Second-generation peroxides: The OZs and artemisone
Abstract
The emergence of multi-drug resistant strains of Plasmodium falciparum has rendered many affordable antimalarials, such as chloroquine, much less effective in addressing the severe health issues in sub-Saharan Africa, Southeast Asia and the Amazon region. In order to overcome the neurotoxicity of an initial series of artemisinin-derived drugs and their relatively high production costs, an intensive and all-inclusive research programme to develop new derivatives has been undertaken. Two efficient antimalarial drug candidates of different chemotype have been devised, the artemisinin derivative artemisone and 1,2,4-troxolane OZ277. Both are nontoxic, more potent than artemisinin and should be affordable to people of endemic regions. The same may hold for the backup candidates artemiside and OZ439.
Source:
Treatment and Prevention of Malaria. Milestones in Drug Therapy, 2012, 41, 191-211
DOI: 10.1007/978-3-0346-0480-2_10
ISBN: 978-303460479-6
Scopus: 2-s2.0-84867014047
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IHTMTY - CHAP AU - Opsenica, Dejan AU - Šolaja, Bogdan PY - 2012 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1142 AB - The emergence of multi-drug resistant strains of Plasmodium falciparum has rendered many affordable antimalarials, such as chloroquine, much less effective in addressing the severe health issues in sub-Saharan Africa, Southeast Asia and the Amazon region. In order to overcome the neurotoxicity of an initial series of artemisinin-derived drugs and their relatively high production costs, an intensive and all-inclusive research programme to develop new derivatives has been undertaken. Two efficient antimalarial drug candidates of different chemotype have been devised, the artemisinin derivative artemisone and 1,2,4-troxolane OZ277. Both are nontoxic, more potent than artemisinin and should be affordable to people of endemic regions. The same may hold for the backup candidates artemiside and OZ439. T2 - Treatment and Prevention of Malaria. Milestones in Drug Therapy T1 - Second-generation peroxides: The OZs and artemisone VL - 41 SP - 191 EP - 211 DO - 10.1007/978-3-0346-0480-2_10 ER -
@inbook{ author = "Opsenica, Dejan and Šolaja, Bogdan", year = "2012", abstract = "The emergence of multi-drug resistant strains of Plasmodium falciparum has rendered many affordable antimalarials, such as chloroquine, much less effective in addressing the severe health issues in sub-Saharan Africa, Southeast Asia and the Amazon region. In order to overcome the neurotoxicity of an initial series of artemisinin-derived drugs and their relatively high production costs, an intensive and all-inclusive research programme to develop new derivatives has been undertaken. Two efficient antimalarial drug candidates of different chemotype have been devised, the artemisinin derivative artemisone and 1,2,4-troxolane OZ277. Both are nontoxic, more potent than artemisinin and should be affordable to people of endemic regions. The same may hold for the backup candidates artemiside and OZ439.", journal = "Treatment and Prevention of Malaria. Milestones in Drug Therapy", booktitle = "Second-generation peroxides: The OZs and artemisone", volume = "41", pages = "191-211", doi = "10.1007/978-3-0346-0480-2_10" }
Opsenica, D.,& Šolaja, B.. (2012). Second-generation peroxides: The OZs and artemisone. in Treatment and Prevention of Malaria. Milestones in Drug Therapy, 41, 191-211. https://doi.org/10.1007/978-3-0346-0480-2_10
Opsenica D, Šolaja B. Second-generation peroxides: The OZs and artemisone. in Treatment and Prevention of Malaria. Milestones in Drug Therapy. 2012;41:191-211. doi:10.1007/978-3-0346-0480-2_10 .
Opsenica, Dejan, Šolaja, Bogdan, "Second-generation peroxides: The OZs and artemisone" in Treatment and Prevention of Malaria. Milestones in Drug Therapy, 41 (2012):191-211, https://doi.org/10.1007/978-3-0346-0480-2_10 . .