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Iron complexes of dietary flavonoids: Combined spectroscopic and mechanistic study of their free radical scavenging activity

Authorized Users Only
2011
Authors
Dimitrić Marković, Jasmina M.
Markovic, Zoran S.
Brdaric, Tanja P.
Pavelkić, Vesna
Jadranin, Milka
Article (Published version)
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Abstract
Combined spectroscopic (UV/visible, Raman, MS) and theoretical approaches were used to assess interaction of iron(III) with quercetin and baicalein in aqueous buffered solutions. Obtained results implicated formation of two iron quercetin complexes, with pH-dependent stoichiometries of 1:2 and 1:1, and one iron baicalein complex with stoichiometry of 1:1. Results of vibrational analysis and theoretical calculations implicated 3-hydroxy-4-carbonyl and the 3'-hydroxy-4'-hydroxy group of catechol as chelating sites for quercetin. For baicalein 5-hydroxy-6-hydroxy group is energetically the most favourable, although 5-hydroxy-4-carbonyl and 6-hydroxy-7-hydroxy chelating sites are energetically similar. Antiradical activity. reaction stoichiometry and number of inactivated DPPH molecules per mole of antioxidant indicated quercetin as a better antioxidant than its iron complex, baicalein and iron baicalein complex. The same structural features appeared to be important both in complexation an...d antioxidant activity. The equilibrium geometries, optimised using the B3LYP/6-31G (d, p) level of theory, predicted structural modifications between the ligand molecules in free state and in the complex structures. Correlation between experimental and theoretical results was very good.

Keywords:
Baicalein / Quercetin / Iron(III) complex formation / Electronic, mass and Raman spectra / DPPH test / B3LYP/6-31G (d, p) level of theory
Source:
Food Chemistry, 2011, 129, 4, 1567-1577
Publisher:
  • Elsevier Sci Ltd, Oxford
Funding / projects:
  • Dynamics of nonlinear physicochemical and biochemical systems with modeling and predicting of their behavior under nonequilibrium conditions (RS-172015)

DOI: 10.1016/j.foodchem.2011.06.008

ISSN: 0308-8146

WoS: 000294979600033

Scopus: 2-s2.0-80051795142
[ Google Scholar ]
41
37
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/857
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Dimitrić Marković, Jasmina M.
AU  - Markovic, Zoran S.
AU  - Brdaric, Tanja P.
AU  - Pavelkić, Vesna
AU  - Jadranin, Milka
PY  - 2011
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/857
AB  - Combined spectroscopic (UV/visible, Raman, MS) and theoretical approaches were used to assess interaction of iron(III) with quercetin and baicalein in aqueous buffered solutions. Obtained results implicated formation of two iron quercetin complexes, with pH-dependent stoichiometries of 1:2 and 1:1, and one iron baicalein complex with stoichiometry of 1:1. Results of vibrational analysis and theoretical calculations implicated 3-hydroxy-4-carbonyl and the 3'-hydroxy-4'-hydroxy group of catechol as chelating sites for quercetin. For baicalein 5-hydroxy-6-hydroxy group is energetically the most favourable, although 5-hydroxy-4-carbonyl and 6-hydroxy-7-hydroxy chelating sites are energetically similar. Antiradical activity. reaction stoichiometry and number of inactivated DPPH molecules per mole of antioxidant indicated quercetin as a better antioxidant than its iron complex, baicalein and iron baicalein complex. The same structural features appeared to be important both in complexation and antioxidant activity. The equilibrium geometries, optimised using the B3LYP/6-31G (d, p) level of theory, predicted structural modifications between the ligand molecules in free state and in the complex structures. Correlation between experimental and theoretical results was very good.
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Chemistry
T1  - Iron complexes of dietary flavonoids: Combined spectroscopic and mechanistic study of their free radical scavenging activity
VL  - 129
IS  - 4
SP  - 1567
EP  - 1577
DO  - 10.1016/j.foodchem.2011.06.008
UR  - Conv_2657
ER  - 
@article{
author = "Dimitrić Marković, Jasmina M. and Markovic, Zoran S. and Brdaric, Tanja P. and Pavelkić, Vesna and Jadranin, Milka",
year = "2011",
abstract = "Combined spectroscopic (UV/visible, Raman, MS) and theoretical approaches were used to assess interaction of iron(III) with quercetin and baicalein in aqueous buffered solutions. Obtained results implicated formation of two iron quercetin complexes, with pH-dependent stoichiometries of 1:2 and 1:1, and one iron baicalein complex with stoichiometry of 1:1. Results of vibrational analysis and theoretical calculations implicated 3-hydroxy-4-carbonyl and the 3'-hydroxy-4'-hydroxy group of catechol as chelating sites for quercetin. For baicalein 5-hydroxy-6-hydroxy group is energetically the most favourable, although 5-hydroxy-4-carbonyl and 6-hydroxy-7-hydroxy chelating sites are energetically similar. Antiradical activity. reaction stoichiometry and number of inactivated DPPH molecules per mole of antioxidant indicated quercetin as a better antioxidant than its iron complex, baicalein and iron baicalein complex. The same structural features appeared to be important both in complexation and antioxidant activity. The equilibrium geometries, optimised using the B3LYP/6-31G (d, p) level of theory, predicted structural modifications between the ligand molecules in free state and in the complex structures. Correlation between experimental and theoretical results was very good.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Chemistry",
title = "Iron complexes of dietary flavonoids: Combined spectroscopic and mechanistic study of their free radical scavenging activity",
volume = "129",
number = "4",
pages = "1567-1577",
doi = "10.1016/j.foodchem.2011.06.008",
url = "Conv_2657"
}
Dimitrić Marković, J. M., Markovic, Z. S., Brdaric, T. P., Pavelkić, V.,& Jadranin, M.. (2011). Iron complexes of dietary flavonoids: Combined spectroscopic and mechanistic study of their free radical scavenging activity. in Food Chemistry
Elsevier Sci Ltd, Oxford., 129(4), 1567-1577.
https://doi.org/10.1016/j.foodchem.2011.06.008
Conv_2657
Dimitrić Marković JM, Markovic ZS, Brdaric TP, Pavelkić V, Jadranin M. Iron complexes of dietary flavonoids: Combined spectroscopic and mechanistic study of their free radical scavenging activity. in Food Chemistry. 2011;129(4):1567-1577.
doi:10.1016/j.foodchem.2011.06.008
Conv_2657 .
Dimitrić Marković, Jasmina M., Markovic, Zoran S., Brdaric, Tanja P., Pavelkić, Vesna, Jadranin, Milka, "Iron complexes of dietary flavonoids: Combined spectroscopic and mechanistic study of their free radical scavenging activity" in Food Chemistry, 129, no. 4 (2011):1567-1577,
https://doi.org/10.1016/j.foodchem.2011.06.008 .,
Conv_2657 .

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