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Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives
dc.creator | Zukic, Selma | |
dc.creator | Veljović, Elma | |
dc.creator | Spirtovic-Halilovic, Selma | |
dc.creator | Muratovic, Samija | |
dc.creator | Osmanovic, Amar | |
dc.creator | Trifunović, Snežana | |
dc.creator | Novaković, Irena | |
dc.creator | Zavrsnik, Davorka | |
dc.date.accessioned | 2019-01-30T18:00:19Z | |
dc.date.available | 2019-01-30T18:00:19Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0011-1643 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/2430 | |
dc.description.abstract | Ten biologically active 2,2,5,5-tetramethy1-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione derivatives were synthesized and their structures were confirmed by IR, H-1 and C-13 NMR spectroscopy and mass spectrometry. Synthesized compounds were scanned for their antioxidant, antimicrobial and antiproliferative activity. Antibacterial activity was tested by the diffusion and dilution method against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, while a ntifunga I activity was tested against Candida albicans and Saccharomyces cerevisiae. Antiproliferative activity was tested against HeLa (cervical carcinoma), SW620 (colorectal adenocarcinoma, metastatic), hepatocellular carcinoma (HEpG2), lung carcinoma cells (A549) and mouse embryo fibroblast cell line (3T3). The best antioxidant activity showed compound 2 with two hydroxy groups substituted on phenyl ring in positions 2' and 3'. The best antimicrobial activity of all synthesized compounds showed compound 8, while the best antiproliferative activity showed compound 6. Results signify the importance of xanthene-1,8-dione derivatives as potential antioxidant and antiproliferative agents. | en |
dc.publisher | Croatian Chemical Soc, Zagreb | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Croatica Chemica Acta | |
dc.subject | xanthene-1,8-diones | en |
dc.subject | antimicrobial activity | en |
dc.subject | antiproliferative activity | en |
dc.subject | antioxidant potency | en |
dc.title | Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives | en |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Вељовиц, Елма; Трифуновиц, Снезана; Муратовиц, Самија; Спиртовиц-Халиловиц, Селма; Османовиц, Aмар; Заврсник, Даворка; Зукиц, Селма; Новаковић, Ирена; | |
dc.citation.volume | 91 | |
dc.citation.issue | 1 | |
dc.citation.spage | 1 | |
dc.citation.epage | 9 | |
dc.citation.other | 91(1): 1-9 | |
dc.citation.rank | M23 | |
dc.identifier.doi | 10.5562/cca3225 | |
dc.identifier.fulltext | https://cer.ihtm.bg.ac.rs//bitstream/id/8792/2428.pdf | |
dc.identifier.scopus | 2-s2.0-85047193004 | |
dc.identifier.wos | 000447334900001 | |
dc.type.version | publishedVersion |