Приказ основних података о документу
Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract
dc.creator | Karaman, M. | |
dc.creator | Janjušević, L. | |
dc.creator | Jakovljević, Dragica | |
dc.creator | Šibul, F. | |
dc.creator | Pejin, Boris | |
dc.date.accessioned | 2019-01-30T17:55:47Z | |
dc.date.available | 2019-01-30T17:55:47Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1478-6419 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/2214 | |
dc.description.abstract | This study outlines antioxidant and anti-AChE activities of the polysaccharide (PSH) extract from the mushroom species Amanita strobiliformis. Both the presence of α and ß glucans within the aforementioned extract was recorded. PSH extract displayed a profound scavenging activity of OH radicals (IC50 value, 11.86 ± 0.59 μg/mL) and high potential for reduction of Fe3+ ions (174.11 ± 8.70 mg eq. AA/g d.w.) being almost 48- and 5-fold more effective than mannitol and butylated hydroxytoluene used as a positive control, respectively. Compared with galanthamine (0.001 μg), the same extract exhibited a moderate anti-AChE activity (10 μg) in solid. Since purified PSH extract exhibited higher bioactivity (IC50 value 7.27 ± 0.31 μg/mL, 197.68 ± 9.47 mg eq. AA/g d.w. and 0.1 μg, respectively), it can be predominantly ascribed to the polysaccharide compounds. A. strobiliformis PSH extract may be considered as a promising resource of potent bioactive polysaccharides of natural origin successfully addressing both oxidative stress and lack of acetylcholine. | en |
dc.publisher | Taylor and Francis Ltd. | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43002/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43004/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS// | |
dc.rights | restrictedAccess | |
dc.source | Natural Product Research | |
dc.subject | Amanitaceae | en |
dc.subject | biological activity | en |
dc.subject | Mushrooms | en |
dc.subject | polar extract | en |
dc.title | Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Шибул, Ф.; Јаковљевић, Драгица; Караман, М.; Пејин, Б.; Јањушевић, Л.; | |
dc.citation.spage | 1 | |
dc.citation.epage | 5 | |
dc.citation.other | : 1-5 | |
dc.citation.rank | M22 | |
dc.identifier.doi | 10.1080/14786419.2017.1422183 | |
dc.identifier.scopus | 2-s2.0-85039854192 | |
dc.identifier.wos | 000469243700024 | |
dc.type.version | publishedVersion |