Sucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture design
Samo za registrovane korisnike
2014
Autori
Todosijević, MarijaCekic, Nebojsa
Savić, Miroslav M.
Gasperlin, Mirjana
Randjelović, Danijela
Savić, Snežana D.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
We assessed the functionality of sucrose esters (sucrose laurate, myristate, palmitate, and stearate), relatively innocuous nonionic surfactants, in formulation of biocompatible microemulsions. The putative influence of surfactant structure on the extension of microemulsion region was explored through the construction of the pseudo-ternary phase diagrams for the isopropyl myristate/sucrose ester-isopropyl alcohol/water system, using the titration method and mixture experimental approach. Minor changes in surfactant tail length strongly affected the microemulsion area boundaries. D-optimal mixture design proved to be highly applicable in detecting the microemulsion regions. Examination of conductivity, rheology, and thermal behavior of the selected sucrose laurate and sucrose myristate-based microemulsions, upon dilution with water, indicated existence of percolation threshold and suggested the phase inversion from water-in-oil to oil-in-water via a bicontinuous structure. Atomic force ...micrographs confirmed the suggested type of microemulsions and were valuable in further exploring their inner structure. The solubilization capacity of aceclofenac as a model drug has decreased as the water volume fraction in microemulsion increased. High surfactant concentration and the measured solubility of aceclofenac in microemulsion components suggested that the interfacial film may mostly contribute to aceclofenac solubilization.
Ključne reči:
Biocompatible sucrose ester / Microemulsion / D-optimal mixture design / Atomic force microscopy / AceclofenacIzvor:
Colloid and Polymer Science, 2014, 292, 12, 3061-3076Izdavač:
- Springer, New York
Finansiranje / projekti:
- Razvoj mikro- i nanosistema kao nosača za lekove sa antiinflamatornim delovanjem i metoda za njihovu karakterizaciju (RS-34031)
- Mikro, nano-sistemi i senzori za primenu u elektroprivredi, procesnoj industriji i zaštiti životne sredine (RS-32008)
DOI: 10.1007/s00396-014-3351-4
ISSN: 0303-402X
WoS: 000344880000001
Scopus: 2-s2.0-84920249616
Institucija/grupa
IHTMTY - JOUR AU - Todosijević, Marija AU - Cekic, Nebojsa AU - Savić, Miroslav M. AU - Gasperlin, Mirjana AU - Randjelović, Danijela AU - Savić, Snežana D. PY - 2014 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1411 AB - We assessed the functionality of sucrose esters (sucrose laurate, myristate, palmitate, and stearate), relatively innocuous nonionic surfactants, in formulation of biocompatible microemulsions. The putative influence of surfactant structure on the extension of microemulsion region was explored through the construction of the pseudo-ternary phase diagrams for the isopropyl myristate/sucrose ester-isopropyl alcohol/water system, using the titration method and mixture experimental approach. Minor changes in surfactant tail length strongly affected the microemulsion area boundaries. D-optimal mixture design proved to be highly applicable in detecting the microemulsion regions. Examination of conductivity, rheology, and thermal behavior of the selected sucrose laurate and sucrose myristate-based microemulsions, upon dilution with water, indicated existence of percolation threshold and suggested the phase inversion from water-in-oil to oil-in-water via a bicontinuous structure. Atomic force micrographs confirmed the suggested type of microemulsions and were valuable in further exploring their inner structure. The solubilization capacity of aceclofenac as a model drug has decreased as the water volume fraction in microemulsion increased. High surfactant concentration and the measured solubility of aceclofenac in microemulsion components suggested that the interfacial film may mostly contribute to aceclofenac solubilization. PB - Springer, New York T2 - Colloid and Polymer Science T1 - Sucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture design VL - 292 IS - 12 SP - 3061 EP - 3076 DO - 10.1007/s00396-014-3351-4 ER -
@article{ author = "Todosijević, Marija and Cekic, Nebojsa and Savić, Miroslav M. and Gasperlin, Mirjana and Randjelović, Danijela and Savić, Snežana D.", year = "2014", abstract = "We assessed the functionality of sucrose esters (sucrose laurate, myristate, palmitate, and stearate), relatively innocuous nonionic surfactants, in formulation of biocompatible microemulsions. The putative influence of surfactant structure on the extension of microemulsion region was explored through the construction of the pseudo-ternary phase diagrams for the isopropyl myristate/sucrose ester-isopropyl alcohol/water system, using the titration method and mixture experimental approach. Minor changes in surfactant tail length strongly affected the microemulsion area boundaries. D-optimal mixture design proved to be highly applicable in detecting the microemulsion regions. Examination of conductivity, rheology, and thermal behavior of the selected sucrose laurate and sucrose myristate-based microemulsions, upon dilution with water, indicated existence of percolation threshold and suggested the phase inversion from water-in-oil to oil-in-water via a bicontinuous structure. Atomic force micrographs confirmed the suggested type of microemulsions and were valuable in further exploring their inner structure. The solubilization capacity of aceclofenac as a model drug has decreased as the water volume fraction in microemulsion increased. High surfactant concentration and the measured solubility of aceclofenac in microemulsion components suggested that the interfacial film may mostly contribute to aceclofenac solubilization.", publisher = "Springer, New York", journal = "Colloid and Polymer Science", title = "Sucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture design", volume = "292", number = "12", pages = "3061-3076", doi = "10.1007/s00396-014-3351-4" }
Todosijević, M., Cekic, N., Savić, M. M., Gasperlin, M., Randjelović, D.,& Savić, S. D.. (2014). Sucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture design. in Colloid and Polymer Science Springer, New York., 292(12), 3061-3076. https://doi.org/10.1007/s00396-014-3351-4
Todosijević M, Cekic N, Savić MM, Gasperlin M, Randjelović D, Savić SD. Sucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture design. in Colloid and Polymer Science. 2014;292(12):3061-3076. doi:10.1007/s00396-014-3351-4 .
Todosijević, Marija, Cekic, Nebojsa, Savić, Miroslav M., Gasperlin, Mirjana, Randjelović, Danijela, Savić, Snežana D., "Sucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture design" in Colloid and Polymer Science, 292, no. 12 (2014):3061-3076, https://doi.org/10.1007/s00396-014-3351-4 . .