An improved preparation of 3-α-acetoxy-11,20-diketo-(5β)-pregnane, the key intermediate in the synthesis of 11-oxygenated corticosteroids
Само за регистроване кориснике
1967
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Although microbiological methods of introducing oxygen at C-11 of the steroid molecule are effective, it is obvious that purely synthetic way of producing cortisone and its analogs from bile acids or hecogenin have never been abandoned. Thus, we succeeded to obtain 3alpha-L-acetoxy-11,20-diketo-(5-beta)-pregnane, the key intermediate in the synthesis of 11-oxygenated corticosteroids in a very improved yield exceeding 13% calculated on starting deoxycholic acid by the following sequence of reactions.
Кључне речи:
oxygen / cortieone / acid / bile acid / ketone / pregnane derivative / article / chemistry / synthesisИзвор:
Tetrahedron Letters, 1967, 8, 48, 4799-4803Издавач:
- Elsevier
DOI: 10.1016/S0040-4039(01)89606-4
ISSN: 0040-4039
PubMed: 6066193
Scopus: 2-s2.0-0014151375
Институција/група
IHTMTY - JOUR AU - Stefanović, Milutin AU - Gašić, Miroslav AU - Hranisavljević, J. AU - Đermanović, Miodrag PY - 1967 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/4662 AB - Although microbiological methods of introducing oxygen at C-11 of the steroid molecule are effective, it is obvious that purely synthetic way of producing cortisone and its analogs from bile acids or hecogenin have never been abandoned. Thus, we succeeded to obtain 3alpha-L-acetoxy-11,20-diketo-(5-beta)-pregnane, the key intermediate in the synthesis of 11-oxygenated corticosteroids in a very improved yield exceeding 13% calculated on starting deoxycholic acid by the following sequence of reactions. PB - Elsevier T2 - Tetrahedron Letters T1 - An improved preparation of 3-α-acetoxy-11,20-diketo-(5β)-pregnane, the key intermediate in the synthesis of 11-oxygenated corticosteroids VL - 8 IS - 48 SP - 4799 EP - 4803 DO - 10.1016/S0040-4039(01)89606-4 ER -
@article{ author = "Stefanović, Milutin and Gašić, Miroslav and Hranisavljević, J. and Đermanović, Miodrag", year = "1967", abstract = "Although microbiological methods of introducing oxygen at C-11 of the steroid molecule are effective, it is obvious that purely synthetic way of producing cortisone and its analogs from bile acids or hecogenin have never been abandoned. Thus, we succeeded to obtain 3alpha-L-acetoxy-11,20-diketo-(5-beta)-pregnane, the key intermediate in the synthesis of 11-oxygenated corticosteroids in a very improved yield exceeding 13% calculated on starting deoxycholic acid by the following sequence of reactions.", publisher = "Elsevier", journal = "Tetrahedron Letters", title = "An improved preparation of 3-α-acetoxy-11,20-diketo-(5β)-pregnane, the key intermediate in the synthesis of 11-oxygenated corticosteroids", volume = "8", number = "48", pages = "4799-4803", doi = "10.1016/S0040-4039(01)89606-4" }
Stefanović, M., Gašić, M., Hranisavljević, J.,& Đermanović, M.. (1967). An improved preparation of 3-α-acetoxy-11,20-diketo-(5β)-pregnane, the key intermediate in the synthesis of 11-oxygenated corticosteroids. in Tetrahedron Letters Elsevier., 8(48), 4799-4803. https://doi.org/10.1016/S0040-4039(01)89606-4
Stefanović M, Gašić M, Hranisavljević J, Đermanović M. An improved preparation of 3-α-acetoxy-11,20-diketo-(5β)-pregnane, the key intermediate in the synthesis of 11-oxygenated corticosteroids. in Tetrahedron Letters. 1967;8(48):4799-4803. doi:10.1016/S0040-4039(01)89606-4 .
Stefanović, Milutin, Gašić, Miroslav, Hranisavljević, J., Đermanović, Miodrag, "An improved preparation of 3-α-acetoxy-11,20-diketo-(5β)-pregnane, the key intermediate in the synthesis of 11-oxygenated corticosteroids" in Tetrahedron Letters, 8, no. 48 (1967):4799-4803, https://doi.org/10.1016/S0040-4039(01)89606-4 . .