CER - Central Repository
Institute of Chemistry, Technology and Metallurgy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   CER
  • IHTM
  • Radovi istraživača / Researchers' publications
  • View Item
  •   CER
  • IHTM
  • Radovi istraživača / Researchers' publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Investigation of antibacterial activity of cinnamyl derivatives of arylpiperazine

Thumbnail
2012
961.pdf (486.8Kb)
Authors
Novaković, Irena
Penjišević, Jelena
Šukalović, Vladimir
Andrić, Deana
Roglić, Goran
Kostić Rajačić, Slađana
Article (Published version)
Metadata
Show full item record
Abstract
The derivatives of cinnamic acid and N-arylpiperazine show antibacterial activity. In this work the potential synergistic effect of cinnamyl derivatives of arylpiperazine in selected bacteria was investigated. The antibacterial activities of the derivatives were evaluated against Gram-positive bacteria: Staphylococcus aureus, Streptosporangium longisporum, Sarcina lutea, Micrococcus flavus, Clostridium sporogenes and Bacillus subtilis and Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis and Proteus vulgaris by the disc diffusion method. The minimum inhibitory concentration (MIC) against the selected bacteria was determined for all compounds that showed activity in the disc diffusion method. The majority of the investigated compounds displayed in vitro antibacterial activity. The effect of the type and structure of the substituent on the aromatic ring on the antibacterial activity is discussed. It was found that two derivatives expressed activity ...toward S. longisporum and P. aeruginosa that was almost as strong as that of amikacin.

Keywords:
arylpiperazine / antibacterial activity / minimum inhibitory concentration / in vitro studies
Source:
Archives of Biological Sciences, 2012, 64, 1, 15-20
Publisher:
  • Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd
Funding / projects:
  • Structure-activity relationship of newly synthesized biological active compound (RS-172032)

DOI: 10.2298/ABS1201015N

ISSN: 0354-4664

WoS: 000303697400003

Scopus: 2-s2.0-84863747149
[ Google Scholar ]
3
3
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/963
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Novaković, Irena
AU  - Penjišević, Jelena
AU  - Šukalović, Vladimir
AU  - Andrić, Deana
AU  - Roglić, Goran
AU  - Kostić Rajačić, Slađana
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/963
AB  - The derivatives of cinnamic acid and N-arylpiperazine show antibacterial activity. In this work the potential synergistic effect of cinnamyl derivatives of arylpiperazine in selected bacteria was investigated. The antibacterial activities of the derivatives were evaluated against Gram-positive bacteria: Staphylococcus aureus, Streptosporangium longisporum, Sarcina lutea, Micrococcus flavus, Clostridium sporogenes and Bacillus subtilis and Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis and Proteus vulgaris by the disc diffusion method. The minimum inhibitory concentration (MIC) against the selected bacteria was determined for all compounds that showed activity in the disc diffusion method. The majority of the investigated compounds displayed in vitro antibacterial activity. The effect of the type and structure of the substituent on the aromatic ring on the antibacterial activity is discussed. It was found that two derivatives expressed activity toward S. longisporum and P. aeruginosa that was almost as strong as that of amikacin.
PB  - Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd
T2  - Archives of Biological Sciences
T1  - Investigation of antibacterial activity of cinnamyl derivatives of arylpiperazine
VL  - 64
IS  - 1
SP  - 15
EP  - 20
DO  - 10.2298/ABS1201015N
ER  - 
@article{
author = "Novaković, Irena and Penjišević, Jelena and Šukalović, Vladimir and Andrić, Deana and Roglić, Goran and Kostić Rajačić, Slađana",
year = "2012",
abstract = "The derivatives of cinnamic acid and N-arylpiperazine show antibacterial activity. In this work the potential synergistic effect of cinnamyl derivatives of arylpiperazine in selected bacteria was investigated. The antibacterial activities of the derivatives were evaluated against Gram-positive bacteria: Staphylococcus aureus, Streptosporangium longisporum, Sarcina lutea, Micrococcus flavus, Clostridium sporogenes and Bacillus subtilis and Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis and Proteus vulgaris by the disc diffusion method. The minimum inhibitory concentration (MIC) against the selected bacteria was determined for all compounds that showed activity in the disc diffusion method. The majority of the investigated compounds displayed in vitro antibacterial activity. The effect of the type and structure of the substituent on the aromatic ring on the antibacterial activity is discussed. It was found that two derivatives expressed activity toward S. longisporum and P. aeruginosa that was almost as strong as that of amikacin.",
publisher = "Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd",
journal = "Archives of Biological Sciences",
title = "Investigation of antibacterial activity of cinnamyl derivatives of arylpiperazine",
volume = "64",
number = "1",
pages = "15-20",
doi = "10.2298/ABS1201015N"
}
Novaković, I., Penjišević, J., Šukalović, V., Andrić, D., Roglić, G.,& Kostić Rajačić, S.. (2012). Investigation of antibacterial activity of cinnamyl derivatives of arylpiperazine. in Archives of Biological Sciences
Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd., 64(1), 15-20.
https://doi.org/10.2298/ABS1201015N
Novaković I, Penjišević J, Šukalović V, Andrić D, Roglić G, Kostić Rajačić S. Investigation of antibacterial activity of cinnamyl derivatives of arylpiperazine. in Archives of Biological Sciences. 2012;64(1):15-20.
doi:10.2298/ABS1201015N .
Novaković, Irena, Penjišević, Jelena, Šukalović, Vladimir, Andrić, Deana, Roglić, Goran, Kostić Rajačić, Slađana, "Investigation of antibacterial activity of cinnamyl derivatives of arylpiperazine" in Archives of Biological Sciences, 64, no. 1 (2012):15-20,
https://doi.org/10.2298/ABS1201015N . .

DSpace software copyright © 2002-2015  DuraSpace
About CeR – Central Repository | Send Feedback

re3dataOpenAIRERCUB
 

 

All of DSpaceInstitutions/communitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About CeR – Central Repository | Send Feedback

re3dataOpenAIRERCUB