TY  - JOUR
AU  - Ortiz, Sergio
AU  - Šavikin, Katarina
AU  - Massicot, France
AU  - Olivier, Elodie
AU  - Dutot, Melody
AU  - Rat, Patrice
AU  - Deguin, Brigitte
AU  - Gođevac, Dejan
AU  - Menković, Nebojša
AU  - Živković, Jelena
AU  - Zdunić, Gordana
AU  - Boutefnouchet, Sabrina
PY  - 2023
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7218
AB  - Medicinal plants used in European folk medicine attached to Lamiales, Gentianales or Asterales orders are used to treat inflammatory disorders. Many targets have been identified but to date, implication of purinergic receptor P2X7 activation has not yet been investigated. We managed to evaluate the protective effect on P2X7 activation by plant extracts used as anti-inflammatory in European folk medicine by the YO-PRO-1 uptake dye in vitro bioassay. Results revealed that among our selected plants, species from Scrophularia and Plantago genus were able to decrease significantly P2X7 activation (>50 % at 0.1 and 1 μg/mL). UPLC/MS, dereplication and metabolomic analysis of Scrophularia extracts, allowed us to identify the cinnamoyl-iridoid harpagoside as putative inhibitor of P2X7 activation. These results open a new research field regarding the anti-inflammatory mechanism of cinnamoyl-iridoids bearing plants, which may involve the P2X7 receptor.
PB  - Wiley
T2  - Chemistry & Biodiversity
T1  - P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants
VL  - 20
IS  - 8
DO  - 10.1002/cbdv.202300427
ER  - 

@article{
author = "Ortiz, Sergio and Šavikin, Katarina and Massicot, France and Olivier, Elodie and Dutot, Melody and Rat, Patrice and Deguin, Brigitte and Gođevac, Dejan and Menković, Nebojša and Živković, Jelena and Zdunić, Gordana and Boutefnouchet, Sabrina",
year = "2023",
abstract = "Medicinal plants used in European folk medicine attached to Lamiales, Gentianales or Asterales orders are used to treat inflammatory disorders. Many targets have been identified but to date, implication of purinergic receptor P2X7 activation has not yet been investigated. We managed to evaluate the protective effect on P2X7 activation by plant extracts used as anti-inflammatory in European folk medicine by the YO-PRO-1 uptake dye in vitro bioassay. Results revealed that among our selected plants, species from Scrophularia and Plantago genus were able to decrease significantly P2X7 activation (>50 % at 0.1 and 1 μg/mL). UPLC/MS, dereplication and metabolomic analysis of Scrophularia extracts, allowed us to identify the cinnamoyl-iridoid harpagoside as putative inhibitor of P2X7 activation. These results open a new research field regarding the anti-inflammatory mechanism of cinnamoyl-iridoids bearing plants, which may involve the P2X7 receptor.",
publisher = "Wiley",
journal = "Chemistry & Biodiversity",
title = "P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants",
volume = "20",
number = "8",
doi = "10.1002/cbdv.202300427"
}

Ortiz, S., Šavikin, K., Massicot, F., Olivier, E., Dutot, M., Rat, P., Deguin, B., Gođevac, D., Menković, N., Živković, J., Zdunić, G.,& Boutefnouchet, S.. (2023). P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants. in Chemistry & Biodiversity
Wiley., 20(8).
https://doi.org/10.1002/cbdv.202300427

Ortiz S, Šavikin K, Massicot F, Olivier E, Dutot M, Rat P, Deguin B, Gođevac D, Menković N, Živković J, Zdunić G, Boutefnouchet S. P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants. in Chemistry & Biodiversity. 2023;20(8).
doi:10.1002/cbdv.202300427 .

Ortiz, Sergio, Šavikin, Katarina, Massicot, France, Olivier, Elodie, Dutot, Melody, Rat, Patrice, Deguin, Brigitte, Gođevac, Dejan, Menković, Nebojša, Živković, Jelena, Zdunić, Gordana, Boutefnouchet, Sabrina, "P2X7‐Receptor Pathway Involvement in the Anti‐Inflammatory Activity of Medicinal Plants" in Chemistry & Biodiversity, 20, no. 8 (2023),
https://doi.org/10.1002/cbdv.202300427 . .

TY  - JOUR
AU  - Živković, Jelena
AU  - Jadranin, Milka
AU  - Przić, Zoran
AU  - Marković, Nebojša
AU  - Sokolović, Danijel
AU  - Savikin, Katarina
AU  - Menković, Nebojša
PY  - 2021
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/4249
AB  - In this study we have analyzed the anthocyanin composition of skin extracts of three red grape varieties Prokupac, Evita and Čokot Zemun in order to distinguish these cultivars based on their anthocyanin profile. Also, mechanical analysis of grape bunches and berries was performed. According to our results, seventeen anthocyanins were identified using LC‐MS technique and quantitative differences were recorded using HPLC‐DAD method. The highest content of total anthocyanins was obtained for Evita variety and the lowest one was recorded in Prokupac. Also, clear differences were observed in anthocyanins ratios. In comparison to Prokupac and Evita varieties, Čokot Zemun was characterized with a high content of cumaroyl derivatives of anthocyanin compounds, while high levels of acetylated derivatives were recorded in Prokupac. Data reported in this study represent a certain contribution to a database of mechanical properties and chemical composition of grape varieties originating from Balkan.
T2  - Chemistry & Biodiversity
T1  - Varietal differences of Prokupac, Evita and Čokot Zemun based on their anthocyanins content in grape skin extract
DO  - 10.1002/cbdv.202000858
ER  - 

@article{
author = "Živković, Jelena and Jadranin, Milka and Przić, Zoran and Marković, Nebojša and Sokolović, Danijel and Savikin, Katarina and Menković, Nebojša",
year = "2021",
abstract = "In this study we have analyzed the anthocyanin composition of skin extracts of three red grape varieties Prokupac, Evita and Čokot Zemun in order to distinguish these cultivars based on their anthocyanin profile. Also, mechanical analysis of grape bunches and berries was performed. According to our results, seventeen anthocyanins were identified using LC‐MS technique and quantitative differences were recorded using HPLC‐DAD method. The highest content of total anthocyanins was obtained for Evita variety and the lowest one was recorded in Prokupac. Also, clear differences were observed in anthocyanins ratios. In comparison to Prokupac and Evita varieties, Čokot Zemun was characterized with a high content of cumaroyl derivatives of anthocyanin compounds, while high levels of acetylated derivatives were recorded in Prokupac. Data reported in this study represent a certain contribution to a database of mechanical properties and chemical composition of grape varieties originating from Balkan.",
journal = "Chemistry & Biodiversity",
title = "Varietal differences of Prokupac, Evita and Čokot Zemun based on their anthocyanins content in grape skin extract",
doi = "10.1002/cbdv.202000858"
}

Živković, J., Jadranin, M., Przić, Z., Marković, N., Sokolović, D., Savikin, K.,& Menković, N.. (2021). Varietal differences of Prokupac, Evita and Čokot Zemun based on their anthocyanins content in grape skin extract. in Chemistry & Biodiversity.
https://doi.org/10.1002/cbdv.202000858

Živković J, Jadranin M, Przić Z, Marković N, Sokolović D, Savikin K, Menković N. Varietal differences of Prokupac, Evita and Čokot Zemun based on their anthocyanins content in grape skin extract. in Chemistry & Biodiversity. 2021;.
doi:10.1002/cbdv.202000858 .

Živković, Jelena, Jadranin, Milka, Przić, Zoran, Marković, Nebojša, Sokolović, Danijel, Savikin, Katarina, Menković, Nebojša, "Varietal differences of Prokupac, Evita and Čokot Zemun based on their anthocyanins content in grape skin extract" in Chemistry & Biodiversity (2021),
https://doi.org/10.1002/cbdv.202000858 . .

TY  - JOUR
AU  - Mujic, Ibrahim
AU  - Zekovic, Zoran
AU  - Vidovic, Senka
AU  - Radojkovic, Marija
AU  - Živković, Jelena
AU  - Gođevac, Dejan
PY  - 2011
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/774
AB  - Mushrooms are useful in balancing human diet and treating different health problems. The main determinant of the fluidity of erythrocyte membranes and rheologic properties of blood is the lipid composition of the membrane, which directly depends on lipids present in the diet. Lipid profiles of 4 European wild edible mushrooms, as well as the ability of mushroom lipids to modify the fluidity of erythrocyte membrane, were examined by using gas chromatography-mass spectometry, gas chromatography-flame ionization detector, and electron paramagnetic resonance spin probing technique. Lipids from 2 species-Macrolepiota procera and Collybia platyphylla-provoked an increase in erythrocyte membrane fluidity. Therefore, introduction of these and other wild mushrooms with similar lipid profiles to the human diet could be very beneficial in the treatment of hypertension and other cardiovascular diseases related to decreased fluidity of erythrocyte membranes.
PB  - Mary Ann Liebert Inc, New Rochelle
T2  - Journal of Medicinal Food
T1  - Fatty Acid Profiles of Four Wild Mushrooms and Their Potential Benefits for Hypertension Treatment
VL  - 14
IS  - 11
SP  - 1330
EP  - 1337
DO  - 10.1089/jmf.2010.0352
ER  - 

@article{
author = "Mujic, Ibrahim and Zekovic, Zoran and Vidovic, Senka and Radojkovic, Marija and Živković, Jelena and Gođevac, Dejan",
year = "2011",
abstract = "Mushrooms are useful in balancing human diet and treating different health problems. The main determinant of the fluidity of erythrocyte membranes and rheologic properties of blood is the lipid composition of the membrane, which directly depends on lipids present in the diet. Lipid profiles of 4 European wild edible mushrooms, as well as the ability of mushroom lipids to modify the fluidity of erythrocyte membrane, were examined by using gas chromatography-mass spectometry, gas chromatography-flame ionization detector, and electron paramagnetic resonance spin probing technique. Lipids from 2 species-Macrolepiota procera and Collybia platyphylla-provoked an increase in erythrocyte membrane fluidity. Therefore, introduction of these and other wild mushrooms with similar lipid profiles to the human diet could be very beneficial in the treatment of hypertension and other cardiovascular diseases related to decreased fluidity of erythrocyte membranes.",
publisher = "Mary Ann Liebert Inc, New Rochelle",
journal = "Journal of Medicinal Food",
title = "Fatty Acid Profiles of Four Wild Mushrooms and Their Potential Benefits for Hypertension Treatment",
volume = "14",
number = "11",
pages = "1330-1337",
doi = "10.1089/jmf.2010.0352"
}

Mujic, I., Zekovic, Z., Vidovic, S., Radojkovic, M., Živković, J.,& Gođevac, D.. (2011). Fatty Acid Profiles of Four Wild Mushrooms and Their Potential Benefits for Hypertension Treatment. in Journal of Medicinal Food
Mary Ann Liebert Inc, New Rochelle., 14(11), 1330-1337.
https://doi.org/10.1089/jmf.2010.0352

Mujic I, Zekovic Z, Vidovic S, Radojkovic M, Živković J, Gođevac D. Fatty Acid Profiles of Four Wild Mushrooms and Their Potential Benefits for Hypertension Treatment. in Journal of Medicinal Food. 2011;14(11):1330-1337.
doi:10.1089/jmf.2010.0352 .

Mujic, Ibrahim, Zekovic, Zoran, Vidovic, Senka, Radojkovic, Marija, Živković, Jelena, Gođevac, Dejan, "Fatty Acid Profiles of Four Wild Mushrooms and Their Potential Benefits for Hypertension Treatment" in Journal of Medicinal Food, 14, no. 11 (2011):1330-1337,
https://doi.org/10.1089/jmf.2010.0352 . .

TY  - JOUR
AU  - Živković, Jelena
AU  - Zeković, Z.
AU  - Mujić, I.
AU  - Gođevac, Dejan
AU  - Mojović, Miloš
AU  - Mujić, A.
AU  - Spasojević, Ivan
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/609
AB  - Electron paramagnetic resonance (EPR) spin-trapping and spin-probing techniques were applied to determine antioxidant activity of extracts of catkin, leaves, and spiny burs of Castanea sativa against physiologically relevant reactive species-superoxide and hydroxyl radical generated in simple chemical systems and hydrogen peroxide applied on erythrocytes. Efflux of K + was used as a marker of membrane integrity. Chemical composition of extracts was analyzed using HPLC/DAD and LC/MS. Extracts showed high antioxidative capacity against superoxide but lower activity against hydroxyl radical. They protected fluidity and integrity of membranes of erythrocytes exposed to hydrogen peroxide. Levels of derivatives of ellagitannins showed positive correlation with the antioxidative activity of extracts. Therefore, ellagitannins from chestnut extracts could represent easily accessible natural antioxidants and beneficial component of human diet in pathophysiological conditions related to oxidative stress. In conclusion, EPR spectroscopy represents a valuable tool for evaluation of antioxidant activity in both hydrophilic and lipophilic media.
T2  - Food Biophysics
T1  - EPR spin-trapping and spin-probing spectroscopy in assessing antioxidant properties: Example on extracts of catkin, leaves, and spiny burs of castanea sativa
VL  - 4
IS  - 2
SP  - 126
EP  - 133
DO  - 10.1007/s11483-009-9109-8
ER  - 

@article{
author = "Živković, Jelena and Zeković, Z. and Mujić, I. and Gođevac, Dejan and Mojović, Miloš and Mujić, A. and Spasojević, Ivan",
year = "2009",
abstract = "Electron paramagnetic resonance (EPR) spin-trapping and spin-probing techniques were applied to determine antioxidant activity of extracts of catkin, leaves, and spiny burs of Castanea sativa against physiologically relevant reactive species-superoxide and hydroxyl radical generated in simple chemical systems and hydrogen peroxide applied on erythrocytes. Efflux of K + was used as a marker of membrane integrity. Chemical composition of extracts was analyzed using HPLC/DAD and LC/MS. Extracts showed high antioxidative capacity against superoxide but lower activity against hydroxyl radical. They protected fluidity and integrity of membranes of erythrocytes exposed to hydrogen peroxide. Levels of derivatives of ellagitannins showed positive correlation with the antioxidative activity of extracts. Therefore, ellagitannins from chestnut extracts could represent easily accessible natural antioxidants and beneficial component of human diet in pathophysiological conditions related to oxidative stress. In conclusion, EPR spectroscopy represents a valuable tool for evaluation of antioxidant activity in both hydrophilic and lipophilic media.",
journal = "Food Biophysics",
title = "EPR spin-trapping and spin-probing spectroscopy in assessing antioxidant properties: Example on extracts of catkin, leaves, and spiny burs of castanea sativa",
volume = "4",
number = "2",
pages = "126-133",
doi = "10.1007/s11483-009-9109-8"
}

Živković, J., Zeković, Z., Mujić, I., Gođevac, D., Mojović, M., Mujić, A.,& Spasojević, I.. (2009). EPR spin-trapping and spin-probing spectroscopy in assessing antioxidant properties: Example on extracts of catkin, leaves, and spiny burs of castanea sativa. in Food Biophysics, 4(2), 126-133.
https://doi.org/10.1007/s11483-009-9109-8

Živković J, Zeković Z, Mujić I, Gođevac D, Mojović M, Mujić A, Spasojević I. EPR spin-trapping and spin-probing spectroscopy in assessing antioxidant properties: Example on extracts of catkin, leaves, and spiny burs of castanea sativa. in Food Biophysics. 2009;4(2):126-133.
doi:10.1007/s11483-009-9109-8 .

Živković, Jelena, Zeković, Z., Mujić, I., Gođevac, Dejan, Mojović, Miloš, Mujić, A., Spasojević, Ivan, "EPR spin-trapping and spin-probing spectroscopy in assessing antioxidant properties: Example on extracts of catkin, leaves, and spiny burs of castanea sativa" in Food Biophysics, 4, no. 2 (2009):126-133,
https://doi.org/10.1007/s11483-009-9109-8 . .