Electrochemical characterization of phenytoin and its derivatives on bare gold electrode
Samo za registrovane korisnike
2015
Autori
Trišović, NemanjaBožić, Bojan
Lović, Jelena
Vitnik, Vesna
Vitnik, Željko
Petrović, Slobodan D.
Avramov Ivić, Milka
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Phenytoin (5,5-diphenylhydantoin), one of the most frequently used anticonvulsant and antiarrhythmic drugs, was examined and determined at bare gold electrode in 0.05 M NaHCO3 using its anodic activity by cyclic voltammetry (CV) and square wave voltammetry (SWV). Gold electrode is highly sensitive to the phenytoin concentration (the investigated level of concentrations is usually found in human serum of patients treated with phenytoin), providing linear relationships for a set of lower concentrations (0.5, 0.6, 0.8, 1.0 mu mol dm(-3)) and for a set of higher concentrations (10, 20, 30, 40, 50 mu mol dm(-3)). The effects of the substituent on the phenyl rings on the electrochemical behavior of two derivatives, 5,5-di(4-chlorophenyl) hydantoin and 5,5-di(4-methylphenyl) hydantoin, were examined by CV. A computational study in correlation with the experimental voltammetric results enabled to propose the oxidation mechanisms: the investigated compounds undergo oxidation involving transfer ...of 1e(-) and 1 proton by irreversible, diffusion controlled process.
Ključne reči:
phenytoin derivatives / gold electrode / concentration dependency / DFT calculationIzvor:
Electrochimica Acta, 2015, 161, 378-387Izdavač:
- Oxford : Pergamon-Elsevier Science Ltd
Finansiranje / projekti:
- Proučavanje sinteze, strukture i aktivnosti organskih jedinjenja prirodnog i sintetskog porekla (RS-MESTD-Basic Research (BR or ON)-172013)
- Racionalni dizajn i sinteza biološki aktivnih i koordinacionih jedinjenja i funkcionalnih materijala, relevantnih u (bio)nanotehnologiji (RS-MESTD-Basic Research (BR or ON)-172035)
- Nov pristup dizajniranju materijala za konverziju i skladištenje energije (RS-MESTD-Basic Research (BR or ON)-172060)
- Modeliranje i numeričke simulacije složenih višečestičnih sistema (RS-MESTD-Basic Research (BR or ON)-171017)
DOI: 10.1016/j.electacta.2015.02.114
ISSN: 0013-4686
WoS: 000351693500049
Scopus: 2-s2.0-84923375507
Institucija/grupa
IHTMTY - JOUR AU - Trišović, Nemanja AU - Božić, Bojan AU - Lović, Jelena AU - Vitnik, Vesna AU - Vitnik, Željko AU - Petrović, Slobodan D. AU - Avramov Ivić, Milka PY - 2015 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1756 AB - Phenytoin (5,5-diphenylhydantoin), one of the most frequently used anticonvulsant and antiarrhythmic drugs, was examined and determined at bare gold electrode in 0.05 M NaHCO3 using its anodic activity by cyclic voltammetry (CV) and square wave voltammetry (SWV). Gold electrode is highly sensitive to the phenytoin concentration (the investigated level of concentrations is usually found in human serum of patients treated with phenytoin), providing linear relationships for a set of lower concentrations (0.5, 0.6, 0.8, 1.0 mu mol dm(-3)) and for a set of higher concentrations (10, 20, 30, 40, 50 mu mol dm(-3)). The effects of the substituent on the phenyl rings on the electrochemical behavior of two derivatives, 5,5-di(4-chlorophenyl) hydantoin and 5,5-di(4-methylphenyl) hydantoin, were examined by CV. A computational study in correlation with the experimental voltammetric results enabled to propose the oxidation mechanisms: the investigated compounds undergo oxidation involving transfer of 1e(-) and 1 proton by irreversible, diffusion controlled process. PB - Oxford : Pergamon-Elsevier Science Ltd T2 - Electrochimica Acta T1 - Electrochemical characterization of phenytoin and its derivatives on bare gold electrode VL - 161 SP - 378 EP - 387 DO - 10.1016/j.electacta.2015.02.114 ER -
@article{ author = "Trišović, Nemanja and Božić, Bojan and Lović, Jelena and Vitnik, Vesna and Vitnik, Željko and Petrović, Slobodan D. and Avramov Ivić, Milka", year = "2015", abstract = "Phenytoin (5,5-diphenylhydantoin), one of the most frequently used anticonvulsant and antiarrhythmic drugs, was examined and determined at bare gold electrode in 0.05 M NaHCO3 using its anodic activity by cyclic voltammetry (CV) and square wave voltammetry (SWV). Gold electrode is highly sensitive to the phenytoin concentration (the investigated level of concentrations is usually found in human serum of patients treated with phenytoin), providing linear relationships for a set of lower concentrations (0.5, 0.6, 0.8, 1.0 mu mol dm(-3)) and for a set of higher concentrations (10, 20, 30, 40, 50 mu mol dm(-3)). The effects of the substituent on the phenyl rings on the electrochemical behavior of two derivatives, 5,5-di(4-chlorophenyl) hydantoin and 5,5-di(4-methylphenyl) hydantoin, were examined by CV. A computational study in correlation with the experimental voltammetric results enabled to propose the oxidation mechanisms: the investigated compounds undergo oxidation involving transfer of 1e(-) and 1 proton by irreversible, diffusion controlled process.", publisher = "Oxford : Pergamon-Elsevier Science Ltd", journal = "Electrochimica Acta", title = "Electrochemical characterization of phenytoin and its derivatives on bare gold electrode", volume = "161", pages = "378-387", doi = "10.1016/j.electacta.2015.02.114" }
Trišović, N., Božić, B., Lović, J., Vitnik, V., Vitnik, Ž., Petrović, S. D.,& Avramov Ivić, M.. (2015). Electrochemical characterization of phenytoin and its derivatives on bare gold electrode. in Electrochimica Acta Oxford : Pergamon-Elsevier Science Ltd., 161, 378-387. https://doi.org/10.1016/j.electacta.2015.02.114
Trišović N, Božić B, Lović J, Vitnik V, Vitnik Ž, Petrović SD, Avramov Ivić M. Electrochemical characterization of phenytoin and its derivatives on bare gold electrode. in Electrochimica Acta. 2015;161:378-387. doi:10.1016/j.electacta.2015.02.114 .
Trišović, Nemanja, Božić, Bojan, Lović, Jelena, Vitnik, Vesna, Vitnik, Željko, Petrović, Slobodan D., Avramov Ivić, Milka, "Electrochemical characterization of phenytoin and its derivatives on bare gold electrode" in Electrochimica Acta, 161 (2015):378-387, https://doi.org/10.1016/j.electacta.2015.02.114 . .