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Investigation of the chemical composition-antibacterial activity relationship of essential oils by chemometric methods

Samo za registrovane korisnike
2012
Autori
Miladinovic, Dragoljub L.
Ilic, Budimir S.
Mihajilov-Krstev, Tatjana M.
Nikolic, Nikola D.
Miladinovic, Ljiljana C.
Cvetković, Olga
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentu
Apstrakt
The antibacterial effects of Thymus vulgaris (Lamiaceae), Lavandula angustifolia (Lamiaceae), and Calamintha nepeta (Lamiaceae) Savi subsp. nepeta var. subisodonda (Borb.) Hayek essential oils on five different bacteria were estimated. Laboratory control strain and clinical isolates from different pathogenic media were researched by broth microdilution method, with an emphasis on a chemical composition-antibacterial activity relationship. The main constituents of thyme oil were thymol (59.95%) and p-cymene (18.34%). Linalool acetate (38.23%) and beta-linalool (35.01%) were main compounds in lavender oil. C. nepeta essential oil was characterized by a high percentage of piperitone oxide (59.07%) and limonene (9.05%). Essential oils have been found to have antimicrobial activity against all tested microorganisms. Classification and comparison of essential oils on the basis of their chemical composition and antibacterial activity were made by utilization of appropriate chemometric methods.... The chemical principal component analysis (PCA) and hierachical cluster analysis (HCA) separated essential oils into two groups and two sub-groups. Thyme essential oil forms separate chemical HCA group and exhibits highest antibacterial activity, similar to tetracycline. Essential oils of lavender and C. nepeta in the same chemical HCA group were classified in different groups, within antibacterial PCA and HCA analyses. Lavender oil exhibits higher antibacterial ability in comparison with C. nepeta essential oil, probably based on the concept of synergistic activity of essential oil components.

Ključne reči:
Chemometrics / Essential oil / Antibacterial activity
Izvor:
Analytical and Bioanalytical Chemistry, 2012, 403, 4, 1007-1018
Izdavač:
  • Springer Heidelberg, Heidelberg
Finansiranje / projekti:
  • Električni proboj gasova, površinski procesi i primene (RS-171025)

DOI: 10.1007/s00216-012-5866-1

ISSN: 1618-2642

PubMed: 22389175

WoS: 000303410600012

Scopus: 2-s2.0-84862091801
[ Google Scholar ]
39
35
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/954
Kolekcije
  • Radovi istraživača / Researchers' publications
Institucija/grupa
IHTM
TY  - JOUR
AU  - Miladinovic, Dragoljub L.
AU  - Ilic, Budimir S.
AU  - Mihajilov-Krstev, Tatjana M.
AU  - Nikolic, Nikola D.
AU  - Miladinovic, Ljiljana C.
AU  - Cvetković, Olga
PY  - 2012
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/954
AB  - The antibacterial effects of Thymus vulgaris (Lamiaceae), Lavandula angustifolia (Lamiaceae), and Calamintha nepeta (Lamiaceae) Savi subsp. nepeta var. subisodonda (Borb.) Hayek essential oils on five different bacteria were estimated. Laboratory control strain and clinical isolates from different pathogenic media were researched by broth microdilution method, with an emphasis on a chemical composition-antibacterial activity relationship. The main constituents of thyme oil were thymol (59.95%) and p-cymene (18.34%). Linalool acetate (38.23%) and beta-linalool (35.01%) were main compounds in lavender oil. C. nepeta essential oil was characterized by a high percentage of piperitone oxide (59.07%) and limonene (9.05%). Essential oils have been found to have antimicrobial activity against all tested microorganisms. Classification and comparison of essential oils on the basis of their chemical composition and antibacterial activity were made by utilization of appropriate chemometric methods. The chemical principal component analysis (PCA) and hierachical cluster analysis (HCA) separated essential oils into two groups and two sub-groups. Thyme essential oil forms separate chemical HCA group and exhibits highest antibacterial activity, similar to tetracycline. Essential oils of lavender and C. nepeta in the same chemical HCA group were classified in different groups, within antibacterial PCA and HCA analyses. Lavender oil exhibits higher antibacterial ability in comparison with C. nepeta essential oil, probably based on the concept of synergistic activity of essential oil components.
PB  - Springer Heidelberg, Heidelberg
T2  - Analytical and Bioanalytical Chemistry
T1  - Investigation of the chemical composition-antibacterial activity relationship of essential oils by chemometric methods
VL  - 403
IS  - 4
SP  - 1007
EP  - 1018
DO  - 10.1007/s00216-012-5866-1
ER  - 
@article{
author = "Miladinovic, Dragoljub L. and Ilic, Budimir S. and Mihajilov-Krstev, Tatjana M. and Nikolic, Nikola D. and Miladinovic, Ljiljana C. and Cvetković, Olga",
year = "2012",
abstract = "The antibacterial effects of Thymus vulgaris (Lamiaceae), Lavandula angustifolia (Lamiaceae), and Calamintha nepeta (Lamiaceae) Savi subsp. nepeta var. subisodonda (Borb.) Hayek essential oils on five different bacteria were estimated. Laboratory control strain and clinical isolates from different pathogenic media were researched by broth microdilution method, with an emphasis on a chemical composition-antibacterial activity relationship. The main constituents of thyme oil were thymol (59.95%) and p-cymene (18.34%). Linalool acetate (38.23%) and beta-linalool (35.01%) were main compounds in lavender oil. C. nepeta essential oil was characterized by a high percentage of piperitone oxide (59.07%) and limonene (9.05%). Essential oils have been found to have antimicrobial activity against all tested microorganisms. Classification and comparison of essential oils on the basis of their chemical composition and antibacterial activity were made by utilization of appropriate chemometric methods. The chemical principal component analysis (PCA) and hierachical cluster analysis (HCA) separated essential oils into two groups and two sub-groups. Thyme essential oil forms separate chemical HCA group and exhibits highest antibacterial activity, similar to tetracycline. Essential oils of lavender and C. nepeta in the same chemical HCA group were classified in different groups, within antibacterial PCA and HCA analyses. Lavender oil exhibits higher antibacterial ability in comparison with C. nepeta essential oil, probably based on the concept of synergistic activity of essential oil components.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Analytical and Bioanalytical Chemistry",
title = "Investigation of the chemical composition-antibacterial activity relationship of essential oils by chemometric methods",
volume = "403",
number = "4",
pages = "1007-1018",
doi = "10.1007/s00216-012-5866-1"
}
Miladinovic, D. L., Ilic, B. S., Mihajilov-Krstev, T. M., Nikolic, N. D., Miladinovic, L. C.,& Cvetković, O.. (2012). Investigation of the chemical composition-antibacterial activity relationship of essential oils by chemometric methods. in Analytical and Bioanalytical Chemistry
Springer Heidelberg, Heidelberg., 403(4), 1007-1018.
https://doi.org/10.1007/s00216-012-5866-1
Miladinovic DL, Ilic BS, Mihajilov-Krstev TM, Nikolic ND, Miladinovic LC, Cvetković O. Investigation of the chemical composition-antibacterial activity relationship of essential oils by chemometric methods. in Analytical and Bioanalytical Chemistry. 2012;403(4):1007-1018.
doi:10.1007/s00216-012-5866-1 .
Miladinovic, Dragoljub L., Ilic, Budimir S., Mihajilov-Krstev, Tatjana M., Nikolic, Nikola D., Miladinovic, Ljiljana C., Cvetković, Olga, "Investigation of the chemical composition-antibacterial activity relationship of essential oils by chemometric methods" in Analytical and Bioanalytical Chemistry, 403, no. 4 (2012):1007-1018,
https://doi.org/10.1007/s00216-012-5866-1 . .

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