Приказ основних података о документу
Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin
dc.creator | Karaman, M. | |
dc.creator | Tesanovic, K. | |
dc.creator | Novakovic, A. | |
dc.creator | Jakovljević, Dragica | |
dc.creator | Janjusevic, L. | |
dc.creator | Sibul, F. | |
dc.creator | Pejin, Boris | |
dc.date.accessioned | 2019-01-30T17:59:27Z | |
dc.date.available | 2019-01-30T17:59:27Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1478-6419 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/2388 | |
dc.description.abstract | In vitro acetylholinesterase (AChE) inhibitory activity of an autochthonous sample of the mushroom Coprinus comatus (encompassing fruiting body FB, mycelia M and filtrate F from the submerged cultivation) was the subject of this study. C. comatus F extract exhibited rather potent anti-AChE activity (73.0 ± 1.5%) at in liquid conditions, comparable to those of the conventional drug donepezil (80.6 ± 1.4%). Also, the same extract exhibited high anti-AChE activity (1 µg) in solid. While its FTIR spectrum indicated the presence of phenolic compounds, quercetin (28.1 µg g−1 d.w.) was found to affect the observed bioactivity (59.8 ± 0.9%). This is the first report of profound anti-AChE activity of any C. comatus extract, a medicinal mushroom that has been successfully cultivated in P.R. China, due to the demanding needs of food industry. | en |
dc.publisher | Taylor and Francis Ltd. | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43002/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43010/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46001/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172058/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173040/RS// | |
dc.rights | restrictedAccess | |
dc.source | Natural Product Research | |
dc.subject | AChE inhibitory activity | en |
dc.subject | Coprinus comatus filtrate extract | en |
dc.subject | new AD health promoting product | en |
dc.subject | polyphenolic profile | en |
dc.subject | quercetin | en |
dc.title | Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јаковљевић, Драгица; Новаковиц, A.; Јањусевиц, Л.; Сибул, Ф.; Тесановиц, К.; Пејин, Б.; Караман, М.; | |
dc.citation.volume | 34 | |
dc.citation.issue | 16 | |
dc.citation.spage | 2346 | |
dc.citation.epage | 2350 | |
dc.citation.other | ||
dc.citation.rank | M22 | |
dc.identifier.doi | 10.1080/14786419.2018.1533831 | |
dc.identifier.scopus | 2-s2.0-85057546516 | |
dc.identifier.wos | 000561132800017 | |
dc.type.version | publishedVersion |