dc.creator | Šukalović, Vladimir | |
dc.creator | Ignjatović, Đurđica S. | |
dc.creator | Tovilović, Gordana | |
dc.creator | Andrić, Deana | |
dc.creator | Shakib, Kaveh | |
dc.creator | Kostić Rajačić, Slađana | |
dc.creator | Šoškić, Vukić | |
dc.date.accessioned | 2019-01-30T17:29:46Z | |
dc.date.available | 2019-01-30T17:29:46Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0960-894X | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/974 | |
dc.description.abstract | It is suggested that the ratio of dopamine D-2 to 5-hydroxytryptamine 5-HT1A activity is an important parameter that determines the efficiency of antipsychotic drugs. Here we present the synthesis of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas and their structure-activity relationship studies on dopamine D-2 and 5-hydrohytryptamine 5-HT1A receptors. It was shown that ligand selectivity and affinity strongly depends on their topology and the presence of a pyridyl group in the head of molecules. Molecular modeling studies using homology modeling and docking simulation revealed a rational explanation for the ligand behavior. The observed binding modes and receptor-ligand interactions provided us with a clue for optimizing the optimal selectivity towards 5-HT1A receptors. | en |
dc.publisher | Oxford : Pergamon-Elsevier Science Ltd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172032/RS// | |
dc.rights | restrictedAccess | |
dc.source | Bioorganic and Medicinal Chemistry Letters | |
dc.subject | Dopamine | en |
dc.subject | 5-Hydroxytryptamine | en |
dc.subject | Receptor | en |
dc.subject | Arylpiperazine | en |
dc.subject | Molecular docking | en |
dc.title | Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D-2 and 5-hydroxytryptamine 5HT(1A) receptors | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Схакиб, Кавех; Шукаловић, Владимир; Aндриц, Деана; Соскиц, Вукиц; Игњатовић, Ђурђица С.; Костић Рајачић, Слађана; Товиловиц, Гордана; | |
dc.citation.volume | 22 | |
dc.citation.issue | 12 | |
dc.citation.spage | 3967 | |
dc.citation.epage | 3972 | |
dc.citation.other | 22(12): 3967-3972 | |
dc.citation.rank | M22 | |
dc.identifier.pmid | 22607670 | |
dc.identifier.doi | 10.1016/j.bmcl.2012.04.098 | |
dc.identifier.scopus | 2-s2.0-84861576055 | |
dc.identifier.wos | 000304484600023 | |
dc.type.version | publishedVersion | |