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Investigation of the chemical composition-antibacterial activity relationship of essential oils by chemometric methods

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2012
Authors
Miladinovic, Dragoljub L.
Ilic, Budimir S.
Mihajilov-Krstev, Tatjana M.
Nikolic, Nikola D.
Miladinovic, Ljiljana C.
Cvetković, Olga
Article (Published version)
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Abstract
The antibacterial effects of Thymus vulgaris (Lamiaceae), Lavandula angustifolia (Lamiaceae), and Calamintha nepeta (Lamiaceae) Savi subsp. nepeta var. subisodonda (Borb.) Hayek essential oils on five different bacteria were estimated. Laboratory control strain and clinical isolates from different pathogenic media were researched by broth microdilution method, with an emphasis on a chemical composition-antibacterial activity relationship. The main constituents of thyme oil were thymol (59.95%) and p-cymene (18.34%). Linalool acetate (38.23%) and beta-linalool (35.01%) were main compounds in lavender oil. C. nepeta essential oil was characterized by a high percentage of piperitone oxide (59.07%) and limonene (9.05%). Essential oils have been found to have antimicrobial activity against all tested microorganisms. Classification and comparison of essential oils on the basis of their chemical composition and antibacterial activity were made by utilization of appropriate chemometric methods.... The chemical principal component analysis (PCA) and hierachical cluster analysis (HCA) separated essential oils into two groups and two sub-groups. Thyme essential oil forms separate chemical HCA group and exhibits highest antibacterial activity, similar to tetracycline. Essential oils of lavender and C. nepeta in the same chemical HCA group were classified in different groups, within antibacterial PCA and HCA analyses. Lavender oil exhibits higher antibacterial ability in comparison with C. nepeta essential oil, probably based on the concept of synergistic activity of essential oil components.

Keywords:
Chemometrics / Essential oil / Antibacterial activity
Source:
Analytical and Bioanalytical Chemistry, 2012, 403, 4, 1007-1018
Publisher:
  • Springer Heidelberg, Heidelberg
Projects:
  • The electrical breakdown of gases, surface processes and applications (RS-171025)

DOI: 10.1007/s00216-012-5866-1

ISSN: 1618-2642

PubMed: 22389175

WoS: 000303410600012

Scopus: 2-s2.0-84862091801
[ Google Scholar ]
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33
URI
http://cer.ihtm.bg.ac.rs/handle/123456789/954
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IHTM

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