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Investigation of antibacterial activity of cinnamyl derivatives of arylpiperazine

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2012
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Authors
Novaković, Irena
Penjišević, Jelena
Šukalović, Vladimir
Andrić, Deana
Roglić, Goran
Kostić Rajačić, Slađana
Article (Published version)
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Abstract
The derivatives of cinnamic acid and N-arylpiperazine show antibacterial activity. In this work the potential synergistic effect of cinnamyl derivatives of arylpiperazine in selected bacteria was investigated. The antibacterial activities of the derivatives were evaluated against Gram-positive bacteria: Staphylococcus aureus, Streptosporangium longisporum, Sarcina lutea, Micrococcus flavus, Clostridium sporogenes and Bacillus subtilis and Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis and Proteus vulgaris by the disc diffusion method. The minimum inhibitory concentration (MIC) against the selected bacteria was determined for all compounds that showed activity in the disc diffusion method. The majority of the investigated compounds displayed in vitro antibacterial activity. The effect of the type and structure of the substituent on the aromatic ring on the antibacterial activity is discussed. It was found that two derivatives expressed activity ...toward S. longisporum and P. aeruginosa that was almost as strong as that of amikacin.

Keywords:
arylpiperazine / antibacterial activity / minimum inhibitory concentration / in vitro studies
Source:
Archives of Biological Sciences, 2012, 64, 1, 15-20
Publisher:
  • Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd
Projects:
  • Structure-activity relationship of newly synthesized biological active compound (RS-172032)

DOI: 10.2298/ABS1201015N

ISSN: 0354-4664

WoS: 000303697400003

Scopus: 2-s2.0-84863747149
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/963
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