Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment
Authorized Users Only
2020
Authors
Jurišić Dukovski, BiseraJuretić, Marina
Bračko, Danka
Randjelović, Danijela
Savić, Snežana
Crespo Moral, Mario
Diebold, Yolanda
Filipović-Grčić, Jelena
Pepić, Ivan
Lovrić, Jasmina
Article (Published version)
Metadata
Show full item recordAbstract
Abstract: Inflammation plays a key role in dry eye disease (DED)affecting millions of people worldwide. Non-steroidal anti-inflammatorydrugs (NSAIDs) can be used topically to act on the inflammatory componentof DED, but their limited aqueous solubility raises formulation issues.The aim of this study was development and optimization of functionalcationic nanoemulsions (NEs) for DED treatment, as a formulation approachto circumvent solubility problems, prolong drug residence at the ocularsurface and stabilize the tear film. Ibuprofen was employed as the modelNSAID, chitosan as the cationic agent, and lecithin as the anionicsurfactant enabling chitosan incorporation. Moreover, lecithin is amixture of phospholipids including phosphatidylcholine andphosphatidylethanolamine, two constituents of the natural tear filmimportant for its stability. NEs were characterized in terms of dropletsize, polydispersity index, zeta-potential, pH, viscosity, osmolarity,surface tension, entrapment efficiency..., stability, sterilizability and invitro release. NEs mucoadhesive properties were tested rheologicallyafter mixing with mucin dispersion. Biocompatibility was assessedemploying 3D HCE-T cell-based model and ex vivo model using porcinecorneas. The results of our study pointed out the NE formulation with0.05 % (w/w) chitosan as the lead formulation with physicochemicalproperties adequate for ophthalmic application, mucoadhesive characterand excellent biocompatibility.
Keywords:
dry eye disease / nanoemulsion / NSAID / chitosan / lecithinSource:
International Journal of Pharmaceutics, 2020, 576, 118979-Publisher:
- Elsevier
Funding / projects:
- Spanish Government Grant RTI2018-094071-B-C21 (MCIU/AEI/FEDER, UE)
- opical nanodelivery systems funded by the University of Zagreb (Z169)
- “Modelling of the Pharmaceutical Spray Drying Process of the Emulsions in Laboratory and Pilot Scale” in collaboration with the industrial partner PLIVA Croatia Ltd.
Note:
- The peer-reviewed version: https://cer.ihtm.bg.ac.rs/handle/123456789/4011
DOI: 10.1016/j.ijpharm.2019.118979
ISSN: 0378-5173
PubMed: 31870964
WoS: 000512972500015
Scopus: 2-s2.0-85077471068
Collections
Institution/Community
IHTMTY - JOUR AU - Jurišić Dukovski, Bisera AU - Juretić, Marina AU - Bračko, Danka AU - Randjelović, Danijela AU - Savić, Snežana AU - Crespo Moral, Mario AU - Diebold, Yolanda AU - Filipović-Grčić, Jelena AU - Pepić, Ivan AU - Lovrić, Jasmina PY - 2020 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/4012 AB - Abstract: Inflammation plays a key role in dry eye disease (DED)affecting millions of people worldwide. Non-steroidal anti-inflammatorydrugs (NSAIDs) can be used topically to act on the inflammatory componentof DED, but their limited aqueous solubility raises formulation issues.The aim of this study was development and optimization of functionalcationic nanoemulsions (NEs) for DED treatment, as a formulation approachto circumvent solubility problems, prolong drug residence at the ocularsurface and stabilize the tear film. Ibuprofen was employed as the modelNSAID, chitosan as the cationic agent, and lecithin as the anionicsurfactant enabling chitosan incorporation. Moreover, lecithin is amixture of phospholipids including phosphatidylcholine andphosphatidylethanolamine, two constituents of the natural tear filmimportant for its stability. NEs were characterized in terms of dropletsize, polydispersity index, zeta-potential, pH, viscosity, osmolarity,surface tension, entrapment efficiency, stability, sterilizability and invitro release. NEs mucoadhesive properties were tested rheologicallyafter mixing with mucin dispersion. Biocompatibility was assessedemploying 3D HCE-T cell-based model and ex vivo model using porcinecorneas. The results of our study pointed out the NE formulation with0.05 % (w/w) chitosan as the lead formulation with physicochemicalproperties adequate for ophthalmic application, mucoadhesive characterand excellent biocompatibility. PB - Elsevier T2 - International Journal of Pharmaceutics T1 - Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment VL - 576 SP - 118979 DO - 10.1016/j.ijpharm.2019.118979 ER -
@article{ author = "Jurišić Dukovski, Bisera and Juretić, Marina and Bračko, Danka and Randjelović, Danijela and Savić, Snežana and Crespo Moral, Mario and Diebold, Yolanda and Filipović-Grčić, Jelena and Pepić, Ivan and Lovrić, Jasmina", year = "2020", abstract = "Abstract: Inflammation plays a key role in dry eye disease (DED)affecting millions of people worldwide. Non-steroidal anti-inflammatorydrugs (NSAIDs) can be used topically to act on the inflammatory componentof DED, but their limited aqueous solubility raises formulation issues.The aim of this study was development and optimization of functionalcationic nanoemulsions (NEs) for DED treatment, as a formulation approachto circumvent solubility problems, prolong drug residence at the ocularsurface and stabilize the tear film. Ibuprofen was employed as the modelNSAID, chitosan as the cationic agent, and lecithin as the anionicsurfactant enabling chitosan incorporation. Moreover, lecithin is amixture of phospholipids including phosphatidylcholine andphosphatidylethanolamine, two constituents of the natural tear filmimportant for its stability. NEs were characterized in terms of dropletsize, polydispersity index, zeta-potential, pH, viscosity, osmolarity,surface tension, entrapment efficiency, stability, sterilizability and invitro release. NEs mucoadhesive properties were tested rheologicallyafter mixing with mucin dispersion. Biocompatibility was assessedemploying 3D HCE-T cell-based model and ex vivo model using porcinecorneas. The results of our study pointed out the NE formulation with0.05 % (w/w) chitosan as the lead formulation with physicochemicalproperties adequate for ophthalmic application, mucoadhesive characterand excellent biocompatibility.", publisher = "Elsevier", journal = "International Journal of Pharmaceutics", title = "Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment", volume = "576", pages = "118979", doi = "10.1016/j.ijpharm.2019.118979" }
Jurišić Dukovski, B., Juretić, M., Bračko, D., Randjelović, D., Savić, S., Crespo Moral, M., Diebold, Y., Filipović-Grčić, J., Pepić, I.,& Lovrić, J.. (2020). Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment. in International Journal of Pharmaceutics Elsevier., 576, 118979. https://doi.org/10.1016/j.ijpharm.2019.118979
Jurišić Dukovski B, Juretić M, Bračko D, Randjelović D, Savić S, Crespo Moral M, Diebold Y, Filipović-Grčić J, Pepić I, Lovrić J. Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment. in International Journal of Pharmaceutics. 2020;576:118979. doi:10.1016/j.ijpharm.2019.118979 .
Jurišić Dukovski, Bisera, Juretić, Marina, Bračko, Danka, Randjelović, Danijela, Savić, Snežana, Crespo Moral, Mario, Diebold, Yolanda, Filipović-Grčić, Jelena, Pepić, Ivan, Lovrić, Jasmina, "Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment" in International Journal of Pharmaceutics, 576 (2020):118979, https://doi.org/10.1016/j.ijpharm.2019.118979 . .