A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids
Authorized Users Only
2012
Authors
Trmcic, Milena V.Matović, Radomir
Tovilović, Gordana
Ristic, Biljana Z.
Trajković, Vladimir
Ferjančić, Zorana
Saičić, Radomir N.
Article (Published version)
Metadata
Show full item recordAbstract
The design, synthesis and biological evaluation of a novel C, D-spirolactone analogue of paclitaxel is described. This is the first paclitaxel analogue without an oxetane D-ring that shows a significant cytotoxic effect (activity one order of magnitude lower than paclitaxel). More importantly, its cytotoxicity is a result of a different mechanism of action, involving mTOR inhibition-dependent autophagy instead of G(2)/M cell cycle arrest-dependent apoptosis.
Source:
Organic & Biomolecular Chemistry, 2012, 10, 25, 4933-4942Publisher:
- Royal Soc Chemistry, Cambridge
Funding / projects:
- The development of new synthetic methods and their application in the synthesis of natural products and biologically active molecules (RS-MESTD-Basic Research (BR or ON)-172027)
- Modulation of intracellular energy balance-controlling signalling pathways in therapy of cancer and neuro-immuno-endocrine disorders (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41025)
DOI: 10.1039/c2ob25514f
ISSN: 1477-0520
PubMed: 22614284
WoS: 000304885200015
Scopus: 2-s2.0-84862224265
Collections
Institution/Community
IHTMTY - JOUR AU - Trmcic, Milena V. AU - Matović, Radomir AU - Tovilović, Gordana AU - Ristic, Biljana Z. AU - Trajković, Vladimir AU - Ferjančić, Zorana AU - Saičić, Radomir N. PY - 2012 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/981 AB - The design, synthesis and biological evaluation of a novel C, D-spirolactone analogue of paclitaxel is described. This is the first paclitaxel analogue without an oxetane D-ring that shows a significant cytotoxic effect (activity one order of magnitude lower than paclitaxel). More importantly, its cytotoxicity is a result of a different mechanism of action, involving mTOR inhibition-dependent autophagy instead of G(2)/M cell cycle arrest-dependent apoptosis. PB - Royal Soc Chemistry, Cambridge T2 - Organic & Biomolecular Chemistry T1 - A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids VL - 10 IS - 25 SP - 4933 EP - 4942 DO - 10.1039/c2ob25514f ER -
@article{ author = "Trmcic, Milena V. and Matović, Radomir and Tovilović, Gordana and Ristic, Biljana Z. and Trajković, Vladimir and Ferjančić, Zorana and Saičić, Radomir N.", year = "2012", abstract = "The design, synthesis and biological evaluation of a novel C, D-spirolactone analogue of paclitaxel is described. This is the first paclitaxel analogue without an oxetane D-ring that shows a significant cytotoxic effect (activity one order of magnitude lower than paclitaxel). More importantly, its cytotoxicity is a result of a different mechanism of action, involving mTOR inhibition-dependent autophagy instead of G(2)/M cell cycle arrest-dependent apoptosis.", publisher = "Royal Soc Chemistry, Cambridge", journal = "Organic & Biomolecular Chemistry", title = "A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids", volume = "10", number = "25", pages = "4933-4942", doi = "10.1039/c2ob25514f" }
Trmcic, M. V., Matović, R., Tovilović, G., Ristic, B. Z., Trajković, V., Ferjančić, Z.,& Saičić, R. N.. (2012). A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids. in Organic & Biomolecular Chemistry Royal Soc Chemistry, Cambridge., 10(25), 4933-4942. https://doi.org/10.1039/c2ob25514f
Trmcic MV, Matović R, Tovilović G, Ristic BZ, Trajković V, Ferjančić Z, Saičić RN. A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids. in Organic & Biomolecular Chemistry. 2012;10(25):4933-4942. doi:10.1039/c2ob25514f .
Trmcic, Milena V., Matović, Radomir, Tovilović, Gordana, Ristic, Biljana Z., Trajković, Vladimir, Ferjančić, Zorana, Saičić, Radomir N., "A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids" in Organic & Biomolecular Chemistry, 10, no. 25 (2012):4933-4942, https://doi.org/10.1039/c2ob25514f . .