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Thin-layer chromatography in quantitative structure-activity relationship studies
dc.creator | Milojković-Opsenica, Dušanka | |
dc.creator | Andrić, Filip | |
dc.creator | Šegan, Sandra | |
dc.creator | Trifković, Jelena | |
dc.creator | Tešić, Živoslav | |
dc.date.accessioned | 2019-01-30T18:01:19Z | |
dc.date.available | 2019-01-30T18:01:19Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1082-6076 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/2475 | |
dc.description.abstract | The methods of correlating molecular structure of substances expressed as descriptors, to their biological activity are commonly denoted as Quantitative Structure-Activity Relationships (QSARs). This concept, typically applied in drug discovery processes, is also widely used for correlation of molecular structure and physicochemical properties of solutes in so-called quantitative structure-property relationship (QSPR) studies, as well as for explanation of chromatographic behavior, i.e., separation mechanisms of analytes, where is termed as quantitative structure-retention relationship (QSRR). Mathematical expressions of structural characteristics of substances, named as molecular descriptors, can be calculated by various computational techniques or experimentally determined by different analytical methods. Thin-layer chromatography as a rapid, sensitive, and economical liquid chromatographic method has been widely used for determination of various chromatographic descriptors applicable in QSAR/QSPR studies. An overview of recently published papers dealing with this concept is presented. [GRAPHICS] . | en |
dc.publisher | Taylor & Francis Inc, Philadelphia | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172017/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Liquid Chromatography & Related Technologies | |
dc.subject | Molecular descriptors | en |
dc.subject | quantitative structure-activity | en |
dc.subject | property relationships | en |
dc.subject | statistical evaluation | en |
dc.subject | thin-layer chromatography | en |
dc.title | Thin-layer chromatography in quantitative structure-activity relationship studies | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Aндриц, Филип; Шеган, Сандра; Трифковиц, Јелена; Тесиц, Зивослав; Милојковиц-Опсеница, Дусанка; | |
dc.citation.volume | 41 | |
dc.citation.issue | 6 | |
dc.citation.spage | 272 | |
dc.citation.epage | 281 | |
dc.citation.other | 41(6): 272-281 | |
dc.citation.rank | M23 | |
dc.identifier.doi | 10.1080/10826076.2018.1447892 | |
dc.identifier.scopus | 2-s2.0-85047494333 | |
dc.identifier.wos | 000433144300003 | |
dc.type.version | publishedVersion |