dc.creator | Krstić, Natalija | |
dc.creator | Bjelaković, Mira | |
dc.creator | Žižak, Željko | |
dc.creator | Pavlović, Mirjana | |
dc.creator | Juranić, Zorica | |
dc.creator | Pavlović, Vladimir D. | |
dc.date.accessioned | 2019-01-30T17:16:38Z | |
dc.date.available | 2019-01-30T17:16:38Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0039-128X | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/363 | |
dc.description.abstract | The antiproliferative activity of previously synthesized (Z)-cholest-4-en-6-one oxime (1), (E)-cholest-4-en-6-one oxime (2), 7-aza-B-homocholest-4-en-6-one (3) and 6-aza-B-homocholest-4-en-7-one (4) and newly synthesized 6-thioxo-7-aza-B-homocholest-4-ene (5) and 6-aza-7-thioxo-B-homocholest-4-ene (6) was tested for their possible effects against two human tumor cell lines, cervical carcinoma (HeLa) and chronic myelogenous leukemia (K-562). Compounds 1-6, exerted a dose-dependent antiproliferative effect toward cell lines used in experimental design, showing high selectivity in their action for tumor cells in comparison to normal immunocompetent cells (non-stimulated PBMC and PHA-stimulated PBMC). Compounds 2, 3 and 4 exhibited a very high but selective antitumor activity, by inducing apoptosis in sensitive, for that purpose targeted tumor cell line (HeLa cells). Low toxic effect upon both non-stimulated, and PHA stimulated PBMCs from control, healthy volunteers, has been detected for compounds 1, 2, 3 and 4. The possible reasons for profound differences in the effects of this spectrum of steroidal compounds between tumor cell lines and normal stimulated and non-stimulated PBMCs are discussed. The molecular mechanisms for apoptotic events in HeLa cell line are suggested. The guidelines for further research are underlined. | en |
dc.publisher | Elsevier | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142033/RS// | |
dc.rights | restrictedAccess | |
dc.source | Steroids | |
dc.subject | Antiproliferative activity | en |
dc.subject | Steroidal lactams | en |
dc.subject | Steroidal oximes | en |
dc.subject | Steroidal thiolactams | en |
dc.title | Synthesis of some steroidal oximes, lactams, thiolactams and their antitumor activities | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Павловић, Владимир Д.; Крстић, Наталија; Павловић, М.Д.; Јуранић, З.Д.; Жижак, З.; Бјелаковић, Мира; | |
dc.citation.volume | 72 | |
dc.citation.issue | 5 | |
dc.citation.spage | 406 | |
dc.citation.epage | 414 | |
dc.citation.other | 72(5): 406-414 | |
dc.citation.rank | M22 | |
dc.identifier.pmid | 17433824 | |
dc.identifier.doi | 10.1016/j.steroids.2007.02.005 | |
dc.identifier.scopus | 2-s2.0-34247205206 | |
dc.identifier.wos | 000246604100002 | |
dc.type.version | publishedVersion | |