Biotransformation of nitric oxide in the cerebrospinal fluid of amyotrophic lateral sclerosis patients
Само за регистроване кориснике
2005
Аутори
Nikolić-Kokić, AleksandraStević, Zorica
Stojanović, Srđan
Blagojević, Duško
Jones, David
Pavlović, Sanja
Nikrtić, Vesna
Apostolski, Slobodan
Spasić, Mihajlo
Чланак у часопису (Објављена верзија)
,
W. S. Maney & Son Ltd
Метаподаци
Приказ свих података о документуАпстракт
Recent findings indicate that nitric oxide (NO•) over-production might be an important factor in thepathogenesis of sporadic amyotrophic lateral sclerosis (SALS). We measured significantly higherconcentrations of uric acid and thiol group-containing molecules (R–SH groups) in thecerebrospinal fluid (CSF) from SALS patients compared to controls. The above factors, togetherwith a slightly increased free iron concentration found in the CSF, favour conditions necessary forthe formation of the dinitrosyl iron complex, capable of NO•bio-transformation. Thus, weperformed ex vivosaturation of CSF (from both SALS patients and controls) with NO•. A decreasein the level of R–SH was found. This was more pronounced in the CSF from SALS patients. In theCSF from SALS patients the production of nitrite and hydroxylamine was greater than that observedin the CSF from controls. Moreover, we also found increased Cu,Zn-SOD activity in the CSF fromSALS ... patients (when compared to control subjects) but no activity corresponding to Mn-SOD inany CSF samples. As Cu,Zn-SOD can react with nitroxyl forming NO•, the conditions for a closed,but continuous, loop of NO•biotransformation are present in the CSF of ALS patients.
Кључне речи:
Dinitrosyl iron complex / uric acid / nitric oxide / cerebrospinal fluid / amyotrophic lateralsclerosisИзвор:
Redox Report, 2005, 10, 5, 265-270Издавач:
- Maney Publishing
Финансирање / пројекти:
- Ministry for Science,Technology and Development of Serbia (grant 1669)
- Ministry for Science,Technology and Development of Serbia (grant 1559)
DOI: 10.1179/135100005X70242
ISSN: 1351-0002
PubMed: 16354415
WoS: 000234389600004
Scopus: 2-s2.0-33646711195
Институција/група
IHTMTY - JOUR AU - Nikolić-Kokić, Aleksandra AU - Stević, Zorica AU - Stojanović, Srđan AU - Blagojević, Duško AU - Jones, David AU - Pavlović, Sanja AU - Nikrtić, Vesna AU - Apostolski, Slobodan AU - Spasić, Mihajlo PY - 2005 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3868 AB - Recent findings indicate that nitric oxide (NO•) over-production might be an important factor in thepathogenesis of sporadic amyotrophic lateral sclerosis (SALS). We measured significantly higherconcentrations of uric acid and thiol group-containing molecules (R–SH groups) in thecerebrospinal fluid (CSF) from SALS patients compared to controls. The above factors, togetherwith a slightly increased free iron concentration found in the CSF, favour conditions necessary forthe formation of the dinitrosyl iron complex, capable of NO•bio-transformation. Thus, weperformed ex vivosaturation of CSF (from both SALS patients and controls) with NO•. A decreasein the level of R–SH was found. This was more pronounced in the CSF from SALS patients. In theCSF from SALS patients the production of nitrite and hydroxylamine was greater than that observedin the CSF from controls. Moreover, we also found increased Cu,Zn-SOD activity in the CSF fromSALS patients (when compared to control subjects) but no activity corresponding to Mn-SOD inany CSF samples. As Cu,Zn-SOD can react with nitroxyl forming NO•, the conditions for a closed,but continuous, loop of NO•biotransformation are present in the CSF of ALS patients. PB - Maney Publishing T2 - Redox Report T1 - Biotransformation of nitric oxide in the cerebrospinal fluid of amyotrophic lateral sclerosis patients VL - 10 IS - 5 SP - 265 EP - 270 DO - 10.1179/135100005X70242 ER -
@article{ author = "Nikolić-Kokić, Aleksandra and Stević, Zorica and Stojanović, Srđan and Blagojević, Duško and Jones, David and Pavlović, Sanja and Nikrtić, Vesna and Apostolski, Slobodan and Spasić, Mihajlo", year = "2005", abstract = "Recent findings indicate that nitric oxide (NO•) over-production might be an important factor in thepathogenesis of sporadic amyotrophic lateral sclerosis (SALS). We measured significantly higherconcentrations of uric acid and thiol group-containing molecules (R–SH groups) in thecerebrospinal fluid (CSF) from SALS patients compared to controls. The above factors, togetherwith a slightly increased free iron concentration found in the CSF, favour conditions necessary forthe formation of the dinitrosyl iron complex, capable of NO•bio-transformation. Thus, weperformed ex vivosaturation of CSF (from both SALS patients and controls) with NO•. A decreasein the level of R–SH was found. This was more pronounced in the CSF from SALS patients. In theCSF from SALS patients the production of nitrite and hydroxylamine was greater than that observedin the CSF from controls. Moreover, we also found increased Cu,Zn-SOD activity in the CSF fromSALS patients (when compared to control subjects) but no activity corresponding to Mn-SOD inany CSF samples. As Cu,Zn-SOD can react with nitroxyl forming NO•, the conditions for a closed,but continuous, loop of NO•biotransformation are present in the CSF of ALS patients.", publisher = "Maney Publishing", journal = "Redox Report", title = "Biotransformation of nitric oxide in the cerebrospinal fluid of amyotrophic lateral sclerosis patients", volume = "10", number = "5", pages = "265-270", doi = "10.1179/135100005X70242" }
Nikolić-Kokić, A., Stević, Z., Stojanović, S., Blagojević, D., Jones, D., Pavlović, S., Nikrtić, V., Apostolski, S.,& Spasić, M.. (2005). Biotransformation of nitric oxide in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. in Redox Report Maney Publishing., 10(5), 265-270. https://doi.org/10.1179/135100005X70242
Nikolić-Kokić A, Stević Z, Stojanović S, Blagojević D, Jones D, Pavlović S, Nikrtić V, Apostolski S, Spasić M. Biotransformation of nitric oxide in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. in Redox Report. 2005;10(5):265-270. doi:10.1179/135100005X70242 .
Nikolić-Kokić, Aleksandra, Stević, Zorica, Stojanović, Srđan, Blagojević, Duško, Jones, David, Pavlović, Sanja, Nikrtić, Vesna, Apostolski, Slobodan, Spasić, Mihajlo, "Biotransformation of nitric oxide in the cerebrospinal fluid of amyotrophic lateral sclerosis patients" in Redox Report, 10, no. 5 (2005):265-270, https://doi.org/10.1179/135100005X70242 . .