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dc.creatorVujic, Jelena M.
dc.creatorKaluđerović, Goran N.
dc.creatorZmejkovski, Bojana
dc.creatorMilovanovic, Marija
dc.creatorVolarevic, Vladislav
dc.creatorArsenijevic, Nebojsa
dc.creatorStanojković, Tatjana
dc.creatorTrifunovic, Srecko R.
dc.date.accessioned2019-01-30T17:29:39Z
dc.date.available2019-01-30T17:29:39Z
dc.date.issued2012
dc.identifier.issn0020-1693
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/969
dc.description.abstractSynthesis of four new platinum(IV) complexes 1-4, with bidentate N,N'-ligand precursors O,O'-dialkyl esters (alkyl = ethyl, n-propyl, n-butyl and n-pentyl), of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)pentanoic acid dihydrochloride [(S,S)-H(4)eddl]Cl-2 were reported. The composition of the novel platinum complexes was determined by elemental analysis and characterizations were performed by infrared, H-1 and C-13 NMR spectroscopy. DFT calculations indicate formation one (R,R) from three possible diastereoisomers (S,S; R,S). Complexes 1-4 displayed potent anticancer activity. IC50 values range from 0.74 to 70 mu M, against tested cell lines, except for CLL cells. The antitumoral activity of 2-4 was found to be considerably stronger to Jurkat and K562. Cell cycle analysis of cell lines showed G1 arrest in the presence of analyzed complexes.en
dc.publisherElsevier Science Sa, Lausanne
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175069/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172016/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//
dc.relationEC under FP7 Research Potential Program (CPCTAS)
dc.rightsrestrictedAccess
dc.sourceInorganica Chimica Acta
dc.subjectPlatinum(IV) complexesen
dc.subjectEDDA-type ligandsen
dc.subjectAntitumoral activityen
dc.subjectCell cycleen
dc.subjectApoptosisen
dc.titleStereospecific ligands and their complexes. Part X: Synthesis, characterization and in vitro antitumoral activity of platinum(IV) complexes with O,O '-dialkyl-(S,S)-ethylenediamine-N,N '-di-2-(4-methyl)pentanoate ligandsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЗмејковски, Бојана; Трифуновиц, Срецко Р.; Aрсенијевиц, Небојса; Калудеровиц, Горан Н.; Станојковиц, Татјана П.; Вујиц, Јелена М.; Миловановиц, Марија; Воларевиц, Владислав;
dc.citation.volume390
dc.citation.spage123
dc.citation.epage128
dc.citation.other390: 123-128
dc.citation.rankM22
dc.identifier.doi10.1016/j.ica.2012.03.048
dc.identifier.rcubConv_2817
dc.identifier.scopus2-s2.0-84861157759
dc.identifier.wos000305811000018
dc.type.versionpublishedVersion


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