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dc.creatorDabić, Dragana
dc.creatorNatić, Maja
dc.creatorDžambaski, Zdravko
dc.creatorStojanović, Milovan
dc.creatorMarković, Rade
dc.creatorMilojković-Opsenica, Dušanka
dc.creatorTešić, Živoslav
dc.date.accessioned2019-01-30T17:28:10Z
dc.date.available2019-01-30T17:28:10Z
dc.date.issued2011
dc.identifier.issn1082-6076
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/897
dc.description.abstractThe chromatographic behavior of 23 new 2-alkylidene-4-oxothiazolidine derivatives was investigated by means of the reversed-phase thin-layer chromatography (RP TLC) on the C18 and CN stationary phases. Binary mixtures of methanol-water, acetonitrile-water, and tetrahydrofuran-water were used as mobile phases. Linear relationships between the volume fraction of the organic mobile phase modifier and the RM values were established for each solute with high correlation coefficient values (r0.99). The investigated 4-oxothiazolidines are a congeneric set of compounds, and significant correlations were obtained between the chromatographically determined [image omitted] and m values. The lipophilicity parameters obtained from the reversed-phase experiments were compared with the calculated log P values. Some of these correlations offer very good predicting models, which are important for a better understanding of the relationships between chemical structure and retention, and can prove helpful in the structure-activity studies as well. Finally, our investigation was focused on chemometric processing of the retention data in different chromatographic systems. To this effect, Principal Component Analysis (PCA) was performed, yielding the results helpful in interpretation of interactions among investigated substances, binary mobile phases, and the two different stationary phases.en
dc.publisherTaylor & Francis Inc, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142062/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Liquid Chromatography & Related Technologies
dc.subjectlipophilicityen
dc.subjectprincipal component analysisen
dc.subjectreversed-phase thin-layer chromatographyen
dc.titleEstimation of lipophilicity of n-substituted 2-alkylidene-4-oxothiazolidines by means of reversed-phase thin-layer chromatographyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТесиц, Зивослав; Милојковиц-Опсеница, Дусанка; Джамбаски, Здравко; Марковиц, Раде; Дабиц, Драгана; Натиц, Маја; Стојановић, Милован;
dc.citation.volume34
dc.citation.issue10-11
dc.citation.spage791
dc.citation.epage804
dc.citation.other34(10-11): 791-804
dc.citation.rankM23
dc.identifier.doi10.1080/10826076.2011.571157
dc.identifier.rcubConv_2620
dc.identifier.scopus2-s2.0-79957492623
dc.identifier.wos000290991600004
dc.type.versionpublishedVersion


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