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Isolation and identification of phenolic compounds from Hypericum richeri Vill. and their antioxidant capacity
dc.creator | Zdunić, Gordana | |
dc.creator | Gođevac, Dejan | |
dc.creator | Savikin, Katarina | |
dc.creator | Novaković, Miroslav | |
dc.creator | Milosavljević, Slobodan | |
dc.creator | Petrovic, Silvana | |
dc.date.accessioned | 2019-01-30T17:28:48Z | |
dc.date.available | 2019-01-30T17:28:48Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1478-6419 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/928 | |
dc.description.abstract | The chemical composition and free radical scavenging properties of the MeOH extract of Hypericum richeri and its subsequent CHCl3, n-BuOH, EtOAc and aqueous extracts were investigated. Four quercetin-3-O-glycosides, three myricetin-3-O-glycosides, 3-O- and 5-O-caffeoylquinic acid, quercetin, I3,II8-biapigenin, pseudohypericin and hypericin were identified. The constituents of the extracts were quantified using HPLC-DAD (high-performance liquid chromatography-diode array detector). Isolation of the compounds from n-BuOH and EtOAc extracts was conducted by column chromatography. Antioxidant capacity of the extracts was evaluated by superoxide radical and ABTS root+ scavenging assays and inhibition of lipid peroxidation. The EtOAc extract of H. richeri was the most potent antioxidant in all experiments. Free radical scavenging compounds were identified by HPLC-DPPH root (high-performance liquid chromatography-2,2-diphenyl-1-picrylhydrazyl) post-column derivatisation method, where all phenolic compounds except I3,II8-biapigenin exhibited radical scavenging properties. This is the first report of the presence of myricetin-3-O-rutinoside, myricetin-3-O-galactoside, myricetin-3-O-glucoside, 5-O-caffeoylquinic acid and I3,II8-biapigenin in H. richeri. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/20035/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/143012/RS// | |
dc.rights | restrictedAccess | |
dc.source | Natural Product Research | |
dc.subject | Hypericum richeri | en |
dc.subject | phenolics | en |
dc.subject | HPLC-DAD | en |
dc.subject | on-line HPLC-DPPH | en |
dc.subject | antioxidant capacity | en |
dc.title | Isolation and identification of phenolic compounds from Hypericum richeri Vill. and their antioxidant capacity | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Милосављевиц, Слободан; Савикин, Катарина; Здуниц, Гордана; Петровиц, Силвана; Новаковић, Мирослав; Гођевац, Дејан; | |
dc.citation.volume | 25 | |
dc.citation.issue | 3 | |
dc.citation.spage | 175 | |
dc.citation.epage | 187 | |
dc.citation.other | 25(3): 175-187 | |
dc.citation.rank | M22 | |
dc.identifier.pmid | 19764002 | |
dc.identifier.doi | 10.1080/14786410802401390 | |
dc.identifier.scopus | 2-s2.0-79551671472 | |
dc.identifier.wos | 000286894900001 | |
dc.type.version | publishedVersion |