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Streptomyces subtilisine (SSL) inhibitor from streptomyces hygroscopius CH-7: Detection and partial characterization
Streptomyces subtilizinu sličan inhibitor (SSL-inhibitor) iz streptomyces hygroscopicus CH-7 - detekcija i delimična karakterizacija
dc.creator | Izrael, Lidija | |
dc.creator | Karadžić, Ivanka | |
dc.creator | Gojgić-Cvijović, Gordana | |
dc.creator | Vrvić, Miroslav | |
dc.date.accessioned | 2019-01-30T17:08:58Z | |
dc.date.available | 2019-01-30T17:08:58Z | |
dc.date.issued | 2000 | |
dc.identifier.issn | 0581-1538 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/8 | |
dc.description.abstract | Strain Streptomyces (S.) hygroscopicus CH-7 during the fermentation of polyketide antibiotic produces as a by product proteolytic complex with significant trypsin like activity. Also, S. hygroscopicus CH-7 produces extracellulary proteinaceous protease inhibitor known as Streptomyces subtilisine like inhibitor (SSL-inhibitor). Detection of SSL-inhibitor is preformed on the base of stability of SSL-inhibitors on very low pH (final concentracion of TCA is 9%). Molecular mass of SSL-inhibitor is approximately 11 kDa, and it provides very wide range of inhibitory activity toward different serin proteases: trypsin, protease from Bacillus (B.) subtilis, proteinase K from Tritirachium (T.) album, protease from B. licheniformis, protease from S. griseus and the complex of proteases from S. hygroscopicus CH-7. | en |
dc.description.abstract | Soj S. hygroscopicus CH-7 u toku fermentacije ekstracelularno proizvodi proteinski inhibitor proteaza koji pripada grupi Streptomyces subtilizinu sličnim inhibitorima (Streptomyces subtilisine like inhibitor: SSL-inhibitor). Postupak za detekciju je jednostavan i bazira se na činjenici da su SSL-inhibitori stabilni na veoma niskim pH. SSL-inhibitor iz S. hygroscopicus CH-7 pokazuje širok spektar inhibitornog dejstva na: tripsin, proteazu iz B. subtilis, proteinazu K iz T. album, proteazu iz B. licheniformis, proteazu iz S. griseus i na sirovi proteoliticki kompleks S. hygroscopicus CH-7. Molekulska masa SSL-inhibitora određena gel filtracijom iznosi 11 kDa, slično većini do sada izolovanih SSL. | sr |
dc.rights | openAccess | |
dc.source | Acta biologica iugoslavica - serija B: Mikrobiologija | |
dc.subject | SSL-inhibitor | en |
dc.subject | Strepromyces hygroscopicus CH-7 | en |
dc.subject | production | en |
dc.subject | detection | en |
dc.subject | partial characterization | en |
dc.title | Streptomyces subtilisine (SSL) inhibitor from streptomyces hygroscopius CH-7: Detection and partial characterization | en |
dc.title | Streptomyces subtilizinu sličan inhibitor (SSL-inhibitor) iz streptomyces hygroscopicus CH-7 - detekcija i delimična karakterizacija | sr |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Израел, Лидија; Гојгић Цвијовић, Гордана; Врвић, Мирослав М.; Караджић, Иванка; | |
dc.citation.volume | 37 | |
dc.citation.issue | 1 | |
dc.citation.spage | 31 | |
dc.citation.epage | 36 | |
dc.citation.other | 37(1): 31-36 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_cer_8 | |
dc.type.version | publishedVersion |
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