AFM studies of DNA structures extracted from adriamycin treated and non-treated Erlich tumor cells
AFM mikroskopija DNA izolovane iz Erlihovih tumorskih ćelija tretiranih i netretiranih adriamicinom
2005
Аутори
Avramov Ivić, MilkaPetrović, Slobodan D.
Kalman, E
Milosavljevic, T
Reljin, I
Reljin, B
Bogdanović, G.
Baltic, VV
Keresztes, Z
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Atomic force microscopy (AFM), a unique tool to investigate drug treatment of cancer cells, was used to analyze the anti-neoplastic activity of adriamycin by comparing DNA structures of non-treated and adriamycin-treated Ehrlich tumor cells. The non-treated cells exhibited a highly branched intact chromatin structure, related to the intensive DNA replication in cancer cells. Images from adriamycin-treated tumor cells showed that the DNA chains were broken and the chromatin structure had been destroyed. Possible explanations for these effects of adriamycin are considered: breakage of hydrogen bonding, oxidation and intercalation effects, as well as the poisoning of topoisomerase enzyme. DNA fractal and multifractal analyses performed in order to evaluate the degree of bond scission, showed that the treated DNA had become more fractal compared to non-treated DNA.
DNA izolovana iz Erlihovih tumorskih ćelija je AFM mikroskopijom posmatrana prethodno tretirana adriamicinom i u netretiranom stanju, radi poređenja. AFM mikroskopija pruža mogućnost dobijanja direktne slike izgleda DNA strukture maligne ćelije koja nije tretirana lekom i iste strukture posle delovanja adrijamicina, što daje nove podatke o delovanju citostatika na malignu ćeliju. Netretirane ćelije (viđene AF Mmikroskopijom) su ispoljile netaknutu strukturu hromatina koja odgovara intenzivnoj DNA replikaciji u malignoj ćeliji. Maligne ćelije tretirane adriamicinom su pokazale da su DNA lanci pokidani tj. dalja replikacija je sprečena, što je jedan od osnova aktivnosti citostatika. Multifraktalna analiza AFM mikroskopskih slika tretirane i netretirane DNA je kvantitativno potvrdila zaključke dobijene mikroskopijom jer su grafici AFM slika uzoraka tretiranih adriamicinom pokazali fraktalniju strukturu od AFM slika netretiranih malignih ćelija kod kojih grafik ukazuje na potpuni gubitak f...raktalnosti, što je znak prisutnog patološkog procesa u organizmu.
Кључне речи:
adriamycin / Ehrlich tumor cells / atomic force microscopy / topoisomerase / fractal and multifractal analysisИзвор:
Journal of the Serbian Chemical Society, 2005, 70, 6, 823-831Издавач:
- Serbian Chemical Society
DOI: 10.2298/JSC0506823A
ISSN: 0352-5139
WoS: 000231057300005
Scopus: 2-s2.0-31544450291
Институција/група
IHTMTY - JOUR AU - Avramov Ivić, Milka AU - Petrović, Slobodan D. AU - Kalman, E AU - Milosavljevic, T AU - Reljin, I AU - Reljin, B AU - Bogdanović, G. AU - Baltic, VV AU - Keresztes, Z PY - 2005 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/189 AB - Atomic force microscopy (AFM), a unique tool to investigate drug treatment of cancer cells, was used to analyze the anti-neoplastic activity of adriamycin by comparing DNA structures of non-treated and adriamycin-treated Ehrlich tumor cells. The non-treated cells exhibited a highly branched intact chromatin structure, related to the intensive DNA replication in cancer cells. Images from adriamycin-treated tumor cells showed that the DNA chains were broken and the chromatin structure had been destroyed. Possible explanations for these effects of adriamycin are considered: breakage of hydrogen bonding, oxidation and intercalation effects, as well as the poisoning of topoisomerase enzyme. DNA fractal and multifractal analyses performed in order to evaluate the degree of bond scission, showed that the treated DNA had become more fractal compared to non-treated DNA. AB - DNA izolovana iz Erlihovih tumorskih ćelija je AFM mikroskopijom posmatrana prethodno tretirana adriamicinom i u netretiranom stanju, radi poređenja. AFM mikroskopija pruža mogućnost dobijanja direktne slike izgleda DNA strukture maligne ćelije koja nije tretirana lekom i iste strukture posle delovanja adrijamicina, što daje nove podatke o delovanju citostatika na malignu ćeliju. Netretirane ćelije (viđene AF Mmikroskopijom) su ispoljile netaknutu strukturu hromatina koja odgovara intenzivnoj DNA replikaciji u malignoj ćeliji. Maligne ćelije tretirane adriamicinom su pokazale da su DNA lanci pokidani tj. dalja replikacija je sprečena, što je jedan od osnova aktivnosti citostatika. Multifraktalna analiza AFM mikroskopskih slika tretirane i netretirane DNA je kvantitativno potvrdila zaključke dobijene mikroskopijom jer su grafici AFM slika uzoraka tretiranih adriamicinom pokazali fraktalniju strukturu od AFM slika netretiranih malignih ćelija kod kojih grafik ukazuje na potpuni gubitak fraktalnosti, što je znak prisutnog patološkog procesa u organizmu. PB - Serbian Chemical Society T2 - Journal of the Serbian Chemical Society T1 - AFM studies of DNA structures extracted from adriamycin treated and non-treated Erlich tumor cells T1 - AFM mikroskopija DNA izolovane iz Erlihovih tumorskih ćelija tretiranih i netretiranih adriamicinom VL - 70 IS - 6 SP - 823 EP - 831 DO - 10.2298/JSC0506823A ER -
@article{ author = "Avramov Ivić, Milka and Petrović, Slobodan D. and Kalman, E and Milosavljevic, T and Reljin, I and Reljin, B and Bogdanović, G. and Baltic, VV and Keresztes, Z", year = "2005", abstract = "Atomic force microscopy (AFM), a unique tool to investigate drug treatment of cancer cells, was used to analyze the anti-neoplastic activity of adriamycin by comparing DNA structures of non-treated and adriamycin-treated Ehrlich tumor cells. The non-treated cells exhibited a highly branched intact chromatin structure, related to the intensive DNA replication in cancer cells. Images from adriamycin-treated tumor cells showed that the DNA chains were broken and the chromatin structure had been destroyed. Possible explanations for these effects of adriamycin are considered: breakage of hydrogen bonding, oxidation and intercalation effects, as well as the poisoning of topoisomerase enzyme. DNA fractal and multifractal analyses performed in order to evaluate the degree of bond scission, showed that the treated DNA had become more fractal compared to non-treated DNA., DNA izolovana iz Erlihovih tumorskih ćelija je AFM mikroskopijom posmatrana prethodno tretirana adriamicinom i u netretiranom stanju, radi poređenja. AFM mikroskopija pruža mogućnost dobijanja direktne slike izgleda DNA strukture maligne ćelije koja nije tretirana lekom i iste strukture posle delovanja adrijamicina, što daje nove podatke o delovanju citostatika na malignu ćeliju. Netretirane ćelije (viđene AF Mmikroskopijom) su ispoljile netaknutu strukturu hromatina koja odgovara intenzivnoj DNA replikaciji u malignoj ćeliji. Maligne ćelije tretirane adriamicinom su pokazale da su DNA lanci pokidani tj. dalja replikacija je sprečena, što je jedan od osnova aktivnosti citostatika. Multifraktalna analiza AFM mikroskopskih slika tretirane i netretirane DNA je kvantitativno potvrdila zaključke dobijene mikroskopijom jer su grafici AFM slika uzoraka tretiranih adriamicinom pokazali fraktalniju strukturu od AFM slika netretiranih malignih ćelija kod kojih grafik ukazuje na potpuni gubitak fraktalnosti, što je znak prisutnog patološkog procesa u organizmu.", publisher = "Serbian Chemical Society", journal = "Journal of the Serbian Chemical Society", title = "AFM studies of DNA structures extracted from adriamycin treated and non-treated Erlich tumor cells, AFM mikroskopija DNA izolovane iz Erlihovih tumorskih ćelija tretiranih i netretiranih adriamicinom", volume = "70", number = "6", pages = "823-831", doi = "10.2298/JSC0506823A" }
Avramov Ivić, M., Petrović, S. D., Kalman, E., Milosavljevic, T., Reljin, I., Reljin, B., Bogdanović, G., Baltic, V.,& Keresztes, Z.. (2005). AFM studies of DNA structures extracted from adriamycin treated and non-treated Erlich tumor cells. in Journal of the Serbian Chemical Society Serbian Chemical Society., 70(6), 823-831. https://doi.org/10.2298/JSC0506823A
Avramov Ivić M, Petrović SD, Kalman E, Milosavljevic T, Reljin I, Reljin B, Bogdanović G, Baltic V, Keresztes Z. AFM studies of DNA structures extracted from adriamycin treated and non-treated Erlich tumor cells. in Journal of the Serbian Chemical Society. 2005;70(6):823-831. doi:10.2298/JSC0506823A .
Avramov Ivić, Milka, Petrović, Slobodan D., Kalman, E, Milosavljevic, T, Reljin, I, Reljin, B, Bogdanović, G., Baltic, VV, Keresztes, Z, "AFM studies of DNA structures extracted from adriamycin treated and non-treated Erlich tumor cells" in Journal of the Serbian Chemical Society, 70, no. 6 (2005):823-831, https://doi.org/10.2298/JSC0506823A . .