Приказ основних података о документу

dc.creatorGođevac, Dejan
dc.creatorTešević, Vele
dc.creatorVajs, Vlatka
dc.creatorMilosavljević, Slobodan
dc.creatorStanković, Miroslava
dc.date.accessioned2019-01-30T17:27:15Z
dc.date.available2019-01-30T17:27:15Z
dc.date.issued2011
dc.identifier.issn0022-1147
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/854
dc.description.abstractThe tentative identification of seed extracts from 3 cultivars of blackberry (blackberry seed extracts [BSEs]) constituents was performed by LC/UV/MS technique. The identified compounds belonged to ellagitannins, galic acid derivatives, and ellagic acid derivatives. Two ellagitannins, Lambertianin C and Sanguiniin H-6, and an ellagic acid derivative, 4-alpha-L-arabinofuranosylellagic acid, were isolated using semipreparative High-performance liquid chromatography. The structure elucidations were based on high resolution-mass spectrometry and nuclear magnetic resonance studies. The BSEs and 3 isolated pure compounds were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (MN) assay. The frequency of MN was scored in binucleated cells, and nuclear proliferation index was calculated. Among the tested extracts, the seeds of cv. Thornfree at concentration of 1 mu g/mL exhibit the most prominent effect decreasing the frequency of MN by 62.4%, when compared with the controls cell cultures. Antioxidant potential of pure ellagitannins cannot explain the strong effect of BSEs. The assumption was that better antioxidant effect of BSEs result from synergistic effects of individual compounds contained in the extracts and/or some minor components possessed strong activity.en
dc.publisherWiley-Blackwell, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Food Science
dc.subjectblackberryen
dc.subjectisolationen
dc.subjectlymphocytesen
dc.subjectmicronucleusen
dc.subjectpolyphenolicsen
dc.titleBlackberry Seed Extracts and Isolated Polyphenolic Compounds Showing Protective Effect on Human Lymphocytes DNAen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГођевац, Дејан; Милосављевиц, Слободан; Вајс, Влатка; Станковиц, Мирослава; Тесевиц, Веле;
dc.citation.volume76
dc.citation.issue7
dc.citation.other76(7):
dc.citation.rankM22
dc.identifier.pmid21824137
dc.identifier.doi10.1111/j.1750-3841.2011.02305.x
dc.identifier.scopus2-s2.0-80053052117
dc.identifier.wos000295076000006
dc.type.versionpublishedVersion


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Приказ основних података о документу