Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones
Само за регистроване кориснике
2009
Аутори
Gligorijević, NevenkaTodorović, Tamara
Radulović, Siniša
Sladić, Dušan
Filipović, N.
Gođevac, Dejan
Jeremić, D.
Anđelković, Katarina
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
New complexes of Pt(II) and Pd(II) with 2-quinolinecarboxaldehyde selenosemicarbazone were synthesized and characterized by elemental analysis, NMR and IR spectroscopy and molar conductivity measurements. The assumed geometry of Pt(II) and Pd(II) complexes was square planar where the ligand was tridentately coordinated via the quinoline and imine nitrogen atoms and the selenium atom. The cytotoxic activity of the new Pt(II) and Pd(II) compounds, as well as of some previously synthesized Cd(II), Zn(II) and Ni(II) complexes with the same or analogous ligand, was tested against a panel of three human cancer cell lines: human cervix carcinoma cells (HeLa), human melanoma cells (FemX) and breast cancer cells (MDA-361). All investigated compounds, except Pt(II) complex, possess a strong dose-dependent cytotoxic activity of the same order of magnitude as cisplatin (CDDP). The investigation of potential of these compounds to induce HeLa cell cycle perturbations was also evaluated.
Кључне речи:
Antitumor activity / Complexes / Heterocyclic compounds / NMR spectroscopy / SelenosemicarbazoneИзвор:
European Journal of Medicinal Chemistry, 2009, 44, 4, 1623-1629Издавач:
- Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
Финансирање / пројекти:
- Синтеза, анализа и активност нових органских полидентатних лиганада и њихових комплекса са d-металима (RS-142062)
- Фармакодинамска и фармакогенетска истраживања нових лекова и предиктивна/прогностичка вредност фармакотерапије у онкологији (RS-145035)
DOI: 10.1016/j.ejmech.2008.07.033
ISSN: 0223-5234
PubMed: 18789831
WoS: 000264920000027
Scopus: 2-s2.0-61349170622
Институција/група
IHTMTY - JOUR AU - Gligorijević, Nevenka AU - Todorović, Tamara AU - Radulović, Siniša AU - Sladić, Dušan AU - Filipović, N. AU - Gođevac, Dejan AU - Jeremić, D. AU - Anđelković, Katarina PY - 2009 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/596 AB - New complexes of Pt(II) and Pd(II) with 2-quinolinecarboxaldehyde selenosemicarbazone were synthesized and characterized by elemental analysis, NMR and IR spectroscopy and molar conductivity measurements. The assumed geometry of Pt(II) and Pd(II) complexes was square planar where the ligand was tridentately coordinated via the quinoline and imine nitrogen atoms and the selenium atom. The cytotoxic activity of the new Pt(II) and Pd(II) compounds, as well as of some previously synthesized Cd(II), Zn(II) and Ni(II) complexes with the same or analogous ligand, was tested against a panel of three human cancer cell lines: human cervix carcinoma cells (HeLa), human melanoma cells (FemX) and breast cancer cells (MDA-361). All investigated compounds, except Pt(II) complex, possess a strong dose-dependent cytotoxic activity of the same order of magnitude as cisplatin (CDDP). The investigation of potential of these compounds to induce HeLa cell cycle perturbations was also evaluated. PB - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux T2 - European Journal of Medicinal Chemistry T1 - Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones VL - 44 IS - 4 SP - 1623 EP - 1629 DO - 10.1016/j.ejmech.2008.07.033 ER -
@article{ author = "Gligorijević, Nevenka and Todorović, Tamara and Radulović, Siniša and Sladić, Dušan and Filipović, N. and Gođevac, Dejan and Jeremić, D. and Anđelković, Katarina", year = "2009", abstract = "New complexes of Pt(II) and Pd(II) with 2-quinolinecarboxaldehyde selenosemicarbazone were synthesized and characterized by elemental analysis, NMR and IR spectroscopy and molar conductivity measurements. The assumed geometry of Pt(II) and Pd(II) complexes was square planar where the ligand was tridentately coordinated via the quinoline and imine nitrogen atoms and the selenium atom. The cytotoxic activity of the new Pt(II) and Pd(II) compounds, as well as of some previously synthesized Cd(II), Zn(II) and Ni(II) complexes with the same or analogous ligand, was tested against a panel of three human cancer cell lines: human cervix carcinoma cells (HeLa), human melanoma cells (FemX) and breast cancer cells (MDA-361). All investigated compounds, except Pt(II) complex, possess a strong dose-dependent cytotoxic activity of the same order of magnitude as cisplatin (CDDP). The investigation of potential of these compounds to induce HeLa cell cycle perturbations was also evaluated.", publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux", journal = "European Journal of Medicinal Chemistry", title = "Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones", volume = "44", number = "4", pages = "1623-1629", doi = "10.1016/j.ejmech.2008.07.033" }
Gligorijević, N., Todorović, T., Radulović, S., Sladić, D., Filipović, N., Gođevac, D., Jeremić, D.,& Anđelković, K.. (2009). Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones. in European Journal of Medicinal Chemistry Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 44(4), 1623-1629. https://doi.org/10.1016/j.ejmech.2008.07.033
Gligorijević N, Todorović T, Radulović S, Sladić D, Filipović N, Gođevac D, Jeremić D, Anđelković K. Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones. in European Journal of Medicinal Chemistry. 2009;44(4):1623-1629. doi:10.1016/j.ejmech.2008.07.033 .
Gligorijević, Nevenka, Todorović, Tamara, Radulović, Siniša, Sladić, Dušan, Filipović, N., Gođevac, Dejan, Jeremić, D., Anđelković, Katarina, "Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones" in European Journal of Medicinal Chemistry, 44, no. 4 (2009):1623-1629, https://doi.org/10.1016/j.ejmech.2008.07.033 . .