Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides
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2011
Authors
Aljančić, IvanaPešić, Milica

Milosavljević, Slobodan

Todorović, Nina

Jadranin, Milka

Miosavljevic, Goran
Povrenovic, Dragan
Bankovic, Jasna
Tanic, Nikola
Markovic, Ivanka D.

Ruzdijic, Sabera
Vajs, Vlatka
Tešević, Vele

Article (Published version)

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From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.
Source:
Journal of Natural Products, 2011, 74, 7, 1613-1620Publisher:
- American Chemical Society (ACS)
Funding / projects:
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)
- Identification of predictive molecular markers for cancer progression, response to therapy and disease outcome (RS-41031)
DOI: 10.1021/np200241c
ISSN: 0163-3864
PubMed: 21707046
WoS: 000293036100009
Scopus: 2-s2.0-79960728011
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IHTMTY - JOUR AU - Aljančić, Ivana AU - Pešić, Milica AU - Milosavljević, Slobodan AU - Todorović, Nina AU - Jadranin, Milka AU - Miosavljevic, Goran AU - Povrenovic, Dragan AU - Bankovic, Jasna AU - Tanic, Nikola AU - Markovic, Ivanka D. AU - Ruzdijic, Sabera AU - Vajs, Vlatka AU - Tešević, Vele PY - 2011 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/883 AB - From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport. PB - American Chemical Society (ACS) T2 - Journal of Natural Products T1 - Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides VL - 74 IS - 7 SP - 1613 EP - 1620 DO - 10.1021/np200241c ER -
@article{ author = "Aljančić, Ivana and Pešić, Milica and Milosavljević, Slobodan and Todorović, Nina and Jadranin, Milka and Miosavljevic, Goran and Povrenovic, Dragan and Bankovic, Jasna and Tanic, Nikola and Markovic, Ivanka D. and Ruzdijic, Sabera and Vajs, Vlatka and Tešević, Vele", year = "2011", abstract = "From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.", publisher = "American Chemical Society (ACS)", journal = "Journal of Natural Products", title = "Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides", volume = "74", number = "7", pages = "1613-1620", doi = "10.1021/np200241c" }
Aljančić, I., Pešić, M., Milosavljević, S., Todorović, N., Jadranin, M., Miosavljevic, G., Povrenovic, D., Bankovic, J., Tanic, N., Markovic, I. D., Ruzdijic, S., Vajs, V.,& Tešević, V.. (2011). Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides. in Journal of Natural Products American Chemical Society (ACS)., 74(7), 1613-1620. https://doi.org/10.1021/np200241c
Aljančić I, Pešić M, Milosavljević S, Todorović N, Jadranin M, Miosavljevic G, Povrenovic D, Bankovic J, Tanic N, Markovic ID, Ruzdijic S, Vajs V, Tešević V. Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides. in Journal of Natural Products. 2011;74(7):1613-1620. doi:10.1021/np200241c .
Aljančić, Ivana, Pešić, Milica, Milosavljević, Slobodan, Todorović, Nina, Jadranin, Milka, Miosavljevic, Goran, Povrenovic, Dragan, Bankovic, Jasna, Tanic, Nikola, Markovic, Ivanka D., Ruzdijic, Sabera, Vajs, Vlatka, Tešević, Vele, "Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides" in Journal of Natural Products, 74, no. 7 (2011):1613-1620, https://doi.org/10.1021/np200241c . .