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Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells
dc.creator | Kaluđerović, Goran N. | |
dc.creator | Mijatović, Sanja | |
dc.creator | Zmejkovski, Bojana | |
dc.creator | Bulatović, Mirna | |
dc.creator | Gómez-Ruiz, Santiago | |
dc.creator | Mojic, Marija K. | |
dc.creator | Steinborn, Dirk | |
dc.creator | Miljkovic, Djordje M. | |
dc.creator | Schmidt, Harry | |
dc.creator | Stosic-Grujicic, Stanislava D. | |
dc.creator | Sabo, Tibor | |
dc.creator | Maksimović-Ivanić, Danijela D. | |
dc.date.accessioned | 2019-01-30T17:32:44Z | |
dc.date.available | 2019-01-30T17:32:44Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1756-5901 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/1112 | |
dc.description.abstract | Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line. | en |
dc.publisher | Royal Soc Chemistry, Cambridge | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS// | |
dc.relation | Alexander von Humboldt Foundation (Germany) | |
dc.rights | restrictedAccess | |
dc.source | Metallomics | |
dc.title | Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Сабо, Тибор Ј.; Змејковски, Бојана; Мојиц, Марија К.; Стеинборн, Дирк; Гомез-Руиз, Сантиаго; Булатовиц, Мирна З.; Мијатовиц, Сања A.; Калудеровиц, Горан Н.; Стосиц-Грујициц, Станислава Д.; Максимовиц-Иваниц, Данијела Д.; Миљковиц, Дјордје М.; Сцхмидт, Харрy; | |
dc.citation.volume | 4 | |
dc.citation.issue | 9 | |
dc.citation.spage | 979 | |
dc.citation.epage | 987 | |
dc.citation.other | 4(9): 979-987 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 22820831 | |
dc.identifier.doi | 10.1039/c2mt20058a | |
dc.identifier.scopus | 2-s2.0-84865492745 | |
dc.identifier.wos | 000307903700013 | |
dc.type.version | publishedVersion |