TY  - CONF
AU  - Marković, Olivera
AU  - Konstantinović, Jelena M.
AU  - Cvijetić, Ilija
AU  - Amézqueta, Susana
AU  - Valko, Klara
AU  - Ràfols, Clara
AU  - Polović, Natalija
AU  - Šolaja, Bogdan
AU  - Verbić, Tatjana
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3403
AB  - Drug molecules in vivo may be bound to proteins and lipids in plasma and/or in tissues, or free (unbound) in diffusion among the aqueous environment of the blood and tissues. Data from in vitro plasma protein binding experiments that determine the fraction of protein-bound drug are  frequently used in drug discovery. Methods used for drug –  plasma protein binding (PPB) studies are numerous and can be divided into two main groups: separation methods (enabling the calculation of binding parameters, i.e. the number of binding sites and their respective affinity constants) and non-separation methods (describing predominantly qualitative parameters of the ligand-protein complex).
PB  - International Association of Physical Chemists
C3  - 6th World Conference on Physico-Chemical Methods in Drug Discovery, Zagreb, Croatia, September 4-7, 2017 - Book of Abstracts
T1  - Measurements of plasma protein binding – variety of experimental techniques
SP  - 30
EP  - 30
UR  - https://hdl.handle.net/21.15107/rcub_cer_3403
ER  - 

@conference{
author = "Marković, Olivera and Konstantinović, Jelena M. and Cvijetić, Ilija and Amézqueta, Susana and Valko, Klara and Ràfols, Clara and Polović, Natalija and Šolaja, Bogdan and Verbić, Tatjana",
year = "2017",
abstract = "Drug molecules in vivo may be bound to proteins and lipids in plasma and/or in tissues, or free (unbound) in diffusion among the aqueous environment of the blood and tissues. Data from in vitro plasma protein binding experiments that determine the fraction of protein-bound drug are  frequently used in drug discovery. Methods used for drug –  plasma protein binding (PPB) studies are numerous and can be divided into two main groups: separation methods (enabling the calculation of binding parameters, i.e. the number of binding sites and their respective affinity constants) and non-separation methods (describing predominantly qualitative parameters of the ligand-protein complex).",
publisher = "International Association of Physical Chemists",
journal = "6th World Conference on Physico-Chemical Methods in Drug Discovery, Zagreb, Croatia, September 4-7, 2017 - Book of Abstracts",
title = "Measurements of plasma protein binding – variety of experimental techniques",
pages = "30-30",
url = "https://hdl.handle.net/21.15107/rcub_cer_3403"
}

Marković, O., Konstantinović, J. M., Cvijetić, I., Amézqueta, S., Valko, K., Ràfols, C., Polović, N., Šolaja, B.,& Verbić, T.. (2017). Measurements of plasma protein binding – variety of experimental techniques. in 6th World Conference on Physico-Chemical Methods in Drug Discovery, Zagreb, Croatia, September 4-7, 2017 - Book of Abstracts
International Association of Physical Chemists., 30-30.
https://hdl.handle.net/21.15107/rcub_cer_3403

Marković O, Konstantinović JM, Cvijetić I, Amézqueta S, Valko K, Ràfols C, Polović N, Šolaja B, Verbić T. Measurements of plasma protein binding – variety of experimental techniques. in 6th World Conference on Physico-Chemical Methods in Drug Discovery, Zagreb, Croatia, September 4-7, 2017 - Book of Abstracts. 2017;:30-30.
https://hdl.handle.net/21.15107/rcub_cer_3403 .

Marković, Olivera, Konstantinović, Jelena M., Cvijetić, Ilija, Amézqueta, Susana, Valko, Klara, Ràfols, Clara, Polović, Natalija, Šolaja, Bogdan, Verbić, Tatjana, "Measurements of plasma protein binding – variety of experimental techniques" in 6th World Conference on Physico-Chemical Methods in Drug Discovery, Zagreb, Croatia, September 4-7, 2017 - Book of Abstracts (2017):30-30,
https://hdl.handle.net/21.15107/rcub_cer_3403 .