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dc.creatorŠukalović, Vladimir
dc.creatorIgnjatović, Đurđica S.
dc.creatorTovilović, Gordana
dc.creatorAndrić, Deana
dc.creatorShakib, Kaveh
dc.creatorKostić Rajačić, Slađana
dc.creatorŠoškić, Vukić
dc.date.accessioned2019-01-30T17:29:46Z
dc.date.available2019-01-30T17:29:46Z
dc.date.issued2012
dc.identifier.issn0960-894X
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/974
dc.description.abstractIt is suggested that the ratio of dopamine D-2 to 5-hydroxytryptamine 5-HT1A activity is an important parameter that determines the efficiency of antipsychotic drugs. Here we present the synthesis of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas and their structure-activity relationship studies on dopamine D-2 and 5-hydrohytryptamine 5-HT1A receptors. It was shown that ligand selectivity and affinity strongly depends on their topology and the presence of a pyridyl group in the head of molecules. Molecular modeling studies using homology modeling and docking simulation revealed a rational explanation for the ligand behavior. The observed binding modes and receptor-ligand interactions provided us with a clue for optimizing the optimal selectivity towards 5-HT1A receptors.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172032/RS//
dc.rightsrestrictedAccess
dc.sourceBioorganic and Medicinal Chemistry Letters
dc.subjectDopamineen
dc.subject5-Hydroxytryptamineen
dc.subjectReceptoren
dc.subjectArylpiperazineen
dc.subjectMolecular dockingen
dc.titleInteractions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D-2 and 5-hydroxytryptamine 5HT(1A) receptorsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСхакиб, Кавех; Шукаловић, Владимир; Aндриц, Деана; Соскиц, Вукиц; Игњатовић, Ђурђица С.; Костић Рајачић, Слађана; Товиловиц, Гордана;
dc.citation.volume22
dc.citation.issue12
dc.citation.spage3967
dc.citation.epage3972
dc.citation.other22(12): 3967-3972
dc.citation.rankM22
dc.identifier.pmid22607670
dc.identifier.doi10.1016/j.bmcl.2012.04.098
dc.identifier.rcubConv_2805
dc.identifier.scopus2-s2.0-84861576055
dc.identifier.wos000304484600023
dc.type.versionpublishedVersion


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