Heracleum orphanidis: chemical characterisation, and comparative evaluation of antioxidant and antimicrobial activities with specific interest in the influence on Pseudomonas aeruginosa PAO1
Аутори
Mileski, Ksenija SCiric, Ana D
Trifunović, Snežana
Ristic, Mihailo S
Soković, Marina
Matevski, Vlado S
Tešević, Vele
Jadranin, Milka
Marin, Petar D.
Dzamic, Ana M
Чланак у часопису (Рецензирана верзија)
Метаподаци
Приказ свих података о документуАпстракт
GC-FID and GC-MS were used to determine the chemical composition of the essential oil of the aerial parts of Heracleum orphanidis Boiss. Also, the HPLC-DAD/ESI-ToF-MS profile of the methanol extracts of aerial parts and roots was determined. The main components of the essential oil were n-octanol, octyl hexanoate and n-octyl acetate, while coumarins were the most prevalent compounds in methanol extracts. An evaluation of antioxidant activity showed that the methanol and aqueous extracts of the aerial parts had the highest potential. In terms of antimicrobial activity determined by microdilution assays, the essential oil and methanol extract of the roots showed the greatest effectiveness. The colonies of Pseudomonas aeruginosa PAO1 treated with H. orphanidis samples produced less toxic pyocyanin, showed lower twitching and flagella mobility and biofilm formatting was reduced. The analyses in this study showed the considerable biological potential of H. orphanidis considering free radica...ls and various pathogenic strains, including the wild type of P. aeruginosa.
Извор:
Food & Function, 2016, 7, 9, 4061-4074Издавач:
- Royal Soc Chemistry, Cambridge
Финансирање / пројекти:
- Микроморфолошка, фитохемијска и молекуларна истраживања биљака - систематски, еколошки и применљиви аспекти (RS-173029)
- Карактеризација и примена метаболита гљива и утврђивање потенцијала нових биофунгицида (RS-173032)
- Биоактивни природни производи самониклих, гајених и јестивих биљака: одређивање структура и активности (RS-172053)
Напомена:
- This is peer-reviewed version of the following article: Mileski, K. S.; Ćirić, A. D.; Trifunović, S. S.; Ristić, M. S.; Soković, M. D.; Matevski, V. S.; Tešević, V. V.; Jadranin, M. B.; Marin, P. D.; Džamić, A. M. Heracleum Orphanidis: Chemical Characterisation, and Comparative Evaluation of Antioxidant and Antimicrobial Activities with Specific Interest in the Influence on Pseudomonas Aeruginosa PAO1. Food and Function 2016, 7 (9), 4061–4074. https://doi.org/10.1039/c6fo01018k
- http://cer.ihtm.bg.ac.rs/handle/123456789/1923
DOI: 10.1039/c6fo01018k
ISSN: 2042-6496
PubMed: 27713984
WoS: 000384254100041
Scopus: 2-s2.0-84987888552
Институција/група
IHTMTY - JOUR AU - Mileski, Ksenija S AU - Ciric, Ana D AU - Trifunović, Snežana AU - Ristic, Mihailo S AU - Soković, Marina AU - Matevski, Vlado S AU - Tešević, Vele AU - Jadranin, Milka AU - Marin, Petar D. AU - Dzamic, Ana M PY - 2016 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3130 AB - GC-FID and GC-MS were used to determine the chemical composition of the essential oil of the aerial parts of Heracleum orphanidis Boiss. Also, the HPLC-DAD/ESI-ToF-MS profile of the methanol extracts of aerial parts and roots was determined. The main components of the essential oil were n-octanol, octyl hexanoate and n-octyl acetate, while coumarins were the most prevalent compounds in methanol extracts. An evaluation of antioxidant activity showed that the methanol and aqueous extracts of the aerial parts had the highest potential. In terms of antimicrobial activity determined by microdilution assays, the essential oil and methanol extract of the roots showed the greatest effectiveness. The colonies of Pseudomonas aeruginosa PAO1 treated with H. orphanidis samples produced less toxic pyocyanin, showed lower twitching and flagella mobility and biofilm formatting was reduced. The analyses in this study showed the considerable biological potential of H. orphanidis considering free radicals and various pathogenic strains, including the wild type of P. aeruginosa. PB - Royal Soc Chemistry, Cambridge T2 - Food & Function T1 - Heracleum orphanidis: chemical characterisation, and comparative evaluation of antioxidant and antimicrobial activities with specific interest in the influence on Pseudomonas aeruginosa PAO1 VL - 7 IS - 9 SP - 4061 EP - 4074 DO - 10.1039/c6fo01018k ER -
@article{ author = "Mileski, Ksenija S and Ciric, Ana D and Trifunović, Snežana and Ristic, Mihailo S and Soković, Marina and Matevski, Vlado S and Tešević, Vele and Jadranin, Milka and Marin, Petar D. and Dzamic, Ana M", year = "2016", abstract = "GC-FID and GC-MS were used to determine the chemical composition of the essential oil of the aerial parts of Heracleum orphanidis Boiss. Also, the HPLC-DAD/ESI-ToF-MS profile of the methanol extracts of aerial parts and roots was determined. The main components of the essential oil were n-octanol, octyl hexanoate and n-octyl acetate, while coumarins were the most prevalent compounds in methanol extracts. An evaluation of antioxidant activity showed that the methanol and aqueous extracts of the aerial parts had the highest potential. In terms of antimicrobial activity determined by microdilution assays, the essential oil and methanol extract of the roots showed the greatest effectiveness. The colonies of Pseudomonas aeruginosa PAO1 treated with H. orphanidis samples produced less toxic pyocyanin, showed lower twitching and flagella mobility and biofilm formatting was reduced. The analyses in this study showed the considerable biological potential of H. orphanidis considering free radicals and various pathogenic strains, including the wild type of P. aeruginosa.", publisher = "Royal Soc Chemistry, Cambridge", journal = "Food & Function", title = "Heracleum orphanidis: chemical characterisation, and comparative evaluation of antioxidant and antimicrobial activities with specific interest in the influence on Pseudomonas aeruginosa PAO1", volume = "7", number = "9", pages = "4061-4074", doi = "10.1039/c6fo01018k" }
Mileski, K. S., Ciric, A. D., Trifunović, S., Ristic, M. S., Soković, M., Matevski, V. S., Tešević, V., Jadranin, M., Marin, P. D.,& Dzamic, A. M.. (2016). Heracleum orphanidis: chemical characterisation, and comparative evaluation of antioxidant and antimicrobial activities with specific interest in the influence on Pseudomonas aeruginosa PAO1. in Food & Function Royal Soc Chemistry, Cambridge., 7(9), 4061-4074. https://doi.org/10.1039/c6fo01018k
Mileski KS, Ciric AD, Trifunović S, Ristic MS, Soković M, Matevski VS, Tešević V, Jadranin M, Marin PD, Dzamic AM. Heracleum orphanidis: chemical characterisation, and comparative evaluation of antioxidant and antimicrobial activities with specific interest in the influence on Pseudomonas aeruginosa PAO1. in Food & Function. 2016;7(9):4061-4074. doi:10.1039/c6fo01018k .
Mileski, Ksenija S, Ciric, Ana D, Trifunović, Snežana, Ristic, Mihailo S, Soković, Marina, Matevski, Vlado S, Tešević, Vele, Jadranin, Milka, Marin, Petar D., Dzamic, Ana M, "Heracleum orphanidis: chemical characterisation, and comparative evaluation of antioxidant and antimicrobial activities with specific interest in the influence on Pseudomonas aeruginosa PAO1" in Food & Function, 7, no. 9 (2016):4061-4074, https://doi.org/10.1039/c6fo01018k . .