From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.
Source:
Journal of Natural Products, 2011, 74, 7, 1613-1620
TY - JOUR
AU - Aljančić, Ivana
AU - Pešić, Milica
AU - Milosavljević, Slobodan
AU - Todorović, Nina
AU - Jadranin, Milka
AU - Miosavljevic, Goran
AU - Povrenovic, Dragan
AU - Bankovic, Jasna
AU - Tanic, Nikola
AU - Markovic, Ivanka D.
AU - Ruzdijic, Sabera
AU - Vajs, Vlatka
AU - Tešević, Vele
PY - 2011
UR - http://cer.ihtm.bg.ac.rs/handle/123456789/883
AB - From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.
PB - American Chemical Society (ACS)
T2 - Journal of Natural Products
T1 - Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides
VL - 74
IS - 7
SP - 1613
EP - 1620
DO - 10.1021/np200241c
ER -
@article{
author = "Aljančić, Ivana and Pešić, Milica and Milosavljević, Slobodan and Todorović, Nina and Jadranin, Milka and Miosavljevic, Goran and Povrenovic, Dragan and Bankovic, Jasna and Tanic, Nikola and Markovic, Ivanka D. and Ruzdijic, Sabera and Vajs, Vlatka and Tešević, Vele",
year = "2011",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/883",
abstract = "From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.",
publisher = "American Chemical Society (ACS)",
journal = "Journal of Natural Products",
title = "Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides",
volume = "74",
number = "7",
pages = "1613-1620",
doi = "10.1021/np200241c"
}
Aljančić, I., Pešić, M., Milosavljević, S., Todorović, N., Jadranin, M., Miosavljevic, G., Povrenovic, D., Bankovic, J., Tanic, N., Markovic, I. D., Ruzdijic, S., Vajs, V.,& Tešević, V. (2011). Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides.
Journal of Natural Products
American Chemical Society (ACS)., 74(7), 1613-1620.
https://doi.org/10.1021/np200241c
Aljančić I, Pešić M, Milosavljević S, Todorović N, Jadranin M, Miosavljevic G, Povrenovic D, Bankovic J, Tanic N, Markovic ID, Ruzdijic S, Vajs V, Tešević V. Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides. Journal of Natural Products. 2011;74(7):1613-1620
Aljančić Ivana, Pešić Milica, Milosavljević Slobodan, Todorović Nina, Jadranin Milka, Miosavljevic Goran, Povrenovic Dragan, Bankovic Jasna, Tanic Nikola, Markovic Ivanka D., Ruzdijic Sabera, Vajs Vlatka, Tešević Vele, "Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides" Journal of Natural Products, 74, no. 7 (2011):1613-1620,
https://doi.org/10.1021/np200241c .
