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Sinteza, karakterizacija i citotoksičnost kompleksa Pd(II), Pt(II) i Pt(IV) sa estrima R[sub]2edda-tipa
Synthesis, characterization and cytotoxity of Pd(II), Pt(II) and Pt(IV) complexes with R2edda-type esters
dc.contributor.advisor | Sabo, Tibor | |
dc.contributor.other | Kaluđerović, Goran N. | |
dc.contributor.other | Grgurić-Šipka, Sanja | |
dc.contributor.other | Juranić, Zorica | |
dc.contributor.other | Leovac, Vukadin | |
dc.creator | Zmejkovski, Bojana | |
dc.date.accessioned | 2019-02-04T12:34:34Z | |
dc.date.available | 2019-02-04T12:34:34Z | |
dc.date.issued | 2010 | |
dc.identifier.uri | http://eteze.bg.ac.rs/application/showtheses?thesesId=1150 | |
dc.identifier.uri | https://fedorabg.bg.ac.rs/fedora/get/o:7943/bdef:Content/download | |
dc.identifier.uri | http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=39270927 | |
dc.identifier.uri | http://nardus.mpn.gov.rs/123456789/3497 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/2593 | |
dc.description.abstract | U ovom radu su opisane sinteze, karakterizacija i antiproliferativna aktivnost liganada u obliku hidrohloridnih soli, estara etilendiamin-N,N’-di-3-propanske kiseline (H2eddp), (S,S)-etilendiamin-N,N’-di-2-propanske kiseline ((S,S)-H2eddip) i (S,S)-etilendiamin-N,N’-di-2-(4-metil)-pentanske kiseline ((S,S)-H2eddl), kao i odgovarajućih kompleksa sa platinom(IV), platinom(II) i paladijumom(II).Sintetisano je osam novih estara, a to su izopropil i izobutil estri svih navedenih kiselina, a sa (S,S)-H2eddip dobijeni su i ciklopentil i cikloheksil estri. Ova jedinjenja su dobijena refluktovanjem suspenzije kiseline u odgovarajućem apsolutnom alkoholu kome je prethodno ukapan tionil-hlorid. Svi estri su dobijeni u obliku dihidrohlorida: [(S,S)-H2iPr2eddip]Cl2, [(S,S)-H2iBu2eddip]Cl2, [(S,S)-H2cPe2eddip]Cl2, [(S,S)-H2Cy2eddip]Cl2, [H2iPr2eddp]Cl2, [H2iBu2eddp]Cl2, [(S,S)-H2iPr2eddl]Cl2 i [(S,S)-H2iBu2eddl]Cl2. Estri su okarakterisani elementalnom analizom, infracrvenom i NMR spektroskopijom, a [(S,S)-H2iPr2eddip]Cl2, [(S,S)-H2cPe2eddip]Cl2 i [(S,S)-H2iBu2eddl]Cl2 urađena je i rendgenostrukturna analiza. U pokušaju sinteze ciklopentil estra (S,S)-etilendiamin-N,N'-di-2-(3-metil)-butanske kiseline (S,S)-H2eddv, dobijeni su neočekivani monokristali sastava [(S,S)-H4eddv]Br0,17Cl1,83.4C5H9OH.Kompleksi platine(IV) dobijeni su u reakciji natrijum- ili kalijum-heksahloroplatinata(IV) sa navedenim estrima. Sintetisano je pet novih kompleksa platine(IV): [PtCl4{(S,S)-iPr2eddip}], [PtCl4{(S,S)-iBu2eddip}], [PtCl4{(S,S)-cPe2eddip}], [PtCl4(iPr2eddp)] i [PtCl4(iBu2eddp)]. Ovi kompleksi su okarakterisani elementalnom analizom, infracrvenom i NMR spektroskopijom. Kristalna struktura određena je kompleksima [PtCl4{(S,S)-iPr2eddip}] i [PtCl4{(S,S)-cPe2eddip}]. Kompleksi platine(II) dobijeni su u reakciji kalijum-tetrahloroplatinata(II) sa estrima. Sintetisano je tri nova kompleksa platine(II): [PtCl2{(S,S)-iPr2eddip}], [PtCl2{(S,S)-iBu2eddip}] i [PtCl2{(S,S)-cPe2eddip}]. Ovi kompleksi su okarakterisani elementalnom analizom, infracrvenom i NMR spektroskopijom.Sedam novih kompleksa paladijuma(II): [PdCl2{(S,S)-iPr2eddip}], [PdCl{(S,S)-iPreddip}], [PdCl2{(S,S)-iBu2eddip}], [PdCl2{(S,S)-cPe2eddip}], [PdCl2{(S,S)-Cy2eddip}], [PdCl2{(S,S)-iPr2eddl}] i [PdCl2{(S,S)-iBu2eddl}] dobijeno je u reakciji kalijum-tetrahloropaladata(II) sa estrima. Ovi kompleksi su okarakterisani elementalnom analizom, infracrvenom i NMR spektroskopijom... | sr |
dc.description.abstract | This work describes synthesis, characterization and antiproliferative activity of ligands precursors, esters of ethylenediamine-N,N’-di-3-propanoic acid (H2eddp), (S,S)-ethylenediamine-N,N’-di-2-propanoic acid ((S,S)-H2eddip) and (S,S)-ethylenediamine-N,N’-di-2-(4-methyl)-pentanoic acid ((S,S)-H2eddl), as well as their complexes with platinum(IV), platinum(II) and palladium(II).Eight novel esters are synthesized, isopropyl and isobutyl esters of the mentioned acids, and cyclopentyl and cyclohexyl esters of (S,S)-H2eddip. Thionyl-chloride was intoduced into a flask containing absolute alcohol. The corresponding acid is added forming a suspension which was reflucted. All of the esters were obtained as dihydrochlorides: [(S,S)-H2iPr2eddip]Cl2, [(S,S)-H2iBu2eddip]Cl2, [(S,S)-H2cPe2eddip]Cl2, [(S,S)-H2Cy2eddip]Cl2, [H2iPr2eddp]Cl2, [H2iBu2eddp]Cl2, [(S,S)-H2iPr2eddl]Cl2, [(S,S)-H2iBu2eddl]Cl2. Esters were characterized by elemental analysis, IR and NMR spectroscopy. Crystal structures of [(S,S)-H2iPr2eddip]Cl2, [(S,S)-H2cPe2eddip]Cl2 and [(S,S)-H2iBu2eddl]Cl2 are solved by X-ray analyses. While trying to synthesize the cyclopentyl ester of (S,S)-ethylenediamine-N,N'-di-2-(3-methyl)-butanoic acid (S,S)-H2eddv, unexpected crystals suitable for X-ray analysis were obtained and determined - [(S,S)-H4eddv]Br0.17Cl1.83.4C5H9OH.Complexes of platinum(IV) are synthesized in a reaction of potassium-hexachloroplatinate(IV) with esters. Five novel platinum(IV) complexes are obtained: [PtCl4{(S,S)-iPr2eddip}], [PtCl4{(S,S)-iBu2eddip}], [PtCl4{(S,S)-cPe2eddip}], [PtCl4(iPr2eddp)] and [PtCl4(iBu2eddip)]. These complexes are characterized by elemental analysis, IR and NMR spectroscopy... | en |
dc.format | application/pdf | |
dc.language | sr | |
dc.publisher | Универзитет у Београду, Хемијски факултет | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Универзитет у Београду | sr |
dc.subject | platina(IV) kompleksi | sr |
dc.subject | platinum(IV) complexes | en |
dc.subject | platinum(II) complexes | en |
dc.subject | palladium(II) complexes | en |
dc.subject | R2edda-type ligands | en |
dc.subject | crystal structure | en |
dc.subject | DFT calculations | en |
dc.subject | antiproliferative activity | en |
dc.subject | platina(II) kompleksi | sr |
dc.subject | paladijum(II) kompleksi | sr |
dc.subject | R2edda ligandi | sr |
dc.subject | kristalna struktura | sr |
dc.subject | DFT proračuni | sr |
dc.subject | antiproliferativna aktivnost | sr |
dc.title | Sinteza, karakterizacija i citotoksičnost kompleksa Pd(II), Pt(II) i Pt(IV) sa estrima R[sub]2edda-tipa | sr |
dc.title | Synthesis, characterization and cytotoxity of Pd(II), Pt(II) and Pt(IV) complexes with R2edda-type esters | en |
dc.type | doctoralThesis | en |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Сабо, Тибор; Калуђеровић, Горан; Јуранић, Зорица; Гргурић-Шипка, Сања; Леовац, Вукадин; Змејковски, Бојана Б.; Синтеза, карактеризација и цитотоксичност комплекса Пд(ИИ), Пт(ИИ) и Пт(ИВ) са естрима Р[суб]2едда-типа; Синтеза, карактеризација и цитотоксичност комплекса Пд(ИИ), Пт(ИИ) и Пт(ИВ) са естрима Р[суб]2едда-типа; | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_nardus_3497 | |
dc.identifier.fulltext | https://cer.ihtm.bg.ac.rs/bitstream/id/5849/Disertacija.pdf | |
dc.type.version | publishedVersion |