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Stereospecific ligands and their complexes. Part X: Synthesis, characterization and in vitro antitumoral activity of platinum(IV) complexes with O,O '-dialkyl-(S,S)-ethylenediamine-N,N '-di-2-(4-methyl)pentanoate ligands
dc.creator | Vujic, Jelena M. | |
dc.creator | Kaluđerović, Goran N. | |
dc.creator | Zmejkovski, Bojana | |
dc.creator | Milovanovic, Marija | |
dc.creator | Volarevic, Vladislav | |
dc.creator | Arsenijevic, Nebojsa | |
dc.creator | Stanojković, Tatjana | |
dc.creator | Trifunovic, Srecko R. | |
dc.date.accessioned | 2019-01-30T17:29:39Z | |
dc.date.available | 2019-01-30T17:29:39Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0020-1693 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/969 | |
dc.description.abstract | Synthesis of four new platinum(IV) complexes 1-4, with bidentate N,N'-ligand precursors O,O'-dialkyl esters (alkyl = ethyl, n-propyl, n-butyl and n-pentyl), of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)pentanoic acid dihydrochloride [(S,S)-H(4)eddl]Cl-2 were reported. The composition of the novel platinum complexes was determined by elemental analysis and characterizations were performed by infrared, H-1 and C-13 NMR spectroscopy. DFT calculations indicate formation one (R,R) from three possible diastereoisomers (S,S; R,S). Complexes 1-4 displayed potent anticancer activity. IC50 values range from 0.74 to 70 mu M, against tested cell lines, except for CLL cells. The antitumoral activity of 2-4 was found to be considerably stronger to Jurkat and K562. Cell cycle analysis of cell lines showed G1 arrest in the presence of analyzed complexes. | en |
dc.publisher | Elsevier Science Sa, Lausanne | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175069/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172016/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS// | |
dc.relation | EC under FP7 Research Potential Program (CPCTAS) | |
dc.rights | restrictedAccess | |
dc.source | Inorganica Chimica Acta | |
dc.subject | Platinum(IV) complexes | en |
dc.subject | EDDA-type ligands | en |
dc.subject | Antitumoral activity | en |
dc.subject | Cell cycle | en |
dc.subject | Apoptosis | en |
dc.title | Stereospecific ligands and their complexes. Part X: Synthesis, characterization and in vitro antitumoral activity of platinum(IV) complexes with O,O '-dialkyl-(S,S)-ethylenediamine-N,N '-di-2-(4-methyl)pentanoate ligands | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Змејковски, Бојана; Трифуновиц, Срецко Р.; Aрсенијевиц, Небојса; Калудеровиц, Горан Н.; Станојковиц, Татјана П.; Вујиц, Јелена М.; Миловановиц, Марија; Воларевиц, Владислав; | |
dc.citation.volume | 390 | |
dc.citation.spage | 123 | |
dc.citation.epage | 128 | |
dc.citation.other | 390: 123-128 | |
dc.citation.rank | M22 | |
dc.identifier.doi | 10.1016/j.ica.2012.03.048 | |
dc.identifier.scopus | 2-s2.0-84861157759 | |
dc.identifier.wos | 000305811000018 | |
dc.type.version | publishedVersion |