Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances
Samo za registrovane korisnike
2020
Autori
Marković, MajaPanić, Vesna
Šešlija, Sanja
Milivojević, Ana D.
Spasojević, Pavle
Bošković-Vragolović, Nevenka
Pjanović, Rada
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Carriers for targeted delivery and controlled release of poorly water-soluble active
substances (PWSAS) are facing three challenges: (a) the encapsulation issues, (b)
limitations of PWSAS water solubility, and (c) burst drug release which can be
pharmacologically dangerous and economically inefficient. The present study
brings a novel strategy for encapsulation and controlled release of PWSAS—
caffeine in concentrations which are higher than its maximal water solubility
without the possibility of burst effect. The modification of hydrophilic carrier
based on poly(methacylic acid) was done using casein and liposomes. To further
increase the maximal caffeine loading inside the carrier nicotinamide was used.
The release study of the encapsulated PWSAS was elaborated with respect to morphology
of the carriers and interactions that could be established between its
structural components. The carriers swelling and the release of caffeine and nicotinamide
were also investigated dep...ending on caffeine concentration, the presence
of different liposomal formulations and the volume ratio of liposomal formulation,
in three media with different pH simulating the path of the carrier through the
human gastrointestinal tract. The synthesized carriers are promising candidates
for encapsulation of PWSAS in concentrations which are higher than its maximal
water solubility and for the targeted delivery of those dosages.
Ključne reči:
liposomes / nicotinamide / pH-sensitive hydrogels / poorly water-soluble substance / targeted deliveryIzvor:
Polymer Engineering & Science, 2020, 60, 2008-2022Izdavač:
- Wiley
Finansiranje / projekti:
- Hemijsko i strukturno dizajniranje nanomaterijala za primenu u medicini i inženjerstvu tkiva (RS-MESTD-Basic Research (BR or ON)-172026)
- Razvoj novih inkapsulacionih i enzimskih tehnologija za proizvodnju biokatalizatora i biološki aktivnih komponenata hrane u cilju povećanja njene konkurentnosti, kvaliteta i bezbednosti (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46010)
DOI: 10.1002/pen.25448
ISSN: 0032-3888
WoS: 000539099700001
Scopus: 2-s2.0-85086154200
Institucija/grupa
IHTMTY - JOUR AU - Marković, Maja AU - Panić, Vesna AU - Šešlija, Sanja AU - Milivojević, Ana D. AU - Spasojević, Pavle AU - Bošković-Vragolović, Nevenka AU - Pjanović, Rada PY - 2020 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3604 AB - Carriers for targeted delivery and controlled release of poorly water-soluble active substances (PWSAS) are facing three challenges: (a) the encapsulation issues, (b) limitations of PWSAS water solubility, and (c) burst drug release which can be pharmacologically dangerous and economically inefficient. The present study brings a novel strategy for encapsulation and controlled release of PWSAS— caffeine in concentrations which are higher than its maximal water solubility without the possibility of burst effect. The modification of hydrophilic carrier based on poly(methacylic acid) was done using casein and liposomes. To further increase the maximal caffeine loading inside the carrier nicotinamide was used. The release study of the encapsulated PWSAS was elaborated with respect to morphology of the carriers and interactions that could be established between its structural components. The carriers swelling and the release of caffeine and nicotinamide were also investigated depending on caffeine concentration, the presence of different liposomal formulations and the volume ratio of liposomal formulation, in three media with different pH simulating the path of the carrier through the human gastrointestinal tract. The synthesized carriers are promising candidates for encapsulation of PWSAS in concentrations which are higher than its maximal water solubility and for the targeted delivery of those dosages. PB - Wiley T2 - Polymer Engineering & Science T1 - Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances VL - 60 SP - 2008 EP - 2022 DO - 10.1002/pen.25448 ER -
@article{ author = "Marković, Maja and Panić, Vesna and Šešlija, Sanja and Milivojević, Ana D. and Spasojević, Pavle and Bošković-Vragolović, Nevenka and Pjanović, Rada", year = "2020", abstract = "Carriers for targeted delivery and controlled release of poorly water-soluble active substances (PWSAS) are facing three challenges: (a) the encapsulation issues, (b) limitations of PWSAS water solubility, and (c) burst drug release which can be pharmacologically dangerous and economically inefficient. The present study brings a novel strategy for encapsulation and controlled release of PWSAS— caffeine in concentrations which are higher than its maximal water solubility without the possibility of burst effect. The modification of hydrophilic carrier based on poly(methacylic acid) was done using casein and liposomes. To further increase the maximal caffeine loading inside the carrier nicotinamide was used. The release study of the encapsulated PWSAS was elaborated with respect to morphology of the carriers and interactions that could be established between its structural components. The carriers swelling and the release of caffeine and nicotinamide were also investigated depending on caffeine concentration, the presence of different liposomal formulations and the volume ratio of liposomal formulation, in three media with different pH simulating the path of the carrier through the human gastrointestinal tract. The synthesized carriers are promising candidates for encapsulation of PWSAS in concentrations which are higher than its maximal water solubility and for the targeted delivery of those dosages.", publisher = "Wiley", journal = "Polymer Engineering & Science", title = "Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances", volume = "60", pages = "2008-2022", doi = "10.1002/pen.25448" }
Marković, M., Panić, V., Šešlija, S., Milivojević, A. D., Spasojević, P., Bošković-Vragolović, N.,& Pjanović, R.. (2020). Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances. in Polymer Engineering & Science Wiley., 60, 2008-2022. https://doi.org/10.1002/pen.25448
Marković M, Panić V, Šešlija S, Milivojević AD, Spasojević P, Bošković-Vragolović N, Pjanović R. Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances. in Polymer Engineering & Science. 2020;60:2008-2022. doi:10.1002/pen.25448 .
Marković, Maja, Panić, Vesna, Šešlija, Sanja, Milivojević, Ana D., Spasojević, Pavle, Bošković-Vragolović, Nevenka, Pjanović, Rada, "Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances" in Polymer Engineering & Science, 60 (2020):2008-2022, https://doi.org/10.1002/pen.25448 . .