Inorganically modified diatomite as a potential prolonged-release drug carrier
Samo za registrovane korisnike
2014
Autori
Janicijevic, JelenaKrajisnik, Danina
Calija, Bojan
Dobricic, Vladimir
Dakovic, Aleksandra
Krstić, Jugoslav
Marković, Marija
Milic, Jela
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Inorganic modification of diatomite was performed with the precipitation product of partially neutralized aluminum sulfate solution at three different mass ratios. The starting and the modified diatomites were characterized by SEM-EDS, FTIR, thermal analysis and zeta potential measurements and evaluated for drug loading capacity in adsorption batch experiments using diclofenac sodium (DS) as a model drug. In vitro drug release studies were performed in phosphate buffer pH 6.8 from comprimates containing: the drug adsorbed onto the selected modified diatomite sample (DAMD), physical mixture of the drug with the selected modified diatomite sample (PMDMD) and physical mixture of the drug with the starting diatomite (PMDD). In vivo acute toxicity testing of the modified diatomite samples was performed on mice. High adsorbent loading of the selected modified diatomite sample (similar to 250 mg/g in 2 h) enabled the preparation of comprimates containing adsorbed DS in the amount near to its ...therapeutic dose. Drug release studies demonstrated prolonged release of DS over a period of 8 h from both DAMD comprimates (18% after 8 h) and PMDMD comprimates (45% after 8 h). The release kinetics for DAMD and PMDMD comprimates fitted well with Korsmeyer-Peppas and Bhaskar models, indicating that the release mechanism was a combination of non-Fickian diffusion and ion exchange process.
Ključne reči:
Diatomite / Inorganic modification / Diclofenac sodium / Adsorption / Prolonged drug releaseIzvor:
Materials Science & Engineering C-Materials For Biological Applications, 2014, 42, 412-420Izdavač:
- Elsevier
Finansiranje / projekti:
- Razvoj mikro- i nanosistema kao nosača za lekove sa antiinflamatornim delovanjem i metoda za njihovu karakterizaciju (RS-MESTD-Technological Development (TD or TR)-34031)
- Porozni materijali na bazi oksida u zaštiti životne sredine od genotoksičnih supstanci (RS-MESTD-Basic Research (BR or ON)-172018)
DOI: 10.1016/j.msec.2014.05.052
ISSN: 0928-4931
PubMed: 25063135
WoS: 000340687400052
Scopus: 2-s2.0-84902655546
Institucija/grupa
IHTMTY - JOUR AU - Janicijevic, Jelena AU - Krajisnik, Danina AU - Calija, Bojan AU - Dobricic, Vladimir AU - Dakovic, Aleksandra AU - Krstić, Jugoslav AU - Marković, Marija AU - Milic, Jela PY - 2014 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1589 AB - Inorganic modification of diatomite was performed with the precipitation product of partially neutralized aluminum sulfate solution at three different mass ratios. The starting and the modified diatomites were characterized by SEM-EDS, FTIR, thermal analysis and zeta potential measurements and evaluated for drug loading capacity in adsorption batch experiments using diclofenac sodium (DS) as a model drug. In vitro drug release studies were performed in phosphate buffer pH 6.8 from comprimates containing: the drug adsorbed onto the selected modified diatomite sample (DAMD), physical mixture of the drug with the selected modified diatomite sample (PMDMD) and physical mixture of the drug with the starting diatomite (PMDD). In vivo acute toxicity testing of the modified diatomite samples was performed on mice. High adsorbent loading of the selected modified diatomite sample (similar to 250 mg/g in 2 h) enabled the preparation of comprimates containing adsorbed DS in the amount near to its therapeutic dose. Drug release studies demonstrated prolonged release of DS over a period of 8 h from both DAMD comprimates (18% after 8 h) and PMDMD comprimates (45% after 8 h). The release kinetics for DAMD and PMDMD comprimates fitted well with Korsmeyer-Peppas and Bhaskar models, indicating that the release mechanism was a combination of non-Fickian diffusion and ion exchange process. PB - Elsevier T2 - Materials Science & Engineering C-Materials For Biological Applications T1 - Inorganically modified diatomite as a potential prolonged-release drug carrier VL - 42 SP - 412 EP - 420 DO - 10.1016/j.msec.2014.05.052 ER -
@article{ author = "Janicijevic, Jelena and Krajisnik, Danina and Calija, Bojan and Dobricic, Vladimir and Dakovic, Aleksandra and Krstić, Jugoslav and Marković, Marija and Milic, Jela", year = "2014", abstract = "Inorganic modification of diatomite was performed with the precipitation product of partially neutralized aluminum sulfate solution at three different mass ratios. The starting and the modified diatomites were characterized by SEM-EDS, FTIR, thermal analysis and zeta potential measurements and evaluated for drug loading capacity in adsorption batch experiments using diclofenac sodium (DS) as a model drug. In vitro drug release studies were performed in phosphate buffer pH 6.8 from comprimates containing: the drug adsorbed onto the selected modified diatomite sample (DAMD), physical mixture of the drug with the selected modified diatomite sample (PMDMD) and physical mixture of the drug with the starting diatomite (PMDD). In vivo acute toxicity testing of the modified diatomite samples was performed on mice. High adsorbent loading of the selected modified diatomite sample (similar to 250 mg/g in 2 h) enabled the preparation of comprimates containing adsorbed DS in the amount near to its therapeutic dose. Drug release studies demonstrated prolonged release of DS over a period of 8 h from both DAMD comprimates (18% after 8 h) and PMDMD comprimates (45% after 8 h). The release kinetics for DAMD and PMDMD comprimates fitted well with Korsmeyer-Peppas and Bhaskar models, indicating that the release mechanism was a combination of non-Fickian diffusion and ion exchange process.", publisher = "Elsevier", journal = "Materials Science & Engineering C-Materials For Biological Applications", title = "Inorganically modified diatomite as a potential prolonged-release drug carrier", volume = "42", pages = "412-420", doi = "10.1016/j.msec.2014.05.052" }
Janicijevic, J., Krajisnik, D., Calija, B., Dobricic, V., Dakovic, A., Krstić, J., Marković, M.,& Milic, J.. (2014). Inorganically modified diatomite as a potential prolonged-release drug carrier. in Materials Science & Engineering C-Materials For Biological Applications Elsevier., 42, 412-420. https://doi.org/10.1016/j.msec.2014.05.052
Janicijevic J, Krajisnik D, Calija B, Dobricic V, Dakovic A, Krstić J, Marković M, Milic J. Inorganically modified diatomite as a potential prolonged-release drug carrier. in Materials Science & Engineering C-Materials For Biological Applications. 2014;42:412-420. doi:10.1016/j.msec.2014.05.052 .
Janicijevic, Jelena, Krajisnik, Danina, Calija, Bojan, Dobricic, Vladimir, Dakovic, Aleksandra, Krstić, Jugoslav, Marković, Marija, Milic, Jela, "Inorganically modified diatomite as a potential prolonged-release drug carrier" in Materials Science & Engineering C-Materials For Biological Applications, 42 (2014):412-420, https://doi.org/10.1016/j.msec.2014.05.052 . .