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Investigation of lipophilicity and pharmacokinetic properties of 2-(methoxy) phenylpiperazine dopamine D2 ligands
(Elsevier, 2019)
Reversed-phase thin-layer chromatography and micellar thin-layer chromatography were used in order to investigate retention behaviour and to determine lipophilicity of series of 2(methoxy)phenylpiperazine dopamine D2 ligands ...
A new species of Leonhardia Reitter, 1901 (Coleoptera, Leiodidae, Leptodirini) from Bosnia and Herzegovina, with a key to species of the genus
(Pensoft Publishers, 2021)
A new leptodirine leiodid beetle species belonging to the genus Leonhardia Reitter, 1901, L. solaki sp. nov., from a pit in Bosnia and Herzegovina (western Balkan Peninsula) is described and diagnosed. Important morphological ...
Newly Synthesized Fluorinated Cinnamylpiperazines Possessing Low In Vitro MAO-B Binding
(MDPI, 2020)
Herein, we report on the synthesis and pharmacological evaluation of ten novel fluorinated cinnamylpiperazines as potential monoamine oxidase B (MAO-B) ligands. The designed derivatives consist of either cinnamyl or ...
In vitro and in vivo evaluation of fluorinated indanone derivatives as potential positron emission tomography agents for the imaging of monoamine oxidase B in the brain
(Elsevier, 2021)
Monoamine oxidases (MAOs) play a key role in the metabolism of major monoamine neurotransmitters. In particular, the upregulation of MAO-B in Parkinson's disease, Alzheimer's disease and cancer augmented the development ...
Novel derivatives of aroylacrylic acid phenylamides as inducers of apoptosis through the ROS-mediated pathway in several cancer cell lines
(Elsevier, 2022)
In the present work, the α, β-double bond of the aroylacrylic acid phenylamides was suitably modified to optimize the toxicity–antiproliferative activity ratio of the resulting compounds 1 –5 . The phenylamides were modified ...
3D-QSAR, molecular docking and in silico ADMET studies of propiophenone derivatives with anti-HIV-1 protease activity
(Springer Nature, 2021)
HIV protease inhibitors are one of the most important agents for the treatment of HIV infection. In this work, molecular modeling studies combining 3D-QSAR, molecular docking, MESP, HOMO, and LUMO energy calculations were ...
How aromatic system size affects the sensitivities of highly energetic molecules?
(Royal Society of Chemistry, 2021)
Positive values of electrostatic potentials above the central regions of the molecular surface are strongly related to the high sensitivities of highly energetic molecules. The influence of aromatic system size on the ...
Turbulence recognition in free convective flow by thermal - video post -processing in the case of a thermal power plant mill
(Serbia : Serbian Society of Heat Transfer Engineers, 2021)
This paper presents a study of a free convection flow around the walls of a ventilation mill of the Thermal Power Plant “Kostolac B”, Kostolac, Serbia. A combined method consists of thermography and software post-processing, ...
Recombinant Bet v 1-BanLec chimera modulates functional characteristics of peritoneal murine macrophages by promoting IL-10 secretion
(Elsevier, 2021)
Allergen-specific immunotherapy (AIT) is a desensitizing treatment for allergic diseases that corrects the underlined pathological immune response to innocuous protein antigens, called allergens. Recombinant allergens ...
Assessment of the ecological status of large lowland rivers (Sava and Tisa, Serbia) based on digital microscopic investigation of the diatom communities
(Taylor & Francis, 2024)
Large lowland rivers represent an important type of ecosystem that has been under a constant anthropogenic influence (industry, thermal
power plants, untreated communal water, and agriculture) for centuries, which has led ...