Steroidal geminal dihydroperoxides and 1,2,4,5-tetraoxanes: Structure determination and their antimalarial activity
Само за регистроване кориснике
1996
Аутори
Todorović, NinaStefanović, Milutin
Tinant, Bernard
Declercq, Jean-Paul
Makler, Michael T
Šolaja, Bogdan
Чланак у часопису (Објављена верзија)
,
Elsevier Science Inc.
Метаподаци
Приказ свих података о документуАпстракт
Cholestane-derived gem-dihydroperoxides and tetraoxanes were synthesized starting from 5e~- and 5~3-cholestan3-ones by acid-catalyzed addition of hydrogen peroxide to the ketone. They were characterized by IR, NMR, and
mass spectroscopy analysis aided by molecular mechanics calculations, and, in the instance of 5~3-cholestane3et,3~5-dihydroperoxide (6), by x-ray analysis. The synthesized compounds were tested in vitro against Plasmodium falciparum Sierra Leone (D6) and Indochina (W2) malaria clones. All compounds" were inactive to
both clones, with the exception of tetraoxane 7a, which exhibited modest activity toward D6 clone with IC5o =
155 nM
Кључне речи:
gem-dihydroperoxide / peroxide / tetraoxane / molecular mechanics / antimalarial activityИзвор:
Steroids, 1996, 61, 12, 688-696Издавач:
- Elsevier
Финансирање / пројекти:
- Serbian Academy of Sciences and Arts, Research Fund of Serbia for financial support (grant 02E4)
DOI: 10.1016/S0039-128X(96)00203-6
ISSN: 0039-128X
PubMed: 8987137
WoS: A1996VY35500003
Scopus: 2-s2.0-0030477376
Институција/група
IHTMTY - JOUR AU - Todorović, Nina AU - Stefanović, Milutin AU - Tinant, Bernard AU - Declercq, Jean-Paul AU - Makler, Michael T AU - Šolaja, Bogdan PY - 1996 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3995 AB - Cholestane-derived gem-dihydroperoxides and tetraoxanes were synthesized starting from 5e~- and 5~3-cholestan3-ones by acid-catalyzed addition of hydrogen peroxide to the ketone. They were characterized by IR, NMR, and mass spectroscopy analysis aided by molecular mechanics calculations, and, in the instance of 5~3-cholestane3et,3~5-dihydroperoxide (6), by x-ray analysis. The synthesized compounds were tested in vitro against Plasmodium falciparum Sierra Leone (D6) and Indochina (W2) malaria clones. All compounds" were inactive to both clones, with the exception of tetraoxane 7a, which exhibited modest activity toward D6 clone with IC5o = 155 nM PB - Elsevier T2 - Steroids T1 - Steroidal geminal dihydroperoxides and 1,2,4,5-tetraoxanes: Structure determination and their antimalarial activity VL - 61 IS - 12 SP - 688 EP - 696 DO - 10.1016/S0039-128X(96)00203-6 ER -
@article{ author = "Todorović, Nina and Stefanović, Milutin and Tinant, Bernard and Declercq, Jean-Paul and Makler, Michael T and Šolaja, Bogdan", year = "1996", abstract = "Cholestane-derived gem-dihydroperoxides and tetraoxanes were synthesized starting from 5e~- and 5~3-cholestan3-ones by acid-catalyzed addition of hydrogen peroxide to the ketone. They were characterized by IR, NMR, and mass spectroscopy analysis aided by molecular mechanics calculations, and, in the instance of 5~3-cholestane3et,3~5-dihydroperoxide (6), by x-ray analysis. The synthesized compounds were tested in vitro against Plasmodium falciparum Sierra Leone (D6) and Indochina (W2) malaria clones. All compounds" were inactive to both clones, with the exception of tetraoxane 7a, which exhibited modest activity toward D6 clone with IC5o = 155 nM", publisher = "Elsevier", journal = "Steroids", title = "Steroidal geminal dihydroperoxides and 1,2,4,5-tetraoxanes: Structure determination and their antimalarial activity", volume = "61", number = "12", pages = "688-696", doi = "10.1016/S0039-128X(96)00203-6" }
Todorović, N., Stefanović, M., Tinant, B., Declercq, J., Makler, M. T.,& Šolaja, B.. (1996). Steroidal geminal dihydroperoxides and 1,2,4,5-tetraoxanes: Structure determination and their antimalarial activity. in Steroids Elsevier., 61(12), 688-696. https://doi.org/10.1016/S0039-128X(96)00203-6
Todorović N, Stefanović M, Tinant B, Declercq J, Makler MT, Šolaja B. Steroidal geminal dihydroperoxides and 1,2,4,5-tetraoxanes: Structure determination and their antimalarial activity. in Steroids. 1996;61(12):688-696. doi:10.1016/S0039-128X(96)00203-6 .
Todorović, Nina, Stefanović, Milutin, Tinant, Bernard, Declercq, Jean-Paul, Makler, Michael T, Šolaja, Bogdan, "Steroidal geminal dihydroperoxides and 1,2,4,5-tetraoxanes: Structure determination and their antimalarial activity" in Steroids, 61, no. 12 (1996):688-696, https://doi.org/10.1016/S0039-128X(96)00203-6 . .