Mathematical modeling of the hypothalamic–pituitary–adrenal system activity
Samo za registrovane korisnike
2005
Članak u časopisu (Objavljena verzija)
,
Elsevier
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Mathematical modeling has proven to be valuable in understanding of the complex biological systems dynamics. In the present report we have developed an initial model of the hypothalamic-pituitary-adrenal system self-regulatory activity. A four-dimensional non-linear differential equation model of the hormone secretion was formulated and used to analyze plasma cortisol levels in humans. The aim of this work was to explore in greater detail the role of this system in normal, homeostatic, conditions, since it is the first and unavoidable step in further understanding of the role of this complex neuroendocrine system in pathophysiological conditions. Neither the underlying mechanisms nor the physiological significance of this system are fully understood yet.
Ključne reči:
HPA system / Cortisol / Mathematical model / Non-linear dynamics / Stability analysisIzvor:
Mathematical Biosciences, 2005, 197, 2, 173-187Izdavač:
- Elsevier
Finansiranje / projekti:
- Present report was partially supported by the Ministry of Sciences and Environmental Protection of Serbia under the project no. 1225, 1448, 1807.
DOI: 10.1016/j.mbs.2005.06.006
ISSN: 0025-5564; 1879-3134
WoS: 000232976200004
Scopus: 2-s2.0-25844487749
Institucija/grupa
IHTMTY - JOUR AU - Jelić, Smiljana AU - Čupić, Željko AU - Kolar-Anić, Ljiljana PY - 2005 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/4116 AB - Mathematical modeling has proven to be valuable in understanding of the complex biological systems dynamics. In the present report we have developed an initial model of the hypothalamic-pituitary-adrenal system self-regulatory activity. A four-dimensional non-linear differential equation model of the hormone secretion was formulated and used to analyze plasma cortisol levels in humans. The aim of this work was to explore in greater detail the role of this system in normal, homeostatic, conditions, since it is the first and unavoidable step in further understanding of the role of this complex neuroendocrine system in pathophysiological conditions. Neither the underlying mechanisms nor the physiological significance of this system are fully understood yet. PB - Elsevier T2 - Mathematical Biosciences T1 - Mathematical modeling of the hypothalamic–pituitary–adrenal system activity VL - 197 IS - 2 SP - 173 EP - 187 DO - 10.1016/j.mbs.2005.06.006 ER -
@article{ author = "Jelić, Smiljana and Čupić, Željko and Kolar-Anić, Ljiljana", year = "2005", abstract = "Mathematical modeling has proven to be valuable in understanding of the complex biological systems dynamics. In the present report we have developed an initial model of the hypothalamic-pituitary-adrenal system self-regulatory activity. A four-dimensional non-linear differential equation model of the hormone secretion was formulated and used to analyze plasma cortisol levels in humans. The aim of this work was to explore in greater detail the role of this system in normal, homeostatic, conditions, since it is the first and unavoidable step in further understanding of the role of this complex neuroendocrine system in pathophysiological conditions. Neither the underlying mechanisms nor the physiological significance of this system are fully understood yet.", publisher = "Elsevier", journal = "Mathematical Biosciences", title = "Mathematical modeling of the hypothalamic–pituitary–adrenal system activity", volume = "197", number = "2", pages = "173-187", doi = "10.1016/j.mbs.2005.06.006" }
Jelić, S., Čupić, Ž.,& Kolar-Anić, L.. (2005). Mathematical modeling of the hypothalamic–pituitary–adrenal system activity. in Mathematical Biosciences Elsevier., 197(2), 173-187. https://doi.org/10.1016/j.mbs.2005.06.006
Jelić S, Čupić Ž, Kolar-Anić L. Mathematical modeling of the hypothalamic–pituitary–adrenal system activity. in Mathematical Biosciences. 2005;197(2):173-187. doi:10.1016/j.mbs.2005.06.006 .
Jelić, Smiljana, Čupić, Željko, Kolar-Anić, Ljiljana, "Mathematical modeling of the hypothalamic–pituitary–adrenal system activity" in Mathematical Biosciences, 197, no. 2 (2005):173-187, https://doi.org/10.1016/j.mbs.2005.06.006 . .