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Optimizacija sinteze i in vitro proučavanje antimikrobnog dejstva α,β-nezasićenih i α-bromkarboksilnih kiselina

dc.creatorVitnik, Vesna
dc.creatorMilenković, Marina
dc.creatorDilber, Sanda P.
dc.creatorVitnik, Željko
dc.creatorJuranić, Ivan
dc.date.accessioned2019-01-30T17:29:34Z
dc.date.available2019-01-30T17:29:34Z
dc.date.issued2012
dc.identifier.issn0352-5139
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/964
dc.description.abstractA series of α,β-unsaturated and α-bromo carboxylic acids were identified as potent antimicrobial agents. The antimicrobial activity was evaluated using the broth microdilution method. All acids 1-12 exhibited a significant activity against nine laboratory control strains of bacteria and two strains of yeast Candida albicans. The tested acids were efficiently prepared by optimized phase-transfer-catalyzed (PTC) reactions of ketones with bromoform and aqueous lithium hydroxide in alcoholic solvent with triethylbenzyl ammonium chloride (TEBA) as catalyst.en
dc.description.abstractU ovom radu je prikazano in vitro ispitivanje antimikrobnog dejstva serije α,β-nezasićenih i α-bromkarboksilnih kiselina i pokazano je da su one potencijalno dobri antimikrobni agensi. Sve kiseline 1-12 pokazale su značajnu aktivnost prema devet sojeva bakterija i dva soja gljivica Candida albicans. Ispitivane kiseline sintetisane su u optimizovanoj reakciji ketona sa bromoformom i litijum-hidroksidom u smesi rastvarača (terc-butanol/voda). Kao katalizator za prenos između faza upotrebljen je trietilbenzilamonijum-hlorid (TEBA).sr
dc.publisherSerbian Chemical Society
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173021/RS//
dc.rightsopenAccess
dc.sourceJournal of the Serbian Chemical Society
dc.subjectantimicrobial activityen
dc.subjectone-pot synthesisen
dc.subjectketonesen
dc.subjectbromoformen
dc.titleImproved synthesis and in vitro study of antimicrobial activity of α,β-unsaturated and α-bromo carboxylic acidsen
dc.titleOptimizacija sinteze i in vitro proučavanje antimikrobnog dejstva α,β-nezasićenih i α-bromkarboksilnih kiselinasr
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractЈураниц, Иван О.; Витник, Жељко; Витник, Весна; Дилбер, Санда П.; Миленковиц, Марина Т.; Оптимизација синтезе и ин витро проучавање антимикробног дејства α,β-незасићених и α-бромкарбоксилних киселина; Оптимизација синтезе и ин витро проучавање антимикробног дејства α,β-незасићених и α-бромкарбоксилних киселина;
dc.citation.volume77
dc.citation.issue6
dc.citation.spage741
dc.citation.epage750
dc.citation.other77(6): 741-750
dc.citation.rankM23
dc.identifier.doi10.2298/JSC111104016V
dc.identifier.rcubConv_2823
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/9535/962.pdf
dc.identifier.scopus2-s2.0-84864535005
dc.identifier.wos000306093300004
dc.type.versionpublishedVersion


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