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dc.creatorTrmcic, Milena V.
dc.creatorMatović, Radomir
dc.creatorTovilović, Gordana
dc.creatorRistic, Biljana Z.
dc.creatorTrajković, Vladimir
dc.creatorFerjančić, Zorana
dc.creatorSaičić, Radomir N.
dc.date.accessioned2019-01-30T17:29:53Z
dc.date.available2019-01-30T17:29:53Z
dc.date.issued2012
dc.identifier.issn1477-0520
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/981
dc.description.abstractThe design, synthesis and biological evaluation of a novel C, D-spirolactone analogue of paclitaxel is described. This is the first paclitaxel analogue without an oxetane D-ring that shows a significant cytotoxic effect (activity one order of magnitude lower than paclitaxel). More importantly, its cytotoxicity is a result of a different mechanism of action, involving mTOR inhibition-dependent autophagy instead of G(2)/M cell cycle arrest-dependent apoptosis.en
dc.publisherRoyal Soc Chemistry, Cambridge
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172027/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41025/RS//
dc.rightsrestrictedAccess
dc.sourceOrganic & Biomolecular Chemistry
dc.titleA novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoidsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТрмциц, Милена В.; Трајковиц, Владимир С.; Саициц, Радомир Н.; Ферјанциц, Зорана Б.; Матовић, Радомир; Ристиц, Биљана З.; Товиловиц, Гордана И.;
dc.citation.volume10
dc.citation.issue25
dc.citation.spage4933
dc.citation.epage4942
dc.citation.other10(25): 4933-4942
dc.citation.rankM21
dc.identifier.pmid22614284
dc.identifier.doi10.1039/c2ob25514f
dc.identifier.rcubConv_2809
dc.identifier.scopus2-s2.0-84862224265
dc.identifier.wos000304885200015
dc.type.versionpublishedVersion


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