Investigation of the chemical composition-antibacterial activity relationship of essential oils by chemometric methods
Samo za registrovane korisnike
2012
Autori
Miladinovic, Dragoljub L.Ilic, Budimir S.

Mihajilov-Krstev, Tatjana M.
Nikolic, Nikola D.
Miladinovic, Ljiljana C.
Cvetković, Olga

Članak u časopisu (Objavljena verzija)

Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The antibacterial effects of Thymus vulgaris (Lamiaceae), Lavandula angustifolia (Lamiaceae), and Calamintha nepeta (Lamiaceae) Savi subsp. nepeta var. subisodonda (Borb.) Hayek essential oils on five different bacteria were estimated. Laboratory control strain and clinical isolates from different pathogenic media were researched by broth microdilution method, with an emphasis on a chemical composition-antibacterial activity relationship. The main constituents of thyme oil were thymol (59.95%) and p-cymene (18.34%). Linalool acetate (38.23%) and beta-linalool (35.01%) were main compounds in lavender oil. C. nepeta essential oil was characterized by a high percentage of piperitone oxide (59.07%) and limonene (9.05%). Essential oils have been found to have antimicrobial activity against all tested microorganisms. Classification and comparison of essential oils on the basis of their chemical composition and antibacterial activity were made by utilization of appropriate chemometric methods.... The chemical principal component analysis (PCA) and hierachical cluster analysis (HCA) separated essential oils into two groups and two sub-groups. Thyme essential oil forms separate chemical HCA group and exhibits highest antibacterial activity, similar to tetracycline. Essential oils of lavender and C. nepeta in the same chemical HCA group were classified in different groups, within antibacterial PCA and HCA analyses. Lavender oil exhibits higher antibacterial ability in comparison with C. nepeta essential oil, probably based on the concept of synergistic activity of essential oil components.
Ključne reči:
Chemometrics / Essential oil / Antibacterial activityIzvor:
Analytical and Bioanalytical Chemistry, 2012, 403, 4, 1007-1018Izdavač:
- Springer Heidelberg, Heidelberg
Finansiranje / projekti:
DOI: 10.1007/s00216-012-5866-1
ISSN: 1618-2642
PubMed: 22389175
WoS: 000303410600012
Scopus: 2-s2.0-84862091801
Institucija/grupa
IHTMTY - JOUR AU - Miladinovic, Dragoljub L. AU - Ilic, Budimir S. AU - Mihajilov-Krstev, Tatjana M. AU - Nikolic, Nikola D. AU - Miladinovic, Ljiljana C. AU - Cvetković, Olga PY - 2012 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/954 AB - The antibacterial effects of Thymus vulgaris (Lamiaceae), Lavandula angustifolia (Lamiaceae), and Calamintha nepeta (Lamiaceae) Savi subsp. nepeta var. subisodonda (Borb.) Hayek essential oils on five different bacteria were estimated. Laboratory control strain and clinical isolates from different pathogenic media were researched by broth microdilution method, with an emphasis on a chemical composition-antibacterial activity relationship. The main constituents of thyme oil were thymol (59.95%) and p-cymene (18.34%). Linalool acetate (38.23%) and beta-linalool (35.01%) were main compounds in lavender oil. C. nepeta essential oil was characterized by a high percentage of piperitone oxide (59.07%) and limonene (9.05%). Essential oils have been found to have antimicrobial activity against all tested microorganisms. Classification and comparison of essential oils on the basis of their chemical composition and antibacterial activity were made by utilization of appropriate chemometric methods. The chemical principal component analysis (PCA) and hierachical cluster analysis (HCA) separated essential oils into two groups and two sub-groups. Thyme essential oil forms separate chemical HCA group and exhibits highest antibacterial activity, similar to tetracycline. Essential oils of lavender and C. nepeta in the same chemical HCA group were classified in different groups, within antibacterial PCA and HCA analyses. Lavender oil exhibits higher antibacterial ability in comparison with C. nepeta essential oil, probably based on the concept of synergistic activity of essential oil components. PB - Springer Heidelberg, Heidelberg T2 - Analytical and Bioanalytical Chemistry T1 - Investigation of the chemical composition-antibacterial activity relationship of essential oils by chemometric methods VL - 403 IS - 4 SP - 1007 EP - 1018 DO - 10.1007/s00216-012-5866-1 ER -
@article{ author = "Miladinovic, Dragoljub L. and Ilic, Budimir S. and Mihajilov-Krstev, Tatjana M. and Nikolic, Nikola D. and Miladinovic, Ljiljana C. and Cvetković, Olga", year = "2012", abstract = "The antibacterial effects of Thymus vulgaris (Lamiaceae), Lavandula angustifolia (Lamiaceae), and Calamintha nepeta (Lamiaceae) Savi subsp. nepeta var. subisodonda (Borb.) Hayek essential oils on five different bacteria were estimated. Laboratory control strain and clinical isolates from different pathogenic media were researched by broth microdilution method, with an emphasis on a chemical composition-antibacterial activity relationship. The main constituents of thyme oil were thymol (59.95%) and p-cymene (18.34%). Linalool acetate (38.23%) and beta-linalool (35.01%) were main compounds in lavender oil. C. nepeta essential oil was characterized by a high percentage of piperitone oxide (59.07%) and limonene (9.05%). Essential oils have been found to have antimicrobial activity against all tested microorganisms. Classification and comparison of essential oils on the basis of their chemical composition and antibacterial activity were made by utilization of appropriate chemometric methods. The chemical principal component analysis (PCA) and hierachical cluster analysis (HCA) separated essential oils into two groups and two sub-groups. Thyme essential oil forms separate chemical HCA group and exhibits highest antibacterial activity, similar to tetracycline. Essential oils of lavender and C. nepeta in the same chemical HCA group were classified in different groups, within antibacterial PCA and HCA analyses. Lavender oil exhibits higher antibacterial ability in comparison with C. nepeta essential oil, probably based on the concept of synergistic activity of essential oil components.", publisher = "Springer Heidelberg, Heidelberg", journal = "Analytical and Bioanalytical Chemistry", title = "Investigation of the chemical composition-antibacterial activity relationship of essential oils by chemometric methods", volume = "403", number = "4", pages = "1007-1018", doi = "10.1007/s00216-012-5866-1" }
Miladinovic, D. L., Ilic, B. S., Mihajilov-Krstev, T. M., Nikolic, N. D., Miladinovic, L. C.,& Cvetković, O.. (2012). Investigation of the chemical composition-antibacterial activity relationship of essential oils by chemometric methods. in Analytical and Bioanalytical Chemistry Springer Heidelberg, Heidelberg., 403(4), 1007-1018. https://doi.org/10.1007/s00216-012-5866-1
Miladinovic DL, Ilic BS, Mihajilov-Krstev TM, Nikolic ND, Miladinovic LC, Cvetković O. Investigation of the chemical composition-antibacterial activity relationship of essential oils by chemometric methods. in Analytical and Bioanalytical Chemistry. 2012;403(4):1007-1018. doi:10.1007/s00216-012-5866-1 .
Miladinovic, Dragoljub L., Ilic, Budimir S., Mihajilov-Krstev, Tatjana M., Nikolic, Nikola D., Miladinovic, Ljiljana C., Cvetković, Olga, "Investigation of the chemical composition-antibacterial activity relationship of essential oils by chemometric methods" in Analytical and Bioanalytical Chemistry, 403, no. 4 (2012):1007-1018, https://doi.org/10.1007/s00216-012-5866-1 . .