chromatographic retention relationship (QSRR) model was used to anticipate the experimentally obtained RIs. Five molecular descriptors were selected by factor analysis and genetic algorithm to predict RIs. The obtained accuracy of the QSRR model reached r2 =.912, which showed that these models might be applied for predicting retention indices.",
publisher = "Wiley",
journal = "Flavour and Fragrance Journal",
title = "Biological activity and profiling of Salvia sclarea essential oil obtained by steam and hydrodistillation extraction methods via chemometrics tools",
volume = "37",
number = "1",
pages = "20-32",
doi = "10.1002/ffj.3684"
}

Aćimović, M., Cvetković, M., Stanković Jeremić, J., Pezo, L., Varga, A., Čabarkapa, I.,& Kiprovski, B.. (2022). Biological activity and profiling of Salvia sclarea essential oil obtained by steam and hydrodistillation extraction methods via chemometrics tools. in Flavour and Fragrance Journal
Wiley., 37(1), 20-32.
https://doi.org/10.1002/ffj.3684

Aćimović M, Cvetković M, Stanković Jeremić J, Pezo L, Varga A, Čabarkapa I, Kiprovski B. Biological activity and profiling of Salvia sclarea essential oil obtained by steam and hydrodistillation extraction methods via chemometrics tools. in Flavour and Fragrance Journal. 2022;37(1):20-32.
doi:10.1002/ffj.3684 .

Aćimović, Milica, Cvetković, Mirjana, Stanković Jeremić, Jovana, Pezo, Lato, Varga, Ana, Čabarkapa, Ivana, Kiprovski, Biljana, "Biological activity and profiling of Salvia sclarea essential oil obtained by steam and hydrodistillation extraction methods via chemometrics tools" in Flavour and Fragrance Journal, 37, no. 1 (2022):20-32,
https://doi.org/10.1002/ffj.3684 . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Stanković Jeremić, Jovana
AU  - Todosijević, Marina
AU  - Kiprovski, Biljana
AU  - Vidović, Senka
AU  - Vladić, Jelena
AU  - Pezo, Lato
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5407
AB  - The most abundant volatile compounds of sweet wormwood (Artemisia annua L.) essential oil were artemisia ketone (25.4 %) and trans-caryophyllene (10.2 %), followed by 1,8-cineole, camphor, germacrene D and β-selinene. The major volatile compounds in the hydrosol were camphor (25.1 %), 1,8-cineole (20.5 %) and artemisia ketone (10.7 %), followed by trans-pinocarveol and yomogi alcohol. Tested essential oil was rich in oxygenated monoterpenes and sesquiterpene hydrocarbons, while the former were identified as the major class of volatile compounds in the hydrosol, due to higher water solubility. Classification of all sweet wormwood chemotypes, according to essential oil composition, in available literature (17 studies and 61 accessions) could be done according to four chemotypes: artemisia ketone+artemisia alcohol (most abundant), artemisia ketone, camphor and nonspecific chemotype. According to this classification, essential oil of sweet wormwood from this study belongs to artemisia ketone (content varied between 22.1 and 55.8 %). Bearing in mind that hydrosols are a by-product of industrial production of essential oils, and the fact that sweet wormwood hydrosol has high contents of camphor, 1,8-cineole and artemisia ketone, there is a great potential for the use of this aromatic plant primary processing waste product as a water replacement in cosmetic industry, beverages flavoring, for food preservation, as well as in post-harvest pre-storage treatments in organic agriculture.
PB  - Wiley
T2  - Chemistry and Biodiversity
T1  - Comparative Study of the Essential Oil and Hydrosol Composition of Sweet Wormwood (Artemisia annua L.) from Serbia
VL  - 19
IS  - 3
SP  - e202100954
DO  - 10.1002/cbdv.202100954
ER  - 

@article{
author = "Aćimović, Milica and Stanković Jeremić, Jovana and Todosijević, Marina and Kiprovski, Biljana and Vidović, Senka and Vladić, Jelena and Pezo, Lato",
year = "2022",
abstract = "The most abundant volatile compounds of sweet wormwood (Artemisia annua L.) essential oil were artemisia ketone (25.4 %) and trans-caryophyllene (10.2 %), followed by 1,8-cineole, camphor, germacrene D and β-selinene. The major volatile compounds in the hydrosol were camphor (25.1 %), 1,8-cineole (20.5 %) and artemisia ketone (10.7 %), followed by trans-pinocarveol and yomogi alcohol. Tested essential oil was rich in oxygenated monoterpenes and sesquiterpene hydrocarbons, while the former were identified as the major class of volatile compounds in the hydrosol, due to higher water solubility. Classification of all sweet wormwood chemotypes, according to essential oil composition, in available literature (17 studies and 61 accessions) could be done according to four chemotypes: artemisia ketone+artemisia alcohol (most abundant), artemisia ketone, camphor and nonspecific chemotype. According to this classification, essential oil of sweet wormwood from this study belongs to artemisia ketone (content varied between 22.1 and 55.8 %). Bearing in mind that hydrosols are a by-product of industrial production of essential oils, and the fact that sweet wormwood hydrosol has high contents of camphor, 1,8-cineole and artemisia ketone, there is a great potential for the use of this aromatic plant primary processing waste product as a water replacement in cosmetic industry, beverages flavoring, for food preservation, as well as in post-harvest pre-storage treatments in organic agriculture.",
publisher = "Wiley",
journal = "Chemistry and Biodiversity",
title = "Comparative Study of the Essential Oil and Hydrosol Composition of Sweet Wormwood (Artemisia annua L.) from Serbia",
volume = "19",
number = "3",
pages = "e202100954",
doi = "10.1002/cbdv.202100954"
}

Aćimović, M., Stanković Jeremić, J., Todosijević, M., Kiprovski, B., Vidović, S., Vladić, J.,& Pezo, L.. (2022). Comparative Study of the Essential Oil and Hydrosol Composition of Sweet Wormwood (Artemisia annua L.) from Serbia. in Chemistry and Biodiversity
Wiley., 19(3), e202100954.
https://doi.org/10.1002/cbdv.202100954

Aćimović M, Stanković Jeremić J, Todosijević M, Kiprovski B, Vidović S, Vladić J, Pezo L. Comparative Study of the Essential Oil and Hydrosol Composition of Sweet Wormwood (Artemisia annua L.) from Serbia. in Chemistry and Biodiversity. 2022;19(3):e202100954.
doi:10.1002/cbdv.202100954 .

Aćimović, Milica, Stanković Jeremić, Jovana, Todosijević, Marina, Kiprovski, Biljana, Vidović, Senka, Vladić, Jelena, Pezo, Lato, "Comparative Study of the Essential Oil and Hydrosol Composition of Sweet Wormwood (Artemisia annua L.) from Serbia" in Chemistry and Biodiversity, 19, no. 3 (2022):e202100954,
https://doi.org/10.1002/cbdv.202100954 . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Lončar, Biljana
AU  - Stanković Jeremić, Jovana
AU  - Cvetković, Mirjana
AU  - Pezo, Lato
AU  - Pezo, Milada
AU  - Todosijević, Marina
AU  - Tešević, Vele
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5409
AB  - Lavandula sp. essential oil and hydrolate are commercially valuable in various industry
branches with the potential for wide-ranging applications. This study aimed to evaluate the quality
of these products obtained from L. x intermedia cv. ‘Budrovka’ for the first time cultivated on Fruška
Gora Mt. (Serbia) during three successive seasons (2019, 2020, and 2021). Essential oil extraction
was obtained by steam distillation, and the composition and influence of weather conditions were
also assessed, using flowering tops. The obtained essential oils and hydrolates were analysed by
gas chromatography with a flame ionization detector (GC-FID) and gas chromatography coupled to
mass spectrometry (GC-MS). A linear regression model was developed to predict L. x intermedia cv.
‘Budrovka’ essential oil volatile compound content and hydrolate composition during three years,
according to temperature and precipitation data, and the appropriate regression coefficients were
calculated, while the correlation analysis was employed to analyse the correlations in hydrolate
and essential oil compounds. To completely describe the structure of the research data that would
present a better insight into the similarities and differences among the diverse L. x intermedia cv.
‘Budrovka’ samples, the PCA was used. The most dominant in L. intermedia cv. ‘Budrovka’ essential
oil and hydrolate were oxygenated monoterpenes: linalool, 1,8-cineole, borneol, linalyl acetate, and
terpinene-4-ol. It is established that the temperature was positively correlated with all essential oil
and hydrolate compounds. The precipitations were positively correlated with the main compounds
(linalool, 1,8-cineole, and borneol), while the other compounds’ content negatively correlated to
precipitation. The results indicated that Fruška Gora Mt. has suitable agro-ecological requirements
for cultivating Lavandula sp. and providing satisfactory essential oil and hydrolate.
PB  - Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Horticulturae
T1  - Weather Conditions Influence on Lavandin Essential Oil and Hydrolate Quality
VL  - 8
SP  - 281
DO  - 10.3390/horticulturae8040281
ER  - 

@article{
author = "Aćimović, Milica and Lončar, Biljana and Stanković Jeremić, Jovana and Cvetković, Mirjana and Pezo, Lato and Pezo, Milada and Todosijević, Marina and Tešević, Vele",
year = "2022",
abstract = "Lavandula sp. essential oil and hydrolate are commercially valuable in various industry
branches with the potential for wide-ranging applications. This study aimed to evaluate the quality
of these products obtained from L. x intermedia cv. ‘Budrovka’ for the first time cultivated on Fruška
Gora Mt. (Serbia) during three successive seasons (2019, 2020, and 2021). Essential oil extraction
was obtained by steam distillation, and the composition and influence of weather conditions were
also assessed, using flowering tops. The obtained essential oils and hydrolates were analysed by
gas chromatography with a flame ionization detector (GC-FID) and gas chromatography coupled to
mass spectrometry (GC-MS). A linear regression model was developed to predict L. x intermedia cv.
‘Budrovka’ essential oil volatile compound content and hydrolate composition during three years,
according to temperature and precipitation data, and the appropriate regression coefficients were
calculated, while the correlation analysis was employed to analyse the correlations in hydrolate
and essential oil compounds. To completely describe the structure of the research data that would
present a better insight into the similarities and differences among the diverse L. x intermedia cv.
‘Budrovka’ samples, the PCA was used. The most dominant in L. intermedia cv. ‘Budrovka’ essential
oil and hydrolate were oxygenated monoterpenes: linalool, 1,8-cineole, borneol, linalyl acetate, and
terpinene-4-ol. It is established that the temperature was positively correlated with all essential oil
and hydrolate compounds. The precipitations were positively correlated with the main compounds
(linalool, 1,8-cineole, and borneol), while the other compounds’ content negatively correlated to
precipitation. The results indicated that Fruška Gora Mt. has suitable agro-ecological requirements
for cultivating Lavandula sp. and providing satisfactory essential oil and hydrolate.",
publisher = "Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Horticulturae",
title = "Weather Conditions Influence on Lavandin Essential Oil and Hydrolate Quality",
volume = "8",
pages = "281",
doi = "10.3390/horticulturae8040281"
}

Aćimović, M., Lončar, B., Stanković Jeremić, J., Cvetković, M., Pezo, L., Pezo, M., Todosijević, M.,& Tešević, V.. (2022). Weather Conditions Influence on Lavandin Essential Oil and Hydrolate Quality. in Horticulturae
Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)., 8, 281.
https://doi.org/10.3390/horticulturae8040281

Aćimović M, Lončar B, Stanković Jeremić J, Cvetković M, Pezo L, Pezo M, Todosijević M, Tešević V. Weather Conditions Influence on Lavandin Essential Oil and Hydrolate Quality. in Horticulturae. 2022;8:281.
doi:10.3390/horticulturae8040281 .

Aćimović, Milica, Lončar, Biljana, Stanković Jeremić, Jovana, Cvetković, Mirjana, Pezo, Lato, Pezo, Milada, Todosijević, Marina, Tešević, Vele, "Weather Conditions Influence on Lavandin Essential Oil and Hydrolate Quality" in Horticulturae, 8 (2022):281,
https://doi.org/10.3390/horticulturae8040281 . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Pezo, Lato
AU  - Čabarkapa, Ivana
AU  - Trudić, Anika
AU  - Stanković Jeremić, Jovana
AU  - Varga, Ana
AU  - Lončar, Biljana
AU  - Šovljanski, Olja
AU  - Tešević, Vele
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5587
AB  - This study aimed to investigate the chemical composition of steam distillate essential oil and corresponding hydrolate obtained from S. officinalis grown in Serbia, as well as the influence of weather conditions (temperature and precipitations) on their chemical profiles. Furthermore, their antimicrobial activity was investigated in vitro. The main compounds in essential oil were cis-thujone, followed by camphor, trans-thujone, and 1,8-cineole, while hydrolate was slightly different from the essential oil, with camphor, cis-thujone, and 1,8-cineole as the main compounds. Among the eight respiratory-associated microorganisms, Klebsiella oxytoca was the most sensitive to the tested EOs (minimum inhibitory concentration (MIC)/minimal bactericidal/fungicidal concentration (MBC/MFC) were 14.20 and 28.4 μL mL−1, respectively). MIC and MBC values of other tested bacteria ranged between 28.40 and 227.25 μL mL−1 while for Candida albicans MIC/MFC ranged from 28.40/56.81 to 56.81–113.63 μL mL−1. Antibiotic susceptibility patterns for the analyzed eight respiratory-associated microorganisms showed an intermediate level of resistance to commonly used antibiotics such as ampicillin, levofloxacin, and ciprofloxacin. As a preliminary approach to the antimicrobial profiling of the tested EO, the obtained results revealed that the tested samples possess remarkable antibacterial activities and could be used to develop pharmaceutical formulations as an alternative to conventional antibiotic therapy.
PB  - MDPI AG
T2  - Processes
T1  - Variation of Salvia officinalis L. Essential Oil and Hydrolate Composition and Their Antimicrobial Activity
VL  - 10
IS  - 8
SP  - 1608
DO  - 10.3390/pr10081608
ER  - 

@article{
author = "Aćimović, Milica and Pezo, Lato and Čabarkapa, Ivana and Trudić, Anika and Stanković Jeremić, Jovana and Varga, Ana and Lončar, Biljana and Šovljanski, Olja and Tešević, Vele",
year = "2022",
abstract = "This study aimed to investigate the chemical composition of steam distillate essential oil and corresponding hydrolate obtained from S. officinalis grown in Serbia, as well as the influence of weather conditions (temperature and precipitations) on their chemical profiles. Furthermore, their antimicrobial activity was investigated in vitro. The main compounds in essential oil were cis-thujone, followed by camphor, trans-thujone, and 1,8-cineole, while hydrolate was slightly different from the essential oil, with camphor, cis-thujone, and 1,8-cineole as the main compounds. Among the eight respiratory-associated microorganisms, Klebsiella oxytoca was the most sensitive to the tested EOs (minimum inhibitory concentration (MIC)/minimal bactericidal/fungicidal concentration (MBC/MFC) were 14.20 and 28.4 μL mL−1, respectively). MIC and MBC values of other tested bacteria ranged between 28.40 and 227.25 μL mL−1 while for Candida albicans MIC/MFC ranged from 28.40/56.81 to 56.81–113.63 μL mL−1. Antibiotic susceptibility patterns for the analyzed eight respiratory-associated microorganisms showed an intermediate level of resistance to commonly used antibiotics such as ampicillin, levofloxacin, and ciprofloxacin. As a preliminary approach to the antimicrobial profiling of the tested EO, the obtained results revealed that the tested samples possess remarkable antibacterial activities and could be used to develop pharmaceutical formulations as an alternative to conventional antibiotic therapy.",
publisher = "MDPI AG",
journal = "Processes",
title = "Variation of Salvia officinalis L. Essential Oil and Hydrolate Composition and Their Antimicrobial Activity",
volume = "10",
number = "8",
pages = "1608",
doi = "10.3390/pr10081608"
}

Aćimović, M., Pezo, L., Čabarkapa, I., Trudić, A., Stanković Jeremić, J., Varga, A., Lončar, B., Šovljanski, O.,& Tešević, V.. (2022). Variation of Salvia officinalis L. Essential Oil and Hydrolate Composition and Their Antimicrobial Activity. in Processes
MDPI AG., 10(8), 1608.
https://doi.org/10.3390/pr10081608

Aćimović M, Pezo L, Čabarkapa I, Trudić A, Stanković Jeremić J, Varga A, Lončar B, Šovljanski O, Tešević V. Variation of Salvia officinalis L. Essential Oil and Hydrolate Composition and Their Antimicrobial Activity. in Processes. 2022;10(8):1608.
doi:10.3390/pr10081608 .

Aćimović, Milica, Pezo, Lato, Čabarkapa, Ivana, Trudić, Anika, Stanković Jeremić, Jovana, Varga, Ana, Lončar, Biljana, Šovljanski, Olja, Tešević, Vele, "Variation of Salvia officinalis L. Essential Oil and Hydrolate Composition and Their Antimicrobial Activity" in Processes, 10, no. 8 (2022):1608,
https://doi.org/10.3390/pr10081608 . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Šeregelj, Vanja
AU  - Simić, Katarina
AU  - Varga, Ana
AU  - Pezo, Lato
AU  - Vulić, Jelena
AU  - Čabarkapa, Ivana
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5353
AB  - Essential oil (EO) obtained by hydrodistillation in a Clevenger-type apparatus from aerial parts of Nepeta cataria L. var. citriodora (Becker), cultivated in Serbia was subjected to gas chromatography-mass spectroscopy (GC-MS) to determine the composition. Furthermore, N. cataria var. citriodora essential oil was
tested to determine its antimicrobial, antioxidant, antihyperglycemic and anti-inflammatory activities in vitro.
The antimicrobial activity was tested by broth microdilution method against 16 bacterial strains from American Type Culture Collection (ATCC). Four common tests for measuring in vitro antioxidant activity were used: 2, 2-diphenyl-1-picrylhydrazyl assay (DPPH), reducing power (RP), 2,2-azino-bis-3-ethylbenzothiazoline-
6-sulfonic acid (ABTS) and β-carotene bleaching assay (BCB). Antihyperglycemic activity was examined by using α-glucosidase inhibitory potential (AHgA), while anti-inflammatory activity (AIA) was determined by protein denaturation bioassay, using egg albumin. In total, 36 compounds were isolated and detected by GC-MS technique in N. cataria var. citriodora EO. The EO is mainly comprised of oxygenated monoterpenes (93.1%), and the main compounds were two monoterpenoid alcohols, nerol (38.5%) and geraniol (24.9%), followed by two aliphatic aldehyde, geranial (14.6%) and neral (11.0%). Antimicrobial activity of this EO shows growth inhibition of all tested bacteria strains, and exhibited good antioxidant, antihyperglycemic and anti-inflammatory activities. The EO obtained from N. cataria var. citriodora grown in Serbia shows valuable biological activity, indicating its potential for use as a supplement in everyday diet and as a natural preservative in food industry.
PB  - Lublin : Uniwersytetu  Przyrodniczego Lublin
T2  - Acta Scientiarum Polonorum Hortorum Cultus
T1  - Chemical profile of Nepeta cataria L. var. citriodora (Becker) essential oil and in vitro evaluation of biological activities
VL  - 21
IS  - 4
SP  - 67
EP  - 74
DO  - 10.24326/asphc.2022.4.7
ER  - 

@article{
author = "Aćimović, Milica and Šeregelj, Vanja and Simić, Katarina and Varga, Ana and Pezo, Lato and Vulić, Jelena and Čabarkapa, Ivana",
year = "2022",
abstract = "Essential oil (EO) obtained by hydrodistillation in a Clevenger-type apparatus from aerial parts of Nepeta cataria L. var. citriodora (Becker), cultivated in Serbia was subjected to gas chromatography-mass spectroscopy (GC-MS) to determine the composition. Furthermore, N. cataria var. citriodora essential oil was
tested to determine its antimicrobial, antioxidant, antihyperglycemic and anti-inflammatory activities in vitro.
The antimicrobial activity was tested by broth microdilution method against 16 bacterial strains from American Type Culture Collection (ATCC). Four common tests for measuring in vitro antioxidant activity were used: 2, 2-diphenyl-1-picrylhydrazyl assay (DPPH), reducing power (RP), 2,2-azino-bis-3-ethylbenzothiazoline-
6-sulfonic acid (ABTS) and β-carotene bleaching assay (BCB). Antihyperglycemic activity was examined by using α-glucosidase inhibitory potential (AHgA), while anti-inflammatory activity (AIA) was determined by protein denaturation bioassay, using egg albumin. In total, 36 compounds were isolated and detected by GC-MS technique in N. cataria var. citriodora EO. The EO is mainly comprised of oxygenated monoterpenes (93.1%), and the main compounds were two monoterpenoid alcohols, nerol (38.5%) and geraniol (24.9%), followed by two aliphatic aldehyde, geranial (14.6%) and neral (11.0%). Antimicrobial activity of this EO shows growth inhibition of all tested bacteria strains, and exhibited good antioxidant, antihyperglycemic and anti-inflammatory activities. The EO obtained from N. cataria var. citriodora grown in Serbia shows valuable biological activity, indicating its potential for use as a supplement in everyday diet and as a natural preservative in food industry.",
publisher = "Lublin : Uniwersytetu  Przyrodniczego Lublin",
journal = "Acta Scientiarum Polonorum Hortorum Cultus",
title = "Chemical profile of Nepeta cataria L. var. citriodora (Becker) essential oil and in vitro evaluation of biological activities",
volume = "21",
number = "4",
pages = "67-74",
doi = "10.24326/asphc.2022.4.7"
}

Aćimović, M., Šeregelj, V., Simić, K., Varga, A., Pezo, L., Vulić, J.,& Čabarkapa, I.. (2022). Chemical profile of Nepeta cataria L. var. citriodora (Becker) essential oil and in vitro evaluation of biological activities. in Acta Scientiarum Polonorum Hortorum Cultus
Lublin : Uniwersytetu  Przyrodniczego Lublin., 21(4), 67-74.
https://doi.org/10.24326/asphc.2022.4.7

Aćimović M, Šeregelj V, Simić K, Varga A, Pezo L, Vulić J, Čabarkapa I. Chemical profile of Nepeta cataria L. var. citriodora (Becker) essential oil and in vitro evaluation of biological activities. in Acta Scientiarum Polonorum Hortorum Cultus. 2022;21(4):67-74.
doi:10.24326/asphc.2022.4.7 .

Aćimović, Milica, Šeregelj, Vanja, Simić, Katarina, Varga, Ana, Pezo, Lato, Vulić, Jelena, Čabarkapa, Ivana, "Chemical profile of Nepeta cataria L. var. citriodora (Becker) essential oil and in vitro evaluation of biological activities" in Acta Scientiarum Polonorum Hortorum Cultus, 21, no. 4 (2022):67-74,
https://doi.org/10.24326/asphc.2022.4.7 . .

TY  - JOUR
AU  - Božanić Tanjga, Biljana
AU  - Lončar, Biljana
AU  - Aćimović, Milica
AU  - Kiprovski, Biljana
AU  - Šovljanski, Olja
AU  - Tomić, Ana
AU  - Travičić, Vanja
AU  - Cvetković, Mirjana
AU  - Raičević, Vidak
AU  - Zeremski, Tijana
PY  - 2022
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5364
AB  - Garden rose, Rosa hybrida, is primarily used for decoration and has a wide range of growing
area, contrary to R. damascena that has a limited area of distribution (Turkey and Bulgaria), yet it is
extensively used for commercial production of valuable and expensive rose oil. Since the content of
essential oil in rose petals is low (0.03–0.04%), its production is quite limited; however, during this
process, a significant amount of rose hydrosol is obtained as a secondary product. The aim of this
research was to determine the chemical composition of garden rose hydrosols and to evaluate their
biological properties. Obtained results show that R. hybrida hydrosol containing phenylethyl alcohol,
nerol, linalool, and geraniol may be used as an alternative for R. damascena hydrosol. However, the
total phenolic content was quite low (4.96 _g GAE/mL), which is related to a low level of observed
antioxidant activity based on different antioxidant activity assays. Furthermore, R. hybrida hydrosol
did not exhibit antimicrobial activity against several gram-positive and gram-negative bacteria, as
well as yeast and fungi. Anti-inflammatory activity was also low, while no antihyperglycemic activity
was detected. With these results in mind, no potential is evident for the therapeutic application of
rose hydrosol beyond that found in complimentary medicine such as aromatherapy.
PB  - Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Horticulturae
T1  - Volatile Profile of Garden Rose (Rosa hybrida) Hydrosol and Evaluation of Its Biological Activity In Vitro
VL  - 8
IS  - 10
SP  - 895
DO  - 10.3390/horticulturae8100895
ER  - 

@article{
author = "Božanić Tanjga, Biljana and Lončar, Biljana and Aćimović, Milica and Kiprovski, Biljana and Šovljanski, Olja and Tomić, Ana and Travičić, Vanja and Cvetković, Mirjana and Raičević, Vidak and Zeremski, Tijana",
year = "2022",
abstract = "Garden rose, Rosa hybrida, is primarily used for decoration and has a wide range of growing
area, contrary to R. damascena that has a limited area of distribution (Turkey and Bulgaria), yet it is
extensively used for commercial production of valuable and expensive rose oil. Since the content of
essential oil in rose petals is low (0.03–0.04%), its production is quite limited; however, during this
process, a significant amount of rose hydrosol is obtained as a secondary product. The aim of this
research was to determine the chemical composition of garden rose hydrosols and to evaluate their
biological properties. Obtained results show that R. hybrida hydrosol containing phenylethyl alcohol,
nerol, linalool, and geraniol may be used as an alternative for R. damascena hydrosol. However, the
total phenolic content was quite low (4.96 _g GAE/mL), which is related to a low level of observed
antioxidant activity based on different antioxidant activity assays. Furthermore, R. hybrida hydrosol
did not exhibit antimicrobial activity against several gram-positive and gram-negative bacteria, as
well as yeast and fungi. Anti-inflammatory activity was also low, while no antihyperglycemic activity
was detected. With these results in mind, no potential is evident for the therapeutic application of
rose hydrosol beyond that found in complimentary medicine such as aromatherapy.",
publisher = "Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Horticulturae",
title = "Volatile Profile of Garden Rose (Rosa hybrida) Hydrosol and Evaluation of Its Biological Activity In Vitro",
volume = "8",
number = "10",
pages = "895",
doi = "10.3390/horticulturae8100895"
}

Božanić Tanjga, B., Lončar, B., Aćimović, M., Kiprovski, B., Šovljanski, O., Tomić, A., Travičić, V., Cvetković, M., Raičević, V.,& Zeremski, T.. (2022). Volatile Profile of Garden Rose (Rosa hybrida) Hydrosol and Evaluation of Its Biological Activity In Vitro. in Horticulturae
Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)., 8(10), 895.
https://doi.org/10.3390/horticulturae8100895

Božanić Tanjga B, Lončar B, Aćimović M, Kiprovski B, Šovljanski O, Tomić A, Travičić V, Cvetković M, Raičević V, Zeremski T. Volatile Profile of Garden Rose (Rosa hybrida) Hydrosol and Evaluation of Its Biological Activity In Vitro. in Horticulturae. 2022;8(10):895.
doi:10.3390/horticulturae8100895 .

Božanić Tanjga, Biljana, Lončar, Biljana, Aćimović, Milica, Kiprovski, Biljana, Šovljanski, Olja, Tomić, Ana, Travičić, Vanja, Cvetković, Mirjana, Raičević, Vidak, Zeremski, Tijana, "Volatile Profile of Garden Rose (Rosa hybrida) Hydrosol and Evaluation of Its Biological Activity In Vitro" in Horticulturae, 8, no. 10 (2022):895,
https://doi.org/10.3390/horticulturae8100895 . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Lončar, Biljana
AU  - Kiprovski, Biljana
AU  - Stanković Jeremić, Jovana
AU  - Todosijević, Marina
AU  - Pezo, Lato
AU  - Jeremić, Jelena
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4785
AB  - Ecological conditions of the growing areas, growing practices as well as harvest and postharvest processing influence the yield and quality of chamomile. The aim of this research was to determine the influence of chamomile separation methods, as postharvest treatments, on the essential oil quality and content, with a view to improve current primary processing of this valuable medicinal plant. In order to explain the structure of laboratory data that would give deeper assessment of similarities among various samples of chamomile essential oil, PCA was employed. Tested results showed that separation of chamomile plant material, as postharvest and pre-drying treatment, had significant influence on the number of identified compounds in the chamomile essential oil. The highest content of individual essential oil compounds had chamomile flowers with short stems, especially α-bisabolol, chamazulene, Z-spiroether and E-β-farnesene. In the essential oil obtained from chamomile flowers with long stems, content of α-bisabolol and chamazulene were significantly lower, while E-β-farnesene and Z-spiroether contents were significantly higher. Furthermore, in the essential oil obtained from chamomile plant material without separation, the lowest content of αbisabolol and Z-spiroether, and the highest content of E-β-farnesene were recorded. The correlation analysis was performed to investigate the likeness in the amounts of the active compounds of essential oil from differently processed chamomile samples. All these results indicate the importance of precise and controlled postharvest treatments, since it clearly affects the essential oil quality and content in the primary processing of this valuable medicinal plant.
AB  - Ekološki uslovi proizvodnog područja, tehnologija gajenja kao i žetva, ali i posležetveni tretmani značajno utiču na prinos i kvalitet kamilice. Cilj ovog istraživanja je bio da se odredi uticaj metoda separacije, kao posležetvenog tretmana, na kvalitet etarskog ulja, sa ciljem da se unapredi process primarne prerade ove lekovite biljke. Da bi se objasnila struktura laboratorijskih podataka, procenile i sagledale sličnosti i razlike između uzoraka etarskih ulja kamilice dobijenih primenom različitih metoda separacije, korišćena je PCA metoda. Dobijeni rezultati pokazuju da separacija sirovine kamilice kao posležetveni tretman koji prethodi sušenju, ima značajnog uticaja na broj identifikovanih komponenti u etarskom ulju, ali i njihov udeo. Najmanji broj pojedinačnih komponenti u etarskom ulju je imao uzorak cvetnih glavica sa kratkom drškom, pri čemu je zabeležen najveći sadržaj α-bisabolol, hamazulen, Z-spiroeter i E-β-farnesen. U etarskom ulju dobijenom od biljne sirovine sa većim udelom stabla kamilice, sadržaj α-bisabolola i hamazulena je bio značajno niži, dok je sadržaj E-β-farnesena i Z-spiroetera bio značajno viši. Dalje, u etarskom ulju dobijenom od bioljnog materijala bez separacije, zabeležen je najniži sadržaj α-bisabolola i Z-spiroetera, i najveći sadržaj E-β-farnesena. Analiza korelacije je izvedena da bi se ispitala sličnost u sadržaju aktivnih komponenti u etarskom ulju dobijenom primenom različitih procesa separacije kamilice. Svi rezultati ukazuju na značaj primene posležetvenih tretmana, jer se jasno vidi njihov uticaj na kvalitet etarskog ulja ove veoma važne lekovite biljke.
PB  - Novi Sad : Institut za ratarstvo i povrtarstvo
T2  - Ratarstvo i Povrtarstvo
T1  - Chamomile essential oil quality after postharvest separation treatments
T1  - Uticaj tretmana poslezetvene separacije na kvalitet etarskog ulja kamilice
VL  - 58
VL  - 2
SP  - 72
EP  - 78
DO  - 10.5937/RATPOV58-33346
ER  - 

@article{
author = "Aćimović, Milica and Lončar, Biljana and Kiprovski, Biljana and Stanković Jeremić, Jovana and Todosijević, Marina and Pezo, Lato and Jeremić, Jelena",
year = "2021",
abstract = "Ecological conditions of the growing areas, growing practices as well as harvest and postharvest processing influence the yield and quality of chamomile. The aim of this research was to determine the influence of chamomile separation methods, as postharvest treatments, on the essential oil quality and content, with a view to improve current primary processing of this valuable medicinal plant. In order to explain the structure of laboratory data that would give deeper assessment of similarities among various samples of chamomile essential oil, PCA was employed. Tested results showed that separation of chamomile plant material, as postharvest and pre-drying treatment, had significant influence on the number of identified compounds in the chamomile essential oil. The highest content of individual essential oil compounds had chamomile flowers with short stems, especially α-bisabolol, chamazulene, Z-spiroether and E-β-farnesene. In the essential oil obtained from chamomile flowers with long stems, content of α-bisabolol and chamazulene were significantly lower, while E-β-farnesene and Z-spiroether contents were significantly higher. Furthermore, in the essential oil obtained from chamomile plant material without separation, the lowest content of αbisabolol and Z-spiroether, and the highest content of E-β-farnesene were recorded. The correlation analysis was performed to investigate the likeness in the amounts of the active compounds of essential oil from differently processed chamomile samples. All these results indicate the importance of precise and controlled postharvest treatments, since it clearly affects the essential oil quality and content in the primary processing of this valuable medicinal plant., Ekološki uslovi proizvodnog područja, tehnologija gajenja kao i žetva, ali i posležetveni tretmani značajno utiču na prinos i kvalitet kamilice. Cilj ovog istraživanja je bio da se odredi uticaj metoda separacije, kao posležetvenog tretmana, na kvalitet etarskog ulja, sa ciljem da se unapredi process primarne prerade ove lekovite biljke. Da bi se objasnila struktura laboratorijskih podataka, procenile i sagledale sličnosti i razlike između uzoraka etarskih ulja kamilice dobijenih primenom različitih metoda separacije, korišćena je PCA metoda. Dobijeni rezultati pokazuju da separacija sirovine kamilice kao posležetveni tretman koji prethodi sušenju, ima značajnog uticaja na broj identifikovanih komponenti u etarskom ulju, ali i njihov udeo. Najmanji broj pojedinačnih komponenti u etarskom ulju je imao uzorak cvetnih glavica sa kratkom drškom, pri čemu je zabeležen najveći sadržaj α-bisabolol, hamazulen, Z-spiroeter i E-β-farnesen. U etarskom ulju dobijenom od biljne sirovine sa većim udelom stabla kamilice, sadržaj α-bisabolola i hamazulena je bio značajno niži, dok je sadržaj E-β-farnesena i Z-spiroetera bio značajno viši. Dalje, u etarskom ulju dobijenom od bioljnog materijala bez separacije, zabeležen je najniži sadržaj α-bisabolola i Z-spiroetera, i najveći sadržaj E-β-farnesena. Analiza korelacije je izvedena da bi se ispitala sličnost u sadržaju aktivnih komponenti u etarskom ulju dobijenom primenom različitih procesa separacije kamilice. Svi rezultati ukazuju na značaj primene posležetvenih tretmana, jer se jasno vidi njihov uticaj na kvalitet etarskog ulja ove veoma važne lekovite biljke.",
publisher = "Novi Sad : Institut za ratarstvo i povrtarstvo",
journal = "Ratarstvo i Povrtarstvo",
title = "Chamomile essential oil quality after postharvest separation treatments, Uticaj tretmana poslezetvene separacije na kvalitet etarskog ulja kamilice",
volume = "58, 2",
pages = "72-78",
doi = "10.5937/RATPOV58-33346"
}

Aćimović, M., Lončar, B., Kiprovski, B., Stanković Jeremić, J., Todosijević, M., Pezo, L.,& Jeremić, J.. (2021). Chamomile essential oil quality after postharvest separation treatments. in Ratarstvo i Povrtarstvo
Novi Sad : Institut za ratarstvo i povrtarstvo., 58, 72-78.
https://doi.org/10.5937/RATPOV58-33346

Aćimović M, Lončar B, Kiprovski B, Stanković Jeremić J, Todosijević M, Pezo L, Jeremić J. Chamomile essential oil quality after postharvest separation treatments. in Ratarstvo i Povrtarstvo. 2021;58:72-78.
doi:10.5937/RATPOV58-33346 .

Aćimović, Milica, Lončar, Biljana, Kiprovski, Biljana, Stanković Jeremić, Jovana, Todosijević, Marina, Pezo, Lato, Jeremić, Jelena, "Chamomile essential oil quality after postharvest separation treatments" in Ratarstvo i Povrtarstvo, 58 (2021):72-78,
https://doi.org/10.5937/RATPOV58-33346 . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Pezo, Lato
AU  - Zeremski, Tijana
AU  - Lončar, Biljana
AU  - Marjanović  Jeromela, Ana
AU  - Stanković Jeremić, Jovana
AU  - Cvetković, Mirjana
AU  - Sikora, Vladimir
AU  - Ignjatov, Maja
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4829
AB  - This paper is a study of the chemical composition of Hyssopus officinalis ssp. Officinalis grown during three years (2017-2019) at the Institute of Field and Vegetable Crops Novi Sad (Vojvodina Province, Serbia). Furthermore, comparisons with ISO standards during the years were also investigated, as well as a prediction model of retention indices of compounds from the essential oils. An essential oil obtained by hydrodistillation and analysed by GC-FID and GC-MS was isopinocamphone chemotype. The gathered information about the volatile compounds from H. officinalis was used to classify the samples using the unrooted cluster tree. The correlation analysis was applied to investigate the similarity of different samples, according to GC-MS data. The quantitative structure- retention relationship (QSRR) was also employed to predict the retention indices of the identified compounds. A total of 74 experimentally obtained retention indices were used to build a prediction model. The coefficient of determination for the training cycle was 0.910, indicating that this model could be used for the prediction of retention indices for H. officinalis essential oil compounds.
PB  - MDPI
T2  - Processes
T1  - Weather conditions influence on hyssop essential oil quality
VL  - 9
IS  - 7
SP  - 1152
DO  - 10.3390/pr9071152
ER  - 

@article{
author = "Aćimović, Milica and Pezo, Lato and Zeremski, Tijana and Lončar, Biljana and Marjanović  Jeromela, Ana and Stanković Jeremić, Jovana and Cvetković, Mirjana and Sikora, Vladimir and Ignjatov, Maja",
year = "2021",
abstract = "This paper is a study of the chemical composition of Hyssopus officinalis ssp. Officinalis grown during three years (2017-2019) at the Institute of Field and Vegetable Crops Novi Sad (Vojvodina Province, Serbia). Furthermore, comparisons with ISO standards during the years were also investigated, as well as a prediction model of retention indices of compounds from the essential oils. An essential oil obtained by hydrodistillation and analysed by GC-FID and GC-MS was isopinocamphone chemotype. The gathered information about the volatile compounds from H. officinalis was used to classify the samples using the unrooted cluster tree. The correlation analysis was applied to investigate the similarity of different samples, according to GC-MS data. The quantitative structure- retention relationship (QSRR) was also employed to predict the retention indices of the identified compounds. A total of 74 experimentally obtained retention indices were used to build a prediction model. The coefficient of determination for the training cycle was 0.910, indicating that this model could be used for the prediction of retention indices for H. officinalis essential oil compounds.",
publisher = "MDPI",
journal = "Processes",
title = "Weather conditions influence on hyssop essential oil quality",
volume = "9",
number = "7",
pages = "1152",
doi = "10.3390/pr9071152"
}

Aćimović, M., Pezo, L., Zeremski, T., Lončar, B., Marjanović  Jeromela, A., Stanković Jeremić, J., Cvetković, M., Sikora, V.,& Ignjatov, M.. (2021). Weather conditions influence on hyssop essential oil quality. in Processes
MDPI., 9(7), 1152.
https://doi.org/10.3390/pr9071152

Aćimović M, Pezo L, Zeremski T, Lončar B, Marjanović  Jeromela A, Stanković Jeremić J, Cvetković M, Sikora V, Ignjatov M. Weather conditions influence on hyssop essential oil quality. in Processes. 2021;9(7):1152.
doi:10.3390/pr9071152 .

Aćimović, Milica, Pezo, Lato, Zeremski, Tijana, Lončar, Biljana, Marjanović  Jeromela, Ana, Stanković Jeremić, Jovana, Cvetković, Mirjana, Sikora, Vladimir, Ignjatov, Maja, "Weather conditions influence on hyssop essential oil quality" in Processes, 9, no. 7 (2021):1152,
https://doi.org/10.3390/pr9071152 . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Stanković Jeremić, Jovana
AU  - Simić, Katarina
AU  - Ivanović, Stefan
AU  - Ljujić, Jovana
AU  - Čabarkapa, Ivana
AU  - Radojčin, Milivoj
AU  - Todosijević, Marina
AU  - Cvetković, Mirjana
PY  - 2021
UR  - http://letopisnaucnihradova.rs/wp-content/uploads/2021/09/Essential_oil_quality_of_chamomile_grown_in_Province_of_Vojvodina-Acimovic_et_al..pdf
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5167
AB  - Chamomile (Matricaria chamomilla L., Asteraceae) is one of the most popular medicinal plants used as a herb
infusion for treating numerous ailments, including sleep disorders, anxiety, digestion and intestinal conditions
etc. Chamomile essential oil is used in a wide variety of consumer goods such as detergents, soaps, toiletries,
cosmetics, pharmaceuticals, perfumes, confectionery food products, soft drinks, distilled alcoholic beverages
(hard liquor) and as insecticide. According to the European Pharmacopoeia, there are two types of essential
oils, one rich in bisabolol oxides and the other in α-bisabolol, which are preferred for tea brewing because of
its sweet, grassy, and slightly fruity aroma. From the other side, varieties rich in chamazulene and β-farnesene
have bitter taste, and because of that they are low valuable raw material. According to the results of the
essential oil composition obtained from three different chamomile samples grown in Province of Vojvodina, it
could be concluded that domestic cultivars “Banatska” and “Tetraploidna” contains β-farnesene as dominant
compound, while the content of bisabolol oxides and α-bisabolol was lower than required standards in
European Pharmacopoeia. Because of that they could not be classified as quality raw material. The German
cultivar “Mabamille” grown in agroecological conditions of Vojvodina region, with 37.5% of α-bisabolol can be
classified as a bisabolol rich type, and as high quality row material.
AB  - Kamilica (Matricaria chamomilla L., Asteraceae) je jedna od najpopularnijih lekovitih biljaka koja se 
upotrebljava u obliku infuza (čaja) za lečenje mnogih stanja i bolesti, uključujući poremećaje sna, napetost, probleme organa za varenje itd. Etarsko ulje kamilice se koristi u mnogim granama industrije: hemijskoj (kao dodatak deterdžentima), kozmetičkoj (u sapunima, sredstvima za ličnu higijenu), farmaceutskoj, parfimerijskoj i prehrambenoj industriji (u slatkišima, alkoholnim i bezalkoholnim pićima) i kao insekticid. Prema Evropskoj Farmakopeji, postoje dva tipa etarskog ulja kamilice, prvi koji je bogat bisabolol oksidima i drugi bogat α-bisabololom. Oba tipa su poželjna u industriji čajnih napitaka zbog njihovog slatkog, osvežavajućeg ukusa blago voćne arome. Sa druge strane, varijeteti bogati hamazulenom i β-farnezenom imaju gorak ukus i zbog toga predstavljaju manje vrednu biljnu sirovinu. Na osnovu rezultata hemijskog sastava etarskog ulja tri 
različita uzorka kamilice gajene u Pokrajini Vojvodini od strane individualnih poljoprivrednih proizvođača, može se zaključiti da domaće sorte “Banatska” i “Tetraploidna” sadrže β-farnezen kao dominantnu komponentu, dok je sadržaj bisabolol oksida i α-bisabolola niži nego što zahtevaju standardi u Evropskoj Farmakopeji, zbog čega se ne mogu kategorisati kao kvalitetni biljni materijal. Nemačka sorta “Mabamille” gajena u agroekološkim uslovima pokrajine Vojvodine, sa 37,5% α-bisabolola pripada bisabolol tipu kamilice i predstavlja visoko kvalitetnu sirovinu.
PB  - Novi Sad: Poljoprivredni fakultet
T2  - Letopis naučnih radova Poljoprivrednog fakulteta, Novi Sad
T1  - Essential oil quality of chamomile grown in Province of Vojvodina
VL  - 45
IS  - 1
SP  - 1
EP  - 8
UR  - https://hdl.handle.net/21.15107/rcub_cer_5167
ER  - 

@article{
author = "Aćimović, Milica and Stanković Jeremić, Jovana and Simić, Katarina and Ivanović, Stefan and Ljujić, Jovana and Čabarkapa, Ivana and Radojčin, Milivoj and Todosijević, Marina and Cvetković, Mirjana",
year = "2021",
abstract = "Chamomile (Matricaria chamomilla L., Asteraceae) is one of the most popular medicinal plants used as a herb
infusion for treating numerous ailments, including sleep disorders, anxiety, digestion and intestinal conditions
etc. Chamomile essential oil is used in a wide variety of consumer goods such as detergents, soaps, toiletries,
cosmetics, pharmaceuticals, perfumes, confectionery food products, soft drinks, distilled alcoholic beverages
(hard liquor) and as insecticide. According to the European Pharmacopoeia, there are two types of essential
oils, one rich in bisabolol oxides and the other in α-bisabolol, which are preferred for tea brewing because of
its sweet, grassy, and slightly fruity aroma. From the other side, varieties rich in chamazulene and β-farnesene
have bitter taste, and because of that they are low valuable raw material. According to the results of the
essential oil composition obtained from three different chamomile samples grown in Province of Vojvodina, it
could be concluded that domestic cultivars “Banatska” and “Tetraploidna” contains β-farnesene as dominant
compound, while the content of bisabolol oxides and α-bisabolol was lower than required standards in
European Pharmacopoeia. Because of that they could not be classified as quality raw material. The German
cultivar “Mabamille” grown in agroecological conditions of Vojvodina region, with 37.5% of α-bisabolol can be
classified as a bisabolol rich type, and as high quality row material., Kamilica (Matricaria chamomilla L., Asteraceae) je jedna od najpopularnijih lekovitih biljaka koja se 
upotrebljava u obliku infuza (čaja) za lečenje mnogih stanja i bolesti, uključujući poremećaje sna, napetost, probleme organa za varenje itd. Etarsko ulje kamilice se koristi u mnogim granama industrije: hemijskoj (kao dodatak deterdžentima), kozmetičkoj (u sapunima, sredstvima za ličnu higijenu), farmaceutskoj, parfimerijskoj i prehrambenoj industriji (u slatkišima, alkoholnim i bezalkoholnim pićima) i kao insekticid. Prema Evropskoj Farmakopeji, postoje dva tipa etarskog ulja kamilice, prvi koji je bogat bisabolol oksidima i drugi bogat α-bisabololom. Oba tipa su poželjna u industriji čajnih napitaka zbog njihovog slatkog, osvežavajućeg ukusa blago voćne arome. Sa druge strane, varijeteti bogati hamazulenom i β-farnezenom imaju gorak ukus i zbog toga predstavljaju manje vrednu biljnu sirovinu. Na osnovu rezultata hemijskog sastava etarskog ulja tri 
različita uzorka kamilice gajene u Pokrajini Vojvodini od strane individualnih poljoprivrednih proizvođača, može se zaključiti da domaće sorte “Banatska” i “Tetraploidna” sadrže β-farnezen kao dominantnu komponentu, dok je sadržaj bisabolol oksida i α-bisabolola niži nego što zahtevaju standardi u Evropskoj Farmakopeji, zbog čega se ne mogu kategorisati kao kvalitetni biljni materijal. Nemačka sorta “Mabamille” gajena u agroekološkim uslovima pokrajine Vojvodine, sa 37,5% α-bisabolola pripada bisabolol tipu kamilice i predstavlja visoko kvalitetnu sirovinu.",
publisher = "Novi Sad: Poljoprivredni fakultet",
journal = "Letopis naučnih radova Poljoprivrednog fakulteta, Novi Sad",
title = "Essential oil quality of chamomile grown in Province of Vojvodina",
volume = "45",
number = "1",
pages = "1-8",
url = "https://hdl.handle.net/21.15107/rcub_cer_5167"
}

Aćimović, M., Stanković Jeremić, J., Simić, K., Ivanović, S., Ljujić, J., Čabarkapa, I., Radojčin, M., Todosijević, M.,& Cvetković, M.. (2021). Essential oil quality of chamomile grown in Province of Vojvodina. in Letopis naučnih radova Poljoprivrednog fakulteta, Novi Sad
Novi Sad: Poljoprivredni fakultet., 45(1), 1-8.
https://hdl.handle.net/21.15107/rcub_cer_5167

Aćimović M, Stanković Jeremić J, Simić K, Ivanović S, Ljujić J, Čabarkapa I, Radojčin M, Todosijević M, Cvetković M. Essential oil quality of chamomile grown in Province of Vojvodina. in Letopis naučnih radova Poljoprivrednog fakulteta, Novi Sad. 2021;45(1):1-8.
https://hdl.handle.net/21.15107/rcub_cer_5167 .

Aćimović, Milica, Stanković Jeremić, Jovana, Simić, Katarina, Ivanović, Stefan, Ljujić, Jovana, Čabarkapa, Ivana, Radojčin, Milivoj, Todosijević, Marina, Cvetković, Mirjana, "Essential oil quality of chamomile grown in Province of Vojvodina" in Letopis naučnih radova Poljoprivrednog fakulteta, Novi Sad, 45, no. 1 (2021):1-8,
https://hdl.handle.net/21.15107/rcub_cer_5167 .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Pezo, Lato
AU  - Stanković Jeremić, Jovana
AU  - Todosijević, Marina
AU  - Rat, Milica
AU  - Tešević, Vele
AU  - Cvetković, Mirjana
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/5291
AB  - In the essential oil of yarrow (Achillea millefolium L. sensu lato) collected from natural popula-
tion on Mt. Rtanj (Serbia) and distilled by Clevenger apparatus 104 compounds were detected, and

the most abundant were camphor (9.8%), caryophyllene oxide (6.5%), terpinen-4-ol (6.3%) and 1,8-

cineole (5.6%). The quantitative structure-retention relationship (QSRR) model was employed to pre-
dict the retention indices, using four molecular descriptors selected by factor analysis and a genetic

algorithm. The coefficients of determination reached the value of 0.862, demonstrating that this mo-
del could be used for prediction purposes.
PB  - Novi Sad : Faculty of Technology
T2  - Acta Periodica Technologica
T1  - The quantitative structure retention relationship of the gs ms profile of yarrow essential oil
IS  - 52
SP  - 123
EP  - 132
DO  - 10.2298/APT2152123A
ER  - 

@article{
author = "Aćimović, Milica and Pezo, Lato and Stanković Jeremić, Jovana and Todosijević, Marina and Rat, Milica and Tešević, Vele and Cvetković, Mirjana",
year = "2021",
abstract = "In the essential oil of yarrow (Achillea millefolium L. sensu lato) collected from natural popula-
tion on Mt. Rtanj (Serbia) and distilled by Clevenger apparatus 104 compounds were detected, and

the most abundant were camphor (9.8%), caryophyllene oxide (6.5%), terpinen-4-ol (6.3%) and 1,8-

cineole (5.6%). The quantitative structure-retention relationship (QSRR) model was employed to pre-
dict the retention indices, using four molecular descriptors selected by factor analysis and a genetic

algorithm. The coefficients of determination reached the value of 0.862, demonstrating that this mo-
del could be used for prediction purposes.",
publisher = "Novi Sad : Faculty of Technology",
journal = "Acta Periodica Technologica",
title = "The quantitative structure retention relationship of the gs ms profile of yarrow essential oil",
number = "52",
pages = "123-132",
doi = "10.2298/APT2152123A"
}

Aćimović, M., Pezo, L., Stanković Jeremić, J., Todosijević, M., Rat, M., Tešević, V.,& Cvetković, M.. (2021). The quantitative structure retention relationship of the gs ms profile of yarrow essential oil. in Acta Periodica Technologica
Novi Sad : Faculty of Technology.(52), 123-132.
https://doi.org/10.2298/APT2152123A

Aćimović M, Pezo L, Stanković Jeremić J, Todosijević M, Rat M, Tešević V, Cvetković M. The quantitative structure retention relationship of the gs ms profile of yarrow essential oil. in Acta Periodica Technologica. 2021;(52):123-132.
doi:10.2298/APT2152123A .

Aćimović, Milica, Pezo, Lato, Stanković Jeremić, Jovana, Todosijević, Marina, Rat, Milica, Tešević, Vele, Cvetković, Mirjana, "The quantitative structure retention relationship of the gs ms profile of yarrow essential oil" in Acta Periodica Technologica, no. 52 (2021):123-132,
https://doi.org/10.2298/APT2152123A . .

TY  - JOUR
AU  - Aćimović, Milica G.
AU  - Pezo, Lato L.
AU  - Cvetković, Mirjana
AU  - Stanković, Jovana
AU  - Čabarkapa, Ivana
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4710
AB  - The aim of this study was the prediction model of retention indices of compounds from the aboveground parts of Achillea clypeolata Sibth. & Sm. essential oil, obtained by hydrodistillation and analysed by GC-MS. The quantitative structure-retention relationship analysis was applied in order to anticipate the retention time of the obtained compounds. The selection of the seven molecular descriptors was done by a genetic algorithm. The chosen descriptors were uncorrelated and were used to construct an artificial neural network. A total of 40 experimentally obtained retention indices was used to build this prediction model. The coefficient of determination for the training, testing and validation cycles were: 0.950, 0.825 and 1.000, respectively, indicating that this model could be used for prediction of retention indices for A.
AB  - Циљ ове студије био је израда модела за предвиђања ретенционог времена хемијских једињења из есенцијалног уља надземних делова биљке Achillea clypeolata Sibth. & Sm., добијеног хидродистилацијом и анализираног GC–MS техником. Квантитативна анализа хемијске структуре и предвиђања ретенционог времена (quantitative structure– retention relationship – QSRR) је примењена да би се предвидело време задржавања хемијских једињења добијених коришћењем GC–MS анализе. Избор седам молекулских дескриптора извршен је коришћењем факторске анализе и генетског алгоритма. Примећено је да изабрани дескриптори нису били у међусобној корелацији, па су коришћени као улазни подаци при изградњи вештачке неуронске мреже. У изградњи модела предвиђања ретенционих времена коришћено је укупно 40 експериментално добијених ретенционих времена. Коефицијент детерминације током циклуса припреме, тестирања и i валидације достигао је вредности 0,950; 0,825 и 1,000, редом, што указује на то да се овај модел може користити за предвиђање ретенционих времена хемијских једињења добијених из есенцијалног уља A. clypeolata
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Achillea clypeolata sibth. & sm. essential oil composition and qsrr model for predicting retention indices
T1  - Hemijski sastav etarskog ulja Achillea clypeolata Sibth. & Sm. И QSRR model za predviđanje retencionog vremena
VL  - 86
IS  - 4
SP  - 355
EP  - 366
DO  - 10.2298/JSC200524008A
ER  - 

@article{
author = "Aćimović, Milica G. and Pezo, Lato L. and Cvetković, Mirjana and Stanković, Jovana and Čabarkapa, Ivana",
year = "2021",
abstract = "The aim of this study was the prediction model of retention indices of compounds from the aboveground parts of Achillea clypeolata Sibth. & Sm. essential oil, obtained by hydrodistillation and analysed by GC-MS. The quantitative structure-retention relationship analysis was applied in order to anticipate the retention time of the obtained compounds. The selection of the seven molecular descriptors was done by a genetic algorithm. The chosen descriptors were uncorrelated and were used to construct an artificial neural network. A total of 40 experimentally obtained retention indices was used to build this prediction model. The coefficient of determination for the training, testing and validation cycles were: 0.950, 0.825 and 1.000, respectively, indicating that this model could be used for prediction of retention indices for A., Циљ ове студије био је израда модела за предвиђања ретенционог времена хемијских једињења из есенцијалног уља надземних делова биљке Achillea clypeolata Sibth. & Sm., добијеног хидродистилацијом и анализираног GC–MS техником. Квантитативна анализа хемијске структуре и предвиђања ретенционог времена (quantitative structure– retention relationship – QSRR) је примењена да би се предвидело време задржавања хемијских једињења добијених коришћењем GC–MS анализе. Избор седам молекулских дескриптора извршен је коришћењем факторске анализе и генетског алгоритма. Примећено је да изабрани дескриптори нису били у међусобној корелацији, па су коришћени као улазни подаци при изградњи вештачке неуронске мреже. У изградњи модела предвиђања ретенционих времена коришћено је укупно 40 експериментално добијених ретенционих времена. Коефицијент детерминације током циклуса припреме, тестирања и i валидације достигао је вредности 0,950; 0,825 и 1,000, редом, што указује на то да се овај модел може користити за предвиђање ретенционих времена хемијских једињења добијених из есенцијалног уља A. clypeolata",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Achillea clypeolata sibth. & sm. essential oil composition and qsrr model for predicting retention indices, Hemijski sastav etarskog ulja Achillea clypeolata Sibth. & Sm. И QSRR model za predviđanje retencionog vremena",
volume = "86",
number = "4",
pages = "355-366",
doi = "10.2298/JSC200524008A"
}

Aćimović, M. G., Pezo, L. L., Cvetković, M., Stanković, J.,& Čabarkapa, I.. (2021). Achillea clypeolata sibth. & sm. essential oil composition and qsrr model for predicting retention indices. in Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 86(4), 355-366.
https://doi.org/10.2298/JSC200524008A

Aćimović MG, Pezo LL, Cvetković M, Stanković J, Čabarkapa I. Achillea clypeolata sibth. & sm. essential oil composition and qsrr model for predicting retention indices. in Journal of the Serbian Chemical Society. 2021;86(4):355-366.
doi:10.2298/JSC200524008A .

Aćimović, Milica G., Pezo, Lato L., Cvetković, Mirjana, Stanković, Jovana, Čabarkapa, Ivana, "Achillea clypeolata sibth. & sm. essential oil composition and qsrr model for predicting retention indices" in Journal of the Serbian Chemical Society, 86, no. 4 (2021):355-366,
https://doi.org/10.2298/JSC200524008A . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Varga, Ana
AU  - Cvetković, Mirjana
AU  - Lato, Pezo
AU  - Lončar, Biljana
AU  - Ignjatov, Maja
AU  - Zeremski, Tijana
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4692
AB  - Hyssop (Hyssopus officinalis L., Lamiaceae) is a perennial shrub or subshrub violet-blue flowers in verticillasters and spicy taste with a pungent flavour. Besides being used as a culinary herb for flavouring and food preservation, this plant is also an ornamental, bee attracting plant and a traditional remedy for respiratory diseases and digestive disturbances. Hyssop is an essential oil-bearing plant, and its essential oil (Hyssopi aetheroleum) is used in the pharmaceutical, perfume and cosmetics industries as well as in aromatherapy. The objective of this study was to determine the chemical composition of essential oil of hyssop CV. "Domaći ljubičasti", grown in Serbia, and investigate its antimicrobial activity against 16 bacteria, mainly pathogens in the food industry. A total of 61 compounds were detected in the hyssop essential oil. The bicyclic monoterpene ketones CIS-pinocamphone (43.8%) and trans-pinocamphone (18.3%) were the most abundant, comprising 62.1%, followed by b-pinene (6.3%) and pinocarvone (6.1%). Hyssop essential oil expressed antibacterial activity against: Staphylococcus aureus, Escherichia coli, Bacillus cereus, Proteus hauseri, Listeria monocytogenes, Rhodococcus equi, Listeria ivanovii, Salmonella Enteritidis, Enterococcus faecalis, Listeria innocua and Bacillus spizizenii. Hyssop essential oil did not express antibacterial activity against Pseudomonas aeruginosa, Salmonella Typhimurium, Klebsiella aerogenes and Staphylococcus epidermidis. Results of this study show that hyssop essential oil has potential for using as natural supplement for control of foodborne diseases of microbiological origin, as well as flavor compositions (herbaceous, camphor-like odour with warm and spicy undernotes), especially for meat products, sauces, soups and seasonings.
AB  - Miloduh (Hyssopus officinalis L., Lamiaceae) je višegodišnji žbun ili polužbun aromatičnog i oštrog mirisa zbog čega se koristi kao začinska biljka. Takođe je i ukrasna i medonosna biljka, ali i tradicionalni lek za bolesti organa za disanje i kod poremećaja varenja. Miloduh je cenjena eterično-aromatična biljka, a etarsko ulje se koristi u farmaceutskoj, parfimerijskoj i kozmetičkoj industriji kao i aromaterapiji. Cilj ovog istraživanja je bio da se determiniše hemijski sastav etarskog ulja miloduha kultivara „Domaći ljubičasti“ gajenog u Srbiji, i da se ispita antimikrobna aktivnost na 16 bakterija, uglavnom patogena u prehrambenoj industriji. Ukupno 61 komponenta je detektovana u etarskom ulju, pri čemu su monoterpenski ketoni cis-pinokamfon (43.8%) i trans-pinokamfon (18.3%) bili najzastupljeniji, čineći 62.1%, a potom slede β-pinen i pinokarvon. Etarsko ulje miloduha je ispoljilo antibakterijsku aktivnost na: Staphylococcus aureus, Escherichia coli, Bacillus cereus, Proteus hauseri, Listeria monocytogenes, Rhodococcus equi, Listeria ivanovii, Salmonella Enteritidis, Enterococcus faecalis, Listeria innocua i Bacillus spizizenii, dok nije delovalo na Pseudomonas aeruginosa, Salmonella Typhimurium, Klebsiella aerogenes i Staphylococcus epidermidis.
PB  - Belgrade : Centre for Evaluation in Education and Science
T2  - Ratarstvo i Povrtarstvo
T1  - Chemical composition of hyssop cv. 'Domaći ljubičasti' essential oil and its antimicrobial activity
T1  - Hemijski sastav etarskog ulja miloduha kultivara  'Domaći ljubičasti' i ocena antimikrobne aktivnosti
VL  - 58
IS  - 1
SP  - 23
EP  - 30
DO  - 10.5937/ratpov58-31751
ER  - 

@article{
author = "Aćimović, Milica and Varga, Ana and Cvetković, Mirjana and Lato, Pezo and Lončar, Biljana and Ignjatov, Maja and Zeremski, Tijana",
year = "2021",
abstract = "Hyssop (Hyssopus officinalis L., Lamiaceae) is a perennial shrub or subshrub violet-blue flowers in verticillasters and spicy taste with a pungent flavour. Besides being used as a culinary herb for flavouring and food preservation, this plant is also an ornamental, bee attracting plant and a traditional remedy for respiratory diseases and digestive disturbances. Hyssop is an essential oil-bearing plant, and its essential oil (Hyssopi aetheroleum) is used in the pharmaceutical, perfume and cosmetics industries as well as in aromatherapy. The objective of this study was to determine the chemical composition of essential oil of hyssop CV. "Domaći ljubičasti", grown in Serbia, and investigate its antimicrobial activity against 16 bacteria, mainly pathogens in the food industry. A total of 61 compounds were detected in the hyssop essential oil. The bicyclic monoterpene ketones CIS-pinocamphone (43.8%) and trans-pinocamphone (18.3%) were the most abundant, comprising 62.1%, followed by b-pinene (6.3%) and pinocarvone (6.1%). Hyssop essential oil expressed antibacterial activity against: Staphylococcus aureus, Escherichia coli, Bacillus cereus, Proteus hauseri, Listeria monocytogenes, Rhodococcus equi, Listeria ivanovii, Salmonella Enteritidis, Enterococcus faecalis, Listeria innocua and Bacillus spizizenii. Hyssop essential oil did not express antibacterial activity against Pseudomonas aeruginosa, Salmonella Typhimurium, Klebsiella aerogenes and Staphylococcus epidermidis. Results of this study show that hyssop essential oil has potential for using as natural supplement for control of foodborne diseases of microbiological origin, as well as flavor compositions (herbaceous, camphor-like odour with warm and spicy undernotes), especially for meat products, sauces, soups and seasonings., Miloduh (Hyssopus officinalis L., Lamiaceae) je višegodišnji žbun ili polužbun aromatičnog i oštrog mirisa zbog čega se koristi kao začinska biljka. Takođe je i ukrasna i medonosna biljka, ali i tradicionalni lek za bolesti organa za disanje i kod poremećaja varenja. Miloduh je cenjena eterično-aromatična biljka, a etarsko ulje se koristi u farmaceutskoj, parfimerijskoj i kozmetičkoj industriji kao i aromaterapiji. Cilj ovog istraživanja je bio da se determiniše hemijski sastav etarskog ulja miloduha kultivara „Domaći ljubičasti“ gajenog u Srbiji, i da se ispita antimikrobna aktivnost na 16 bakterija, uglavnom patogena u prehrambenoj industriji. Ukupno 61 komponenta je detektovana u etarskom ulju, pri čemu su monoterpenski ketoni cis-pinokamfon (43.8%) i trans-pinokamfon (18.3%) bili najzastupljeniji, čineći 62.1%, a potom slede β-pinen i pinokarvon. Etarsko ulje miloduha je ispoljilo antibakterijsku aktivnost na: Staphylococcus aureus, Escherichia coli, Bacillus cereus, Proteus hauseri, Listeria monocytogenes, Rhodococcus equi, Listeria ivanovii, Salmonella Enteritidis, Enterococcus faecalis, Listeria innocua i Bacillus spizizenii, dok nije delovalo na Pseudomonas aeruginosa, Salmonella Typhimurium, Klebsiella aerogenes i Staphylococcus epidermidis.",
publisher = "Belgrade : Centre for Evaluation in Education and Science",
journal = "Ratarstvo i Povrtarstvo",
title = "Chemical composition of hyssop cv. 'Domaći ljubičasti' essential oil and its antimicrobial activity, Hemijski sastav etarskog ulja miloduha kultivara  'Domaći ljubičasti' i ocena antimikrobne aktivnosti",
volume = "58",
number = "1",
pages = "23-30",
doi = "10.5937/ratpov58-31751"
}

Aćimović, M., Varga, A., Cvetković, M., Lato, P., Lončar, B., Ignjatov, M.,& Zeremski, T.. (2021). Chemical composition of hyssop cv. 'Domaći ljubičasti' essential oil and its antimicrobial activity. in Ratarstvo i Povrtarstvo
Belgrade : Centre for Evaluation in Education and Science., 58(1), 23-30.
https://doi.org/10.5937/ratpov58-31751

Aćimović M, Varga A, Cvetković M, Lato P, Lončar B, Ignjatov M, Zeremski T. Chemical composition of hyssop cv. 'Domaći ljubičasti' essential oil and its antimicrobial activity. in Ratarstvo i Povrtarstvo. 2021;58(1):23-30.
doi:10.5937/ratpov58-31751 .

Aćimović, Milica, Varga, Ana, Cvetković, Mirjana, Lato, Pezo, Lončar, Biljana, Ignjatov, Maja, Zeremski, Tijana, "Chemical composition of hyssop cv. 'Domaći ljubičasti' essential oil and its antimicrobial activity" in Ratarstvo i Povrtarstvo, 58, no. 1 (2021):23-30,
https://doi.org/10.5937/ratpov58-31751 . .

TY  - JOUR
AU  - Aćimović, Milica G.
AU  - Ivanović, Stefan
AU  - Simić, Katarina
AU  - Pezo, Lato
AU  - Zeremski, Tijana
AU  - Ovuka, Jelena S.
AU  - Sikora, Vladimir Š.
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4601
AB  - Marrubium vulgare is a cosmopolitan medicinal plant from the Lamiaceae family, which produces structurally highly diverse groups of secondary metabolites. A total of 160 compounds were determined in the volatiles from Serbia during two investigated years (2019 and 2020). The main components were E-caryophyllene, followed by germacrene D, α-humulene and α-copaene. All these compounds are from sesquiterpene hydrocarbons class which was dominant in both investigated years. This variation in volatiles composition could be a consequence of weather conditions, as in the case of other aromatic plants. According to the unrooted cluster tree with 37 samples of Marrubium sp. volatiles from literature and average values from this study, it could be said that there are several chemotypes: E-caryophyllene, β-bisabolene, α-pinene, β-farnesene, E-caryophyllene + caryophyllene oxide chemotype, and diverse (unclassified) chemotypes. However, occurring polymorphism could be consequence of adaptation to grow in different environment, especially ecological conditions such as humidity, temperature and altitude, as well as hybridization strongly affected the chemotypes. In addition, this paper aimed to obtain validated models for prediction of retention indices (RIs) of compounds isolated from M. vulgare volatiles. A total of 160 experimentally obtained RIs of volatile compounds was used to build the prediction models. The coefficients of determination were 0.956 and 0.964, demonstrating that these models could be used for predicting RIs, due to low prediction error and high r2 .
PB  - MDPI
T2  - Plants
T1  - Chemical characterization of marrubium vulgare volatiles from Serbia
VL  - 10
IS  - 3
SP  - 600
DO  - 10.3390/plants10030600
ER  - 

@article{
author = "Aćimović, Milica G. and Ivanović, Stefan and Simić, Katarina and Pezo, Lato and Zeremski, Tijana and Ovuka, Jelena S. and Sikora, Vladimir Š.",
year = "2021",
abstract = "Marrubium vulgare is a cosmopolitan medicinal plant from the Lamiaceae family, which produces structurally highly diverse groups of secondary metabolites. A total of 160 compounds were determined in the volatiles from Serbia during two investigated years (2019 and 2020). The main components were E-caryophyllene, followed by germacrene D, α-humulene and α-copaene. All these compounds are from sesquiterpene hydrocarbons class which was dominant in both investigated years. This variation in volatiles composition could be a consequence of weather conditions, as in the case of other aromatic plants. According to the unrooted cluster tree with 37 samples of Marrubium sp. volatiles from literature and average values from this study, it could be said that there are several chemotypes: E-caryophyllene, β-bisabolene, α-pinene, β-farnesene, E-caryophyllene + caryophyllene oxide chemotype, and diverse (unclassified) chemotypes. However, occurring polymorphism could be consequence of adaptation to grow in different environment, especially ecological conditions such as humidity, temperature and altitude, as well as hybridization strongly affected the chemotypes. In addition, this paper aimed to obtain validated models for prediction of retention indices (RIs) of compounds isolated from M. vulgare volatiles. A total of 160 experimentally obtained RIs of volatile compounds was used to build the prediction models. The coefficients of determination were 0.956 and 0.964, demonstrating that these models could be used for predicting RIs, due to low prediction error and high r2 .",
publisher = "MDPI",
journal = "Plants",
title = "Chemical characterization of marrubium vulgare volatiles from Serbia",
volume = "10",
number = "3",
pages = "600",
doi = "10.3390/plants10030600"
}

Aćimović, M. G., Ivanović, S., Simić, K., Pezo, L., Zeremski, T., Ovuka, J. S.,& Sikora, V. Š.. (2021). Chemical characterization of marrubium vulgare volatiles from Serbia. in Plants
MDPI., 10(3), 600.
https://doi.org/10.3390/plants10030600

Aćimović MG, Ivanović S, Simić K, Pezo L, Zeremski T, Ovuka JS, Sikora VŠ. Chemical characterization of marrubium vulgare volatiles from Serbia. in Plants. 2021;10(3):600.
doi:10.3390/plants10030600 .

Aćimović, Milica G., Ivanović, Stefan, Simić, Katarina, Pezo, Lato, Zeremski, Tijana, Ovuka, Jelena S., Sikora, Vladimir Š., "Chemical characterization of marrubium vulgare volatiles from Serbia" in Plants, 10, no. 3 (2021):600,
https://doi.org/10.3390/plants10030600 . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Pezo, Lato
AU  - Ivanović, Stefan
AU  - Simić, Katarina
AU  - Ljujić, Jovana
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7234
AB  - The aim of this study was to predict the retention indices of chemical compounds found in the
aerial parts of Origanum vulgare subsp. vulgare essential oil, obtained by hydrodistillation and
analyzed by GC-MS. A total number of 28 compounds were detected in the essential oil. The
compounds with the highest relative concentrations were germacrene D (21.5%), 1,8-cineole
(14.2%), sabinene (14.0%) and trans-caryophyllene (13.4%). The retention time was predicted by
using the quantitative structure–retention relationship, using seven molecular descriptors chosen
by factor analysis and genetic algorithm. The chosen descriptors were mutually uncorrelated, and
they were used to develop an artificial neural network model. A total number of 28 experimentally
obtained retention indices (log RI) were used to set up a predictive quantitative structure-retention
relationship model. The coefficient of determination for the training cycle was 0.998, indicating
that this model could be used for predicting retention indices for O. vulgare subsp. vulgare
essential oil compounds.
PB  - Niš, Serbia : Department of Chemistry, Faculty of Sciences and Mathematics, University of Niš
T2  - Chemia Naissensis
T1  - Essential oil profile of Origanum vulgare subsp. vulgare native population from Rtanj via chemometrics tools
VL  - 3
IS  - 2
SP  - 100
EP  - 112
DO  - 10.46793/ChemN3.2.100A
ER  - 

@article{
author = "Aćimović, Milica and Pezo, Lato and Ivanović, Stefan and Simić, Katarina and Ljujić, Jovana",
year = "2020",
abstract = "The aim of this study was to predict the retention indices of chemical compounds found in the
aerial parts of Origanum vulgare subsp. vulgare essential oil, obtained by hydrodistillation and
analyzed by GC-MS. A total number of 28 compounds were detected in the essential oil. The
compounds with the highest relative concentrations were germacrene D (21.5%), 1,8-cineole
(14.2%), sabinene (14.0%) and trans-caryophyllene (13.4%). The retention time was predicted by
using the quantitative structure–retention relationship, using seven molecular descriptors chosen
by factor analysis and genetic algorithm. The chosen descriptors were mutually uncorrelated, and
they were used to develop an artificial neural network model. A total number of 28 experimentally
obtained retention indices (log RI) were used to set up a predictive quantitative structure-retention
relationship model. The coefficient of determination for the training cycle was 0.998, indicating
that this model could be used for predicting retention indices for O. vulgare subsp. vulgare
essential oil compounds.",
publisher = "Niš, Serbia : Department of Chemistry, Faculty of Sciences and Mathematics, University of Niš",
journal = "Chemia Naissensis",
title = "Essential oil profile of Origanum vulgare subsp. vulgare native population from Rtanj via chemometrics tools",
volume = "3",
number = "2",
pages = "100-112",
doi = "10.46793/ChemN3.2.100A"
}

Aćimović, M., Pezo, L., Ivanović, S., Simić, K.,& Ljujić, J.. (2020). Essential oil profile of Origanum vulgare subsp. vulgare native population from Rtanj via chemometrics tools. in Chemia Naissensis
Niš, Serbia : Department of Chemistry, Faculty of Sciences and Mathematics, University of Niš., 3(2), 100-112.
https://doi.org/10.46793/ChemN3.2.100A

Aćimović M, Pezo L, Ivanović S, Simić K, Ljujić J. Essential oil profile of Origanum vulgare subsp. vulgare native population from Rtanj via chemometrics tools. in Chemia Naissensis. 2020;3(2):100-112.
doi:10.46793/ChemN3.2.100A .

Aćimović, Milica, Pezo, Lato, Ivanović, Stefan, Simić, Katarina, Ljujić, Jovana, "Essential oil profile of Origanum vulgare subsp. vulgare native population from Rtanj via chemometrics tools" in Chemia Naissensis, 3, no. 2 (2020):100-112,
https://doi.org/10.46793/ChemN3.2.100A . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Zorić, Miroslav
AU  - Zheljazkov, Valtcho
AU  - Pezo, Lato
AU  - Čabarkapa, Ivana
AU  - Stanković Jeremić, Jovana
AU  - Cvetković, Mirjana
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3952
AB  - The objective of this study was to evaluate wild growing Satureja kitaibelii, Thymus serpyllum,
Origanum vulgare, Achillea millefolium and Achillea clypeolata with respect to their essential oil (EO)
content, composition and antimicrobial activity. The five species were collected at Mt. Rtanj and the
village of Sesalac, Eastern Serbia. The main EO constituents of Lamiaceae plants were p-cymene
(24.4%), geraniol (63.4%) and germacrene D (21.5%) in Satureja kitaibelii, Thymus serpyllum and
Origanum vulgare ssp. vulgare, respectively. A. millefolium EO had multiple constituents with major
ones being camphor (9.8%), caryophyllene oxide (6.5%), terpinen-4-ol (6.3%) and 1,8-cineole (5.6%),
while the main EO constituents of A. clypeolata were 1,8-cineole (45.1%) and camphor (18.2%).
Antimicrobial testing of the EO showed that Staphylococcus aureus (Gram-positive) was more sensitive
to all of the tested EOs than Escherichia coli (Gram-negative). S. kitaibelii EO showed the highest
antimicrobial activity against both tested bacterial strains. This is the first study to characterize
the EO composition and antimicrobial activity of these five medicinal species from Eastern Serbia
in comparison with comprehensive literature data. The results can be utilized by the perfumery,
cosmetics, food and pharmaceutical industries, but also for healing purposes in self-medication.
PB  - MDPI
T2  - Molecules
T1  - Chemical characterization and antibacterial activity of essential oil of medicinal plants from Eastern Serbia
VL  - 25
IS  - 22
SP  - 5482
DO  - 10.3390/molecules25225482
ER  - 

@article{
author = "Aćimović, Milica and Zorić, Miroslav and Zheljazkov, Valtcho and Pezo, Lato and Čabarkapa, Ivana and Stanković Jeremić, Jovana and Cvetković, Mirjana",
year = "2020",
abstract = "The objective of this study was to evaluate wild growing Satureja kitaibelii, Thymus serpyllum,
Origanum vulgare, Achillea millefolium and Achillea clypeolata with respect to their essential oil (EO)
content, composition and antimicrobial activity. The five species were collected at Mt. Rtanj and the
village of Sesalac, Eastern Serbia. The main EO constituents of Lamiaceae plants were p-cymene
(24.4%), geraniol (63.4%) and germacrene D (21.5%) in Satureja kitaibelii, Thymus serpyllum and
Origanum vulgare ssp. vulgare, respectively. A. millefolium EO had multiple constituents with major
ones being camphor (9.8%), caryophyllene oxide (6.5%), terpinen-4-ol (6.3%) and 1,8-cineole (5.6%),
while the main EO constituents of A. clypeolata were 1,8-cineole (45.1%) and camphor (18.2%).
Antimicrobial testing of the EO showed that Staphylococcus aureus (Gram-positive) was more sensitive
to all of the tested EOs than Escherichia coli (Gram-negative). S. kitaibelii EO showed the highest
antimicrobial activity against both tested bacterial strains. This is the first study to characterize
the EO composition and antimicrobial activity of these five medicinal species from Eastern Serbia
in comparison with comprehensive literature data. The results can be utilized by the perfumery,
cosmetics, food and pharmaceutical industries, but also for healing purposes in self-medication.",
publisher = "MDPI",
journal = "Molecules",
title = "Chemical characterization and antibacterial activity of essential oil of medicinal plants from Eastern Serbia",
volume = "25",
number = "22",
pages = "5482",
doi = "10.3390/molecules25225482"
}

Aćimović, M., Zorić, M., Zheljazkov, V., Pezo, L., Čabarkapa, I., Stanković Jeremić, J.,& Cvetković, M.. (2020). Chemical characterization and antibacterial activity of essential oil of medicinal plants from Eastern Serbia. in Molecules
MDPI., 25(22), 5482.
https://doi.org/10.3390/molecules25225482

Aćimović M, Zorić M, Zheljazkov V, Pezo L, Čabarkapa I, Stanković Jeremić J, Cvetković M. Chemical characterization and antibacterial activity of essential oil of medicinal plants from Eastern Serbia. in Molecules. 2020;25(22):5482.
doi:10.3390/molecules25225482 .

Aćimović, Milica, Zorić, Miroslav, Zheljazkov, Valtcho, Pezo, Lato, Čabarkapa, Ivana, Stanković Jeremić, Jovana, Cvetković, Mirjana, "Chemical characterization and antibacterial activity of essential oil of medicinal plants from Eastern Serbia" in Molecules, 25, no. 22 (2020):5482,
https://doi.org/10.3390/molecules25225482 . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Pezo, Lato
AU  - Stanković, Jovana
AU  - Cvetković, Mirjana
AU  - Rat, Milica
AU  - Čabarkapa, Ivana
AU  - Tešević, Vele
PY  - 2020
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3951
AB  - A total of 26 experimentally obtained retention indices on a logarithmic scale (log RI) from
Thymus serpyllum essential oil were used to build a robust predictive model. The selected descriptors were
used as inputs of an artificial neural network model to build a predictive quantitative structure-retention time
relationship model. The coefficient of determination for the training cycle was 0.977, indicating that this model
could be used for the prediction of retention indices for T. serpyllum essential oil compounds. These 26
compounds comprise about 99.8 % of the total oil, but among them only 6 compounds had the average relative
concentration over 1 percent: geraniol (63.4 %), nerol (or cis-geraniol) (18.9 %), geranyl acetate (4.7 %), transcaryophyllene (4.6 %), β-bisabolene (2.0 %) and geranial (1.2 %). According to these results, it can be concluded
that T. serpyllum from village Sesalac (Serbia) belongs to geraniol chemotype, in total 82.3 % in both, trans and
cis forms (63.4 % and 18.9 %, respectively).
PB  - Taylor & Francis
T2  - Essential Oil Bearing Plants
T1  - QSRR model for predicting retention indices of geraniol chemotype of Thymus serpyllum essential oil
VL  - 23
IS  - 3
SP  - 464
EP  - 473
DO  - 10.1080/0972060X.2020.1790428
ER  - 

@article{
author = "Aćimović, Milica and Pezo, Lato and Stanković, Jovana and Cvetković, Mirjana and Rat, Milica and Čabarkapa, Ivana and Tešević, Vele",
year = "2020",
abstract = "A total of 26 experimentally obtained retention indices on a logarithmic scale (log RI) from
Thymus serpyllum essential oil were used to build a robust predictive model. The selected descriptors were
used as inputs of an artificial neural network model to build a predictive quantitative structure-retention time
relationship model. The coefficient of determination for the training cycle was 0.977, indicating that this model
could be used for the prediction of retention indices for T. serpyllum essential oil compounds. These 26
compounds comprise about 99.8 % of the total oil, but among them only 6 compounds had the average relative
concentration over 1 percent: geraniol (63.4 %), nerol (or cis-geraniol) (18.9 %), geranyl acetate (4.7 %), transcaryophyllene (4.6 %), β-bisabolene (2.0 %) and geranial (1.2 %). According to these results, it can be concluded
that T. serpyllum from village Sesalac (Serbia) belongs to geraniol chemotype, in total 82.3 % in both, trans and
cis forms (63.4 % and 18.9 %, respectively).",
publisher = "Taylor & Francis",
journal = "Essential Oil Bearing Plants",
title = "QSRR model for predicting retention indices of geraniol chemotype of Thymus serpyllum essential oil",
volume = "23",
number = "3",
pages = "464-473",
doi = "10.1080/0972060X.2020.1790428"
}

Aćimović, M., Pezo, L., Stanković, J., Cvetković, M., Rat, M., Čabarkapa, I.,& Tešević, V.. (2020). QSRR model for predicting retention indices of geraniol chemotype of Thymus serpyllum essential oil. in Essential Oil Bearing Plants
Taylor & Francis., 23(3), 464-473.
https://doi.org/10.1080/0972060X.2020.1790428

Aćimović M, Pezo L, Stanković J, Cvetković M, Rat M, Čabarkapa I, Tešević V. QSRR model for predicting retention indices of geraniol chemotype of Thymus serpyllum essential oil. in Essential Oil Bearing Plants. 2020;23(3):464-473.
doi:10.1080/0972060X.2020.1790428 .

Aćimović, Milica, Pezo, Lato, Stanković, Jovana, Cvetković, Mirjana, Rat, Milica, Čabarkapa, Ivana, Tešević, Vele, "QSRR model for predicting retention indices of geraniol chemotype of Thymus serpyllum essential oil" in Essential Oil Bearing Plants, 23, no. 3 (2020):464-473,
https://doi.org/10.1080/0972060X.2020.1790428 . .

TY  - CONF
AU  - Aćimović, Milica
AU  - Stanković, Jovana
AU  - Cvetković, Mirjana
AU  - Simin, Nataša
AU  - Beara, Ivana
AU  - Lesjak, Marija
AU  - Popović, Vera
PY  - 2020
UR  - uri:http://www.gea.ucg.ac.me
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3954
AB  - Most of the Origanum species are locally distributed within the Mediterranean region
where they grow in the mountainous areas on the islands. Due to this, the rate of endemism is high,
as in case of dittany of Crete (O. dictamnus). O. vulgare possesses the largest distribution area and can
be found throughout the Mediterranean region, however, the yield and quality of the essential oil is
controlled genetically and strongly affected by the environmental influences. Origanum essential oils
predominantly containing carvacrol, are generally of superior quality and highly valuable raw
material for food as well as in pharmaceutical industry. Essential oil of O. dictimus contains 70.8% of
carvacrol, while O. vulgare ssp. hirtum essential oil contains 78.5%. This study indicates the high
quality of investigated Origanum species from Greece, and indicates it to be highly valuable raw
material for food and in pharmaceutical industry.
PB  - Faculty of Architecture – University of Montenegro
PB  - Faculty of Philosophy - University of Montenegro
PB  - Biotecnical faculty - University of Montenegro
C3  - Book of Proceedings - GEA (Geo Eco-Eco Agro) International Conference
T1  - Chemical composition of Origanum dictamnus and Origanum vulgare ssp. hirtum from Greece
VL  - 1
SP  - 244
EP  - 249
UR  - https://hdl.handle.net/21.15107/rcub_cer_3954
ER  - 

@conference{
author = "Aćimović, Milica and Stanković, Jovana and Cvetković, Mirjana and Simin, Nataša and Beara, Ivana and Lesjak, Marija and Popović, Vera",
year = "2020",
abstract = "Most of the Origanum species are locally distributed within the Mediterranean region
where they grow in the mountainous areas on the islands. Due to this, the rate of endemism is high,
as in case of dittany of Crete (O. dictamnus). O. vulgare possesses the largest distribution area and can
be found throughout the Mediterranean region, however, the yield and quality of the essential oil is
controlled genetically and strongly affected by the environmental influences. Origanum essential oils
predominantly containing carvacrol, are generally of superior quality and highly valuable raw
material for food as well as in pharmaceutical industry. Essential oil of O. dictimus contains 70.8% of
carvacrol, while O. vulgare ssp. hirtum essential oil contains 78.5%. This study indicates the high
quality of investigated Origanum species from Greece, and indicates it to be highly valuable raw
material for food and in pharmaceutical industry.",
publisher = "Faculty of Architecture – University of Montenegro, Faculty of Philosophy - University of Montenegro, Biotecnical faculty - University of Montenegro",
journal = "Book of Proceedings - GEA (Geo Eco-Eco Agro) International Conference",
title = "Chemical composition of Origanum dictamnus and Origanum vulgare ssp. hirtum from Greece",
volume = "1",
pages = "244-249",
url = "https://hdl.handle.net/21.15107/rcub_cer_3954"
}

Aćimović, M., Stanković, J., Cvetković, M., Simin, N., Beara, I., Lesjak, M.,& Popović, V.. (2020). Chemical composition of Origanum dictamnus and Origanum vulgare ssp. hirtum from Greece. in Book of Proceedings - GEA (Geo Eco-Eco Agro) International Conference
Faculty of Architecture – University of Montenegro., 1, 244-249.
https://hdl.handle.net/21.15107/rcub_cer_3954

Aćimović M, Stanković J, Cvetković M, Simin N, Beara I, Lesjak M, Popović V. Chemical composition of Origanum dictamnus and Origanum vulgare ssp. hirtum from Greece. in Book of Proceedings - GEA (Geo Eco-Eco Agro) International Conference. 2020;1:244-249.
https://hdl.handle.net/21.15107/rcub_cer_3954 .

Aćimović, Milica, Stanković, Jovana, Cvetković, Mirjana, Simin, Nataša, Beara, Ivana, Lesjak, Marija, Popović, Vera, "Chemical composition of Origanum dictamnus and Origanum vulgare ssp. hirtum from Greece" in Book of Proceedings - GEA (Geo Eco-Eco Agro) International Conference, 1 (2020):244-249,
https://hdl.handle.net/21.15107/rcub_cer_3954 .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Varga, Ana
AU  - Cvetković, Mirjana
AU  - Stanković, Jovana
AU  - Čabarkapa, Ivana
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2381
AB  - The aim of the present study was to clarify the chemical composition of essential oil from seeds of Angelica (Angelica sylvestris) plants growing wild in Serbia. In the essential oil, a total of 27 compounds were detected, among which 22 compounds were identified (comprising 97.9% of all compounds), while five were unidentified (comprising 2.1%). The main components were limonene (66.6%) and alpha-pinene (19.0%), followed by camphene (1.9%), alpha-phellandrene (1.6%), bornyl acetate (1.6%), and trans-caryophyllene (1.0%), while all other compounds were present in amounts of less than 1.0%. The antibacterial effect of the essential oil of wild Angelica seeds was tested against two pathogenic bacteria that cause food poisoning, viz., Staphylococcus aureus and Escherichia coli. According to the obtained results, S. aureus was more sensitive to A. sylvestris seed oil than E. coli. The minimal inhibitory concentrations were 28.40 mu L/mL and 56.81 mu L/mL, respectively, confirming a good antibacterial activity potential of the essential oil against E. coli and S. aureus, and indicating possibilities for its application in the food and pharmaceutical industries.
AB  - Cilj ovog istraživanja je bio da se utvrdi hemijski sastav etarskog ulja divlje anđelike (Angelica sylvestris)
dobijenog hidrodestilacijom semena samoniklih biljaka iz Srbije. U etarskom ulju utvrđeno je 27 komponenti (koje čine 97.9%), među kojima je pet nedeterminisanih komponenti (koje čine 2.1%). Dominantne komponente su limonen (66.6%) i α-pinen (19.0%), a potom slede kamfen (1.9%), α-felandren (1.6%), bornil
acetat (1.6%) i trans-kariofilen (1.0%), dok su ostale komponente bile prisutne sa manje od 1.0%. Takođe, cilj ispitivanja je bio i antibakterijski efekat ovog ulja na dve patogene bakterije koje su uzročnici trovanja hranom: Staphylococcus aureus i Escherichia coli. Na osnovu rezultata, utvrđeno je da je S. aureus značajno osetljiviji na uticaj etarskog ulja semena A. sylvestris u poređenju sa E. coli. Minimalna inhibitorna koncentracija je bili 28.40 µL/mL i 56.81 µL/mL, što potvrđuje dobru antibakterijsku aktivnost na obe bakterije, kao i na mogućnost njegove primene u prehrambenoj i farmaceutskoj industriji.
PB  - University of Belgrade
T2  - Botanica Serbica
T1  - Chemical characterisation and antibacterial activity of the essential oil of wild Angelica seeds
T1  - Hemijska karakterizacija i antibakterijska aktivnost
etarskog ulja semena divlje anđelike
VL  - 42
IS  - 2
SP  - 217
EP  - 221
DO  - 10.5281/zenodo.1468310
ER  - 

@article{
author = "Aćimović, Milica and Varga, Ana and Cvetković, Mirjana and Stanković, Jovana and Čabarkapa, Ivana",
year = "2018",
abstract = "The aim of the present study was to clarify the chemical composition of essential oil from seeds of Angelica (Angelica sylvestris) plants growing wild in Serbia. In the essential oil, a total of 27 compounds were detected, among which 22 compounds were identified (comprising 97.9% of all compounds), while five were unidentified (comprising 2.1%). The main components were limonene (66.6%) and alpha-pinene (19.0%), followed by camphene (1.9%), alpha-phellandrene (1.6%), bornyl acetate (1.6%), and trans-caryophyllene (1.0%), while all other compounds were present in amounts of less than 1.0%. The antibacterial effect of the essential oil of wild Angelica seeds was tested against two pathogenic bacteria that cause food poisoning, viz., Staphylococcus aureus and Escherichia coli. According to the obtained results, S. aureus was more sensitive to A. sylvestris seed oil than E. coli. The minimal inhibitory concentrations were 28.40 mu L/mL and 56.81 mu L/mL, respectively, confirming a good antibacterial activity potential of the essential oil against E. coli and S. aureus, and indicating possibilities for its application in the food and pharmaceutical industries., Cilj ovog istraživanja je bio da se utvrdi hemijski sastav etarskog ulja divlje anđelike (Angelica sylvestris)
dobijenog hidrodestilacijom semena samoniklih biljaka iz Srbije. U etarskom ulju utvrđeno je 27 komponenti (koje čine 97.9%), među kojima je pet nedeterminisanih komponenti (koje čine 2.1%). Dominantne komponente su limonen (66.6%) i α-pinen (19.0%), a potom slede kamfen (1.9%), α-felandren (1.6%), bornil
acetat (1.6%) i trans-kariofilen (1.0%), dok su ostale komponente bile prisutne sa manje od 1.0%. Takođe, cilj ispitivanja je bio i antibakterijski efekat ovog ulja na dve patogene bakterije koje su uzročnici trovanja hranom: Staphylococcus aureus i Escherichia coli. Na osnovu rezultata, utvrđeno je da je S. aureus značajno osetljiviji na uticaj etarskog ulja semena A. sylvestris u poređenju sa E. coli. Minimalna inhibitorna koncentracija je bili 28.40 µL/mL i 56.81 µL/mL, što potvrđuje dobru antibakterijsku aktivnost na obe bakterije, kao i na mogućnost njegove primene u prehrambenoj i farmaceutskoj industriji.",
publisher = "University of Belgrade",
journal = "Botanica Serbica",
title = "Chemical characterisation and antibacterial activity of the essential oil of wild Angelica seeds, Hemijska karakterizacija i antibakterijska aktivnost
etarskog ulja semena divlje anđelike",
volume = "42",
number = "2",
pages = "217-221",
doi = "10.5281/zenodo.1468310"
}

Aćimović, M., Varga, A., Cvetković, M., Stanković, J.,& Čabarkapa, I.. (2018). Chemical characterisation and antibacterial activity of the essential oil of wild Angelica seeds. in Botanica Serbica
University of Belgrade., 42(2), 217-221.
https://doi.org/10.5281/zenodo.1468310

Aćimović M, Varga A, Cvetković M, Stanković J, Čabarkapa I. Chemical characterisation and antibacterial activity of the essential oil of wild Angelica seeds. in Botanica Serbica. 2018;42(2):217-221.
doi:10.5281/zenodo.1468310 .

Aćimović, Milica, Varga, Ana, Cvetković, Mirjana, Stanković, Jovana, Čabarkapa, Ivana, "Chemical characterisation and antibacterial activity of the essential oil of wild Angelica seeds" in Botanica Serbica, 42, no. 2 (2018):217-221,
https://doi.org/10.5281/zenodo.1468310 . .

TY  - JOUR
AU  - Aćimović, Milica
AU  - Stanković, Jovana
AU  - Cvetković, Mirjana
AU  - Kiprovski, Biljana
AU  - Todosijević, Marina
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2350
AB  - Chamomile (Matricaria chamomilla L. syn. Chamomilla recutita (L.) Rauschert) is a herb widely used in the form of dried flower heads (Matricariae flos) infusion tea and steam-distilled essential oil (Matricariae aetheroleum). The subject of this study is to determine the chemical composition of essential oil obtained from dry chamomile flowers of three tetraploid cultivars (Zloty Lan', Manzana' and Lutea') grown in North Banat region, Serbia. Essential oil has been obtained by hydrodistillation process on Clevenger apparatus. Qualitative and quantitative composition of the oil was determined by GC-MS and GC-FID analysis. From 48 compounds detected in total, the most abundant class was sesquiterpene hydrocarbons. In Zloty Lan' and Lutea' the major compound was trans--farnesene while in Manzana' it was -bisabolol.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Essential Oil Bearing Plants
T1  - Essential Oil Quality of Tetraploid Chamomile Cultivars Grown in Serbia
VL  - 21
IS  - 1
SP  - 15
EP  - 22
DO  - 10.1080/0972060X.2017.1401962
ER  - 

@article{
author = "Aćimović, Milica and Stanković, Jovana and Cvetković, Mirjana and Kiprovski, Biljana and Todosijević, Marina",
year = "2018",
abstract = "Chamomile (Matricaria chamomilla L. syn. Chamomilla recutita (L.) Rauschert) is a herb widely used in the form of dried flower heads (Matricariae flos) infusion tea and steam-distilled essential oil (Matricariae aetheroleum). The subject of this study is to determine the chemical composition of essential oil obtained from dry chamomile flowers of three tetraploid cultivars (Zloty Lan', Manzana' and Lutea') grown in North Banat region, Serbia. Essential oil has been obtained by hydrodistillation process on Clevenger apparatus. Qualitative and quantitative composition of the oil was determined by GC-MS and GC-FID analysis. From 48 compounds detected in total, the most abundant class was sesquiterpene hydrocarbons. In Zloty Lan' and Lutea' the major compound was trans--farnesene while in Manzana' it was -bisabolol.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Essential Oil Bearing Plants",
title = "Essential Oil Quality of Tetraploid Chamomile Cultivars Grown in Serbia",
volume = "21",
number = "1",
pages = "15-22",
doi = "10.1080/0972060X.2017.1401962"
}

Aćimović, M., Stanković, J., Cvetković, M., Kiprovski, B.,& Todosijević, M.. (2018). Essential Oil Quality of Tetraploid Chamomile Cultivars Grown in Serbia. in Journal of Essential Oil Bearing Plants
Taylor & Francis Ltd, Abingdon., 21(1), 15-22.
https://doi.org/10.1080/0972060X.2017.1401962

Aćimović M, Stanković J, Cvetković M, Kiprovski B, Todosijević M. Essential Oil Quality of Tetraploid Chamomile Cultivars Grown in Serbia. in Journal of Essential Oil Bearing Plants. 2018;21(1):15-22.
doi:10.1080/0972060X.2017.1401962 .

Aćimović, Milica, Stanković, Jovana, Cvetković, Mirjana, Kiprovski, Biljana, Todosijević, Marina, "Essential Oil Quality of Tetraploid Chamomile Cultivars Grown in Serbia" in Journal of Essential Oil Bearing Plants, 21, no. 1 (2018):15-22,
https://doi.org/10.1080/0972060X.2017.1401962 . .

TY  - CHAP
AU  - Aćimović, Milica
AU  - Cvetković, Mirjana
AU  - Stanković, Jovana
AU  - Tešević, Vele
AU  - Todosijević, Marina
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3195
AB  - Parsley (Petroselinum crispum L.), celery (Apium graveolens L.), celeriac (Apium graveolens var. rapaceum), carrot (Daucus carota L.), parsnip (Pastinaca sativa L.), lovage (Levisticum officinale Koch.) and angelica (Angelica archangelica L.) are vegetable plants belonging to the Apiaceae family. They are often used as spices due to their characteristic aroma, originating from the volatile compounds present in the plant tissues. Mainly, all parts of the plant i.e. roots, leaves and fruit are used in nutrition. However, the focus of this chapter is plant fruit (i.e. seed), which is mostly used as spice. The contemporary method used for the analysis of volatiles compounds is called headspace and it is widely applied in flavor chemistry. The dominant compounds in P. crispum are α-pinene (46.2-49.0%) and β-pinene (33.5- 35.4%), while in A. graveolens, it is limonene (84.1-94.4%). In D. carota, the main components are sabinene (28.3%) and α-pinene (25.0%), while in P. sativa fruit, it is octyl ester of butanoic acid (53.8%) and 1-octanol (27.6%). In L. officinale and A. archangelica, the dominant component in fruit is β-phellandrene (77.1% and 84.7%, respectively).
PB  - Bentham Science
T2  - Phytochemicals in Vegetables: A Valuable Source of Bioactive Compounds
T1  - Headspace Analysis of Volatile Compounds From Fruits of Selected Vegetable Species of Apiaceae Family
SP  - 247
EP  - 272
DO  - 10.2174/9781681087399118010009
ER  - 

@inbook{
author = "Aćimović, Milica and Cvetković, Mirjana and Stanković, Jovana and Tešević, Vele and Todosijević, Marina",
year = "2018",
abstract = "Parsley (Petroselinum crispum L.), celery (Apium graveolens L.), celeriac (Apium graveolens var. rapaceum), carrot (Daucus carota L.), parsnip (Pastinaca sativa L.), lovage (Levisticum officinale Koch.) and angelica (Angelica archangelica L.) are vegetable plants belonging to the Apiaceae family. They are often used as spices due to their characteristic aroma, originating from the volatile compounds present in the plant tissues. Mainly, all parts of the plant i.e. roots, leaves and fruit are used in nutrition. However, the focus of this chapter is plant fruit (i.e. seed), which is mostly used as spice. The contemporary method used for the analysis of volatiles compounds is called headspace and it is widely applied in flavor chemistry. The dominant compounds in P. crispum are α-pinene (46.2-49.0%) and β-pinene (33.5- 35.4%), while in A. graveolens, it is limonene (84.1-94.4%). In D. carota, the main components are sabinene (28.3%) and α-pinene (25.0%), while in P. sativa fruit, it is octyl ester of butanoic acid (53.8%) and 1-octanol (27.6%). In L. officinale and A. archangelica, the dominant component in fruit is β-phellandrene (77.1% and 84.7%, respectively).",
publisher = "Bentham Science",
journal = "Phytochemicals in Vegetables: A Valuable Source of Bioactive Compounds",
booktitle = "Headspace Analysis of Volatile Compounds From Fruits of Selected Vegetable Species of Apiaceae Family",
pages = "247-272",
doi = "10.2174/9781681087399118010009"
}

Aćimović, M., Cvetković, M., Stanković, J., Tešević, V.,& Todosijević, M.. (2018). Headspace Analysis of Volatile Compounds From Fruits of Selected Vegetable Species of Apiaceae Family. in Phytochemicals in Vegetables: A Valuable Source of Bioactive Compounds
Bentham Science., 247-272.
https://doi.org/10.2174/9781681087399118010009

Aćimović M, Cvetković M, Stanković J, Tešević V, Todosijević M. Headspace Analysis of Volatile Compounds From Fruits of Selected Vegetable Species of Apiaceae Family. in Phytochemicals in Vegetables: A Valuable Source of Bioactive Compounds. 2018;:247-272.
doi:10.2174/9781681087399118010009 .

Aćimović, Milica, Cvetković, Mirjana, Stanković, Jovana, Tešević, Vele, Todosijević, Marina, "Headspace Analysis of Volatile Compounds From Fruits of Selected Vegetable Species of Apiaceae Family" in Phytochemicals in Vegetables: A Valuable Source of Bioactive Compounds (2018):247-272,
https://doi.org/10.2174/9781681087399118010009 . .