Synthesis of 5-azaandrostane-3β,17β-diol protected at the 17β-hydroxyl group
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In the present paper, the preparation of 3β-hydroxy-17β-dimethyl- tert-butylsilyloxy-5-azaandrostane (15) in fourteen steps is described. B-nor-17-oxoandrost-5-en-3β-yl acetate (1) 1,2 was used as the starting material, which was transformed to the key intermediate of the synthesis, B-nor-17β-dimethyl-tert-butylsilyloxyandrost-4-en-3β-yl acetate (7).
Кључне речи:
5-azasteroids / B-nor-17-oxoandrost-5-en-3-yl acetate / 3β-hydroxy-17β-dimethyl-tert-butylsilyloxy-5-azaandrostaneИзвор:
Journal of the Serbian Chemical Society, 2004, 69, 11, 861-869Издавач:
- Serbian Chemical Society
Финансирање / пројекти:
- Ministry of Science and Enviroment of Serbia (Part of the project “Synthesis and chemical transformations of steroidal and modified steroid molecules” – Project No. 1702)
DOI: 10.2298/JSC0411861P
ISSN: 0352-5139
WoS: 000226120300004
Scopus: 2-s2.0-31544483352
Институција/група
IHTMTY - JOUR AU - Pavlović, Vladimir D. AU - Dabović, Milan AU - Martinović, Saša B. AU - Lorenc, Ljubinka AU - Kalvoda, J PY - 2004 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2705 AB - In the present paper, the preparation of 3β-hydroxy-17β-dimethyl- tert-butylsilyloxy-5-azaandrostane (15) in fourteen steps is described. B-nor-17-oxoandrost-5-en-3β-yl acetate (1) 1,2 was used as the starting material, which was transformed to the key intermediate of the synthesis, B-nor-17β-dimethyl-tert-butylsilyloxyandrost-4-en-3β-yl acetate (7). PB - Serbian Chemical Society T2 - Journal of the Serbian Chemical Society T1 - Synthesis of 5-azaandrostane-3β,17β-diol protected at the 17β-hydroxyl group VL - 69 IS - 11 SP - 861 EP - 869 DO - 10.2298/JSC0411861P ER -
@article{ author = "Pavlović, Vladimir D. and Dabović, Milan and Martinović, Saša B. and Lorenc, Ljubinka and Kalvoda, J", year = "2004", abstract = "In the present paper, the preparation of 3β-hydroxy-17β-dimethyl- tert-butylsilyloxy-5-azaandrostane (15) in fourteen steps is described. B-nor-17-oxoandrost-5-en-3β-yl acetate (1) 1,2 was used as the starting material, which was transformed to the key intermediate of the synthesis, B-nor-17β-dimethyl-tert-butylsilyloxyandrost-4-en-3β-yl acetate (7).", publisher = "Serbian Chemical Society", journal = "Journal of the Serbian Chemical Society", title = "Synthesis of 5-azaandrostane-3β,17β-diol protected at the 17β-hydroxyl group", volume = "69", number = "11", pages = "861-869", doi = "10.2298/JSC0411861P" }
Pavlović, V. D., Dabović, M., Martinović, S. B., Lorenc, L.,& Kalvoda, J.. (2004). Synthesis of 5-azaandrostane-3β,17β-diol protected at the 17β-hydroxyl group. in Journal of the Serbian Chemical Society Serbian Chemical Society., 69(11), 861-869. https://doi.org/10.2298/JSC0411861P
Pavlović VD, Dabović M, Martinović SB, Lorenc L, Kalvoda J. Synthesis of 5-azaandrostane-3β,17β-diol protected at the 17β-hydroxyl group. in Journal of the Serbian Chemical Society. 2004;69(11):861-869. doi:10.2298/JSC0411861P .
Pavlović, Vladimir D., Dabović, Milan, Martinović, Saša B., Lorenc, Ljubinka, Kalvoda, J, "Synthesis of 5-azaandrostane-3β,17β-diol protected at the 17β-hydroxyl group" in Journal of the Serbian Chemical Society, 69, no. 11 (2004):861-869, https://doi.org/10.2298/JSC0411861P . .