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dc.creatorMiladinovic, Dragoljub L.
dc.creatorIlic, Budimir S.
dc.creatorMihajilov-Krstev, Tatjana M.
dc.creatorNikolic, Nikola D.
dc.creatorMiladinovic, Ljiljana C.
dc.creatorCvetković, Olga
dc.date.accessioned2019-01-30T17:29:20Z
dc.date.available2019-01-30T17:29:20Z
dc.date.issued2012
dc.identifier.issn1618-2642
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/954
dc.description.abstractThe antibacterial effects of Thymus vulgaris (Lamiaceae), Lavandula angustifolia (Lamiaceae), and Calamintha nepeta (Lamiaceae) Savi subsp. nepeta var. subisodonda (Borb.) Hayek essential oils on five different bacteria were estimated. Laboratory control strain and clinical isolates from different pathogenic media were researched by broth microdilution method, with an emphasis on a chemical composition-antibacterial activity relationship. The main constituents of thyme oil were thymol (59.95%) and p-cymene (18.34%). Linalool acetate (38.23%) and beta-linalool (35.01%) were main compounds in lavender oil. C. nepeta essential oil was characterized by a high percentage of piperitone oxide (59.07%) and limonene (9.05%). Essential oils have been found to have antimicrobial activity against all tested microorganisms. Classification and comparison of essential oils on the basis of their chemical composition and antibacterial activity were made by utilization of appropriate chemometric methods. The chemical principal component analysis (PCA) and hierachical cluster analysis (HCA) separated essential oils into two groups and two sub-groups. Thyme essential oil forms separate chemical HCA group and exhibits highest antibacterial activity, similar to tetracycline. Essential oils of lavender and C. nepeta in the same chemical HCA group were classified in different groups, within antibacterial PCA and HCA analyses. Lavender oil exhibits higher antibacterial ability in comparison with C. nepeta essential oil, probably based on the concept of synergistic activity of essential oil components.en
dc.publisherSpringer Heidelberg, Heidelberg
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/171025/RS//
dc.rightsrestrictedAccess
dc.sourceAnalytical and Bioanalytical Chemistry
dc.subjectChemometricsen
dc.subjectEssential oilen
dc.subjectAntibacterial activityen
dc.titleInvestigation of the chemical composition-antibacterial activity relationship of essential oils by chemometric methodsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМиладиновиц, Драгољуб Л.; Илиц, Будимир С.; Николиц, Никола Д.; Михајилов-Крстев, Татјана М.; Миладиновиц, Љиљана Ц.; Цветковић, Олга;
dc.citation.volume403
dc.citation.issue4
dc.citation.spage1007
dc.citation.epage1018
dc.citation.other403(4): 1007-1018
dc.citation.rankM21
dc.identifier.pmid22389175
dc.identifier.doi10.1007/s00216-012-5866-1
dc.identifier.rcubConv_2788
dc.identifier.scopus2-s2.0-84862091801
dc.identifier.wos000303410600012
dc.type.versionpublishedVersion


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