Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata
Samo za registrovane korisnike
2019
Autori
Novaković, MiroslavBukvicki, Danka
Anđelković, Boban D.
Ilić-Tomić, Tatjana
Veljić, Milan
Tešević, Vele
Asakawa, Yoshinori
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Seven new bisbibenzyls (1−7) were isolated from the methanol extract of the liverwort Lunularia cruciata along with one previously known bibenzyl and five known bisbibenzyls. The structures of compounds 1−7 were elucidated on the basis of the spectroscopic data. These newly isolated bisbibenzyls may be divided into two groups, the acyclic bisbibenzyls, perrottetins (1− 3), and the cyclic analogues, riccardins (4−7). Besides standard perrottetin and riccardin structures (1 and 4, respectively), they contain phenanthrene (3 and 5), dihydrophenanthrene (2), and quinone moieties (6 and 7), rarely found in natural products. The new compounds 3 and 5, as well as the known riccardin G, exhibited cytotoxic activity against the A549 lung cancer cell line with IC50 values of 5.0, 5.0, and 2.5 μM, respectively.
Ključne reči:
liverwort / bisbibenzyls / Lunularia cruciata / structures of compounds / spectroscopic data / acyclic bisbibenzyls / perrottetins / cyclic analogues / riccardins / perrottetin and riccardin structures / phenanthrene / dihydrophenanthrene / quinone moieties / natural products / riccardin G / lung cancer / cytotoxic activityIzvor:
Journal of Natural Products, 2019, 82, 4, 694-701Izdavač:
- American Chemical Society (ACS)
Finansiranje / projekti:
- Bioaktivni prirodni proizvodi samoniklih, gajenih i jestivih biljaka: određivanje struktura i aktivnosti (RS-MESTD-Basic Research (BR or ON)-172053)
- Mikromorfološka, fitohemijska i molekularna istraživanja biljaka - sistematski, ekološki i primenljivi aspekti (RS-MESTD-Basic Research (BR or ON)-173029)
- Izučavanje mikrobiološkog diverziteta i karakterizacija korisnih sredinskih mikroorganizama (RS-MESTD-Basic Research (BR or ON)-173048)
Napomena:
- Supporting information: https://cer.ihtm.bg.ac.rs/handle/123456789/4449
Povezane informacije:
- Povezani sadržaj
https://cer.ihtm.bg.ac.rs/handle/123456789/4449
DOI: 10.1021/acs.jnatprod.8b00390
ISSN: 0974-5211
PubMed: 30848895
WoS: 000466442100002
Scopus: 2-s2.0-85062828630
Institucija/grupa
IHTMTY - JOUR AU - Novaković, Miroslav AU - Bukvicki, Danka AU - Anđelković, Boban D. AU - Ilić-Tomić, Tatjana AU - Veljić, Milan AU - Tešević, Vele AU - Asakawa, Yoshinori PY - 2019 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2838 AB - Seven new bisbibenzyls (1−7) were isolated from the methanol extract of the liverwort Lunularia cruciata along with one previously known bibenzyl and five known bisbibenzyls. The structures of compounds 1−7 were elucidated on the basis of the spectroscopic data. These newly isolated bisbibenzyls may be divided into two groups, the acyclic bisbibenzyls, perrottetins (1− 3), and the cyclic analogues, riccardins (4−7). Besides standard perrottetin and riccardin structures (1 and 4, respectively), they contain phenanthrene (3 and 5), dihydrophenanthrene (2), and quinone moieties (6 and 7), rarely found in natural products. The new compounds 3 and 5, as well as the known riccardin G, exhibited cytotoxic activity against the A549 lung cancer cell line with IC50 values of 5.0, 5.0, and 2.5 μM, respectively. PB - American Chemical Society (ACS) T2 - Journal of Natural Products T1 - Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata VL - 82 IS - 4 SP - 694 EP - 701 DO - 10.1021/acs.jnatprod.8b00390 ER -
@article{ author = "Novaković, Miroslav and Bukvicki, Danka and Anđelković, Boban D. and Ilić-Tomić, Tatjana and Veljić, Milan and Tešević, Vele and Asakawa, Yoshinori", year = "2019", abstract = "Seven new bisbibenzyls (1−7) were isolated from the methanol extract of the liverwort Lunularia cruciata along with one previously known bibenzyl and five known bisbibenzyls. The structures of compounds 1−7 were elucidated on the basis of the spectroscopic data. These newly isolated bisbibenzyls may be divided into two groups, the acyclic bisbibenzyls, perrottetins (1− 3), and the cyclic analogues, riccardins (4−7). Besides standard perrottetin and riccardin structures (1 and 4, respectively), they contain phenanthrene (3 and 5), dihydrophenanthrene (2), and quinone moieties (6 and 7), rarely found in natural products. The new compounds 3 and 5, as well as the known riccardin G, exhibited cytotoxic activity against the A549 lung cancer cell line with IC50 values of 5.0, 5.0, and 2.5 μM, respectively.", publisher = "American Chemical Society (ACS)", journal = "Journal of Natural Products", title = "Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata", volume = "82", number = "4", pages = "694-701", doi = "10.1021/acs.jnatprod.8b00390" }
Novaković, M., Bukvicki, D., Anđelković, B. D., Ilić-Tomić, T., Veljić, M., Tešević, V.,& Asakawa, Y.. (2019). Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata. in Journal of Natural Products American Chemical Society (ACS)., 82(4), 694-701. https://doi.org/10.1021/acs.jnatprod.8b00390
Novaković M, Bukvicki D, Anđelković BD, Ilić-Tomić T, Veljić M, Tešević V, Asakawa Y. Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata. in Journal of Natural Products. 2019;82(4):694-701. doi:10.1021/acs.jnatprod.8b00390 .
Novaković, Miroslav, Bukvicki, Danka, Anđelković, Boban D., Ilić-Tomić, Tatjana, Veljić, Milan, Tešević, Vele, Asakawa, Yoshinori, "Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata" in Journal of Natural Products, 82, no. 4 (2019):694-701, https://doi.org/10.1021/acs.jnatprod.8b00390 . .