Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers
Samo za registrovane korisnike
2018
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Gelatin hydrogels have great potential in regenerative medicine but their weak mechanical properties are a major drawback for the load-bearing applications, such as scaffolds for tissue engineering. To overcome this deficiency, novel biodegradable hydrogels with improved mechanical properties were prepared by combining gelatine with 2-hydroxyethyl methacrylate (HEMA), using a double network synthetic procedure. The first, superporous and mechanically strong network, was obtained by free radical polymerization of HEMA at cryogenic temperature, in the presence of gelatin. Degradable poly (beta-amino ester) (PBAE) macromers of different chemical composition or molecular weight were used as crosslinkers to introduce hydrolytically labile bonds in PHEMA. The second gelatin network was formed by crosslinking gelatin with glutaraldehyde. For comparison, a set of biodegradable PHEMA networks was obtained by polymerization of HEMA at cryogenic temperature. All samples were characterized reveali...ng that mechanical strength, swelling behavior and degradation rate as well as high biocompatibility of new IPNs are in accordance with values required for scaffolds in tissue engineering applications and that tuning of these properties is accomplished by simply using different PBAE macromers.
Ključne reči:
HEMA / PBAE / Biocompatible / Degradable / Porous scaffoldsIzvor:
Polymer Testing, 2018, 68, 270-278Izdavač:
- Elsevier Sci Ltd, Oxford
Finansiranje / projekti:
- SCOPES programme of the Swiss National Science Foundation
- Swiss Agency for Development and Cooperation - IZ73ZO_152327
- Sinteza i karakterizacija novih funkcionalnih polimera i polimernih nanokompozita (RS-MESTD-Basic Research (BR or ON)-172062)
- Geološka i ekotoksikološka istraživanja u identifikaciji geopatogenih zona toksičnih elemenata u akumulacijama vode za piće-istraživanje metoda i postupaka smanjivanja uticaja biogeohemijskih anomalija (RS-MESTD-Basic Research (BR or ON)-176018)
Napomena:
- The peer-reviewed version: https://cer.ihtm.bg.ac.rs/handle/123456789/4293
DOI: 10.1016/j.polymertesting.2018.04.024
ISSN: 0142-9418
WoS: 000437076000034
Scopus: 2-s2.0-85046032696
Institucija/grupa
IHTMTY - JOUR AU - Filipović, Vuk AU - Nedeljkovic, Biljana D. Bozic AU - Vukomanović, Marija AU - Tomić, Simonida Lj. PY - 2018 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2440 AB - Gelatin hydrogels have great potential in regenerative medicine but their weak mechanical properties are a major drawback for the load-bearing applications, such as scaffolds for tissue engineering. To overcome this deficiency, novel biodegradable hydrogels with improved mechanical properties were prepared by combining gelatine with 2-hydroxyethyl methacrylate (HEMA), using a double network synthetic procedure. The first, superporous and mechanically strong network, was obtained by free radical polymerization of HEMA at cryogenic temperature, in the presence of gelatin. Degradable poly (beta-amino ester) (PBAE) macromers of different chemical composition or molecular weight were used as crosslinkers to introduce hydrolytically labile bonds in PHEMA. The second gelatin network was formed by crosslinking gelatin with glutaraldehyde. For comparison, a set of biodegradable PHEMA networks was obtained by polymerization of HEMA at cryogenic temperature. All samples were characterized revealing that mechanical strength, swelling behavior and degradation rate as well as high biocompatibility of new IPNs are in accordance with values required for scaffolds in tissue engineering applications and that tuning of these properties is accomplished by simply using different PBAE macromers. PB - Elsevier Sci Ltd, Oxford T2 - Polymer Testing T1 - Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers VL - 68 SP - 270 EP - 278 DO - 10.1016/j.polymertesting.2018.04.024 ER -
@article{ author = "Filipović, Vuk and Nedeljkovic, Biljana D. Bozic and Vukomanović, Marija and Tomić, Simonida Lj.", year = "2018", abstract = "Gelatin hydrogels have great potential in regenerative medicine but their weak mechanical properties are a major drawback for the load-bearing applications, such as scaffolds for tissue engineering. To overcome this deficiency, novel biodegradable hydrogels with improved mechanical properties were prepared by combining gelatine with 2-hydroxyethyl methacrylate (HEMA), using a double network synthetic procedure. The first, superporous and mechanically strong network, was obtained by free radical polymerization of HEMA at cryogenic temperature, in the presence of gelatin. Degradable poly (beta-amino ester) (PBAE) macromers of different chemical composition or molecular weight were used as crosslinkers to introduce hydrolytically labile bonds in PHEMA. The second gelatin network was formed by crosslinking gelatin with glutaraldehyde. For comparison, a set of biodegradable PHEMA networks was obtained by polymerization of HEMA at cryogenic temperature. All samples were characterized revealing that mechanical strength, swelling behavior and degradation rate as well as high biocompatibility of new IPNs are in accordance with values required for scaffolds in tissue engineering applications and that tuning of these properties is accomplished by simply using different PBAE macromers.", publisher = "Elsevier Sci Ltd, Oxford", journal = "Polymer Testing", title = "Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers", volume = "68", pages = "270-278", doi = "10.1016/j.polymertesting.2018.04.024" }
Filipović, V., Nedeljkovic, B. D. B., Vukomanović, M.,& Tomić, S. Lj.. (2018). Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers. in Polymer Testing Elsevier Sci Ltd, Oxford., 68, 270-278. https://doi.org/10.1016/j.polymertesting.2018.04.024
Filipović V, Nedeljkovic BDB, Vukomanović M, Tomić SL. Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers. in Polymer Testing. 2018;68:270-278. doi:10.1016/j.polymertesting.2018.04.024 .
Filipović, Vuk, Nedeljkovic, Biljana D. Bozic, Vukomanović, Marija, Tomić, Simonida Lj., "Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers" in Polymer Testing, 68 (2018):270-278, https://doi.org/10.1016/j.polymertesting.2018.04.024 . .