TY  - CONF
AU  - Mudrinić, Tihana
AU  - Mojović, Zorica
AU  - Jovanović, Dušan
AU  - Ignjatović, Aleksandar
AU  - Mojović, Miloš
AU  - Bačić, Goran
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6826
AB  - The diagnosis of amyotrophic lateral sclerosis (ALS) based on ALS functional rating scale-revised (ALSFRS-R) scores is often shown be unreliable and false. On the other hand, magnetic resonance imaging (MRI) studies of a brain of ALS patients showed the presence of iron deposits in the precentral gyruses of gray matter (PGGM) and also the potential leakage of iron to cerebro-spinal fluid (CSF) through compromised blood-brain barrier. The aim of this study was to determine if there is a specific feature in CSF that distinguishes patients with ALS from the control subjects. CSF obtained from ALS patients and normal controls were analyzed using the technique of cyclic voltammetry. The results show that at the potential of 1.1 – 1.2 V vs. Ag/AgCl electrode, the plateau appeared and the potential of oxygen evolution with shifted toward more positive values from the ALS patients. These voltammogram features were not present for the control patients showing this technique to be promising candidate for evaluating new biomarkers for ALS.
PB  - Biophysical Society of Serbia
C3  - Proceedings - Regional Biophysics Conference 2012, September 03-07, Kladovo-Belgrade, Serbia
T1  - Cyclic voltammetry in diagnosis of ALS
SP  - 23
EP  - 25
UR  - https://hdl.handle.net/21.15107/rcub_cer_6826
ER  - 

@conference{
author = "Mudrinić, Tihana and Mojović, Zorica and Jovanović, Dušan and Ignjatović, Aleksandar and Mojović, Miloš and Bačić, Goran",
year = "2012",
abstract = "The diagnosis of amyotrophic lateral sclerosis (ALS) based on ALS functional rating scale-revised (ALSFRS-R) scores is often shown be unreliable and false. On the other hand, magnetic resonance imaging (MRI) studies of a brain of ALS patients showed the presence of iron deposits in the precentral gyruses of gray matter (PGGM) and also the potential leakage of iron to cerebro-spinal fluid (CSF) through compromised blood-brain barrier. The aim of this study was to determine if there is a specific feature in CSF that distinguishes patients with ALS from the control subjects. CSF obtained from ALS patients and normal controls were analyzed using the technique of cyclic voltammetry. The results show that at the potential of 1.1 – 1.2 V vs. Ag/AgCl electrode, the plateau appeared and the potential of oxygen evolution with shifted toward more positive values from the ALS patients. These voltammogram features were not present for the control patients showing this technique to be promising candidate for evaluating new biomarkers for ALS.",
publisher = "Biophysical Society of Serbia",
journal = "Proceedings - Regional Biophysics Conference 2012, September 03-07, Kladovo-Belgrade, Serbia",
title = "Cyclic voltammetry in diagnosis of ALS",
pages = "23-25",
url = "https://hdl.handle.net/21.15107/rcub_cer_6826"
}

Mudrinić, T., Mojović, Z., Jovanović, D., Ignjatović, A., Mojović, M.,& Bačić, G.. (2012). Cyclic voltammetry in diagnosis of ALS. in Proceedings - Regional Biophysics Conference 2012, September 03-07, Kladovo-Belgrade, Serbia
Biophysical Society of Serbia., 23-25.
https://hdl.handle.net/21.15107/rcub_cer_6826

Mudrinić T, Mojović Z, Jovanović D, Ignjatović A, Mojović M, Bačić G. Cyclic voltammetry in diagnosis of ALS. in Proceedings - Regional Biophysics Conference 2012, September 03-07, Kladovo-Belgrade, Serbia. 2012;:23-25.
https://hdl.handle.net/21.15107/rcub_cer_6826 .

Mudrinić, Tihana, Mojović, Zorica, Jovanović, Dušan, Ignjatović, Aleksandar, Mojović, Miloš, Bačić, Goran, "Cyclic voltammetry in diagnosis of ALS" in Proceedings - Regional Biophysics Conference 2012, September 03-07, Kladovo-Belgrade, Serbia (2012):23-25,
https://hdl.handle.net/21.15107/rcub_cer_6826 .

TY  - CONF
AU  - Mudrinić, Tihana
AU  - Ignjatović, Aleksandar
AU  - Mojović, Zorica
AU  - Jovanović, Dušan
AU  - Mojović, Miloš
AU  - Bačić, Goran
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7016
AB  - The diagnosis of amyotrophic lateral sclerosis (ALS) based on ALS functional rating score (ALSFRS) is often shown to be unreliable and false. On the other hand, it is a fact that MRI studies of a brain of ALS patients showthe presence of iron deposits in precentral gyruses of gray matter (PGGM), meaning that blood-brain barrier is compromised. Therefore, various studies have been performed with the goal to detect excess of iron in the cerebrospinal fluid (CSF) of ALS patients (e.g. EPR detection of •OH radicals as products of Fenton reaction after supplementation of H2O2 to the CSF). Unfortunately, no acceptable correlation could emerge, probably caused by the presence of a range of iron complexes in CSF. Therefore, a different approach to detect iron states in CFS is required. The aim of thisworkwas to determine if there is a specific feature in CSF that distinguishes patients with ALS from those with purely motor peripheral neuropathy (PN) and healthy control subjects. CSF obtained from ALS patients and normal controls were analyzed using the technique of cyclic voltammetry. The results show that, at potential of 1.1 - 1.2 V vs. Ag/AgCl electrode, for the ALS patients, the plateau appeared and the potential of oxygen evolutionwas shifted toward more positive values. These voltammogram features were not present for the control patients. The cyclic voltammetry is fast and inexpensive technique and showed to be promising candidate for evaluating new biomarkers for ALS.
PB  - Biophysical Society of Serbia
C3  - Book of Abstracts - Regional Biophysics Conference 2012, September 03-07, Kladovo-Belgrade, Serbia
T1  - Cyclic voltammetry in diagnosis of ALS
SP  - 75
EP  - 75
UR  - https://hdl.handle.net/21.15107/rcub_cer_7016
ER  - 

@conference{
author = "Mudrinić, Tihana and Ignjatović, Aleksandar and Mojović, Zorica and Jovanović, Dušan and Mojović, Miloš and Bačić, Goran",
year = "2012",
abstract = "The diagnosis of amyotrophic lateral sclerosis (ALS) based on ALS functional rating score (ALSFRS) is often shown to be unreliable and false. On the other hand, it is a fact that MRI studies of a brain of ALS patients showthe presence of iron deposits in precentral gyruses of gray matter (PGGM), meaning that blood-brain barrier is compromised. Therefore, various studies have been performed with the goal to detect excess of iron in the cerebrospinal fluid (CSF) of ALS patients (e.g. EPR detection of •OH radicals as products of Fenton reaction after supplementation of H2O2 to the CSF). Unfortunately, no acceptable correlation could emerge, probably caused by the presence of a range of iron complexes in CSF. Therefore, a different approach to detect iron states in CFS is required. The aim of thisworkwas to determine if there is a specific feature in CSF that distinguishes patients with ALS from those with purely motor peripheral neuropathy (PN) and healthy control subjects. CSF obtained from ALS patients and normal controls were analyzed using the technique of cyclic voltammetry. The results show that, at potential of 1.1 - 1.2 V vs. Ag/AgCl electrode, for the ALS patients, the plateau appeared and the potential of oxygen evolutionwas shifted toward more positive values. These voltammogram features were not present for the control patients. The cyclic voltammetry is fast and inexpensive technique and showed to be promising candidate for evaluating new biomarkers for ALS.",
publisher = "Biophysical Society of Serbia",
journal = "Book of Abstracts - Regional Biophysics Conference 2012, September 03-07, Kladovo-Belgrade, Serbia",
title = "Cyclic voltammetry in diagnosis of ALS",
pages = "75-75",
url = "https://hdl.handle.net/21.15107/rcub_cer_7016"
}

Mudrinić, T., Ignjatović, A., Mojović, Z., Jovanović, D., Mojović, M.,& Bačić, G.. (2012). Cyclic voltammetry in diagnosis of ALS. in Book of Abstracts - Regional Biophysics Conference 2012, September 03-07, Kladovo-Belgrade, Serbia
Biophysical Society of Serbia., 75-75.
https://hdl.handle.net/21.15107/rcub_cer_7016

Mudrinić T, Ignjatović A, Mojović Z, Jovanović D, Mojović M, Bačić G. Cyclic voltammetry in diagnosis of ALS. in Book of Abstracts - Regional Biophysics Conference 2012, September 03-07, Kladovo-Belgrade, Serbia. 2012;:75-75.
https://hdl.handle.net/21.15107/rcub_cer_7016 .

Mudrinić, Tihana, Ignjatović, Aleksandar, Mojović, Zorica, Jovanović, Dušan, Mojović, Miloš, Bačić, Goran, "Cyclic voltammetry in diagnosis of ALS" in Book of Abstracts - Regional Biophysics Conference 2012, September 03-07, Kladovo-Belgrade, Serbia (2012):75-75,
https://hdl.handle.net/21.15107/rcub_cer_7016 .