Determination of ionization constants of selected monocarbohydrazone derivatives
Authors
Mrđan, GoranaVerbić, Tatjana
Marković, Olivera
Matijević, Borko
Vaštag, Đenđi
Apostolov, Suzana
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Carbohydrazone derivatives represent a very significant class of compounds due to their wide biological activity. Ionization states of functional groups present in the molecule are of vital importance for understanding of the pharmacokinetic and pharmacodynamic properties of the newly synthesized compounds. One of the physicochemical parameters, the ionization constant (pKa), can be used as a molecular descriptor in order to relate structure and activity of a compound, which may indicate further potential application of newly synthesized derivatives. In this work, ionization constants of twenty monocarbohydrazone derivatives were determined using potentiometric method, in order to obtain information about their ionization states under certain conditions.
Keywords:
biological activity / ionization constants / monocarbohydrazones / molecular descriptors / potentiometrySource:
13th International Scientific Conference Contemporary Materials 2020, Programme and the Book of Abstracts, 11.09.2020., 2020, 50-50Publisher:
- Academy of Sciences and Arts of the Republic of Srpska
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200125 (University of Novi Sad, Faculty of Science) (RS-200125)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM) (RS-200026)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200168 (University of Belgrade, Faculty of Chemistry) (RS-200168)
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IHTMTY - CONF AU - Mrđan, Gorana AU - Verbić, Tatjana AU - Marković, Olivera AU - Matijević, Borko AU - Vaštag, Đenđi AU - Apostolov, Suzana PY - 2020 UR - http://savremenimaterijali.info/ UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3688 AB - Carbohydrazone derivatives represent a very significant class of compounds due to their wide biological activity. Ionization states of functional groups present in the molecule are of vital importance for understanding of the pharmacokinetic and pharmacodynamic properties of the newly synthesized compounds. One of the physicochemical parameters, the ionization constant (pKa), can be used as a molecular descriptor in order to relate structure and activity of a compound, which may indicate further potential application of newly synthesized derivatives. In this work, ionization constants of twenty monocarbohydrazone derivatives were determined using potentiometric method, in order to obtain information about their ionization states under certain conditions. PB - Academy of Sciences and Arts of the Republic of Srpska C3 - 13th International Scientific Conference Contemporary Materials 2020, Programme and the Book of Abstracts, 11.09.2020. T1 - Determination of ionization constants of selected monocarbohydrazone derivatives SP - 50 EP - 50 UR - https://hdl.handle.net/21.15107/rcub_cer_3688 ER -
@conference{ author = "Mrđan, Gorana and Verbić, Tatjana and Marković, Olivera and Matijević, Borko and Vaštag, Đenđi and Apostolov, Suzana", year = "2020", abstract = "Carbohydrazone derivatives represent a very significant class of compounds due to their wide biological activity. Ionization states of functional groups present in the molecule are of vital importance for understanding of the pharmacokinetic and pharmacodynamic properties of the newly synthesized compounds. One of the physicochemical parameters, the ionization constant (pKa), can be used as a molecular descriptor in order to relate structure and activity of a compound, which may indicate further potential application of newly synthesized derivatives. In this work, ionization constants of twenty monocarbohydrazone derivatives were determined using potentiometric method, in order to obtain information about their ionization states under certain conditions.", publisher = "Academy of Sciences and Arts of the Republic of Srpska", journal = "13th International Scientific Conference Contemporary Materials 2020, Programme and the Book of Abstracts, 11.09.2020.", title = "Determination of ionization constants of selected monocarbohydrazone derivatives", pages = "50-50", url = "https://hdl.handle.net/21.15107/rcub_cer_3688" }
Mrđan, G., Verbić, T., Marković, O., Matijević, B., Vaštag, Đ.,& Apostolov, S.. (2020). Determination of ionization constants of selected monocarbohydrazone derivatives. in 13th International Scientific Conference Contemporary Materials 2020, Programme and the Book of Abstracts, 11.09.2020. Academy of Sciences and Arts of the Republic of Srpska., 50-50. https://hdl.handle.net/21.15107/rcub_cer_3688
Mrđan G, Verbić T, Marković O, Matijević B, Vaštag Đ, Apostolov S. Determination of ionization constants of selected monocarbohydrazone derivatives. in 13th International Scientific Conference Contemporary Materials 2020, Programme and the Book of Abstracts, 11.09.2020.. 2020;:50-50. https://hdl.handle.net/21.15107/rcub_cer_3688 .
Mrđan, Gorana, Verbić, Tatjana, Marković, Olivera, Matijević, Borko, Vaštag, Đenđi, Apostolov, Suzana, "Determination of ionization constants of selected monocarbohydrazone derivatives" in 13th International Scientific Conference Contemporary Materials 2020, Programme and the Book of Abstracts, 11.09.2020. (2020):50-50, https://hdl.handle.net/21.15107/rcub_cer_3688 .